Research Topics
Genomes and GenesSpecies | David LacomisSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Neuromuscular disorders in critically ill patients: review and updateDavid Lacomis
Department of Neurology and Pathology Neuropathology, University of Pittsburgh School of Medicine, PA, USA
J Clin Neuromuscul Dis 12:197-218. 2011..Future studies of well-characterized patients with CIP and CIM should refine our understanding of risk factors, outcomes, and pathogenic mechanisms, leading to better interventions...- Electrodiagnostic approach to the patient with suspected myopathyDavid Lacomis
Division of Neuromuscular Diseases, University of Pittsburgh School of Medicine, UPMC Presbyterian, F875, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Neurol Clin 30:641-60. 2012..Electromyography may also be used to detect subclinical myopathy, assess disease activity, and help select a suitable muscle for biopsy... 
Approach to vasculitic neuropathiesDavid Lacomis
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Clin Neuromuscul Dis 9:265-76. 2007..The mainstays of treatment are corticosteroids and cyclophosphamide, but other drugs are used in specific conditions. With early diagnosis and careful monitoring of treatment regimens, the prognosis is usually good...- Myasthenic crisisDavid Lacomis
Department of Neurology, University of Pittsburgh School of Medicine Pittsburgh, PA 15213, USA
Neurocrit Care 3:189-94. 2005..The mortality rate should be 5% or less, with the elderly being most vulnerable... - Neuropathy and Fabry's diseaseDavid Lacomis
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Muscle Nerve 31:102-7. 2005..Histopathologic assessment of nerve and muscle biopsy specimens led to the diagnosis of Fabry's disease, thus allowing the patient to receive enzyme replacement therapy that may slow progression and preserve the transplanted kidney... - The MG-QOL15 for following the health-related quality of life of patients with myasthenia gravisTed M Burns
Department of Neurology, University of Virginia, PO Box 800394, Charlottesville, Virginia 22908, USA
Muscle Nerve 43:14-8. 2011..More objective measures, such as the MG Composite, should also be used to follow disease severity... 
The MG Composite: A valid and reliable outcome measure for myasthenia gravisTed M Burns
University of Virginia, Department of Neurology, PO Box 800394, Charlottesville, VA 22908, USA
Neurology 74:1434-40. 2010..To study the concurrent and construct validity and test-retest reliability in the practice setting of an outcome measure for myasthenia gravis (MG)...- MG-ADL: still a relevant outcome measureSrikanth Muppidi
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Muscle Nerve 44:727-31. 2011..The aim of this analysis was to examine the performance of the Myasthenia Gravis-specific Activities of Daily Living scale (MG-ADL) during a multicenter scale validation study... - Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomicsHenrik Ryberg
Department of Pathology, University of Pittsburgh School of Medicine, BST S 420, 200 Lothrop Street, Pittsburgh, Pennsylvania 15261, USA
Muscle Nerve 42:104-11. 2010..CRP levels were increased in the CSF of ALS patients, and cystatin C level correlated with survival in patients with limb-onset disease. Our biomarker panel predicted ALS with an overall accuracy of 82%... - The utility of muscle biopsyDavid Lacomis
University of Pittsburgh Medical Center, UPMC Presbyterian, 200 Lothrop Street, F878, Pittsburgh, PA 15213, USA
Curr Neurol Neurosci Rep 4:81-6. 2004..Muscle biopsy specimens are used in diagnosing many inherited as well as inflammatory and toxic myopathies. Furthermore, the study of muscle histopathology can also enhance our understanding of disease pathogenesis... - Applying proteomics to the diagnosis and treatment of ALS and related diseasesRobert Bowser
Department of Pathology, University of Pittsburgh School of Medicine, BST S 420, 200 Lothrop Street, Pittsburgh, Pennsylvania 15261, USA
Muscle Nerve 40:753-62. 2009..The continued development of protein biomarkers for MNDs requires extensive collaboration between academic clinicians and scientists in conjunction with the biotechnology and pharmaceutical industries... - Severe sensory neuropathy associated with long-term linezolid useSasa A Zivkovic
Department of Neurology, University of Pittsburgh School of Medicine, PA, USA
Neurology 64:926-7. 2005 - Critical illness myopathyDavid Lacomis
University of Pittsburgh Medical Center Presbyterian, 200 Lothrop Street, F878, Pittsburgh, PA 15213, USA
Curr Rheumatol Rep 4:403-8. 2002..In some patients, there is also upregulation of proteolytic pathways, involving calpain and ubiquitin, in conjunction with increased apoptosis. Fortunately, the disorder is reversible, but there may be considerable morbidity... - Electrodiagnostic approach to the patient with suspected myopathyDavid Lacomis
Departments of Neurology and Pathology Neuropathology, University of Pittsburgh, School of Medicine, 200 Lothrop Street, PUH F 878, Pittsburgh, PA 15213, USA
