Stephen Y Lai

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
    Charles J Lin
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Head Neck 29:163-88. 2007
  2. ncbi request reprint Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
    Stephen Y Lai
    Department of Otolaryngology Head and Neck Surgery, The Eye and Ear Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Oncogene 24:4442-9. 2005
  3. doi request reprint Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy
    Trevor M Feinstein
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Head Neck 33:318-23. 2011
  4. doi request reprint Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 75:1493-500. 2009
  5. pmc Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer
    Athanassios Argiris
    University of Pittsburgh Medical Center Cancer Pavilion, 5th Floor, Pittsburgh, PA 15232, USA
    J Clin Oncol 28:5294-300. 2010
  6. pmc Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms
    Stephen Y Lai
    Departments of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Clin Oncol 27:1235-42. 2009
  7. doi request reprint Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy
    Elmer R Cano
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Head Neck 31:1431-8. 2009
  8. pmc Head and neck cancer: an evolving treatment paradigm
    David M Cognetti
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Cancer 113:1911-32. 2008
  9. pmc Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    In Vivo 24:1-8. 2010
  10. pmc Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma
    Melonie A Nance
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer 113:2082-9. 2008

Detail Information

Publications24

  1. ncbi request reprint Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
    Charles J Lin
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Head Neck 29:163-88. 2007
    ..An easily accessible guide that organizes important characteristics of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for in vitro or in vivo studies...
  2. ncbi request reprint Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
    Stephen Y Lai
    Department of Otolaryngology Head and Neck Surgery, The Eye and Ear Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Oncogene 24:4442-9. 2005
    ..Increased levels of EPO and EPOR in lymph node metastases as compared to primary tumors from HNSCC patients further support the role of EPO/EPOR in HNSCC disease progression and metastasis...
  3. doi request reprint Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy
    Trevor M Feinstein
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Head Neck 33:318-23. 2011
    ..This study was designed to identify the factors associated with the outcome after standard treatment with surgery and postoperative radiotherapy (RT) for locally advanced salivary gland cancers...
  4. doi request reprint Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 75:1493-500. 2009
    ..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) in previously irradiated patients with squamous cell carcinoma of the head and neck (SCCHN)...
  5. pmc Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer
    Athanassios Argiris
    University of Pittsburgh Medical Center Cancer Pavilion, 5th Floor, Pittsburgh, PA 15232, USA
    J Clin Oncol 28:5294-300. 2010
    ..We incorporated cetuximab, a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR), into the induction therapy and subsequent chemoradiotherapy of head and neck cancer (HNC)...
  6. pmc Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms
    Stephen Y Lai
    Departments of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Clin Oncol 27:1235-42. 2009
    ..A phase I clinical trial was conducted to evaluate the safety and biologic effects of EGFR AS...
  7. doi request reprint Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy
    Elmer R Cano
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Head Neck 31:1431-8. 2009
    ..We report a program consisting of concurrent chemoradiation followed by brachytherapy for these patients...
  8. pmc Head and neck cancer: an evolving treatment paradigm
    David M Cognetti
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Cancer 113:1911-32. 2008
    ..This review focuses on the evolution of treatment approaches for head and neck cancer and future directions while recognizing the historic contributions recorded within this journal...
  9. pmc Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    In Vivo 24:1-8. 2010
    ..015) compared to irradiation only. The addition of MnSOD-PL, TPZ, and C225 to irradiation optimized the therapeutic ratio for the local control of hypoxic region-containing CAL-33 orthotopic tumors...
  10. pmc Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma
    Melonie A Nance
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer 113:2082-9. 2008
    ..The treatment protocol and survival outcomes of patients treated for MEC of the head and neck was investigated...
  11. ncbi request reprint Deferring planned neck dissection following chemoradiation for stage IV head and neck cancer: the utility of PET-CT
    Jayakar V Nayak
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Laryngoscope 117:2129-34. 2007
