PETER LAIRD

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
  2. ncbi request reprint Modeling exposures for DNA methylation profiles
    Kimberly D Siegmund
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 15:567-72. 2006
  3. pmc DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines
    Sahar Houshdaran
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 5:e9359. 2010
  4. pmc Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling
    Toshinori Hinoue
    USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    PLoS ONE 4:e8357. 2009
  5. pmc Analysis of repetitive element DNA methylation by MethyLight
    Daniel J Weisenberger
    Department of Surgery, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Los Angeles, CA, USA
    Nucleic Acids Res 33:6823-36. 2005
  6. pmc DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Nucleic Acids Res 36:4689-98. 2008
  7. pmc Genome-scale screen for DNA methylation-based detection markers for ovarian cancer
    Mihaela Campan
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e28141. 2011
  8. pmc Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors
    Xinhui Wang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e25985. 2011
  9. pmc DNA methylation as a biomarker for cardiovascular disease risk
    Myungjin Kim
    Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 5:e9692. 2010
  10. pmc Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer
    Christopher P E Lange
    Department of Surgery, Groene Hart Hospital, Gouda, The Netherlands
    PLoS ONE 7:e50266. 2012

Research Grants

Detail Information

Publications60

  1. ncbi request reprint CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
    ..Sporadic cases of mismatch repair deficiency occur almost exclusively as a consequence of CIMP-associated methylation of MLH1 . We propose a robust new marker panel to classify CIMP+ tumors...
  2. ncbi request reprint Modeling exposures for DNA methylation profiles
    Kimberly D Siegmund
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 15:567-72. 2006
    ..Thus, when the clusters are not identified with certainty, the extended mixture model is preferred for valid estimation of the OR and CI...
  3. pmc DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines
    Sahar Houshdaran
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 5:e9359. 2010
    ..This study applied recently developed methods for high-throughput DNA methylation profiling to characterize ovarian cancer cell lines and tumors, including representatives of three major histologies...
  4. pmc Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling
    Toshinori Hinoue
    USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    PLoS ONE 4:e8357. 2009
    ..Our data will be useful for future investigations toward understanding CIMP in colorectal cancer and gaining insights into the role of aberrant DNA hypermethylation in colorectal tumorigenesis...
  5. pmc Analysis of repetitive element DNA methylation by MethyLight
    Daniel J Weisenberger
    Department of Surgery, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Los Angeles, CA, USA
    Nucleic Acids Res 33:6823-36. 2005
    ....
  6. pmc DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Nucleic Acids Res 36:4689-98. 2008
    ..Using digital MethyLight, we identified single-molecule, cancer-specific DNA hypermethylation events in the CpG islands of RUNX3, CLDN5 and FOXE1 present in plasma samples from breast cancer patients...
  7. pmc Genome-scale screen for DNA methylation-based detection markers for ovarian cancer
    Mihaela Campan
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e28141. 2011
    ..We developed a systematic multi-step biomarker discovery and verification strategy to identify candidate DNA methylation markers for the blood-based detection of ovarian cancer...
  8. pmc Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors
    Xinhui Wang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e25985. 2011
    ..We used DNA methylation analysis to identify subtype-specific markers and new subgroups of gastroesophageal adenocarcinomas, and studied their association with epidemiological risk factors and clinical outcomes...
  9. pmc DNA methylation as a biomarker for cardiovascular disease risk
    Myungjin Kim
    Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 5:e9692. 2010
    ..This may reflect a reduced systemic remethylation capacity, which would be expected to cause decreased genomic DNA methylation in peripheral blood leukocytes (PBL)...
  10. pmc Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer
    Christopher P E Lange
    Department of Surgery, Groene Hart Hospital, Gouda, The Netherlands
    PLoS ONE 7:e50266. 2012
    ..We employed a genome-scale marker discovery method to identify and verify candidate DNA methylation biomarkers for blood-based detection of colorectal cancer...
