Li Wen Lai

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Homologous recombination based gene therapy
    L W Lai
    Department of Medicine, Sections of Endocrinology and Nephrology, University of Arizona Health Sciences Center, Tucson, Ariz 95724, USA
    Exp Nephrol 7:11-4. 1999
  2. ncbi request reprint Therapeutic application of chimeric RNA/DNA oligonucleotide based gene therapy
    L W Lai
    Department of Medicine, Sections of Endocrinology and Nephrology, University of Arizona Health Sciences Center, Tucson, Arizona, USA
    Expert Opin Biol Ther 1:41-7. 2001
  3. pmc Site-specific expression of IQGAP1, a key mediator of cytoskeleton, in mouse renal tubules
    Li Wen Lai
    Department of Medicine, University of Arizona College of Medicine, PO BOX 245022, Tucson, AZ 85724, USA
    J Histochem Cytochem 56:659-66. 2008
  4. pmc Functionally improved bone in calbindin-D28k knockout mice
    David S Margolis
    Orthopaedic Research Lab, Department of Orthopaedic Surgery, University of Arizona, Tucson, AZ 85721, USA
    Bone 39:477-84. 2006
  5. ncbi request reprint Renal gene transfer: nonviral approaches
    Yeong Hau H Lien
    Department of Medicine, University of Arizona Health Sciences Center, Tuscon, AZ, 85724, USA
    Mol Biotechnol 24:283-94. 2003
  6. pmc Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury
    Li Wen Lai
    Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721 0106, USA
    Kidney Int 81:983-92. 2012
  7. ncbi request reprint Cyclosporine A-induced hypercalciuria in calbindin-D28k knockout and wild-type mice
    Chien Te Lee
    Department of Medicine, University of Arizona Health Sciences Centers, Tucson, Arizona 85724, USA
    Kidney Int 62:2055-61. 2002
  8. ncbi request reprint Cytoprotective effects of calbindin-D(28k) against antimycin-A induced hypoxic injury in proximal tubular cells
    Ming Ju Wu
    Department of Medicine, Nephrology Section, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Life Sci 71:559-69. 2002
  9. ncbi request reprint Chimeric RNA/DNA oligonucleotide-based gene therapy
    Li Wen Lai
    Department of Medicine, Sections of Endocrinology and Nephrology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Kidney Int 61:S47-51. 2002
  10. ncbi request reprint Bilateral symmetry of biomechanical properties in mouse femora
    David S Margolis
    Orthopaedic Research Lab, Department of Orthopaedic Surgery, Arizona Health Sciences Centre, University of Arizona, Room 8352, P O Box 245194, Tucson, AZ 85724 5064, USA
    Med Eng Phys 26:349-53. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Homologous recombination based gene therapy
    L W Lai
    Department of Medicine, Sections of Endocrinology and Nephrology, University of Arizona Health Sciences Center, Tucson, Ariz 95724, USA
    Exp Nephrol 7:11-4. 1999
    ..Homologous recombination, initially considered to be of limited use for gene therapy because of its low frequency in mammalian cells, has recently emerged as a potential strategy for developing gene therapy...
  2. ncbi request reprint Therapeutic application of chimeric RNA/DNA oligonucleotide based gene therapy
    L W Lai
    Department of Medicine, Sections of Endocrinology and Nephrology, University of Arizona Health Sciences Center, Tucson, Arizona, USA
    Expert Opin Biol Ther 1:41-7. 2001
    ..Chimera based gene therapy has the potential to develop into powerful therapeutic modality for genetic diseases...
  3. pmc Site-specific expression of IQGAP1, a key mediator of cytoskeleton, in mouse renal tubules
    Li Wen Lai
    Department of Medicine, University of Arizona College of Medicine, PO BOX 245022, Tucson, AZ 85724, USA
    J Histochem Cytochem 56:659-66. 2008
    ..The site-specific expression pattern of this potent modulator of multiple biological pathways in the renal tubules suggests that IQGAP1 may have multiple important roles in various renal functions...
  4. pmc Functionally improved bone in calbindin-D28k knockout mice
    David S Margolis
    Orthopaedic Research Lab, Department of Orthopaedic Surgery, University of Arizona, Tucson, AZ 85721, USA
    Bone 39:477-84. 2006
    ..6 N +/- 2.1) compared to WT mice (15.0 N +/- 1.7). In conclusion, Calbindin-D28k KO mice had increased bone volume and stiffness indicating that Calbindin-D28k plays an important role in bone remodeling...
  5. ncbi request reprint Renal gene transfer: nonviral approaches
    Yeong Hau H Lien
    Department of Medicine, University of Arizona Health Sciences Center, Tuscon, AZ, 85724, USA
    Mol Biotechnol 24:283-94. 2003
    ..Potential clinical applications and safety concerns of gene therapy for renal diseases are discussed...
  6. pmc Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury
    Li Wen Lai
    Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721 0106, USA
    Kidney Int 81:983-92. 2012
    ..Thus, Tregs recruited to the kidney by DMS ameliorate acute kidney injury and provide a new approach to control inflammatory diseases...
  7. ncbi request reprint Cyclosporine A-induced hypercalciuria in calbindin-D28k knockout and wild-type mice
    Chien Te Lee
    Department of Medicine, University of Arizona Health Sciences Centers, Tucson, Arizona 85724, USA
    Kidney Int 62:2055-61. 2002
    ..We investigated the role of the kidney and bone in CsA-induced hypercalciuria in calbindin-D28k knockout (KO) and wild-type (WT) mice...
