Henry Lai

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat
    H Lai
    Department of Pharmacology, University of Washington, Seattle 98195, USA
    Pharmacol Biochem Behav 53:613-6. 1996
  2. doi request reprint Development of artemisinin compounds for cancer treatment
    Henry C Lai
    Department of Bioengineering, University of Washington, Box 355061, Seattle, WA 98195, USA
    Invest New Drugs 31:230-46. 2013
  3. ncbi request reprint Artemisinin-transferrin conjugate retards growth of breast tumors in the rat
    Henry Lai
    Department of Bioengineering, Box 355061, University of Washington, Seattle, WA 98195 5061, USA
    Anticancer Res 29:3807-10. 2009
  4. ncbi request reprint Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat
    Henry Lai
    Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
    Cancer Lett 231:43-8. 2006
  5. ncbi request reprint Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds
    Henry Lai
    University of Washington, Department of Bioengineering, Box 357962, Seattle, Washington 98195 7962, USA
    Expert Opin Ther Targets 9:995-1007. 2005
  6. ncbi request reprint Effects of artemisinin-tagged holotransferrin on cancer cells
    Henry Lai
    Department of Bioengineering, Box 357962, University of Washington, Seattle, WA 98195 7962, USA
    Life Sci 76:1267-79. 2005
  7. ncbi request reprint Interaction of microwaves and a temporally incoherent magnetic field on spatial learning in the rat
    Henry Lai
    Bioelectromagnetics Research Laboratory, Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
    Physiol Behav 82:785-9. 2004
  8. pmc Magnetic-field-induced DNA strand breaks in brain cells of the rat
    Henry Lai
    Bioelectromagnetics Research Laboratory, Department of Bioengineering, University of Washington, Seattle, Washington 98195 7962, USA
    Environ Health Perspect 112:687-94. 2004
  9. ncbi request reprint Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells
    H Lai
    Bioelectromagnetics Research Laboratory, Center for Bioengineering, University of Washington, Seattle 98195, USA
    J Pineal Res 22:152-62. 1997
  10. ncbi request reprint 60 Hz magnetic fields and central cholinergic activity: effects of exposure intensity and duration
    H Lai
    Department of Bioengineering, University of Washington, Seattle 98195 7962, USA
    Bioelectromagnetics 20:284-9. 1999

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat
    H Lai
    Department of Pharmacology, University of Washington, Seattle 98195, USA
    Pharmacol Biochem Behav 53:613-6. 1996
    ..6 W/kg can activate endogenous opioids in the brain...
  2. doi request reprint Development of artemisinin compounds for cancer treatment
    Henry C Lai
    Department of Bioengineering, University of Washington, Box 355061, Seattle, WA 98195, USA
    Invest New Drugs 31:230-46. 2013
    ..These compounds are promising potent anticancer compounds that produce significantly less side effect than traditional chemotherapeutic agents...
  3. ncbi request reprint Artemisinin-transferrin conjugate retards growth of breast tumors in the rat
    Henry Lai
    Department of Bioengineering, Box 355061, University of Washington, Seattle, WA 98195 5061, USA
    Anticancer Res 29:3807-10. 2009
    ..In the present research, artemisinin-transferrin conjugate was tested in a rat breast cancer model...
  4. ncbi request reprint Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat
    Henry Lai
    Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
    Cancer Lett 231:43-8. 2006
    ..05) when compared with controls. Since artemisinin is a relatively safe compound that causes no known side effects even at high oral doses, the present data indicate that artemisinin may be a potent cancer-chemoprevention agent...
  5. ncbi request reprint Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds
    Henry Lai
    University of Washington, Department of Bioengineering, Box 357962, Seattle, Washington 98195 7962, USA
    Expert Opin Ther Targets 9:995-1007. 2005
    ..The authors have found that artemisinin-tagged transferrin is highly selective and potent in killing cancer cells. Thus, artemisinin and artemisinin-tagged iron-carrying compounds could be developed into powerful anticancer drugs...
  6. ncbi request reprint Effects of artemisinin-tagged holotransferrin on cancer cells
    Henry Lai
    Department of Bioengineering, Box 357962, University of Washington, Seattle, WA 98195 7962, USA
    Life Sci 76:1267-79. 2005
    ..Thus, this 'tagged-compound' could potentially be developed into an effective chemotherapeutic agent for cancer treatment...
