Research Topics
Genomes and GenesSpecies | Eric C LaiSummaryAffiliation: University of California Country: USA Publications
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Publications
The mirtron pathway generates microRNA-class regulatory RNAs in DrosophilaKatsutomo Okamura
Memorial Sloan Kettering Cancer Center, Department of Developmental Biology, 1275 York Ave, Box 252, New York, NY 10021, USA
Cell 130:89-100. 2007..These findings reveal that mirtrons are an alternate source of miRNA-type regulatory RNAs...- Diverse roles for RNA in gene regulationNelson C Lau
Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
Genome Biol 6:315. 2005 - Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAsEric C Lai
Department of Molecular and Cell Biology Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3200, USA
Genes Dev 19:1067-80. 2005..Collectively, these data establish insights into miRNA target recognition and demonstrate that the Notch signaling pathway is a major target of miRNA-mediated regulation in Drosophila... - miRNAs: whys and wherefores of miRNA-mediated regulationEric C Lai
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Curr Biol 15:R458-60. 2005..New bioinformatic and genetic studies are setting the stage for unraveling the specific biological functions of miRNAs... - The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and DeltaEric C Lai
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
Development 132:2319-32. 2005..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development... - Predicting and validating microRNA targetsEric C Lai
545 Life Sciences Addition, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3200, USA
Genome Biol 5:115. 2004..There has been considerable progress, but assessing success and biological significance requires a move into the 'wet' lab... - Notch signaling: control of cell communication and cell fateEric C Lai
Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Development 131:965-73. 2004..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns... - Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexesEric C Lai
Howard Hughes Medical Institute, University of California, Berkeley, Department of Molecular and Cell Biology, Berkeley, California 94720 3200, USA
RNA 10:171-5. 2004.... - microRNAs: runts of the genome assert themselvesEric C Lai
Department of Molecular and Cell Biology, University of California/HHMI, 645 Life Sciences Addition, Berkeley, CA 94720-3200, USA
Curr Biol 13:R925-36. 2003 - Lipid rafts make for slippery platformsEric C Lai
J Cell Biol 162:365-70. 2003..The answers will shape our views of signaling and of membrane dynamics... - Computational identification of Drosophila microRNA genesEric C Lai
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, 539 Life Sciences Addition, Berkeley, CA 94720, USA
Genome Biol 4:R42. 2003..Second, miRNAs are usually highly conserved between the genomes of related species. Third, miRNAs display a characteristic pattern of evolutionary divergence... - Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteinsEric C Lai
Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
EMBO Rep 3:840-5. 2002..This review highlights differences in composition and similarities in function of different CSL co-repressor complexes, which actively repress Notch pathway target genes in the absence of Notch pathway activity... - RNA sensors and riboswitches: self-regulating messagesEric C Lai
545 Life Sciences Addition, University of California, Department of Molecular and Cell Biology, Berkeley, CA 94720 3200, USA
Curr Biol 13:R285-91. 2003..Remarkably, these sensors allow associated mRNAs to regulate their own transcription or translation accordingly, without the need for regulatory proteins... - Drosophila tufted is a gain-of-function allele of the proneural gene amosEric C Lai
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Genetics 163:1413-25. 2003..This phenomenon seems instead to be related to their shared ability to activate Asense and Senseless... - Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulationEric C Lai
University of California at Berkeley, Department of Molecular and Cell Biology, 545 Life Sciences Addition 3200, Berkeley, California 94720 3200, USA
Nat Genet 30:363-4. 2002..These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes... - A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversityEric C Lai
Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Dev Biol 269:1-17. 2004..We propose that most Drosophila sensory organs are built from an archetypal lineage, and we speculate about how this stereotyped pattern of cell divisions may have been built during evolution... - Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systemsPelin Cayirlioglu
Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Science 319:1256-60. 2008..We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species-specific behaviors elicited by CO2... - Functional screening identifies miR-315 as a potent activator of Wingless signalingSerena J Silver
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:18151-6. 2007..In summary, activity-based screening can selectively identify miRNAs whose deregulation can lead to interpretable phenotypic consequences... - Developmental signaling: shrimp and strawberries help flies make conesEric C Lai
545 Life Sciences Addition, University of California, Department of Molecular and Cell Biology, Berkeley, CA 947200 3200, USA