  11. pmc Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer
    Paul P Anglim
    Department of Surgery, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089 9176, USA
    Mol Cancer 7:62. 2008
    ....
  12. pmc Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma
    Jeffrey A Tsou
    Norris Cancer Center and Department of Surgery and of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Mol Cancer 6:70. 2007
    ....
  13. pmc Sensitivity and reproducibility of standardized-competitive RT-PCR for transcript quantification and its comparison with real time RT-PCR
    Vincenzo Pagliarulo
    Department of Pathology, University of Southern California, Keck School of Medicine, 2011 Zonal Ave, HMR 312C, Los Angeles, CA 90033, USA
    Mol Cancer 3:5. 2004
    ..The CT serves as an ideal internal control. The transcript numbers are expressed as copies per million transcripts of a control gene such as beta-actin (ACTB)...
  14. pmc Modeling measurement error in tumor characterization studies
    Cyril Rakovski
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California 90089 9176, USA
    BMC Bioinformatics 12:284. 2011
    ..We illustrate the phenomenon using the MethyLight technology, applying our proposed analysis to compare MLH1 DNA methylation levels in males and females studied in the Colon Cancer Family Registry...
  15. pmc Cluster analysis for DNA methylation profiles having a detection threshold
    Paul Marjoram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    BMC Bioinformatics 7:361. 2006
    ..This suggests that conventional clustering methodology may not perform well on this data...
  16. ncbi request reprint The power and the promise of DNA methylation markers
    Peter W Laird
    University of Southern California, Norris Comprehensive Cancer Center, Room 6418, 1441 Eastlake Avenue, Los Angeles, California 90089 9176, USA
    Nat Rev Cancer 3:253-66. 2003
    ..The ubiquity of DNA methylation changes has opened the way to a host of innovative diagnostic and therapeutic strategies. Recent advances attest to the great promise of DNA methylation markers as powerful future tools in the clinic...
  17. doi request reprint Principles and challenges of genomewide DNA methylation analysis
    Peter W Laird
    USC Epigenome Center, University of Southern California, Keck School of Medicine, Los Angeles, 90089 9601, USA
    Nat Rev Genet 11:191-203. 2010
    ..This Review discusses the different approaches and their relative merits and introduces considerations for data analysis...
  18. doi request reprint The USC Epigenome Center
    Peter W Laird
    University of Southern California, Keck School of Medicine, USC Epigenome Center, 1450 Biggy Street, Los Angeles, CA 90089 99601, USA
    Epigenomics 1:29-31. 2009
    ..This unique facility promises to be a valuable resource for multidisciplinary research, education and training in genomics, epigenomics, bioinformatics, and translational medicine...
  19. pmc Hormone therapy, DNA methylation and colon cancer
    Anna H Wu
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, USA
    Carcinogenesis 31:1060-7. 2010
    ..055) and increased DNA methylation of ESR1 in the 'tumorous' colonic tissues (P = 0.056). These findings on DNA methylation and hormone therapy use need confirmation in larger studies...
  20. ncbi request reprint A comparison of cluster analysis methods using DNA methylation data
    Kimberly D Siegmund
    Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles 90089, USA
    Bioinformatics 20:1896-904. 2004
    ..Established tools to analyze this type of data do not exist. Here, we evaluate a variety of methods for cluster analysis to determine which is most reliable...
  21. ncbi request reprint Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung
    Jeffrey A Tsou
    Norris Cancer Center and Department of Surgery and Biochemistry, Room NOR 6420, 1441 Eastlake Ave, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Lung Cancer 47:193-204. 2005
    ..Our observations support the strong potential of methylation markers as tools for accurate diagnosis of neoplasms in and around the lung...
  22. doi request reprint Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice
    Christine B Yoo
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 9181, USA
    Cancer Prev Res (Phila) 1:233-40. 2008
    ..Importantly, prolonged treatment of mice with epigenetic drugs resulted in only minor developmental and histologic changes...
