W Ladiges

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Expression of human PKR protein kinase in transgenic mice
    Warren Ladiges
    Comparative Mouse Genomics Center, Nathan Shock Center for Excellence in the Biology of Aging, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    J Interferon Cytokine Res 22:329-34. 2002
  2. ncbi request reprint Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice
    Dianne Botta
    Department of Environmental and Occupational Health Sciences, Comparative Medicine, and Pathology, and UW NIEHS Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 68105, USA
    J Biol Chem 281:28865-75. 2006
  3. pmc Protein kinase A is a target for aging and the aging heart
    Linda C Enns
    Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Aging (Albany NY) 2:238-43. 2010
  4. pmc Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A
    Linda C Enns
    Department of Comparative Medicine, University of Washington, Seattle, WA, 98915, USA
    J Gerontol A Biol Sci Med Sci 64:1221-31. 2009
  5. pmc Disruption of protein kinase A in mice enhances healthy aging
    Linda C Enns
    Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5963. 2009
  6. pmc Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner
    Jorming Goh
    Interdisciplinary Program in Nutritional Sciences, University of Washington, Seattle, Washington, United States of America Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e80123. 2013
  7. pmc A novel long term short interval physical activity regime improves body composition in mice
    Jorming Goh
    Interdisciplinary Program in Nutritional Sciences Medicine, University of Washington, Seattle, WA, USA
    BMC Res Notes 6:66. 2013
  8. pmc Mitochondrial targeted catalase suppresses invasive breast cancer in mice
    Jorming Goh
    Department of Comparative Medicine University of Washington, Seattle, USA
    BMC Cancer 11:191. 2011
  9. ncbi request reprint A mitochondrial view of aging, reactive oxygen species and metastatic cancer
    Warren Ladiges
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Aging Cell 9:462-5. 2010
  10. pmc Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction
    Linda C Enns
    Departments of Comparative Medicine, Physiology and Biophysics, and Biostatistics, University of Washington, Seattle, WA, 98195, USA
    BMC Res Notes 3:307. 2010

Research Grants

  1. Alzheimer's Disease and Impaired APP Proteolysis
    Warren Ladiges; Fiscal Year: 2006
  2. TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASE
    Warren Ladiges; Fiscal Year: 1999
  3. TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASE
    Warren Ladiges; Fiscal Year: 2000
  4. TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASE
    Warren Ladiges; Fiscal Year: 2001
  5. IMMUNOBIOLOGY OF AGING IN GENETICALLY ALTERED MICE
    Warren Ladiges; Fiscal Year: 2004
  6. Comparative Mouse Genomics Center
    Warren Ladiges; Fiscal Year: 2006