    ..To determine whether combined positron emission tomography and computed tomography (PET-CT) may be of value in deferring planned neck dissections for patients with advanced head and neck squamous cell carcinoma (HNSCC)...
  12. doi request reprint Reconstruction of the through-and-through anterior mandibulectomy defect: indications and limitations of the double-skin paddle fibular free flap
    Frederic W B Deleyiannis
    Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 118:1329-34. 2008
    ....
  13. pmc Minimally invasive video-assisted thyroidectomy: expanded indications and oncologic completeness
    Stephen Y Lai
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Head Neck 30:1403-7. 2008
    ..Minimally invasive video-assisted thyroidectomy (MIVAT) has received increasing attention as a technique applicable for a subset of thyroid nodules...
  14. ncbi request reprint Research education and training in otolaryngology: meeting summary and research opportunities
    Jennifer R Grandis
    Departments of Otolaryngology and Pharmacology, Eye and Ear Institute Building, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Otolaryngol Head Neck Surg 135:361-7. 2006
  15. pmc Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature
    Bryan K Ward
    Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Head Neck Oncol 1:41. 2009
    ..Basal cell adenocarcinoma of a minor salivary gland is extremely rare. The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment...
  16. ncbi request reprint Radiology quiz case 2. Parapharyngeal second branchial cleft cyst
    Seshu Gadiparthi
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 130:1121, 1124-5. 2004
  17. pmc Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma
    Ahmed Mohyeldin
    Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neoplasia 7:537-43. 2005
    ..This mechanism may also be activated by recombinant Epo therapy and could potentially produce detrimental effects in rhEpo-treated cancer patients...
  18. ncbi request reprint Dysregulation of hypoxia inducible factor-1alpha in head and neck squamous cell carcinoma cell lines correlates with invasive potential
    Noam A Cohen
    Department of Otorhinolaryngology Head and Neck Surgery Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 114:418-23. 2004
    ..The study investigated whether overexpression of HIF-1alpha in head and neck squamous cell carcinoma results from a physiological response to local hypoxia or from oncogenic mutational progression...
  19. doi request reprint Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
    Charles L Bennett
    VA Chicago Healthcare System, Department of Medicine, Northwestern University Feinberg School of Medicine, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    JAMA 299:914-24. 2008
    ..Although systematic overviews of trials have identified venous thromboembolism (VTE) risks, none have identified mortality risks with ESAs...
  20. ncbi request reprint Understanding the presence and function of erythropoietin receptors on cancer cells
    Stephen Y Lai
    J Clin Oncol 24:4675-6. 2006
  21. ncbi request reprint High-risk non-melanoma skin cancer of the head and neck
    Stephen Y Lai
    University of Pittsburgh School of Medicine, USA
    Curr Oncol Rep 7:154-8. 2005
    ..A multidisciplinary approach to the assessment and treatment of high-risk NMSC is required to provide comprehensive care. This review also covers recent advances in the understanding of NMSC biology and new approaches in chemoprevention...
  22. ncbi request reprint Bilateral squamous cell carcinoma of the external auditory canals
    Stephen G Wolfe
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia 19104, USA
    Laryngoscope 112:1003-5. 2002
    ..To report a case of bilateral squamous cell carcinoma of the external auditory canals and to present a management algorithm for this difficult clinical scenario...
  23. ncbi request reprint Parotidectomy in the treatment of aggressive cutaneous malignancies
    Stephen Y Lai
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Medical Center, 5 Silverstein Ravdin, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Otolaryngol Head Neck Surg 128:521-6. 2002
    ..Aggressive nonmelanoma skin cancer (ANMSC) of the head and neck may require parotidectomy because of neurotropic spread, direct invasion of the parotid gland, or parotid metastasis...
  24. ncbi request reprint Clinical care pathway for head and neck cancer: a valuable tool for decreasing resource utilization
    Kristin M Gendron
    Department of Otorhinolaryngology Head and Neck Surgery, 3400 Spruce St, 5 Ravdin, Philadelphia, PA 19104, USA
    Arch Otolaryngol Head Neck Surg 128:258-62. 2002
    ..To evaluate the durability over time of the reduction of resource utilization after implementing a clinical care pathway (CCP) for head and neck cancer surgery...

Research Grants2

  1. Regulation of Invasion and Metastasis by HIF-1 Oral Squamous Cell Carcinoma
    Stephen Lai; Fiscal Year: 2007
    ..These studies will directly benefit patients with head and neck cancer and may provide valuable insight into the regulation of tumor spread in other types of cancer. ..