Satyan Lakshminrusimha

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, New York, USA
    J Appl Physiol 111:1441-7. 2011
  2. pmc The pulmonary circulation in neonatal respiratory failure
    Satyan Lakshminrusimha
    Division of Neonatology, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    Clin Perinatol 39:655-83. 2012
  3. pmc Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Pediatr Res 62:313-8. 2007
  4. doi request reprint Use of CT angiography in the diagnosis of total anomalous venous return
    S Lakshminrusimha
    Division of Neonatology, State University of New York at Buffalo, Buffalo, NY, USA
    J Perinatol 29:458-61. 2009
  5. pmc Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York, Buffalo, New York 14214, USA
    Pediatr Res 66:539-44. 2009
  6. pmc The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow
    Satyan Lakshminrusimha
    Department of Pediatrics, Women s and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Physiol Heart Circ Physiol 293:H1491-7. 2007
  7. pmc Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    Am J Respir Crit Care Med 174:1370-7. 2006
  8. pmc Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn
    Satyan Lakshminrusimha
    Department of Pediatrics, University of Buffalo, Buffalo, NY, USA
    Pediatr Crit Care Med 10:106-12. 2009
  9. pmc Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, New York 14222, USA
    Pediatr Res 59:137-41. 2006
  10. pmc Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation
    Satyan Lakshminrusimha
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
    J Appl Physiol 101:135-9. 2006

