K Lai

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi GALT deficiency causes UDP-hexose deficit in human galactosemic cells
    K Lai
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, GA 30322, USA
    Glycobiology 13:285-94. 2003
  2. ncbi Molecular basis for Duarte and Los Angeles variant galactosemia
    S D Langley
    Department of Pediatrics, Division of Medical Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 60:366-72. 1997
  3. ncbi Functional analysis of the human galactose-1-phosphate uridyltransferase promoter in Duarte and LA variant galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Genet Metab 72:297-305. 2001
  4. ncbi Structure-function analyses of a common mutation in blacks with transferase-deficiency galactosemia
    K Lai
    Division of Medical Genetics, Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, Georgia 30322, USA
    Mol Genet Metab 74:264-72. 2001
  5. ncbi The molecular biology of galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Med 1:40-8. 1998
  6. ncbi Innovative therapy for Classic Galactosemia - tale of two HTS
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Mol Genet Metab 105:44-55. 2012
  7. ncbi A prevalent mutation for galactosemia among black Americans
    K Lai
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pediatr 128:89-95. 1996
  8. ncbi Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, 50 N Mario Capecchi Drive, SOM Room 2C412, Salt Lake City, UT 84132, USA
    Bioorg Med Chem 19:5886-95. 2011
  9. ncbi Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model
    Tatiana Slepak
    The Dr. John T. Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, University of Miami Miller School of Medicine, P.O. Box 016820D-20, Miami, FL 33101, USA
    Mol Genet Metab 86:360-71. 2005
  10. ncbi Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model
    Tatiana I Slepak
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, The Leonard M Miller School of Medicine, University of Miami, P O Box 016820 D 820, Miami, FL 33101, USA
    Mol Genet Metab 92:78-87. 2007

Research Grants

  1. Innovative Therapies and Clinical Studies for Classic Galactosemia
    Kent Lai; Fiscal Year: 2007

Collaborators

  • M Tang
  • Tatiana Slepak
  • L J Elsas
  • S I Odejinmi
  • H Vankayalapati
  • Tatiana I Slepak
  • Manshu Tang
  • Deborah Barbouth
  • S D Langley
  • K J Wierenga
  • Y M Allette
  • Vladlen Z Slepak
  • Helene Klapper
  • Louis J Elsas
  • Freda Addo
  • C J Saunders
  • L N Hjelm
  • P P Dembure

Detail Information

Publications12

  1. ncbi GALT deficiency causes UDP-hexose deficit in human galactosemic cells
    K Lai
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, GA 30322, USA
    Glycobiology 13:285-94. 2003
    ..Reduced Sambucus nigra agglutinin binding to glycoproteins isolated from cells with increased Gal-1-P is consistent with the resultant inhibition of glycoprotein glycosylation...
  2. ncbi Molecular basis for Duarte and Los Angeles variant galactosemia
    S D Langley
    Department of Pediatrics, Division of Medical Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 60:366-72. 1997
    ..A favorable codon bias for the mutated codon with consequently increased translation rates is postulated as the mechanism...
  3. ncbi Functional analysis of the human galactose-1-phosphate uridyltransferase promoter in Duarte and LA variant galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Genet Metab 72:297-305. 2001
    ..The -119 to -116delGTCA reduces hGALT transcription resulting in reduced GALT activity in the Duarte allele...
  4. ncbi Structure-function analyses of a common mutation in blacks with transferase-deficiency galactosemia
    K Lai
    Division of Medical Genetics, Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, Georgia 30322, USA
    Mol Genet Metab 74:264-72. 2001
    ..We conclude that a hydroxyl group on amino acid 135 is required for the catalysis of uridyl transfer from UDP-glucose to UDP-galactose in the presence of galactose 1-phosphate, and plays a role in the bio-stability of hGALT...
  5. ncbi The molecular biology of galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Med 1:40-8. 1998
    ..In this review, we discuss the structural biology of these mutations as they affect both the GALT enzyme and patient outcome...
  6. ncbi Innovative therapy for Classic Galactosemia - tale of two HTS
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Mol Genet Metab 105:44-55. 2012
    ..While this finding may render the on-going hit-to-lead process more challenging, there is growing evidence that such cross-inhibition could also lead to advances in antimicrobial and anti-cancer therapies...
  7. ncbi A prevalent mutation for galactosemia among black Americans
    K Lai
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pediatr 128:89-95. 1996
    ..To define the mutation causing galactosemia in patients of black American origin who have no galactose-1-phosphate uridyltransferase (GALT) activity in erythrocytes but good clinical outcome...
  8. ncbi Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, 50 N Mario Capecchi Drive, SOM Room 2C412, Salt Lake City, UT 84132, USA
    Bioorg Med Chem 19:5886-95. 2011
    ....
  9. ncbi Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model
    Tatiana Slepak
    The Dr. John T. Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, University of Miami Miller School of Medicine, P.O. Box 016820D-20, Miami, FL 33101, USA
    Mol Genet Metab 86:360-71. 2005
    ..Our data thus suggested that RNA metabolism, ribosome biogenesis, and inositol metabolism were likely targets for galactose-1-phosphate, a toxic intermediate that is uniquely accumulated under GALT-deficiency...
  10. ncbi Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model
    Tatiana I Slepak
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, The Leonard M Miller School of Medicine, University of Miami, P O Box 016820 D 820, Miami, FL 33101, USA
    Mol Genet Metab 92:78-87. 2007
    ....
  11. ncbi Prevention of a molecular misdiagnosis in galactosemia
    Deborah Barbouth
    Dr. John T. Macdonald Foundation Center for Medical Genetics, Department of Pediatrics and Biochemistry, Miller School of Medicine, University of Miami, FL 33136, USA
    Genet Med 8:178-82. 2006
    ....
  12. ncbi Alternative pathways of galactose assimilation: could inverse metabolic engineering provide an alternative to galactosemic patients?
    Kent Lai
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, University of Miami School of Medicine, FL 33101, USA
    Metab Eng 6:239-44. 2004
    ....

Research Grants3

  1. Innovative Therapies and Clinical Studies for Classic Galactosemia
    Kent Lai; Fiscal Year: 2007
    ....