  23. ncbi request reprint Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice
    Nicole M Sodir
    Department of Surgery and Biochemistry, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
    Cancer Res 66:8430-8. 2006
    ....
  24. pmc DNA methylation profile of 28 potential marker loci in malignant mesothelioma
    Jeffrey A Tsou
    Norris Cancer Center and Department of Surgery, Keck School of Medicine, University of Southern California, Room NOR6420, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Lung Cancer 58:220-30. 2007
    ....
  25. pmc DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair
    Binh N Trinh
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9176, USA
    Mol Cell Biol 22:2906-17. 2002
    ....
  26. pmc Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
    Erika M Wolff
    Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Res 70:8169-78. 2010
    ..In addition, an epithelium-wide epigenetic defect in bladders with cancer might contribute to a loss of epithelial integrity and create a permissible environment for tumors to arise...
  27. doi request reprint Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns
    Hyang Min Byun
    Jane Anne Nohl Division of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 18:4808-17. 2009
    ..05). Finally, we found that the Illumina GoldenGate assay features a large number of probes (265/1505 probes, 17.6%) that contain single-nucleotide polymorphisms, which may interfere with DNA methylation analyses in genome-wide studies...
  28. ncbi request reprint Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice
    Cindy A Eads
    Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Room 6418, Los Angeles, California 90089 9176, USA
    Cancer Res 62:1296-9. 2002
    ....
  29. pmc Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033 9176, USA
    Cancer Epidemiol Biomarkers Prev 17:3208-15. 2008
    ..These results reinforce the importance of distinguishing between the underlying causes of MSI in studies of etiology and prognosis...
  30. doi request reprint MethyLight
    Mihaela Campan
    Department of Surgery, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Methods Mol Biol 507:325-37. 2009
    ..We show that these control reactions perform as expected in a time-course experiment interrupting sodium bisulfite conversion at various timepoints...
  31. ncbi request reprint Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen
    Martin Widschwendter
    Department of Urology, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, 90089 9176, USA
    Cancer Res 64:3807-13. 2004
    ....
  32. pmc Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    Houtan Noushmehr
    USC Epigenome Center, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Cell 17:510-22. 2010
    ..Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds...
  33. pmc Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
    Gangning Liang
    USC Norris Comprehensive Cancer Center, Department of Urology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9181, USA
    Mol Cell Biol 22:480-91. 2002
    ..Our results reveal a previously unrecognized degree of cooperativity among mammalian DNA methyltransferases in ES cells...
  34. pmc 2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1
    Hyang Min Byun
    Division of Hematology, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Room 6428, Los Angeles, CA, USA
    Cancer Lett 266:238-48. 2008
    ..Theses differences between decitabine and NPEOC-DAC are dependent on the cleavage of the carboxylester bond, and could be potentially exploited pharmacologically...
  35. ncbi request reprint Diet, cancer and aging in DNA mismatch repair deficient mice
    Jen Lan Tsao
    Department of Pathology, Molecular Biology and Surgery, Norris Cancer Center, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Carcinogenesis 23:1807-10. 2002
    ..Our studies indicate that MMR deficiency may be epistatic to certain otherwise strong environmental influences on carcinogenesis or aging...
  36. pmc DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    Kimberly D Siegmund
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 2:e895. 2007
    ..Therefore, DNA methylation is dynamically regulated in the human cerebral cortex throughout the lifespan, involves differentiated neurons, and affects a substantial portion of genes predominantly by an age-related increase...
  37. ncbi request reprint Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells
    Hui Chen
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, University of Southern California, Los Angeles, California 90033, USA
    Gastroenterology 133:207-18. 2007
    ..The role of MAT2A in colon cancer in unknown. The aims of this study were to examine whether MAT2A expression and SAMe and its metabolite methylthioadenosine (MTA) can modulate growth of colon cancer cells...
