James R Lambert

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth
    James R Lambert
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Cell Physiol 208:566-74. 2006
  2. pmc Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation
    David L Bain
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Nucleic Acids Res 42:691-700. 2014
  3. doi request reprint p53 controls prostate-derived factor/macrophage inhibitory cytokine/NSAID-activated gene expression in response to cell density, DNA damage and hypoxia through diverse mechanisms
    Julie A Kelly
    Department of Pathology, University of Colorado Denver, 12801 E 17th Avenue, Aurora, CO 80045, USA
    Cancer Lett 277:38-47. 2009
  4. pmc Analysis of a glucocorticoid-estrogen receptor chimera reveals that dimerization energetics are under ionic control
    Keith D Connaghan
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Biophys Chem 172:8-17. 2013
  5. ncbi request reprint Aberrant HOXC expression accompanies the malignant phenotype in human prostate
    Gary J Miller
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cancer Res 63:5879-88. 2003
  6. doi request reprint HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes
    Sunshine Daddario Axlund
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, 12801 E 17th Ave, Aurora, CO 80045, USA
    Mol Cancer Res 8:1643-55. 2010
  7. ncbi request reprint Mechanistic and pharmacodynamic studies of a 25-hydroxyvitamin D3 derivative in prostate cancer cells
    James R Lambert
    Department of Pathology, University of Colorado Health Science Center, Aurora, CO, USA
    Biochem Biophys Res Commun 361:189-95. 2007
  8. pmc Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin
    Steven K Nordeen
    Department of Pathology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Horm Cancer 4:293-300. 2013
  9. doi request reprint Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2)
    Ramon J Whitson
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Cell Biochem 114:1424-33. 2013
  10. doi request reprint Glucocorticoid receptor-DNA interactions: binding energetics are the primary determinant of sequence-specific transcriptional activity
    David L Bain
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    J Mol Biol 422:18-32. 2012

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth
    James R Lambert
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Cell Physiol 208:566-74. 2006
    ..These data demonstrate that PDF exerts antitumorigenic properties on PCa cells and its regulation by 1,25D may provide insights into the action of 1,25D in PCa...
  2. pmc Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation
    David L Bain
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Nucleic Acids Res 42:691-700. 2014
    ..Finally, we examine the implications of these findings for considering the unique gene regulatory properties of the individual receptors. ..
  3. doi request reprint p53 controls prostate-derived factor/macrophage inhibitory cytokine/NSAID-activated gene expression in response to cell density, DNA damage and hypoxia through diverse mechanisms
    Julie A Kelly
    Department of Pathology, University of Colorado Denver, 12801 E 17th Avenue, Aurora, CO 80045, USA
    Cancer Lett 277:38-47. 2009
    ..Thus, PDF may represent a novel target of p53 in response to cell stress...
  4. pmc Analysis of a glucocorticoid-estrogen receptor chimera reveals that dimerization energetics are under ionic control
    Keith D Connaghan
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Biophys Chem 172:8-17. 2013
    ..Since the ER-╬▒ HBD is the primary contributor to dimerization, we suggest that GR residues constrain an ion-regulated HBD assembly reaction...
  5. ncbi request reprint Aberrant HOXC expression accompanies the malignant phenotype in human prostate
    Gary J Miller
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cancer Res 63:5879-88. 2003
    ..We speculate that HOXC overexpression may predispose tumor cells to androgen independence by necessitating adaptation to diminished androgen signaling...
  6. doi request reprint HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes
    Sunshine Daddario Axlund
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, 12801 E 17th Ave, Aurora, CO 80045, USA
    Mol Cancer Res 8:1643-55. 2010
    ..A greater understanding of HOXC8 actions in the prostate and its interactions with androgen signaling pathways may elucidate mechanisms driving the onset and progression of prostate cancer...
  7. ncbi request reprint Mechanistic and pharmacodynamic studies of a 25-hydroxyvitamin D3 derivative in prostate cancer cells
    James R Lambert
    Department of Pathology, University of Colorado Health Science Center, Aurora, CO, USA
    Biochem Biophys Res Commun 361:189-95. 2007
    ..Furthermore, we carried out cellular uptake and serum stability studies of 25-OH-D(3)-3-BE to demonstrate potential therapeutic applicability of 25-OH-D(3)-3-BE in hormone-sensitive and hormone-insensitive prostate cancer...
  8. pmc Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin
    Steven K Nordeen
    Department of Pathology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Horm Cancer 4:293-300. 2013
    ..These results highlight the promise and peril of flavonoid nutraceuticals and suggest caution in supplementation beyond levels attained in a healthy, plant-rich diet. ..
  9. doi request reprint Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2)
    Ramon J Whitson
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Cell Biochem 114:1424-33. 2013
    ..Furthermore, antagonism of CCN2 mediated angiogenesis by GDF-15 may provide insight into the functional role of GDF-15 in disease states...
  10. doi request reprint Glucocorticoid receptor-DNA interactions: binding energetics are the primary determinant of sequence-specific transcriptional activity
    David L Bain
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    J Mol Biol 422:18-32. 2012
    ..Thus, despite the complexity of GR function, DNA binding energetics are the primary determinant of sequence-specific transcriptional activity...
  11. ncbi request reprint Growth factors in benign prostatic hyperplasia: basic science implications
    M Scott Lucia
    Department of Pathology, University of Colorado DHSC, 12800 East 19th Avenue, PO Box 6511, Aurora, CO 80045, USA
    Curr Urol Rep 9:272-8. 2008
    ..As we begin to unravel the precise mechanisms involved, new treatments for BPH aimed at these interacting pathways may emerge...
  12. ncbi request reprint Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells
    Vanessa Soto-Cerrato
    Department of Pathology and Experimental Therapeutics, Cancer Cell Biology Research Group, Universitat de Barcelona, Pavell├│ Central, 5a planta, LR 5101 C Feixa Llarga s n, E 08907 L Hospitalet, Barcelona, Spain
    Mol Cancer Ther 6:362-9. 2007
    ..These findings suggest that prodigiosin-mediated GSK-3beta activation is a key event in regulating the molecular pathways that trigger the apoptosis induced by this anticancer agent...
  13. ncbi request reprint The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway
    Vanessa Soto-Cerrato
    Department of Pathology and Experimental Therapeutics, Cancer Cell Biology Research Group, Universitat de Barcelona, and Laboratori de Recerca Translacional, ICO IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Biochem Pharmacol 74:1340-9. 2007
    ..Taken together, these results suggest the TGF-beta pathway is required for induction of p21 expression after prodigiosin treatment of MCF-7 cells...