P W Laird

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint The role of DNA methylation in cancer genetic and epigenetics
    P W Laird
    Department of Surgery, University of Southern California, School of Medicine Norris Comprehensive Cancer Center, Los Angeles 90033, USA
    Annu Rev Genet 30:441-64. 1996
  2. ncbi request reprint Oncogenic mechanisms mediated by DNA methylation
    P W Laird
    University of Southern California School of Medicine, Dept of Surgery, Los Angeles, USA
    Mol Med Today 3:223-9. 1997
  3. pmc DNA methylation: an alternative pathway to cancer
    S A Wajed
    Department of Surgery, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Ann Surg 234:10-20. 2001
  4. ncbi request reprint Cancer epigenetics comes of age
    P A Jones
    Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, The Norris Comprehensive Cancer Center, Los Angeles 90033, USA
    Nat Genet 21:163-7. 1999
  5. pmc COBRA: a sensitive and quantitative DNA methylation assay
    Z Xiong
    Department of Surgery, University of Southern California School of Medicine, The Norris Comprehensive Cancer Center, Room 6415, Mailstop 73, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Nucleic Acids Res 25:2532-4. 1997
  6. ncbi request reprint Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas
    Z Xiong
    Departments of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089-9176, USA
    Cancer Epidemiol Biomarkers Prev 10:799-803. 2001
  7. ncbi request reprint Epigenetic patterns in the progression of esophageal adenocarcinoma
    C A Eads
    Department of Surgery, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9176, USA
    Cancer Res 61:3410-8. 2001
  8. ncbi request reprint Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time
    I D Markl
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 61:5875-84. 2001
  9. pmc Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells
    M F Chan
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, 90089-9176, USA
    Mol Cell Biol 21:7587-600. 2001
  10. ncbi request reprint DNA methylation analysis by MethyLight technology
    B N Trinh
    Department of Surgery, University of Southern California, Keck School of Medicine, Room 6418, 1441 Eastlake Avenue, Los Angeles, California 90089-9176, USA
    Methods 25:456-62. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The role of DNA methylation in cancer genetic and epigenetics
    P W Laird
    Department of Surgery, University of Southern California, School of Medicine Norris Comprehensive Cancer Center, Los Angeles 90033, USA
    Annu Rev Genet 30:441-64. 1996
    ..It is our task not only to identify these mechanisms, but to determine their relative importance for each stage and type of cancer. Our hope then will be to translate that knowledge into clinical applications...
  2. ncbi request reprint Oncogenic mechanisms mediated by DNA methylation
    P W Laird
    University of Southern California School of Medicine, Dept of Surgery, Los Angeles, USA
    Mol Med Today 3:223-9. 1997
    ..This article reviews current insights into the contribution of DNA methylation to mutational and epigenetic mechanisms of oncogenesis...
  3. pmc DNA methylation: an alternative pathway to cancer
    S A Wajed
    Department of Surgery, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Ann Surg 234:10-20. 2001
    ....
  4. ncbi request reprint Cancer epigenetics comes of age
    P A Jones
    Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, The Norris Comprehensive Cancer Center, Los Angeles 90033, USA
    Nat Genet 21:163-7. 1999
    ..We review here current mechanistic understanding of the role of DNA methylation in malignant transformation, and suggest Knudson's two-hit hypothesis should now be expanded to include epigenetic mechanisms of gene inactivation...
  5. pmc COBRA: a sensitive and quantitative DNA methylation assay
    Z Xiong
    Department of Surgery, University of Southern California School of Medicine, The Norris Comprehensive Cancer Center, Room 6415, Mailstop 73, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Nucleic Acids Res 25:2532-4. 1997
    ..COBRA thus combines the powerful features of ease of use, quantitative accuracy, and compatibility with paraffin sections...
  6. ncbi request reprint Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas
    Z Xiong
    Departments of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089-9176, USA
    Cancer Epidemiol Biomarkers Prev 10:799-803. 2001
    ....
  7. ncbi request reprint Epigenetic patterns in the progression of esophageal adenocarcinoma
    C A Eads
    Department of Surgery, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9176, USA
    Cancer Res 61:3410-8. 2001
    ....
  8. ncbi request reprint Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time
    I D Markl
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 61:5875-84. 2001
    ....
  9. pmc Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells
    M F Chan
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, 90089-9176, USA
    Mol Cell Biol 21:7587-600. 2001
    ..We conclude that Dnmt1 deficiency and the accompanying genomic DNA hypomethylation result in a reduction of three major pathways of gene inactivation in our model system...
  10. ncbi request reprint DNA methylation analysis by MethyLight technology
    B N Trinh
    Department of Surgery, University of Southern California, Keck School of Medicine, Room 6418, 1441 Eastlake Avenue, Los Angeles, California 90089-9176, USA
    Methods 25:456-62. 2001
    ....
  11. pmc DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status
    B L Pike
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90089, USA
    Leukemia 22:1035-43. 2008
    ..Overall, further investigation of the highlighted CpG islands as potential clinical biomarkers is warranted...
  12. ncbi request reprint Phase I trial of continuous infusion 5-aza-2'-deoxycytidine
    A Aparicio
    Department of Medicine, Keck USC School of Medicine, Los Angeles, CA, USA
    Cancer Chemother Pharmacol 51:231-9. 2003
    ....
  13. ncbi request reprint DNA methylation profiles of female steroid hormone-driven human malignancies
    M Campan
    Department of Surgery and Department of Biochemistry and Molecular Biology, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9176, USA
    Curr Top Microbiol Immunol 310:141-78. 2006
    ..One such pathway may include MLH1 methylation in the context of the CpG island methylator phenotype...