Affiliation: University of Wisconsin
- The aging respiratory system--pulmonary structure, function and neural controlPeter M Lalley
Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
Respir Physiol Neurobiol 187:199-210. 2013..Nervous system adaptations that accompany structural and functional changes in the elderly are poorly understood...
- D1/D2-dopamine receptor agonist dihydrexidine stimulates inspiratory motor output and depresses medullary expiratory neuronsPeter M Lalley
Department of Physiology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
Am J Physiol Regul Integr Comp Physiol 296:R1829-36. 2009..The stimulatory action of DHD on inspiratory motor output is attributed to D1R effects, while the depression of Aug-E neurons seems to be linked to D2R actions on the postsynaptic membrane...
- Opioidergic and dopaminergic modulation of respirationPeter M Lalley
Department of Physiology, The University of Wisconsin School of Medicine and Public Health, Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
Respir Physiol Neurobiol 164:160-7. 2008..Cellular targets and intracellular mechanisms responsible for opioidergic and dopaminergic respiratory effects for the most part remain to be determined...
- Post-inspiratory discharges are the centrepiece of respiratory disrhythmia in a gene knockout model of Rett syndromePeter M Lalley
Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
J Physiol 579:565. 2007
- Opiate slowing of feline respiratory rhythm and effects on putative medullary phase-regulating neuronsPeter M Lalley
Dept of Physiology, Medical Sciences Center, Univ of Wisconsin, 1300 Univ Ave, Madison, WI 53706, USA
Am J Physiol Regul Integr Comp Physiol 290:R1387-96. 2006....
- D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the catPeter M Lalley
The University of Wisconsin, Department of Physiology, Medical Sciences Center, 1300 Univ Ave, Madison, WI 53706, USA
Am J Physiol Regul Integr Comp Physiol 289:R45-51. 2005..The results suggest that D(1)R agonists might be therapeutically useful for the treatment of opioid disturbances of breathing without impeding analgesia...
- D1-dopamine receptor blockade slows respiratory rhythm and enhances opioid-mediated depressionPeter M Lalley
The University of Wisconsin Madison, Medical Sciences Center, Department of Physiology, 1300 University Avenue, 127 Service Memorial Institute, Madison, WI 53706, USA
Respir Physiol Neurobiol 145:13-22. 2005....
- Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivityPeter M Lalley
Department of Physiology, Medical Sciences Center, The University of Wisconsin, Madison, 1300 University Avenue, Madison, WI 53706, USA
Respir Physiol Neurobiol 139:247-62. 2004..Intravenous fentanyl on the other hand decreased CO(2) reactivity by shifting the phrenic nerve apnea threshold and the response curve to higher et(CO(2)) levels. Fentanyl effects on reactivity were partially reversed by D(1)R agonists...
- Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbancesPeter M Lalley
Department of Physiology, The University of Wisconsin, Madison, Wisconsin 53706m, USA
Am J Physiol Regul Integr Comp Physiol 285:R1287-304. 2003..Opioid effects on the respiratory neurons were similar in anesthetized and decerebrate preparations...
- Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammalsPeter M Lalley
J Appl Physiol 103:724; author reply 726-7. 2007
- Serotonergic modulation of intracellular calcium dynamics in neonatal hypoglossal motoneurons from mouseThomas Ladewig
Georg August Universitat Gottingen, Zentrum Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Brain Res 1001:1-12. 2004..Taken together, our results therefore identify 5HT-dependent signal pathways as a versatile tool to modulate hypoglossal motoneuron excitability under various physiological and pathophysiological conditions...
- Spatial profiles of store-dependent calcium release in motoneurones of the nucleus hypoglossus from newborn mouseThomas Ladewig
Centre of Physiology, Humboldtallee 23, University of Gottingen, 37073 Gottingen, Germany
J Physiol 547:775-87. 2003..This might expose HMN to exceptional risks during pathophysiological organelle disruptions and other ALS-related, cellular disturbances...
- OPIOID DEPRESSION OF RESPIRATORY NEURONSPETER LALLEY; Fiscal Year: 2003..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..