  8. ncbi request reprint Cytoprotective effects of calbindin-D(28k) against antimycin-A induced hypoxic injury in proximal tubular cells
    Ming Ju Wu
    Department of Medicine, Nephrology Section, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Life Sci 71:559-69. 2002
    ..In conclusion, this study demonstrated that transfection of calbindin-D(28k) gene into MCT cells provide protective effects against chemical hypoxic injury probably through its buffering effects on [Ca+2]i...
  9. ncbi request reprint Chimeric RNA/DNA oligonucleotide-based gene therapy
    Li Wen Lai
    Department of Medicine, Sections of Endocrinology and Nephrology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Kidney Int 61:S47-51. 2002
    ..Chimeric RNA/DNA oligonucleotides, emerging as a potential strategy for gene therapy, have been shown to induce site-specific correction of point mutations in several genetic disease models...
  10. ncbi request reprint Bilateral symmetry of biomechanical properties in mouse femora
    David S Margolis
    Orthopaedic Research Lab, Department of Orthopaedic Surgery, Arizona Health Sciences Centre, University of Arizona, Room 8352, P O Box 245194, Tucson, AZ 85724 5064, USA
    Med Eng Phys 26:349-53. 2004
    ..0%. Statistical analysis showed there were no significant differences in strain, modulus, or failure load values for the mice, indicating mechanical and geometrical symmetry of mouse femora in cantilever bending...
  11. ncbi request reprint Gene therapy for renal disorders
    Yeong Hau H Lien
    University of Arizona Health Sciences Center, Section of Nephrology, Department of Medicine, Tucson, AZ 85724, USA
    Expert Opin Biol Ther 4:919-26. 2004
    ....
  12. ncbi request reprint Gene therapy for renal disorders: what are the benefits for the elderly?
    Yeong Hau H Lien
    Department of Medicine, University of Arizona Health Sciences Center, Tucson 85724, USA
    Drugs Aging 19:553-60. 2002
    ..Once these problems are solved, gene therapy will have a role in treating age-related renal impairment...
  13. doi request reprint Phenotypic characteristics of bone in carbonic anhydrase II-deficient mice
    David S Margolis
    Orthopaedic Research Lab, Department of Orthopaedic Surgery, University of Arizona, Tucson, AZ 85721, USA
    Calcif Tissue Int 82:66-76. 2008
    ..The metaphyseal widening and changes in the trabecular bone are consistent with osteopetrosis, making the CAII-deficient mouse a valuable model of human disease...
  14. ncbi request reprint A novel alpha-galactosidase a mutant (M42L) identified in a renal variant of Fabry disease
    David Rosenthal
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Kidney Dis 44:e85-9. 2004
    ..Because treatment for Fabry disease recently has become available, it is important for clinicians to be aware of this disease and pursue the diagnosis in cases of otherwise unexplained renal dysfunction...
  15. ncbi request reprint Pathogenesis of renal ischemia/reperfusion injury: lessons from knockout mice
    Yeong Hau H Lien
    Nephrology Section, Department of Medicine, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Life Sci 74:543-52. 2003
    ..The knowledge obtained from these studies provides new direction for designing potential therapeutic agents for treating ischemia/reperfusion injury...
  16. ncbi request reprint Bilateral femoral head and distal tibial osteonecrosis in a patient with Fabry disease
    Yeong Hau H Lien
    Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Am J Orthop (Belle Mead NJ) 34:192-4. 2005
    ..This case suggests that Fabry disease may be a risk factor for development of osteonecrosis. The enzyme replacement therapy currently available may be an effective method of preventing this complication...
  17. doi request reprint Delivery of intercellular adhesion molecule-1 antisense oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy/ischemia model
    Hardeep Phull
    Department of Surgery, Section of Urology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Urology 72:690-5. 2008
    ..The objective of this study was to use and evaluate this method against intercellular adhesion molecule-1 (ICAM-1) to prevent tissue damage...
  18. doi request reprint Unexpected severe LVH in the elderly: consider Fabry's disease
    Vincent L Sorrell
    Section of Cardiology, Sarver Heart Center, University of Arizona, College of Medicine, Tucson, AZ 85724, USA
    Echocardiography 25:345-8. 2008
  19. pmc Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis
    Yeong Hau H Lien
    Arizona Kidney Disease and Hypertension Center, 4511 North Campbell Avenue, Suite 100, Tucson, AZ 85718, USA
    Nat Rev Nephrol 7:85-95. 2011
    ....
  20. ncbi request reprint Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model
    Sanjay Ramakumar
    Department of Surgery, University of Arizona, Tucson 85724 5077, USA
    J Urol 174:1133-6. 2005
    ..To overcome these limitations we developed a novel murine partial nephrectomy model to evaluate polyethylene-glycol (PEG) hydrogel tissue sealant as a topical oligonucleotide delivery system...
  21. ncbi request reprint Effect of thiazide on renal gene expression of apical calcium channels and calbindins
    Chien Te Lee
    Division of Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Taiwan
    Am J Physiol Renal Physiol 287:F1164-70. 2004
    ....
  22. ncbi request reprint Effects of furosemide on renal calcium handling
    Chien Te Lee
    Division of Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Am J Physiol Renal Physiol 293:F1231-7. 2007
    ..Increased abundance of calcium transport molecules in the distal convoluted tubule represents a solute load-dependent effect in response to increased calcium delivery and serves as a compensatory adaptation in the downstream segment...
  23. ncbi request reprint Effect of calbindin-D28K on cyclosporine toxicity in cultured renal proximal tubular cells
    Ming Ju Wu
    Division of Nephrology, Taichung Veterans General Hospital, Chung Shan Medical University, Taiwan
    J Cell Physiol 200:395-9. 2004
    ..The expression of calbindin-D28k in renal tubular cells provides cytoprotective effects against CsA toxicity, probably through its buffering effects on [Ca2+]i...