Rajesh V Lalla

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. doi request reprint A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy
    Rajesh V Lalla
    Section of Oral Medicine and Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT, USA
    Support Care Cancer 20:1797-804. 2012
  2. ncbi request reprint Identification of a region of the fibrin molecule involved in upregulation of interleukin-8 expression from human oral squamous cell carcinoma cells
    Rajesh V Lalla
    Department of Oral Diagnosis, Division of Oral Medicine, University of Connecticut School of Dental Medicine, Farmington, CT 06030, USA
    Arch Oral Biol 48:263-71. 2003
  3. pmc Management of oral mucositis in patients who have cancer
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center MC 1605, 263 Farmington Avenue, Farmington, CT 06030, USA
    Dent Clin North Am 52:61-77, viii. 2008
  4. ncbi request reprint Treatment of mucositis, including new medications
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences and the Head and Neck Oral Oncology Program, Neag Comprehensive Cancer Center University of Connecticut Health Center, Farmington, CT 06030, USA
    Cancer J 12:348-54. 2006
  5. ncbi request reprint Anti-inflammatory agents in the management of alimentary mucositis
    Rajesh V Lalla
    Department of Oral Health and Diagnostic Sciences MC1605, University of Connecticut Health Center, 263, Farmington Avenue, Farmington, 06030 1605, USA
    Support Care Cancer 14:558-65. 2006
  6. ncbi request reprint Velafermin (CuraGen)
    Rajesh V Lalla
    Department of Oral Health and Diagnostic Sciences MC1605, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
    Curr Opin Investig Drugs 6:1179-85. 2005
  7. ncbi request reprint Oral mucositis
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Diagnosis, University of Connecticut School of Dental Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Dent Clin North Am 49:167-84, ix. 2005
  8. pmc Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial
    Rajesh V Lalla
    Section of Oral Medicine, University of Connecticut Health Center, Farmington, Conn 06030 1605, USA
    J Am Dent Assoc 143:370-6. 2012
  9. pmc Association between interactive voice response adherence and subject retention in a randomized controlled trial
    Christopher S Gatehouse
    School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1605, USA
    Contemp Clin Trials 33:589-92. 2012
  10. ncbi request reprint Association of fibrin and interleukin 8 in human oral squamous cell carcinoma
    Rajesh V Lalla
    University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:452-7. 2003

