Eric C Lai

Summary

Affiliation: University of California
Country: USA

Publications

  1. Lai E. Drosophila tufted is a gain-of-function allele of the proneural gene amos. Genetics. 2003;163:1413-25 pubmed
    ..This phenomenon seems instead to be related to their shared ability to activate Asense and Senseless. ..
  2. request reprint
    Lai E. Notch signaling: control of cell communication and cell fate. Development. 2004;131:965-73 pubmed
    ..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns. ..
  3. request reprint
    Lai E, Roegiers F, Qin X, Jan Y, Rubin G. The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development. 2005;132:2319-32 pubmed
    ..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development. ..
  4. Lai E, Tam B, Rubin G. Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev. 2005;19:1067-80 pubmed
    ..Collectively, these data establish insights into miRNA target recognition and demonstrate that the Notch signaling pathway is a major target of miRNA-mediated regulation in Drosophila. ..

Locale

Collaborators

Detail Information

Publications4

  1. Lai E. Drosophila tufted is a gain-of-function allele of the proneural gene amos. Genetics. 2003;163:1413-25 pubmed
    ..This phenomenon seems instead to be related to their shared ability to activate Asense and Senseless. ..
  2. request reprint
    Lai E. Notch signaling: control of cell communication and cell fate. Development. 2004;131:965-73 pubmed
    ..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns. ..
  3. request reprint
    Lai E, Roegiers F, Qin X, Jan Y, Rubin G. The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development. 2005;132:2319-32 pubmed
    ..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development. ..
  4. Lai E, Tam B, Rubin G. Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev. 2005;19:1067-80 pubmed
    ..Collectively, these data establish insights into miRNA target recognition and demonstrate that the Notch signaling pathway is a major target of miRNA-mediated regulation in Drosophila. ..