  7. ncbi request reprint Interaction of microwaves and a temporally incoherent magnetic field on spatial learning in the rat
    Henry Lai
    Bioelectromagnetics Research Laboratory, Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
    Physiol Behav 82:785-9. 2004
    ..Thus, simultaneous exposure to a temporally incoherent magnetic field blocks microwave-induced spatial learning and memory deficits in the rat...
  8. pmc Magnetic-field-induced DNA strand breaks in brain cells of the rat
    Henry Lai
    Bioelectromagnetics Research Laboratory, Department of Bioengineering, University of Washington, Seattle, Washington 98195 7962, USA
    Environ Health Perspect 112:687-94. 2004
    ..This hypothesis could have an important implication for the possible health effects associated with exposure to extremely low-frequency magnetic fields in the public and occupational environments...
  9. ncbi request reprint Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells
    H Lai
    Bioelectromagnetics Research Laboratory, Center for Bioengineering, University of Washington, Seattle 98195, USA
    J Pineal Res 22:152-62. 1997
    ..Since melatonin and PBN are efficient free radical scavengers, these data suggest that free radicals may play a role in magnetic field-induced DNA damage...
  10. ncbi request reprint 60 Hz magnetic fields and central cholinergic activity: effects of exposure intensity and duration
    H Lai
    Department of Bioengineering, University of Washington, Seattle 98195 7962, USA
    Bioelectromagnetics 20:284-9. 1999
    ..It is concluded that the intensity and duration of exposure interact. By increasing the duration of exposure, effects can be observed at lower intensities...
  11. ncbi request reprint Intracerebroventricular injection of mu- and delta-opiate receptor antagonists block 60 Hz magnetic field-induced decreases in cholinergic activity in the frontal cortex and hippocampus of the rat
    H Lai
    Department of Bioengineering, University of Washington, Seattle 98195 7962, USA
    Bioelectromagnetics 19:432-7. 1998
    ..These data indicate that both mu- and delta-opiate receptors in the brain are involved in the magnetic field-induced decreases in cholinergic activity in the frontal cortex and hippocampus of the rat...
  12. ncbi request reprint Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation
    Ikuhiko Nakase
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Int J Pharm 354:28-33. 2008
    ..The conjugation enables targeted delivery of artemisinin into cancer cells. In this review, we discuss the anticancer activities and mechanisms of action of artemisinins and the transferrin-conjugate...
  13. ncbi request reprint Effects of transferrin conjugates of artemisinin and artemisinin dimer on breast cancer cell lines
    Yongmei Gong
    Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195 1700, USA
    Anticancer Res 33:123-32. 2013
    ....
  14. doi request reprint Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide
    Steve Oh
    Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195 1700, USA
    Cancer Lett 274:33-9. 2009
    ..The artemisinin-peptide conjugates showed potent anti-cancer activity against Molt-4 leukemia cells with a significantly improved cancer/normal cells selectivity...
  15. doi request reprint Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosis
    Ikuhiko Nakase
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Cancer Lett 274:290-8. 2009
    ..We also demonstrate that the ART-Tf conjugate kills the prostate carcinoma cell line DU 145 by the mitochondrial pathway of apoptosis...
  16. ncbi request reprint 60 Hz magnetic field exposure induces DNA crosslinks in rat brain cells
    N Singh
    Bioelectromagnetics Research Laboratory, Department of Bioengineering, University of Washington, Seattle, WA, USA
    Mutat Res 400:313-20. 1998
    ..The pattern of effects is similar between the two agents. These data suggest that both DNA-protein and DNA-DNA crosslinks are formed in brain cells of rats after acute exposure to a 60 Hz magnetic field...
  17. ncbi request reprint Visual quantification of DNA double-strand breaks in bacteria
    N P Singh
    Department of Bioengineering, University of Washington, Bioelectromagnetics Research Laboratory, Box 357962, Seattle, WA, USA
    Mutat Res 429:159-68. 1999
    ..5 rad and an increase in the number of DNA breaks induced by a dose as low as 25 rad. The extent of DNA migration and number of breaks were directly correlated to X-ray dosage...
  18. ncbi request reprint Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells
    N P Singh
    Department of Bioengineering, University of Washington, Seattle 98195 7962, USA
    Life Sci 70:49-56. 2001
    ..Since it is relatively easy to increase the iron content inside cancer cells in vivo, administration of artemisinin-like drugs and intracellular iron-enhancing compounds may be a simple, effective, and economical treatment for cancer...
  19. ncbi request reprint Comment on "Radial arm maze performance of rats following repeated low level microwave radiation exposure"
    Henry Lai
    Bioelectromagnetics 26:81. 2005