Fernanda Laezza

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Modulation of the FGF14:FGF14 homodimer interaction through short peptide fragments
    Syed Ali
    Fernanda Laezza Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555, Texas, USA
    CNS Neurol Disord Drug Targets 13:1559-70. 2014
  2. pmc Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase
    Norelle C Wildburger
    Department of Pharmacology and Toxicology, University of Texas Medical Branch Galveston, TX, USA
    Front Mol Neurosci 5:80. 2012
  3. pmc Induction and expression rules of synaptic plasticity in hippocampal interneurons
    Fernanda Laezza
    University Texas Medical Branch, Department of Pharmacology and Toxicology, 301 University Boulevard, Galveston, TX 77555, USA
    Neuropharmacology 60:720-9. 2011
  4. pmc Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation
    Wei chun Hsu
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America M D Ph D Combined Degree Program, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 10:e0117246. 2015
  5. pmc Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain
    Norelle C Wildburger
    From the Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, 77555 0617 Neuroscience Graduate Program, Graduate School of Biomedical Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, 77555 0617 UTMB Cancer Center, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, 77555 1074
    Mol Cell Proteomics 14:1288-300. 2015
  6. pmc The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)
    Alexander S Shavkunov
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 288:19370-85. 2013
  7. pmc Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism
    Miroslav N Nenov
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas
    J Neurophysiol 113:1712-26. 2015
  8. pmc The Nav1.2 channel is regulated by GSK3
    Thomas F James
    Department of Pharmacology and Toxicology, USA Neuroscience Graduate Program, USA
    Biochim Biophys Acta 1850:832-44. 2015
  9. doi request reprint Split-luciferase complementation assay to detect channel-protein interactions in live cells
    Alexander S Shavkunov
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Medical Research Building, 301 University Boulevard, Galveston, TX, 77555, USA
    Methods Mol Biol 1278:497-514. 2015
  10. pmc Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex
    Alexander Shavkunov
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Assay Drug Dev Technol 10:148-60. 2012

Collaborators

  • Kelly T Dineley
  • Larry Denner
  • Rovshan G Sadygov
  • Miroslav N Nenov
  • Norelle C Wildburger
  • Alexander S Shavkunov
  • Alexander Shavkunov
  • Filippo Tempia
  • Neli I Panova-Elektronova
  • Thomas F James
  • Neli Panova
  • Syed R Ali
  • Cheryl F Lichti
  • Carol L Nilsson
  • Wei chun Hsu
  • Thomas A Green
  • Syed Ali
  • Svetla Stoilova-McPhie
  • Nigel Bourne
  • Fernanda Vergara
  • Eriola Hoxha
  • Jai S Rudra
  • Musaad A Alshammari
  • Ming Zhan
  • Neli I Panova-Electronova
  • Ekaterina Mostovenko
  • Mark R Emmett
  • Giulia Negro
  • Demetrio Labate
  • Wei Chun J Hsu
  • Tahani K Alshammari
  • Neli Panova-Elektronova
  • Jonathan Luisi
  • Richard D LeDuc
  • Jonathan M Starkey
  • Heidi Spratt
  • Sigmund J Haidacher
  • Yingxin Zhao
  • Bruce A Luxon
  • Tetyana P Buzhdygan
  • Ronald L Veselenak
  • Ron Veselenak
  • Anesh Prasai

Detail Information

Publications12

  1. ncbi request reprint Modulation of the FGF14:FGF14 homodimer interaction through short peptide fragments
    Syed Ali
    Fernanda Laezza Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555, Texas, USA
    CNS Neurol Disord Drug Targets 13:1559-70. 2014
    ..These data suggest that the β12 strand of FGF14 might serve as scaffold for drug design against neuronal FGF14 dimers and Nav channels. ..
  2. pmc Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase
    Norelle C Wildburger
    Department of Pharmacology and Toxicology, University of Texas Medical Branch Galveston, TX, USA
    Front Mol Neurosci 5:80. 2012
    ....
  3. pmc Induction and expression rules of synaptic plasticity in hippocampal interneurons
    Fernanda Laezza
    University Texas Medical Branch, Department of Pharmacology and Toxicology, 301 University Boulevard, Galveston, TX 77555, USA
    Neuropharmacology 60:720-9. 2011
    ..This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'...
  4. pmc Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation
    Wei chun Hsu
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America M D Ph D Combined Degree Program, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 10:e0117246. 2015
    ....
  5. pmc Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain
    Norelle C Wildburger
    From the Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, 77555 0617 Neuroscience Graduate Program, Graduate School of Biomedical Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, 77555 0617 UTMB Cancer Center, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, 77555 1074
    Mol Cell Proteomics 14:1288-300. 2015
    ..Our studies will provide invaluable information to parse out the molecular determinant underlying neuronal excitability and plasticity, and extending the relevance of iFGFs signaling in the normal and diseased brain. ..
  6. pmc The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)
    Alexander S Shavkunov
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 288:19370-85. 2013
    ....
  7. pmc Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism
    Miroslav N Nenov
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas
    J Neurophysiol 113:1712-26. 2015
    ..That these parameters were restored by PPARγ activation emphasizes the therapeutic value of RSG against early AD cognitive impairment...
  8. pmc The Nav1.2 channel is regulated by GSK3
    Thomas F James
    Department of Pharmacology and Toxicology, USA Neuroscience Graduate Program, USA
    Biochim Biophys Acta 1850:832-44. 2015
    ..We posited that glycogen synthase kinase 3 (GSK3), a critical kinase found associated with numerous brain disorders, might directly regulate neuronal Na(v) channels...
  9. doi request reprint Split-luciferase complementation assay to detect channel-protein interactions in live cells
    Alexander S Shavkunov
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Medical Research Building, 301 University Boulevard, Galveston, TX, 77555, USA
    Methods Mol Biol 1278:497-514. 2015
    ....
  10. pmc Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex
    Alexander Shavkunov
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Assay Drug Dev Technol 10:148-60. 2012
    ..We envision the methodology presented here as a new valuable tool to allow functional evaluations of protein-channel complexes toward probe development and drug discovery targeting ion channels implicated in human disorders...
  11. doi request reprint Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27
    Filippo Tempia
    Department of Pharmacology and Toxicology, University of Texas Medical Branch Galveston, TX, USA Department of Neuroscience, University of Torino Torino, Italy Neuroscience Institute Cavalieri Ottolenghi Torino, Italy National Institute of Neuroscience Torino Italy
    Front Cell Neurosci 9:205. 2015
    ..These results provide evidence of a critical role of FGF14 in maintaining presynaptic function at PF-Purkinje neuron synapses highlighting critical target mechanisms to recapitulate the complexity of the SCA27 disease. ..
  12. pmc Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice
    Miroslav N Nenov
    Department of Neurology, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Preventive Medicine and Community Health, Mitchell Center for Neurodegenerative Diseases, Center for Addiction Research, Center for Biomedical Engineering, and Sealy Center for Molecular Medicine, Institute for Translational Science, University of Texas Medical Branch, Galveston, Texas 77555
    J Neurosci 34:1028-36. 2014
    ....