PETER LALLEY

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi request reprint The aging respiratory system--pulmonary structure, function and neural control
    Peter M Lalley
    Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Respir Physiol Neurobiol 187:199-210. 2013
  2. pmc D1/D2-dopamine receptor agonist dihydrexidine stimulates inspiratory motor output and depresses medullary expiratory neurons
    Peter M Lalley
    Department of Physiology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1829-36. 2009
  3. pmc Opioidergic and dopaminergic modulation of respiration
    Peter M Lalley
    Department of Physiology, The University of Wisconsin School of Medicine and Public Health, Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Respir Physiol Neurobiol 164:160-7. 2008
  4. pmc Post-inspiratory discharges are the centrepiece of respiratory disrhythmia in a gene knockout model of Rett syndrome
    Peter M Lalley
    Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Physiol 579:565. 2007
  5. ncbi request reprint Opiate slowing of feline respiratory rhythm and effects on putative medullary phase-regulating neurons
    Peter M Lalley
    Dept of Physiology, Medical Sciences Center, Univ of Wisconsin, 1300 Univ Ave, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1387-96. 2006
  6. ncbi request reprint D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the cat
    Peter M Lalley
    The University of Wisconsin, Department of Physiology, Medical Sciences Center, 1300 Univ Ave, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 289:R45-51. 2005
  7. ncbi request reprint D1-dopamine receptor blockade slows respiratory rhythm and enhances opioid-mediated depression
    Peter M Lalley
    The University of Wisconsin Madison, Medical Sciences Center, Department of Physiology, 1300 University Avenue, 127 Service Memorial Institute, Madison, WI 53706, USA
    Respir Physiol Neurobiol 145:13-22. 2005
  8. ncbi request reprint Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivity
    Peter M Lalley
    Department of Physiology, Medical Sciences Center, The University of Wisconsin, Madison, 1300 University Avenue, Madison, WI 53706, USA
    Respir Physiol Neurobiol 139:247-62. 2004
  9. ncbi request reprint Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances
    Peter M Lalley
    Department of Physiology, The University of Wisconsin, Madison, Wisconsin 53706m, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1287-304. 2003
  10. ncbi request reprint Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
    Peter M Lalley
    J Appl Physiol 103:724; author reply 726-7. 2007

Research Grants

  1. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003

Collaborators

Detail Information

Publications12

  1. doi request reprint The aging respiratory system--pulmonary structure, function and neural control
    Peter M Lalley
    Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Respir Physiol Neurobiol 187:199-210. 2013
    ..Nervous system adaptations that accompany structural and functional changes in the elderly are poorly understood...
  2. pmc D1/D2-dopamine receptor agonist dihydrexidine stimulates inspiratory motor output and depresses medullary expiratory neurons
    Peter M Lalley
    Department of Physiology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1829-36. 2009
    ..The stimulatory action of DHD on inspiratory motor output is attributed to D1R effects, while the depression of Aug-E neurons seems to be linked to D2R actions on the postsynaptic membrane...
  3. pmc Opioidergic and dopaminergic modulation of respiration
    Peter M Lalley
    Department of Physiology, The University of Wisconsin School of Medicine and Public Health, Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Respir Physiol Neurobiol 164:160-7. 2008
    ..Cellular targets and intracellular mechanisms responsible for opioidergic and dopaminergic respiratory effects for the most part remain to be determined...
  4. pmc Post-inspiratory discharges are the centrepiece of respiratory disrhythmia in a gene knockout model of Rett syndrome
    Peter M Lalley
    Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Physiol 579:565. 2007
  5. ncbi request reprint Opiate slowing of feline respiratory rhythm and effects on putative medullary phase-regulating neurons
    Peter M Lalley
    Dept of Physiology, Medical Sciences Center, Univ of Wisconsin, 1300 Univ Ave, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1387-96. 2006
    ....
  6. ncbi request reprint D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the cat
    Peter M Lalley
    The University of Wisconsin, Department of Physiology, Medical Sciences Center, 1300 Univ Ave, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 289:R45-51. 2005
    ..The results suggest that D(1)R agonists might be therapeutically useful for the treatment of opioid disturbances of breathing without impeding analgesia...
  7. ncbi request reprint D1-dopamine receptor blockade slows respiratory rhythm and enhances opioid-mediated depression
    Peter M Lalley
    The University of Wisconsin Madison, Medical Sciences Center, Department of Physiology, 1300 University Avenue, 127 Service Memorial Institute, Madison, WI 53706, USA
    Respir Physiol Neurobiol 145:13-22. 2005
    ....
  8. ncbi request reprint Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivity
    Peter M Lalley
    Department of Physiology, Medical Sciences Center, The University of Wisconsin, Madison, 1300 University Avenue, Madison, WI 53706, USA
    Respir Physiol Neurobiol 139:247-62. 2004
    ..Intravenous fentanyl on the other hand decreased CO(2) reactivity by shifting the phrenic nerve apnea threshold and the response curve to higher et(CO(2)) levels. Fentanyl effects on reactivity were partially reversed by D(1)R agonists...
  9. ncbi request reprint Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances
    Peter M Lalley
    Department of Physiology, The University of Wisconsin, Madison, Wisconsin 53706m, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1287-304. 2003
    ..Opioid effects on the respiratory neurons were similar in anesthetized and decerebrate preparations...
  10. ncbi request reprint Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
    Peter M Lalley
    J Appl Physiol 103:724; author reply 726-7. 2007
  11. ncbi request reprint Serotonergic modulation of intracellular calcium dynamics in neonatal hypoglossal motoneurons from mouse
    Thomas Ladewig
    Georg August Universitat Gottingen, Zentrum Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Brain Res 1001:1-12. 2004
    ..Taken together, our results therefore identify 5HT-dependent signal pathways as a versatile tool to modulate hypoglossal motoneuron excitability under various physiological and pathophysiological conditions...
  12. pmc Spatial profiles of store-dependent calcium release in motoneurones of the nucleus hypoglossus from newborn mouse
    Thomas Ladewig
    Centre of Physiology, Humboldtallee 23, University of Gottingen, 37073 Gottingen, Germany
    J Physiol 547:775-87. 2003
    ..This might expose HMN to exceptional risks during pathophysiological organelle disruptions and other ALS-related, cellular disturbances...

Research Grants4

  1. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003
    ..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..