  38. ncbi request reprint Combined bisulfite restriction analysis (COBRA)
    Cindy A Eads
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Methods Mol Biol 200:71-85. 2002
  39. ncbi request reprint Analysis of complex methylation data
    Kimberly D Siegmund
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Methods 27:170-8. 2002
    ..We then describe the basic statistics and bioinformatic principles relevant to the analysis of simple and complex methylation data...
  40. pmc Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells
    Myungjin Kim
    Department of Surgery, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
    Nucleic Acids Res 32:5742-9. 2004
    ..The enhanced MSI was associated with higher levels of histone H3 acetylation and lower MeCP2 binding at regions near the assayed microsatellite, suggesting that Dnmt1 loss may decrease MMR efficiency by modifying chromatin structure...
  41. ncbi request reprint Cancer epigenetics
    Peter W Laird
    Department of Surgery and Biochemistry and Molecular Biology, University of Southern California, 90086 9176, USA
    Hum Mol Genet 14:R65-76. 2005
    ..Sensitive detection technology has expanded from primarily blood-based cancer detection to include applications on a wide diversity of sample sources and is now also making inroads as a molecular risk assessment tool...
  42. ncbi request reprint Sex differential in methylation patterns of selected genes in Singapore Chinese
    Barbara Sarter
    Kenneth Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Hum Genet 117:402-3. 2005
    ..13 and 0.96, respectively). Our data suggest that gender is at least as strong a predictor of methylation level in the four genes under study as age, with males showing higher PMRs...
  43. ncbi request reprint Rapid and quantitative method of allele-specific DNA methylation analysis
    Hui Lee Wong
    University of Southern California, Los Angeles, CA 90089, USA
    Biotechniques 41:734-9. 2006
    ..Although we could reliably determine allele-specific methylation with our technique, additional studies will be required to confirm the ability of our assay to measure loss of imprinting...
  44. pmc Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm
    Sahar Houshdaran
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 2:e1289. 2007
    ..Incomplete reprogramming of the male germ line could, in theory, result in both altered sperm DNA methylation and compromised spermatogenesis...
  45. ncbi request reprint Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1219-23. 2005
    ..No association between CDKN2A, PTGS2, or PGR methylation and adenoma recurrence was observed. These data suggest that ESR1 methylation may play a role in subsequent adenoma recurrence...
  46. ncbi request reprint Hierarchical clustering of lung cancer cell lines using DNA methylation markers
    Arvind K Virmani
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9593, USA
    Cancer Epidemiol Biomarkers Prev 11:291-7. 2002
    ..Our results show that DNA methylation patterns differ between NSCLC and SCLC cell lines and suggest that these patterns could be developed into a powerful molecular marker to achieve accurate diagnosis of lung cancer...
  47. ncbi request reprint DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis
    Gyeong Hoon Kang
    Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Lab Invest 88:161-70. 2008
    ..Through our large-scale screening of 170 CpG island loci, we found 17 new DNA methylation markers of GC, which may serve as useful markers that may identify a distinct subset of GC...
  48. ncbi request reprint Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 30:1175-83. 2006
    ..Both MSI and CIMP appear to play a role in the pathogenesis of specific morphologic patterns of colorectal carcinoma...
  49. ncbi request reprint Hypomethylation and hypermethylation of DNA in Wilms tumors
    Melanie Ehrlich
    Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana, LA 70112, USA
    Oncogene 21:6694-702. 2002
    ..This suggests that the DNA hypomethylation contributes independently to oncogenesis or tumor progression...
  50. ncbi request reprint Epigenetic stem cell signature in cancer
    Martin Widschwendter
    Department of Gynecological Oncology, Institute for Women s Health, University College London, London WC1E 6DH, UK
    Nat Genet 39:157-8. 2007
    ....