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Expression of human PKR protein kinase in transgenic mice
    Warren Ladiges
    Comparative Mouse Genomics Center, Nathan Shock Center for Excellence in the Biology of Aging, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    J Interferon Cytokine Res 22:329-34. 2002
    ..The initial characterization of this transgenic mouse line suggests it may be useful as a model for investigating biology and diseases relative to a number of scientific disciplines...
  2. ncbi request reprint Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice
    Dianne Botta
    Department of Environmental and Occupational Health Sciences, Comparative Medicine, and Pathology, and UW NIEHS Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 68105, USA
    J Biol Chem 281:28865-75. 2006
    ..Because people are known to vary in their glutamate-cysteine ligase activity, this enzyme may also be an important determinant of sensitivity to acetaminophen-induced liver injury in humans...
  3. pmc Protein kinase A is a target for aging and the aging heart
    Linda C Enns
    Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Aging (Albany NY) 2:238-43. 2010
    ..Since PKA is a major metabolic regulator of gene signaling, the human gene homologs are potential pharmacological targets for age-related conditions including heart disease associated with declining cardiac performance...
  4. pmc Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A
    Linda C Enns
    Department of Comparative Medicine, University of Washington, Seattle, WA, 98915, USA
    J Gerontol A Biol Sci Med Sci 64:1221-31. 2009
    ..These findings have relevant pharmacological implications because aging in mammals is characterized by metabolic decline associated with obesity, altered body fat distribution, and insulin resistance...
  5. pmc Disruption of protein kinase A in mice enhances healthy aging
    Linda C Enns
    Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5963. 2009
    ..These findings help establish the highly conserved nature of PKA and suggest that disruption of PKA affects physiological mechanisms known to be associated with healthy aging...
  6. pmc Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner
    Jorming Goh
    Interdisciplinary Program in Nutritional Sciences, University of Washington, Seattle, Washington, United States of America Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e80123. 2013
    ..These observations suggest that the initiation of moderate exercise training for adjunctive therapeutic benefit early in the course of invasive breast cancer should be considered for further investigation...
  7. pmc A novel long term short interval physical activity regime improves body composition in mice
    Jorming Goh
    Interdisciplinary Program in Nutritional Sciences Medicine, University of Washington, Seattle, WA, USA
    BMC Res Notes 6:66. 2013
    ..Mice were randomized and given access to voluntary wheel running (N = 6) or locked wheels (N = 5) for 1 hour per night during the dark cycle, 5 days per week...
  8. pmc Mitochondrial targeted catalase suppresses invasive breast cancer in mice
    Jorming Goh
    Department of Comparative Medicine University of Washington, Seattle, USA
    BMC Cancer 11:191. 2011
    ....
  9. ncbi request reprint A mitochondrial view of aging, reactive oxygen species and metastatic cancer
    Warren Ladiges
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Aging Cell 9:462-5. 2010
    ..Based on this evidence, therapeutics focused on mitochondrial function and mitochondrial ROS production are an attractive approach to modulating the progression of metastatic cancer and the general improvement of human health span...
  10. pmc Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction
    Linda C Enns
    Departments of Comparative Medicine, Physiology and Biophysics, and Biostatistics, University of Washington, Seattle, WA, 98195, USA
    BMC Res Notes 3:307. 2010
    ....
  11. doi request reprint Lifespan extension in genetically modified mice
    Warren Ladiges
    Department of Comparative Medicine, University of Washington, Seattle, 98195, USA
    Aging Cell 8:346-52. 2009
    ..Only then will it be possible to confidently determine that the genetic modification extends lifespan and alters aging...
  12. ncbi request reprint Tissue specific expression of PKR protein kinase in aging B6D2F1 mice
    W Ladiges
    The Nathan Shock Center for Excellence in the Biology of Aging, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 114:123-32. 2000
    ....
  13. ncbi request reprint Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK
    Warren C Ladiges
    Department of Comparative Medicine, Comparative Mouse Genomics Center, University of Washington, Seattle, Washington 98195, USA
    Diabetes 54:1074-81. 2005
    ..P58(IPK) function and activity may therefore provide a novel area of investigation into ER-mediated mechanistic and therapeutic approaches for diabetes...
  14. ncbi request reprint Mouse models of XRCC1 DNA repair polymorphisms and cancer
    W C Ladiges
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Oncogene 25:1612-9. 2006
    ....
  15. ncbi request reprint Human gene variation: from SNPs to phenotypes
    W Ladiges
    Department of Comparative Medicine, University of Washington, 357190, Seattle, 98195, USA
    Mutat Res 545:131-9. 2004
  16. ncbi request reprint Polymorphisms in the DNA repair gene XRCC1 and age-related disease
    Warren Ladiges
    Comparative Mouse Genomics Center and Department of Comparative Medicine, University of Washington, P O Box 357190, Seattle, WA 98195, USA
    Mech Ageing Dev 124:27-32. 2003
    ..XRCC1 SNPs will be useful probes for investigating age-associated pathobiology in epidemiological and mechanistic studies...
  17. pmc Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy
    Michelle L Chaisson
    Department of Pathology, University of Washington, Seattle 98195, USA
    J Clin Invest 110:193-202. 2002
    ..As NF-kappaB activation was not inhibited in liver NPCs, it is likely that these cells are responsible for mediating the proliferative and antiapoptotic effects of NF-kappaB during liver regeneration...
  18. ncbi request reprint Comparative Mouse Genomics Centers Consortium: the Mouse Genotype Database
    Jesse C Wiley
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Mutat Res 595:137-44. 2006
    ..niehs.nih.gov/genotype/), which maintains both a consortium specific and public access display of the available and developing mouse models...
  19. ncbi request reprint Extension of murine life span by overexpression of catalase targeted to mitochondria
    Samuel E Schriner
    Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
    Science 308:1909-11. 2005
    ..These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals...
  20. pmc Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet
    Gina Moore
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States
    Mech Ageing Dev 129:201-6. 2008
    ..These observations suggest that Wrn null mice have impaired glucose homeostasis and fat metabolism, and may be a useful model to investigate metabolic conditions associated with aging...
  21. ncbi request reprint Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice
    Carol B Ware
    Department of Comparative Medicine, University of Washington, Box 357190, Seattle, WA 98195 7190, USA
    Transgenic Res 12:743-6. 2003
    ..Thus, although less efficient than 129 ES lines, the C57BL/6 ES line is a relatively competent line and useful for the routine generation of targeted mutations in mice on a defined genetic background...
  22. pmc Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis
    Ranga N Venkatesan
    Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
    Mol Cell Biol 27:7669-82. 2007
    ....
  23. ncbi request reprint Mitochondrial point mutations do not limit the natural lifespan of mice
    Marc Vermulst
    Department of Pathology, University of Washington, Seattle, Washington 91895, USA
    Nat Genet 39:540-3. 2007
    ..Thus, our results strongly indicate that mitochondrial mutations do not limit the lifespan of wild-type mice...
  24. ncbi request reprint Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria
    Piper M Treuting
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195 7190, USA
    J Gerontol A Biol Sci Med Sci 63:813-22. 2008
    ..The variability of the MCAT effect across tissues, however, illustrates the importance of developing semiquantitative histopathology for assessment of comorbidity in life-span studies...
  25. ncbi request reprint Detection of transgene product in mouse peripheral blood lymphocytes: a minimally invasive microassay
    Sonja T Chou
    Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Comp Med 52:543-7. 2002
    ....
  26. ncbi request reprint Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice
    Lisa A McConnachie
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    Toxicol Sci 99:628-36. 2007
    ..Collectively, these data reassert the importance of GSH in protection against APAP-induced hepatotoxicity, and indicate critical roles for GCL activity and gender in APAP-induced liver damage in mice...
  27. ncbi request reprint Approaches to determine clinical significance of genetic variants
    Alasdair MacAuley
    Comparative Mouse Genomics Center, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Mutat Res 573:205-20. 2005
    ..Informative mouse models will also provide the basis of pursuing relevant SNPs in epidemiological and clinical investigations...

Research Grants7

  1. Alzheimer's Disease and Impaired APP Proteolysis
    Warren Ladiges; Fiscal Year: 2006
    ....
  2. TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASE
    Warren Ladiges; Fiscal Year: 1999
    ..abstract_text> ..
  3. TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASE
    Warren Ladiges; Fiscal Year: 2000
    ..abstract_text> ..
  4. TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASE
    Warren Ladiges; Fiscal Year: 2001
    ..abstract_text> ..
  5. IMMUNOBIOLOGY OF AGING IN GENETICALLY ALTERED MICE
    Warren Ladiges; Fiscal Year: 2004
    ....
  6. Comparative Mouse Genomics Center
    Warren Ladiges; Fiscal Year: 2006
    ....