Collaborators

Detail Information

Publications31

  1. pmc Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, New York, USA
    J Appl Physiol 111:1441-7. 2011
    ..Furthermore, 100% O(2) also induces oxidative stress and increases PA contractility. These findings support the new neonatal resuscitation guidelines recommending 21% O(2) for initial resuscitation of asphyxiated neonates...
  2. pmc The pulmonary circulation in neonatal respiratory failure
    Satyan Lakshminrusimha
    Division of Neonatology, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    Clin Perinatol 39:655-83. 2012
    ..Various management strategies to correct respiratory failure are also discussed...
  3. pmc Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Pediatr Res 62:313-8. 2007
    ..We conclude that, while ventilation with 100% O2 at birth results in a greater initial decrease in PVR, subsequent pulmonary vasodilation to NO/acetylcholine is impaired...
  4. doi request reprint Use of CT angiography in the diagnosis of total anomalous venous return
    S Lakshminrusimha
    Division of Neonatology, State University of New York at Buffalo, Buffalo, NY, USA
    J Perinatol 29:458-61. 2009
    ..We suggest that CT with contrast is a noninvasive modality to obtain anatomic details of pulmonary venous drainage in TAPVR when echocardiography is inconclusive...
  5. pmc Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York, Buffalo, New York 14214, USA
    Pediatr Res 66:539-44. 2009
    ..Hypoxia increases PVR but hyperoxia does not confer significant additional pulmonary vasodilation in lambs with PPHN...
  6. pmc The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow
    Satyan Lakshminrusimha
    Department of Pediatrics, Women s and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Physiol Heart Circ Physiol 293:H1491-7. 2007
    ..The redox environment, influenced by the balance between production and scavenging of ROS, may have important consequences on pulmonary vascular reactivity in the setting of increased Q(p)...
  7. pmc Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    Am J Respir Crit Care Med 174:1370-7. 2006
    ....
  8. pmc Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn
    Satyan Lakshminrusimha
    Department of Pediatrics, University of Buffalo, Buffalo, NY, USA
    Pediatr Crit Care Med 10:106-12. 2009
    ..Forskolin is a direct stimulant of AC. Phosphodiesterase 3 hydrolyzes cAMP and is inhibited by milrinone...
  9. pmc Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, New York 14222, USA
    Pediatr Res 59:137-41. 2006
    ..PA contractility to NE and KCl is increased following both brief (30 min) and prolonged (24 h) exposure to 100% oxygen during mechanical ventilation. In contrast, normoxic resuscitation and ventilation do not increase PA contractility...
  10. pmc Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation
    Satyan Lakshminrusimha
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
    J Appl Physiol 101:135-9. 2006
    ..We speculate that BrDRF may have an important role in postnatal changes in pulmonary arterial reactivity...
  11. ncbi request reprint Adjacent bronchus attenuates pulmonary arterial contractility
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Center for Developmental Biology of the Lung, USA
    Am J Physiol Lung Cell Mol Physiol 291:L473-8. 2006
    ..NO gas relaxed PA when administered on the endothelial side only. We speculate that BrDRF is a diffusible factor that crosses the adventitia and stimulates production of NO within the PA...
  12. doi request reprint Exposure to supplemental oxygen downregulates antioxidant enzymes and increases pulmonary arterial contractility in premature lambs
    Anupama Patel
    Center for Developmental Biology of the Lung, Department of Pediatrics, University at Buffalo, Buffalo, NY 14222 2006, USA
    Neonatology 96:182-92. 2009
    ....
  13. pmc Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep
    Bernadette Chen
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Pediatr Res 66:682-7. 2009
    ..The vasodilatory effects of milrinone were most pronounced in vessels from lambs with the highest PDE3 activity, i.e., 1dSB and 100% O2 + iNO lambs. Thus, milrinone may be most beneficial when used in conjunction with iNO...
  14. pmc Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells
    Kathryn N Farrow
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA
    Antioxid Redox Signal 17:460-70. 2012
    ..PDE5 degrades cyclic GMP (cGMP) and inhibits nitric oxide (NO)-mediated cGMP-dependent vasorelaxation. We sought to determine the mechanism by which hyperoxia initiates reactive oxygen species (ROS) production and regulates PDE5...
  15. doi request reprint Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension
    Vasanth H Kumar
    Division of Neonatology, Department of Pediatrics, University at Buffalo, The Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222 2006, USA
    J Appl Physiol 109:677-84. 2010
    ..Milrinone enhances the vasodilatory effects of PGI2 on the pulmonary vasculature but caution must be exercised regarding systemic hypotension...
  16. ncbi request reprint Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation
    Nasir Rashid
    Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Pediatr Res 60:624-9. 2006
    ..We conclude that intravenous milrinone potentiates the pulmonary vasodilator effects of PGI(2) at lower doses...
  17. pmc Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, NY, USA
    Shock 39:278-85. 2013
    ..Collectively, these data suggest that consumption of NO due to excess superoxide resulting in peroxynitrite formation leads to diminished vascular reactivity following LC...
  18. pmc Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells
    Kathryn N Farrow
    Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Circ Res 102:226-33. 2008
    ..These data suggest that PDE5 expression and activity play a critical role in modulating neonatal pulmonary vascular tone in response to common clinical treatments for PPHN, such as oxygen and inhaled NO...
  19. doi request reprint Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release
    Christopher A D'Angelis
    Department of Pathology and Anatomical Sciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    Pediatr Res 63:239-44. 2008
    ..We speculate that increased activity of the ANP/NPR-A pathway in late gestation may prime the surfactant system, preparing the lung for air breathing...
  20. pmc Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension
    Stephen Wedgwood
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, 310 E Superior St, Chicago, IL 60611, USA
    Antioxid Redox Signal 15:1497-506. 2011
    ..The associated decrease in extracellular superoxide augments vasodilation, suggesting that H(2)O(2) scavengers may represent an effective therapy in the clinical management of PPHN...
  21. pmc Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells
    Monica R Shah
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA
    Int J Mol Sci 14:4334-48. 2013
    ..A better understanding of the interplay between these two distinct pathways could provide key insights into future avenues to treat infants with pulmonary hypertension...
  22. pmc Increased p22(phox)/Nox4 Expression Is Involved in Remodeling Through Hydrogen Peroxide Signaling in Experimental Persistent Pulmonary Hypertension of the Newborn
    Stephen Wedgwood
    1 Department of Pediatrics, Northwestern University, Chicago, Illinois
    Antioxid Redox Signal 18:1765-76. 2013
    ..Approaches that inhibit the pulmonary arterial Nox4 activity may attenuate vasoconstriction and vascular remodeling in PPHN. Antioxid. Redox Signal. 18, 1765-1776...
  23. pmc Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs
    Robert C Dukarm
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    J Appl Physiol 99:2331-6. 2005
    ..In contrast, the effects on E4021 on net lung liquid production appear to be independent of nitric oxide synthase, suggesting that these two critical perinatal events might be modulated independently...
  24. doi request reprint Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia
    Rita M Ryan
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Buffalo, NY, USA
    Clin Rev Allergy Immunol 34:174-90. 2008
    ....
  25. ncbi request reprint Growth factors in lung development
    Vasanth H Kumar
    Department of Pediatrics Neonatology, State University of New York, The Women and Children s Hospital of Buffalo, Buffalo, New York, USA
    Adv Clin Chem 40:261-316. 2005
    ....
  26. doi request reprint Randomized Controlled Trial of Vinyl Bags versus Thermal Mattress to Prevent Hypothermia in Extremely Low-Gestational-Age Infants
    Bobby Mathew
    Department of Pediatrics, Women and Children s Hospital of Buffalo, University of Buffalo, Buffalo, New York
    Am J Perinatol 30:317-22. 2013
    ..Improvements in other areas such as delivery room temperature may be needed to achieve the goal of preventing hypothermia in this vulnerable population...
  27. doi request reprint Association between caffeine citrate exposure and necrotizing enterocolitis in preterm infants
    Stacie J Lampkin
    Department of Pharmacy Practice, School of Pharmacy, D Youville College, 320 Porter Avenue, Buffalo, NY 14201, USA
    Am J Health Syst Pharm 70:603-8. 2013
    ..The results of a case-control study of the potential role of caffeine citrate therapy in the development of necrotizing enterocolitis (NEC) are presented...
  28. ncbi request reprint Pleural effusion with parenteral nutrition solution: an unusual complication of an "appropriately" placed umbilical venous catheter
    Maria Janina U Pabalan
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Perinatol 24:581-5. 2007
    ..We report for the first time a case of right-sided pleural effusion with parenteral nutrition solution following a UVC that appeared to be positioned appropriately in the inferior vena cava...
  29. ncbi request reprint Vinyl bags prevent hypothermia at birth in preterm infants
    Bobby Mathew
    Division of Neonatology, Department of Pediatrics, Women and Children s Hospital of Buffalo, Buffalo, USA
    Indian J Pediatr 74:249-53. 2007
    ..To compare the effect of standard care vs. the use of vinyl bags (Vi-Drape (R) isolation bag) on admission temperature in extremely premature infants < or = 28 weeks gestational age at birth...
  30. pmc eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally
    Eugenia Mata-Greenwood
    Dept of Pediatrics, Northwestern Univ, Ward 12 191, 303 E Chicago Ave, Chicago, IL 60611 008, USA
    Am J Physiol Lung Cell Mol Physiol 290:L232-41. 2006
    ..We speculate this may be related to cellular production and/or maintenance of BH4 levels...
  31. pmc Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn
    Stephen Wedgwood
    Dept of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 289:L660-6. 2005
    ..Overall our data suggest a role for H(2)O(2) in the abnormal vasodilation associated with the pulmonary arteries of PPHN lambs...