  51. ncbi request reprint Sensitive detection of DNA methylation
    Susan E Cottrell
    Epigenomics, Inc, Seattle, Washington 98101, USA
    Ann N Y Acad Sci 983:120-30. 2003
    ..Once these technical concerns have been addressed, the sensitive detection of methylation will provide a powerful diagnostic and prognostic tool, especially for the early detection of preneoplastic and neoplastic lesions...
  52. ncbi request reprint Distinct methylation profiles of glioma subtypes
    Karen Uhlmann
    Institut fur Medizinische Genetik, Universitatsklinikum Charite, Humboldt Universitat, Berlin, Germany
    Int J Cancer 106:52-9. 2003
    ..Our results show that glioma subtypes have characteristic methylation profiles and, with the exception of pilocytic astrocytomas, show both locus specific hyper- as well as hypomethylation...
  53. ncbi request reprint DNA hypomethylation and ovarian cancer biology
    Martin Widschwendter
    Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria
    Cancer Res 64:4472-80. 2004
    ....
  54. ncbi request reprint Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia
    Qinghua Feng
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 16:1178-84. 2007
    ..This study shows the potential feasibility of using molecular markers detected in urine for cervical cancer screening...
  55. ncbi request reprint Promoter hypermethylation: a new therapeutic target emerges in urothelial cancer
    Richard J Cote
    J Clin Oncol 23:2879-81. 2005
  56. pmc The role of DNA methylation in the development and progression of lung adenocarcinoma
    Keith M Kerr
    Department of Pathology, Aberdeen Royal Infirmary, Link Building, Foresterhill, Aberdeen, AB25 2ZN, UK
    Dis Markers 23:5-30. 2007
    ....
  57. ncbi request reprint Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer
    Heidi Fiegl
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Cancer Res 66:29-33. 2006
    ..04). These data support the view that in addition to HER-2/neu-associated signaling, epigenetic changes in cancer as well as in tumor stroma cells might attribute to the specific biological features of HER-2/neu-positive cancers...
  58. pmc Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 8:209-17. 2006
    ..In conclusion, sodium bisulfite conversion and quantitative MethyLight assays have good precision and linearity and can be effectively used for high-throughput DNA methylation analysis on paraffin-embedded tissue...
  59. doi request reprint Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines
    Eloisi C Lopes
    Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 68:7258-63. 2008
    ..Because Kaiso inactivation sensitized colon cancer cell lines to chemotherapy, it is possible that therapeutic targeting of Kaiso could improve the efficacy of current treatment regimens...

Research Grants25

  1. DNA Methylation Markers in Ovarian Cancer
    PETER LAIRD; Fiscal Year: 2004
    ..Finally, we propose to use the most promising biomarkers to evaluate the capacity to detect preclinical relapse of disease, as a function of time before clinical diagnosis of relapse. ..
  2. DNA Methylation Markers in Esophageal Adenocarcinoma
    PETER LAIRD; Fiscal Year: 2004
    ..We will also investigate whether factors known to increase the risk of adenocarcinoma of the esophagus, increase the risk of DNA methylation in normal tissue, or in the resulting adenocarcinoma. ..
  3. DNA Methylation Markers in Esophageal Adenocarcinoma
    PETER LAIRD; Fiscal Year: 2003
    ..We will also investigate whether factors known to increase the risk of adenocarcinoma of the esophagus, increase the risk of DNA methylation in normal tissue, or in the resulting adenocarcinoma. ..
  4. DNA Methylation Markers in Ovarian Cancer
    PETER LAIRD; Fiscal Year: 2003
    ..Finally, we propose to use the most promising biomarkers to evaluate the capacity to detect preclinical relapse of disease, as a function of time before clinical diagnosis of relapse. ..
  5. DNA Methylation Markers in Esophageal Adenocarcinoma
    PETER LAIRD; Fiscal Year: 2006
    ..We will also investigate whether factors known to increase the risk of adenocarcinoma of the esophagus, increase the risk of DNA methylation in normal tissue, or in the resulting adenocarcinoma. ..
