Alice D Lam

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions
    Alice D Lam
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Biol Cell 19:485-97. 2008
  2. ncbi Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation
    Antionette L Williams
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:14542-53. 2011
  3. ncbi Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET
    Alice D Lam
    Department of Molecular and Integrative Physiology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 99:1311-20. 2010
  4. ncbi Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking
    Matthew D'Andrea-Merrins
    Department of Molecular and Integrative Physiology, Life Sciences Institute, University of Michigan, Ann Arbor 48109 0622, USA
    J Biol Chem 282:16553-66. 2007
  5. ncbi Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells
    Svetlana E Gladycheva
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:22887-99. 2007

Research Grants

  1. Defining the Role of Lipid Rafts in Neurotransmission
    ALICE LAM; Fiscal Year: 2007

Collaborators

  • Nicolas Vitale
  • Svetlana E Gladycheva
  • Antionette L Williams
  • Stephen A Ernst
  • Edward L Stuenkel
  • Matthew D'Andrea-Merrins
  • Noa Bielopolski
  • Daphna Meroz
  • Nir Ben-Tal
  • Daniel R Passmore
  • Uri Ashery
  • Louise Chang

Detail Information

Publications5

  1. ncbi SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions
    Alice D Lam
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Biol Cell 19:485-97. 2008
    ..Altogether, these data suggest that Syntaxin1A-lipid interactions are a critical determinant of the energetics of SNARE-catalyzed fusion events...
  2. ncbi Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation
    Antionette L Williams
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:14542-53. 2011
    ..Together these results suggest that multiple domains outside the R-SNARE of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion...
  3. ncbi Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET
    Alice D Lam
    Department of Molecular and Integrative Physiology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 99:1311-20. 2010
    ..These results demonstrate an initial spatiotemporal mapping of a dynamic protein-protein interaction on individual secretory granules that is linked to a specific granule behavior in living cells...
  4. ncbi Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking
    Matthew D'Andrea-Merrins
    Department of Molecular and Integrative Physiology, Life Sciences Institute, University of Michigan, Ann Arbor 48109 0622, USA
    J Biol Chem 282:16553-66. 2007
    ..Therefore, in contradiction to previous models, our data indicates that the conformational "opening" of syntaxin 4 rather than the dissociation of Munc18c is the critical event required for GLUT4 vesicle docking...
  5. ncbi Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells
    Svetlana E Gladycheva
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:22887-99. 2007
    ..Thus, modulation of the tomosyn-syntaxin 1A interaction in response to secretagogue activation is an important mechanism allowing for dynamic regulation of the secretory response...

Research Grants1

  1. Defining the Role of Lipid Rafts in Neurotransmission
    ALICE LAM; Fiscal Year: 2007
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