K Lai

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint GALT deficiency causes UDP-hexose deficit in human galactosemic cells
    K Lai
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, GA 30322, USA
    Glycobiology 13:285-94. 2003
  2. pmc Molecular basis for Duarte and Los Angeles variant galactosemia
    S D Langley
    Department of Pediatrics, Division of Medical Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 60:366-72. 1997
  3. ncbi request reprint Functional analysis of the human galactose-1-phosphate uridyltransferase promoter in Duarte and LA variant galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Genet Metab 72:297-305. 2001
  4. ncbi request reprint Structure-function analyses of a common mutation in blacks with transferase-deficiency galactosemia
    K Lai
    Division of Medical Genetics, Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, Georgia 30322, USA
    Mol Genet Metab 74:264-72. 2001
  5. ncbi request reprint The molecular biology of galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Med 1:40-8. 1998
  6. pmc Innovative therapy for Classic Galactosemia - tale of two HTS
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Mol Genet Metab 105:44-55. 2012
  7. ncbi request reprint A prevalent mutation for galactosemia among black Americans
    K Lai
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pediatr 128:89-95. 1996
  8. pmc Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, 50 N Mario Capecchi Drive, SOM Room 2C412, Salt Lake City, UT 84132, USA
    Bioorg Med Chem 19:5886-95. 2011
  9. ncbi request reprint Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model
    Tatiana Slepak
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, University of Miami Miller School of Medicine, P O Box 016820D 20, Miami, FL 33101, USA
    Mol Genet Metab 86:360-71. 2005
  10. pmc Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model
    Tatiana I Slepak
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, The Leonard M Miller School of Medicine, University of Miami, P O Box 016820 D 820, Miami, FL 33101, USA
    Mol Genet Metab 92:78-87. 2007

Collaborators

  • M Tang
  • Tatiana Slepak
  • L J Elsas
  • S I Odejinmi
  • H Vankayalapati
  • Tatiana I Slepak
  • Deborah Barbouth
  • Manshu Tang
  • S D Langley
  • K J Wierenga
  • Y M Allette
  • Vladlen Z Slepak
  • Louis J Elsas
  • Helene Klapper
  • Freda Addo
  • C J Saunders
  • P P Dembure
  • L N Hjelm

Detail Information

Publications12

  1. ncbi request reprint GALT deficiency causes UDP-hexose deficit in human galactosemic cells
    K Lai
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, GA 30322, USA
    Glycobiology 13:285-94. 2003
    ..Reduced Sambucus nigra agglutinin binding to glycoproteins isolated from cells with increased Gal-1-P is consistent with the resultant inhibition of glycoprotein glycosylation...
  2. pmc Molecular basis for Duarte and Los Angeles variant galactosemia
    S D Langley
    Department of Pediatrics, Division of Medical Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 60:366-72. 1997
    ..A favorable codon bias for the mutated codon with consequently increased translation rates is postulated as the mechanism...
  3. ncbi request reprint Functional analysis of the human galactose-1-phosphate uridyltransferase promoter in Duarte and LA variant galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Genet Metab 72:297-305. 2001
    ..The -119 to -116delGTCA reduces hGALT transcription resulting in reduced GALT activity in the Duarte allele...
  4. ncbi request reprint Structure-function analyses of a common mutation in blacks with transferase-deficiency galactosemia
    K Lai
    Division of Medical Genetics, Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, Georgia 30322, USA
    Mol Genet Metab 74:264-72. 2001
    ..We conclude that a hydroxyl group on amino acid 135 is required for the catalysis of uridyl transfer from UDP-glucose to UDP-galactose in the presence of galactose 1-phosphate, and plays a role in the bio-stability of hGALT...
  5. ncbi request reprint The molecular biology of galactosemia
    L J Elsas
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Med 1:40-8. 1998
    ..In this review, we discuss the structural biology of these mutations as they affect both the GALT enzyme and patient outcome...
  6. pmc Innovative therapy for Classic Galactosemia - tale of two HTS
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Mol Genet Metab 105:44-55. 2012
    ..While this finding may render the on-going hit-to-lead process more challenging, there is growing evidence that such cross-inhibition could also lead to advances in antimicrobial and anti-cancer therapies...
  7. ncbi request reprint A prevalent mutation for galactosemia among black Americans
    K Lai
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pediatr 128:89-95. 1996
    ..To define the mutation causing galactosemia in patients of black American origin who have no galactose-1-phosphate uridyltransferase (GALT) activity in erythrocytes but good clinical outcome...
  8. pmc Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria
    M Tang
    Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, 50 N Mario Capecchi Drive, SOM Room 2C412, Salt Lake City, UT 84132, USA
    Bioorg Med Chem 19:5886-95. 2011
    ....
  9. ncbi request reprint Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model
    Tatiana Slepak
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, University of Miami Miller School of Medicine, P O Box 016820D 20, Miami, FL 33101, USA
    Mol Genet Metab 86:360-71. 2005
    ..Our data thus suggested that RNA metabolism, ribosome biogenesis, and inositol metabolism were likely targets for galactose-1-phosphate, a toxic intermediate that is uniquely accumulated under GALT-deficiency...
  10. pmc Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model
    Tatiana I Slepak
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, The Leonard M Miller School of Medicine, University of Miami, P O Box 016820 D 820, Miami, FL 33101, USA
    Mol Genet Metab 92:78-87. 2007
    ....
  11. ncbi request reprint Prevention of a molecular misdiagnosis in galactosemia
    Deborah Barbouth
    Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics and Biochemistry, Miller School of Medicine, University of Miami, FL 33136, USA
    Genet Med 8:178-82. 2006
    ..This method is problematic when used in families of Ashkenazi Jewish descent...
  12. ncbi request reprint Alternative pathways of galactose assimilation: could inverse metabolic engineering provide an alternative to galactosemic patients?
    Kent Lai
    The Dr John T Macdonald Foundation Center for Medical Genetics, Department of Pediatrics, University of Miami School of Medicine, FL 33101, USA
    Metab Eng 6:239-44. 2004
    ....

Research Grants3