JOHN LAITY

Summary

Affiliation: University of Missouri-Kansas City
Country: USA

Publications

  1. ncbi request reprint Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)
    John H Laity
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    Arch Biochem Biophys 463:201-10. 2007
  2. pmc The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 26:5580-7. 2006
  3. ncbi request reprint The six zinc fingers of metal-responsive element binding transcription factor-1 form stable and quasi-ordered structures with relatively small differences in zinc affinities
    Belinda M Potter
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    J Biol Chem 280:28529-40. 2005
  4. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
  5. doi request reprint Preparation and zinc-binding properties of multi-fingered zinc-sensing domains
    John H Laity
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO, USA
    Methods Mol Biol 649:411-35. 2010
  6. ncbi request reprint Solution structure of a Zap1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae
    Zhonghua Wang
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    J Mol Biol 357:1167-83. 2006

Research Grants

  1. Mechanisms of Eukaryotic Zinc Homeostasis
    JOHN LAITY; Fiscal Year: 2007
  2. Mechanisms of Eukaryotic Zinc Homeostasis
    JOHN LAITY; Fiscal Year: 2009
  3. Mechanisms of Eukaryotic Zinc Homeostasis
    JOHN HAROLD LAITY; Fiscal Year: 2010

Collaborators

  • Glen Andrews
  • Tomoki Kimura
  • Yong Li
  • Zhonghua Wang
  • Priya Parasuram
  • Linda S Feng
  • Belinda M Potter
  • Ryan W Huyck
  • Viktor Matskevich
  • Krishna Venkataraman
  • Jed A Wilson
  • Viktor A Matskevich

Detail Information

Publications6

  1. ncbi request reprint Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)
    John H Laity
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    Arch Biochem Biophys 463:201-10. 2007
    ....
  2. pmc The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 26:5580-7. 2006
    ..Zinc may modulate highly specific, linker-mediated zinc finger interactions in MTF-1, thus affecting its zinc- and DNA-binding activities, resulting in translocation to the nucleus and binding to the MT-I gene promoter...
  3. ncbi request reprint The six zinc fingers of metal-responsive element binding transcription factor-1 form stable and quasi-ordered structures with relatively small differences in zinc affinities
    Belinda M Potter
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    J Biol Chem 280:28529-40. 2005
    ..These analyses further suggested that metal sensing by MTF-1 in eukaryotic cells involves multiple zinc fingers and occurs over a 100-fold or less range of accessible Zn(II) concentration...
  4. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
    ....
  5. doi request reprint Preparation and zinc-binding properties of multi-fingered zinc-sensing domains
    John H Laity
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO, USA
    Methods Mol Biol 649:411-35. 2010
    ..NMR and calorimetric methods are described to measure relative and individual zinc ion affinities in multi-fingered proteins, which is an essential step in unraveling the zinc-sensing mechanism of MTF-1 and Zap1...
  6. ncbi request reprint Solution structure of a Zap1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae
    Zhonghua Wang
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    J Mol Biol 357:1167-83. 2006
    ..Moreover, in contrast to earlier reports of <<1 labile zinc ion/Escherichia coli cell, the zf1-zf2 zinc affinities determined calorimetrically are consistent with Zn(II) levels >>1 labile zinc ion/eukaryotic cell...

Research Grants4

  1. Mechanisms of Eukaryotic Zinc Homeostasis
    JOHN LAITY; Fiscal Year: 2007
    ....
  2. Mechanisms of Eukaryotic Zinc Homeostasis
    JOHN LAITY; Fiscal Year: 2009
    ....
  3. Mechanisms of Eukaryotic Zinc Homeostasis
    JOHN HAROLD LAITY; Fiscal Year: 2010
    ....