Curr Biol 12:R722-4. 2002..A new study has revealed a serial linkage between them, via Ebi and Strawberry Notch, which is important in determining the cone cell fate in the Drosophila eye... - The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wingsMatthew Ronshaugen
Department of Molecular and Cell Biology, Division of Genetics, Center for Integrative Genomics, University of California, Berkeley, 94720, USA
Genes Dev 19:2947-52. 2005..These findings provide the first evidence for a noncoding homeotic gene and raise the possibility that other such genes occur within the Bithorax complex. We also discuss the regulation of mir-iab-4 expression during development... - Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic developmentA Aziz Aboobaker
Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
Proc Natl Acad Sci U S A 102:18017-22. 2005..Intriguingly, the expression patterns of several fly miRNAs are analogous to those of their vertebrate counterparts, suggesting that these miRNAs may have ancient roles in animal patterning... - Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsionHailan Hu
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 102:4613-8. 2005..Dosage-sensitive genetic interactions among CrGAP, Robo, and Rac support a model in which CrGAP transduces signals downstream of Robo receptor to regulate Rac-dependent cytoskeletal changes... - Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAsQingfa Wu
Department of Plant Pathology and Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
Proc Natl Acad Sci U S A 107:1606-11. 2010..We propose that invertebrate viruses discovered by this approach may include previously undescribed human and vertebrate viral pathogens that are transmitted by arthropod vectors... - Notch cleavage: Nicastrin helps Presenilin make the final cutEric C Lai
University of California, Department of Molecular and Cell Biology, Berkeley 94720 3200, USA
Curr Biol 12:R200-2. 2002..Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex... - Protein degradation: four E3s for the notch pathwayEric C Lai
University of California, Department of Molecular and Cell Biology, Berkeley, California 94720 3200, USA
Curr Biol 12:R74-8. 2002..These include Suppressor of deltex/Itch and Sel-10, which both regulate Notch, Neuralized, which regulates the Notch ligand Delta, and LNX, which regulates the Notch antagonist Numb... - Biological principles of microRNA-mediated regulation: shared themes amid diversityAlex S Flynt
Sloan Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Labs, 1275 York Avenue, Box 252, New York, New York 10065, USA
Nat Rev Genet 9:831-42. 2008..Such themes may reflect some of the inherent advantages of exploiting microRNA control in biological circuits, and provide insight into the consequences of microRNA dysfunction in disease... - The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAsKatsutomo Okamura
Sloan Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA
Cell Cycle 7:2840-5. 2008..We compare and contrast the miRNA and hpRNA pathways in this review, and describe some of the key questions that the recognition of this novel pathway raises... - Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogasterKatsutomo Okamura
Sloan Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA
Nat Struct Mol Biol 15:581-90. 2008..These newly recognized siRNA pathways broaden the scope of regulatory networks mediated by small RNAs... - The Drosophila hairpin RNA pathway generates endogenous short interfering RNAsKatsutomo Okamura
Sloan Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA
Nature 453:803-6. 2008..These novel regulatory RNAs reveal unexpected complexity in the sorting of small RNAs, and open a window onto the biological usage of endogenous RNA interference in Drosophila... - The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolutionKatsutomo Okamura
Sloan Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Laboratories, 1275 York Ave, Box 252, New York, New York 10065, USA
Nat Struct Mol Biol 15:354-63. 2008..These data broaden the reach of the miRNA regulatory network and suggest an important mechanism that diversifies miRNA function during evolution... - Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA lociDavid M Tyler
Department of Developmental Biology, Sloan Kettering Institute, New York, New York 10021, USA
Genes Dev 22:26-36. 2008..These findings demonstrate that antisense transcription and processing contributes to the functional diversification of miRNA genes... - Discovery of functional elements in 12 Drosophila genomes using evolutionary signaturesAlexander Stark
The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
Nature 450:219-32. 2007..We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies... - Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAsJ Graham Ruby
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genome Res 17:1850-64. 2007.... - Mammalian mirtron genesEugene Berezikov
Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Mol Cell 28:328-36. 2007..This notion is supported by our observation of several clade-specific features of mammalian and invertebrate mirtrons... - Endogenous RNA interference provides a somatic defense against Drosophila transposonsWei Jen Chung
Department of Developmental Biology, Sloan Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Ave, Box 252, New York, New York 10065, USA
Curr Biol 18:795-802. 2008..The piRNA system is thought to provide primarily a germline defense against TE activity...