Michael J Lace

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Upstream regulatory region alterations found in human papillomavirus type 16 (HPV-16) isolates from cervical carcinomas increase transcription, ori function, and HPV immortalization capacity in culture
    Michael J Lace
    Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Virol 83:7457-66. 2009
  2. doi request reprint The truncated C-terminal E2 (E2-TR) protein of bovine papillomavirus (BPV) type-1 is a transactivator that modulates transcription in vivo and in vitro in a manner distinct from the E2-TA and E8^E2 gene products
    Michael J Lace
    Veterans Affairs Healthcare System, Iowa City, IA 52246, USA
    Virology 429:99-111. 2012
  3. pmc Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers
    Michael J Lace
    Department of Pathology, University of Iowa Roy J and Lucille A Carver College ofMedicine, Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Virol 85:1645-54. 2011
  4. doi request reprint Interferon regulatory factor (IRF)-2 activates the HPV-16 E6-E7 promoter in keratinocytes
    Michael J Lace
    Department of Pathology, VAMC, University of Iowa, Iowa City, IA 52242, USA
    Virology 399:270-9. 2010
  5. pmc Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs
    Michael J Lace
    Veterans Affairs Medical Center, 601 Highway 6 West, Iowa City, IA 52246, USA
    J Virol 83:11784-94. 2009
  6. doi request reprint Cellular factor YY1 downregulates the human papillomavirus 16 E6/E7 promoter, P97, in vivo and in vitro from a negative element overlapping the transcription-initiation site
    Michael J Lace
    Veterans Affairs Medical Center, 601 Highway 6 West, Iowa City, IA 52246, USA
    J Gen Virol 90:2402-12. 2009
  7. doi request reprint Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1
    Michael J Lace
    Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Carcinogenesis 30:1336-44. 2009
  8. doi request reprint Cellular factors are required to activate bovine papillomavirus-1 early gene transcription and to establish viral plasmid persistence but are not required for cellular transformation
    Thomas H Haugen
    Veterans Affairs Medical Center, The Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Virology 389:82-90. 2009
  9. pmc Functional mapping of the human papillomavirus type 16 E1 cistron
    Michael J Lace
    Department of Pathology, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Virol 82:10724-34. 2008
  10. pmc The E8--E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes
    Michael J Lace
    Department of Pathology, Veterans Affairs Medical Center, and The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Virol 82:10841-53. 2008

Collaborators

Detail Information

Publications11

  1. pmc Upstream regulatory region alterations found in human papillomavirus type 16 (HPV-16) isolates from cervical carcinomas increase transcription, ori function, and HPV immortalization capacity in culture
    Michael J Lace
    Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Virol 83:7457-66. 2009
    ..Our results thus provide evidence that nucleotide alterations in HPV regulatory sequences could serve as potential prognostic markers of HPV-associated carcinogenesis...
  2. doi request reprint The truncated C-terminal E2 (E2-TR) protein of bovine papillomavirus (BPV) type-1 is a transactivator that modulates transcription in vivo and in vitro in a manner distinct from the E2-TA and E8^E2 gene products
    Michael J Lace
    Veterans Affairs Healthcare System, Iowa City, IA 52246, USA
    Virology 429:99-111. 2012
    ..E2-TR also partially inhibited the BPV-1 P89 or heterologous promoters whereas E8^E2 led to complete repression. Thus, the BPV-1 E2-TR modulates viral gene expression in a manner distinct from other E2 proteins...
  3. pmc Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers
    Michael J Lace
    Department of Pathology, University of Iowa Roy J and Lucille A Carver College ofMedicine, Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Virol 85:1645-54. 2011
    ..Furthermore, our results demonstrate that this selection also takes place and can be studied in primary human keratinocytes in culture...
  4. doi request reprint Interferon regulatory factor (IRF)-2 activates the HPV-16 E6-E7 promoter in keratinocytes
    Michael J Lace
    Department of Pathology, VAMC, University of Iowa, Iowa City, IA 52242, USA
    Virology 399:270-9. 2010
    ..Taken together, these observations reveal a complex viral strategy utilizing multiple signal transduction pathways during the establishment and maintenance of HPV persistence...
  5. pmc Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs
    Michael J Lace
    Veterans Affairs Medical Center, 601 Highway 6 West, Iowa City, IA 52246, USA
    J Virol 83:11784-94. 2009
    ....
  6. doi request reprint Cellular factor YY1 downregulates the human papillomavirus 16 E6/E7 promoter, P97, in vivo and in vitro from a negative element overlapping the transcription-initiation site
    Michael J Lace
    Veterans Affairs Medical Center, 601 Highway 6 West, Iowa City, IA 52246, USA
    J Gen Virol 90:2402-12. 2009
    ....
  7. doi request reprint Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1
    Michael J Lace
    Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Carcinogenesis 30:1336-44. 2009
    ....
  8. doi request reprint Cellular factors are required to activate bovine papillomavirus-1 early gene transcription and to establish viral plasmid persistence but are not required for cellular transformation
    Thomas H Haugen
    Veterans Affairs Medical Center, The Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Virology 389:82-90. 2009
    ..We conclude that cellular factors necessary for activating viral early gene transcription, establishment of viral plasmid replication and cell immortalization are not required during the maintenance phase of BPV-1 infection...
  9. pmc Functional mapping of the human papillomavirus type 16 E1 cistron
    Michael J Lace
    Department of Pathology, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Virol 82:10724-34. 2008
    ..We conclude that P14-initiated E1 expression is critical for and limiting in the initial amplification of the HPV-16 genome...
  10. pmc The E8--E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes
    Michael J Lace
    Department of Pathology, Veterans Affairs Medical Center, and The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Virol 82:10841-53. 2008
    ....
  11. pmc Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras
    Kristi L Berger
    Department of Microbiology, Holden Comprehensive Cancer Research Center, University of Iowa, 375 Newton Road, 2202 MERF, Iowa City, IA 52242, USA
    Virology 356:68-78. 2006
    ..In conclusion, our results indicate that Ras-mediated transformation depends on the context of HPV oncogene expression and that this is an important point to address when developing HPV tumor models...