Neurol Clin 20:587-603. 2002..Histopathologic or molecular studies, or both may follow. Ultimately, this approach usually allows the clinician to make the correct diagnosis... - Cystatin C: a candidate biomarker for amyotrophic lateral sclerosisMeghan E Wilson
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 5:e15133. 2010.... - Severe hydroxychloroquine myopathyHoda Abdel-Hamid
Department of Pediatrics, Division of Child Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Muscle Nerve 38:1206-10. 2008..The ventilatory failure and subsequent medical complications led to death despite discontinuation of hydroxychloroquine, thereby underscoring the potential severity of hydroxychloroquine myopathy and the need for its early recognition... - Clinical utility of peripheral nerve biopsyDavid Lacomis
University of Pittsburgh Medical Center, UPMC Presbyterian, 200 Lothrop Street, F878, Pittsburgh, PA 15213, USA
Curr Neurol Neurosci Rep 5:41-7. 2005..In addition, the study of nerve histopathology can also enhance our understanding of disease pathogenesis... - Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathyAlan R Berger
Department of Neurology, University of Florida, USA
J Peripher Nerv Syst 8:282-4. 2003 - Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animalsMunmun Chattopadhyay
Department of Neurology, University of Pittsburgh, USA
Eur J Neurosci 17:732-40. 2003.... - Paraproteinemic neuropathySasa A Zivkovic
VA Pittsburgh Healthcare System, MSSL Neurology, Pittsburgh, PA, USA
Leuk Lymphoma 50:1422-33. 2009..At this time it is not clear whether mere presence of neuropathy warrants more aggressive treatment of otherwise quiescent hematologic malignances (e.g. smoldering myeloma)... - Critical illness neuromyopathiesDavid Lacomis
Departments of Neurology and Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Adv Neurol 88:325-35. 2002 - Characteristics of late-onset myasthenia gravisSasa A Zivkovic
Neurology Service, Department of Veterans Affairs, Pittsburgh, PA 15240, USA
J Neurol 259:2167-71. 2012..However, overall disease severity may not be higher with aging. These observations have implications for design of MG clinical trials and outcomes studies... - Neuromuscular pathology caseAngela Lu
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
J Clin Neuromuscul Dis 9:361-3. 2008 - Small-fiber neuropathyDavid Lacomis
Department of Neurology, University of Pittsburgh School of Medicine, UPMC Presbyterian, 200 Lothrop Street, F878, Pittsburgh, Pennsylvania 15213, USA
Muscle Nerve 26:173-88. 2002..Each has certain advantages and disadvantages, and the tests may be complementary. Unless an underlying disease is identified, treatment is usually directed toward alleviation of neuropathic pain... - Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathyAmy H Kao
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Arthritis Rheum 50:209-15. 2004..Severe muscle weakness and atrophy were prominent features in PM patients with anti-SRP. Cardiac involvement was less common and survival was better in patients with anti-SRP than has previously been reported... - Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosisSrikanth Ranganathan
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neurochem 95:1461-71. 2005..We validated the SELDI-TOF-MS results for transthyretin and cystatin C by immunoblot and immunohistochemistry using commercially available antibodies. These findings identify a panel of CSF protein biomarkers for ALS... - R+ pramipexole as a mitochondrially focused neuroprotectant: initial early phase studies in ALSHua Wang
Department of Neurology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Amyotroph Lateral Scler 9:50-8. 2008..High doses of R+PPX were tolerated well and yielded neuroprotective plasma levels. These findings support longer-term testing of higher R+PPX doses as a potential disease-altering therapy for SALS... - Construct and concurrent validation of the MG-QOL15 in the practice settingTed M Burns
Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA
Muscle Nerve 41:219-26. 2010..The study findings shed light on what troubles MG patients. The MG-QOL15 has construct validity in the clinical practice setting and represents an efficient and valuable tool for assessing HRQOL for patients with MG... - Chronic eosinophilic perimyositis with persistent myalgiasSasa A Zivkovic
Department of Neurology, University of Pittsburgh School of Medicine, BST South, Room S515, Pittsburgh, Pennsylvania 15213, USA
Muscle Nerve 25:461-5. 2002..This case illustrates that the diagnosis of eosinophilic perimyositis requires histopathological evaluation, which should be pursued in patients with eosinophilia and persistent myalgia despite normal electromyography and muscle enzymes... - Muscle cramps associated with localized scleroderma skin lesions: focal dystonia, neuromyotonia, or nerve entrapment?Sasa A Zivkovic
J Rheumatol 33:2549. 2006