  6. DNA Methylation Markers in Ovarian Cancer
    PETER LAIRD; Fiscal Year: 2006
    ..Finally, we propose to use the most promising biomarkers to evaluate the capacity to detect preclinical relapse of disease, as a function of time before clinical diagnosis of relapse. ..
  7. SUPPRESSION OF NEOPLASIA BY DNA HYPOMETHYLATION
    PETER LAIRD; Fiscal Year: 2007
    ..abstract_text> ..
  8. SUPPRESSION OF NEOPLASIA BY DNA HYPOMETHYLATION
    PETER LAIRD; Fiscal Year: 2000
    ..He proposes to use a tissue culture selection assay to determine the effect of DNA methylation on chromosome stability. ..
  9. DNA Methylation Markers in Ovarian Cancer
    PETER LAIRD; Fiscal Year: 2005
    ..Finally, we propose to use the most promising biomarkers to evaluate the capacity to detect preclinical relapse of disease, as a function of time before clinical diagnosis of relapse. ..
  10. SUPPRESSION OF NEOPLASIA BY DNA HYPOMETHYLATION
    PETER LAIRD; Fiscal Year: 2006
    ..abstract_text> ..
  11. CpG Island Methylator Phenotype in Human Colorectal Cancer
    PETER LAIRD; Fiscal Year: 2009
    ..This study will investigate how some colorectal tumors acquire an unusually high number of epigenetic changes, with the long-term goal of using this knowledge to block or reverse these types of deleterious changes. ..
  12. DNA Methylation Markers in Ovarian Cancer
    PETER LAIRD; Fiscal Year: 2002
    ..Finally, we propose to use the most promising biomarkers to evaluate the capacity to detect preclinical relapse of disease, as a function of time before clinical diagnosis of relapse. ..
  13. Visualizing the effect of epigenetic modifications on transcription and mutation
    Peter W Laird; Fiscal Year: 2010
    ....
  14. Environmental Epigenomics
    PETER LAIRD; Fiscal Year: 2004
    ..At the end of the planning period, they intend to submit an application to establish a Center for Environmental Epigenomics, to be affiliated with the Environmental Genome Project. ..
  15. SUPPRESSION OF NEOPLASIA BY DNA HYPOMETHYLATION
    PETER LAIRD; Fiscal Year: 1999
    ..He proposes to use a tissue culture selection assay to determine the effect of DNA methylation on chromosome stability. ..
  16. CpG Island Methylator Phenotype in Human Colorectal Cancer
    Peter W Laird; Fiscal Year: 2010
    ..This study will investigate how some colorectal tumors acquire an unusually high number of epigenetic changes, with the long-term goal of using this knowledge to block or reverse these types of deleterious changes. ..
  17. CpG Island Methylator Phenotype in Human Colorectal Cancer
    PETER LAIRD; Fiscal Year: 2007
    ..This study will investigate how some colorectal tumors acquire an unusually high number of epigenetic changes, with the long-term goal of using this knowledge to block or reverse these types of deleterious changes. ..
  18. SUPPRESSION OF NEOPLASIA BY DNA HYPOMETHYLATION
    PETER LAIRD; Fiscal Year: 2003
    ..abstract_text> ..
  19. DNA Methylation Markers in Esophageal Adenocarcinoma
    PETER LAIRD; Fiscal Year: 2002
    ..We will also investigate whether factors known to increase the risk of adenocarcinoma of the esophagus, increase the risk of DNA methylation in normal tissue, or in the resulting adenocarcinoma. ..
  20. DNA Methylation Markers in Esophageal Adenocarcinoma
    PETER LAIRD; Fiscal Year: 2005
    ..We will also investigate whether factors known to increase the risk of adenocarcinoma of the esophagus, increase the risk of DNA methylation in normal tissue, or in the resulting adenocarcinoma. ..