Research Topics
| W LadigesSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Expression of human PKR protein kinase in transgenic miceWarren Ladiges
Comparative Mouse Genomics Center, Nathan Shock Center for Excellence in the Biology of Aging, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
J Interferon Cytokine Res 22:329-34. 2002..The initial characterization of this transgenic mouse line suggests it may be useful as a model for investigating biology and diseases relative to a number of scientific disciplines...- Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic miceDianne Botta
Department of Environmental and Occupational Health Sciences, Comparative Medicine, and Pathology, and UW NIEHS Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 68105, USA
J Biol Chem 281:28865-75. 2006..Because people are known to vary in their glutamate-cysteine ligase activity, this enzyme may also be an important determinant of sensitivity to acetaminophen-induced liver injury in humans... 
Mitochondrial targeted catalase suppresses invasive breast cancer in miceJorming Goh
Department of Comparative Medicine University of Washington, Seattle, USA
BMC Cancer 11:191. 2011....- Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunctionLinda C Enns
Departments of Comparative Medicine, Physiology and Biophysics, and Biostatistics, University of Washington, Seattle, WA, 98195, USA
BMC Res Notes 3:307. 2010.... 
A mitochondrial view of aging, reactive oxygen species and metastatic cancerWarren Ladiges
Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
Aging Cell 9:462-5. 2010..Based on this evidence, therapeutics focused on mitochondrial function and mitochondrial ROS production are an attractive approach to modulating the progression of metastatic cancer and the general improvement of human health span...- Lifespan extension in genetically modified miceWarren Ladiges
Department of Comparative Medicine, University of Washington, Seattle, 98195, USA
Aging Cell 8:346-52. 2009..Only then will it be possible to confidently determine that the genetic modification extends lifespan and alters aging... - Mouse models of XRCC1 DNA repair polymorphisms and cancerW C Ladiges
Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
Oncogene 25:1612-9. 2006.... - Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPKWarren C Ladiges
Department of Comparative Medicine, Comparative Mouse Genomics Center, University of Washington, Seattle, Washington 98195, USA
Diabetes 54:1074-81. 2005..P58(IPK) function and activity may therefore provide a novel area of investigation into ER-mediated mechanistic and therapeutic approaches for diabetes... - Tissue specific expression of PKR protein kinase in aging B6D2F1 miceW Ladiges
The Nathan Shock Center for Excellence in the Biology of Aging, School of Medicine, University of Washington, Seattle, WA 98195, USA
Mech Ageing Dev 114:123-32. 2000.... - Polymorphisms in the DNA repair gene XRCC1 and age-related diseaseWarren Ladiges
Comparative Mouse Genomics Center and Department of Comparative Medicine, University of Washington, P O Box 357190, Seattle, WA 98195, USA
Mech Ageing Dev 124:27-32. 2003..XRCC1 SNPs will be useful probes for investigating age-associated pathobiology in epidemiological and mechanistic studies... - Human gene variation: from SNPs to phenotypesW Ladiges
Department of Comparative Medicine, University of Washington, 357190, Seattle, 98195, USA
Mutat Res 545:131-9. 2004 - Extension of murine life span by overexpression of catalase targeted to mitochondriaSamuel E Schriner
Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
Science 308:1909-11. 2005..These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals... - Comparative Mouse Genomics Centers Consortium: the Mouse Genotype DatabaseJesse C Wiley
Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
Mutat Res 595:137-44. 2006..niehs.nih.gov/genotype/), which maintains both a consortium specific and public access display of the available and developing mouse models... - Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomyMichelle L Chaisson
Department of Pathology, University of Washington, Seattle 98195, USA
J Clin Invest 110:193-202. 2002..As NF-kappaB activation was not inhibited in liver NPCs, it is likely that these cells are responsible for mediating the proliferative and antiapoptotic effects of NF-kappaB during liver regeneration... - Protein kinase A is a target for aging and the aging heartLinda C Enns
Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
Aging (Albany NY) 2:238-43. 2010..Since PKA is a major metabolic regulator of gene signaling, the human gene homologs are potential pharmacological targets for age-related conditions including heart disease associated with declining cardiac performance... - Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic dietGina Moore
Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States
Mech Ageing Dev 129:201-6. 2008..These observations suggest that Wrn null mice have impaired glucose homeostasis and fat metabolism, and may be a useful model to investigate metabolic conditions associated with aging... - Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondriaPiper M Treuting
Department of Comparative Medicine, University of Washington, Seattle, WA 98195 7190, USA
J Gerontol A Biol Sci Med Sci 63:813-22. 2008..The variability of the MCAT effect across tissues, however, illustrates the importance of developing semiquantitative histopathology for assessment of comorbidity in life-span studies... - Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesisRanga N Venkatesan
Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
Mol Cell Biol 27:7669-82. 2007.... - Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in miceCarol B Ware
Department of Comparative Medicine, University of Washington, Box 357190, Seattle, WA 98195 7190, USA
Transgenic Res 12:743-6. 2003..Thus, although less efficient than 129 ES lines, the C57BL/6 ES line is a relatively competent line and useful for the routine generation of targeted mutations in mice on a defined genetic background... - Mitochondrial point mutations do not limit the natural lifespan of miceMarc Vermulst
Department of Pathology, University of Washington, Seattle, Washington 91895, USA
Nat Genet 39:540-3. 2007..Thus, our results strongly indicate that mitochondrial mutations do not limit the lifespan of wild-type mice... - Detection of transgene product in mouse peripheral blood lymphocytes: a minimally invasive microassaySonja T Chou
Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Comp Med 52:543-7. 2002.... - Approaches to determine clinical significance of genetic variantsAlasdair MacAuley
Comparative Mouse Genomics Center, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
Mutat Res 573:205-20. 2005..Informative mouse models will also provide the basis of pursuing relevant SNPs in epidemiological and clinical investigations... - Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in miceLisa A McConnachie
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
Toxicol Sci 99:628-36. 2007..Collectively, these data reassert the importance of GSH in protection against APAP-induced hepatotoxicity, and indicate critical roles for GCL activity and gender in APAP-induced liver damage in mice...
Research Grants
- Alzheimer's Disease and Impaired APP ProteolysisWarren Ladiges; Fiscal Year: 2006....
- TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASEWarren Ladiges; Fiscal Year: 2001..abstract_text> ..
- IMMUNOBIOLOGY OF AGING IN GENETICALLY ALTERED MICEWarren Ladiges; Fiscal Year: 2004....
- Comparative Mouse Genomics CenterWarren Ladiges; Fiscal Year: 2006....