Research Grants

Detail Information

Publications24

  1. doi request reprint A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy
    Rajesh V Lalla
    Section of Oral Medicine and Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT, USA
    Support Care Cancer 20:1797-804. 2012
    ..The objective of this study was to evaluate the efficacy of misoprostol oral rinse in reducing the severity of oral mucosal injury caused by high-dose chemotherapy...
  2. ncbi request reprint Identification of a region of the fibrin molecule involved in upregulation of interleukin-8 expression from human oral squamous cell carcinoma cells
    Rajesh V Lalla
    Department of Oral Diagnosis, Division of Oral Medicine, University of Connecticut School of Dental Medicine, Farmington, CT 06030, USA
    Arch Oral Biol 48:263-71. 2003
    ..Future studies to further characterise the role of the Bbeta15-42 region in tumour cell activation may lead to the design of peptide antagonists with important therapeutic potential...
  3. pmc Management of oral mucositis in patients who have cancer
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center MC 1605, 263 Farmington Avenue, Farmington, CT 06030, USA
    Dent Clin North Am 52:61-77, viii. 2008
    ..These agents are discussed in the context of recently updated evidence-based clinical management guidelines...
  4. ncbi request reprint Treatment of mucositis, including new medications
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences and the Head and Neck Oral Oncology Program, Neag Comprehensive Cancer Center University of Connecticut Health Center, Farmington, CT 06030, USA
    Cancer J 12:348-54. 2006
    ..In addition, several agents in clinical development for mucositis are discussed in the context of the current pathobiologic model as well as the recently updated evidence-based clinical management guidelines...
  5. ncbi request reprint Anti-inflammatory agents in the management of alimentary mucositis
    Rajesh V Lalla
    Department of Oral Health and Diagnostic Sciences MC1605, University of Connecticut Health Center, 263, Farmington Avenue, Farmington, 06030 1605, USA
    Support Care Cancer 14:558-65. 2006
    ..Alimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications...
  6. ncbi request reprint Velafermin (CuraGen)
    Rajesh V Lalla
    Department of Oral Health and Diagnostic Sciences MC1605, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
    Curr Opin Investig Drugs 6:1179-85. 2005
    ....
  7. ncbi request reprint Oral mucositis
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Diagnosis, University of Connecticut School of Dental Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Dent Clin North Am 49:167-84, ix. 2005
    ..This article reviews the current knowledge on the pathogenesis, clinical presentation, diagnosis, and management of oral mucositis...
  8. pmc Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial
    Rajesh V Lalla
    Section of Oral Medicine, University of Connecticut Health Center, Farmington, Conn 06030 1605, USA
    J Am Dent Assoc 143:370-6. 2012
    ..Recurrent aphthous stomatitis (RAS) is a painful condition of unknown etiology, affecting more than 2.5 billion people worldwide. Vitamin deficiencies have been implicated as a possible cause...
  9. pmc Association between interactive voice response adherence and subject retention in a randomized controlled trial
    Christopher S Gatehouse
    School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1605, USA
    Contemp Clin Trials 33:589-92. 2012
    ..Interactive voice response (IVR) technology uses the telephone to collect patient reports. This study examined whether IVR adherence during a year-long clinical trial was related to subject retention in the trial...
  10. ncbi request reprint Association of fibrin and interleukin 8 in human oral squamous cell carcinoma
    Rajesh V Lalla
    University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:452-7. 2003
    ..In this study we begin to test the hypothesis that fibrin induces IL-8 expression from tumor cells in vivo by studying their in vivo association in OSCC...
  11. pmc Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study
    Rajesh V Lalla
    Section of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Head and Neck Oral Oncology Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, MC 1605, Room L6062, 263, Farmington Avenue, Farmington, CT 06030, USA
    Support Care Cancer 18:95-103. 2010
    ..The objective of this small (n = 3) pilot study was to examine the role of the COX pathway in causing mucosal injury and pain in chemotherapy-induced oral mucositis...
  12. ncbi request reprint Expression of vascular endothelial growth factor receptors on tumor cells in head and neck squamous cell carcinoma
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington, Conn, USA
    Arch Otolaryngol Head Neck Surg 129:882-8. 2003
    ..We hypothesize that VEGFRs are also expressed on HNSCC tumor cells in vitro and in vivo and likely control tumor function in vivo...
  13. doi request reprint Supportive care treatment guidelines: value, limitations, and opportunities
    Douglas E Peterson
    Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030 1605, USA
    Semin Oncol 38:367-73. 2011
    ....
  14. doi request reprint Development of the MASCC/ISOO Clinical Practice Guidelines for Mucositis: considerations underlying the process
    Sharon Elad
    Division of Oral Medicine, Eastman Institute for Oral Medicine, University of Rochester Medical Center, 625 Elmwood Ave, Rochester, NY 14620, USA
    Support Care Cancer 21:309-12. 2013
    ..Here, we discuss the details of some considerations underlying the process used...
  15. pmc Oral mucositis: the new paradigms
    Douglas E Peterson
    Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine and Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, Connecticut 06030 1605, USA
    Curr Opin Oncol 22:318-22. 2010
    ..This review addresses recent advances regarding mucosal injury in cancer patients, with emphasis on symptom clusters, genetically based tissue susceptibility and risk prediction, imaging technology, and computational biology...
  16. pmc A systematic review of oral fungal infections in patients receiving cancer therapy
    Rajesh V Lalla
    University of Connecticut Health Center, Farmington, CT 06030, USA
    Support Care Cancer 18:985-92. 2010
    ....
  17. ncbi request reprint Oral candidiasis: pathogenesis, clinical presentation, diagnosis and treatment strategies
    Rajesh V Lalla
    Section of Oral Medicine, University of Connecticut School of Dental Medicine, USA
    J Calif Dent Assoc 41:263-8. 2013
    ..This article reviews the pathogenesis, clinical presentations, diagnosis and treatmentstrategies for oral candidiasis...
  18. doi request reprint Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy
    Douglas E Peterson
    Section of Oral Medicine, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine and Program in Head and Neck Cancer and Oral Oncology, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030 1605, USA
    Support Care Cancer 21:327-32. 2013
    ..This systematic review analyzed the strength of the literature and defined clinical practice guidelines for the use of oral cryotherapy for the prevention and/or treatment of oral mucositis caused by cancer therapy...
  19. pmc Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis
    Laura B Huling
    School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA
    J Oral Pathol Med 41:149-52. 2012
    ..The goal of this study was to examine the relationship between the occurrence, type, and magnitude of stressful events and the onset and duration of RAS episodes...
  20. pmc Miconazole mucoadhesive tablet for oropharyngeal candidiasis
    Rajesh V Lalla
    Section of Oral Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
    Expert Rev Anti Infect Ther 9:13-7. 2011
    ..This tablet adheres to the oral mucosa and provides sustained local release of miconazole over a period of several hours with just one daily application. This article reviews the pharmacology, safety and efficacy of this novel agent...
  21. ncbi request reprint Antifungal medications or disinfectants for denture stomatitis
    Rajesh V Lalla
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT, USA
    Evid Based Dent 15:61-2. 2014
    ..04-1.04; Z=-1.9; p=0.056).ConclusionsThe findings of this review and meta-analysis suggest that disinfection methods could be considered as an adjunct or alternative to antifungal medications in the treatment of denture stomatitis. ..
  22. doi request reprint Chemotherapy or radiation-induced oral mucositis
    Rajesh V Lalla
    Section of Oral Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA Electronic address
    Dent Clin North Am 58:341-9. 2014
    ..Evidence-based clinical practice guidelines are available to guide clinicians in the selection of effective management strategies. ..
  23. pmc Electronic versus paper diaries: a pilot study of concordance and adherence in head and neck cancer patients receiving radiation therapy
    Joseph M Blondin
    School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Head Neck Oncol 2:29. 2010
    ..However, these methods have not been compared in head and neck (H&N) cancer patients receiving radiation therapy...
  24. ncbi request reprint Amifostine in the management of radiation-induced and chemo-induced mucositis
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, 33 av de Valombrose, 06189, Nice, Cedex 2, France
    Support Care Cancer 14:566-72. 2006
    ..The goal of this literature review is to update previously published guidelines for the management of mucositis...

Research Grants2

  1. COX-2 Inhibition in Radiation-induced Oral Mucositis
    RAJESH LALLA; Fiscal Year: 2007
    ..2. To examine mechanisms leading to mucosal injury in radiation-induced OM and effects of the selective COX-2 inhibitor on these mechanisms. ..