A R La Spada

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Trinucleotide repeat instability: genetic features and molecular mechanisms
    A R La Spada
    Department of Laboratory Medicine and Pharmacology, University of Washington Medical Center, Seattle 98195, USA
    Brain Pathol 7:943-63. 1997
  2. ncbi request reprint Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability
    A R La Spada
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 7:959-67. 1998
  3. ncbi request reprint Insights into the molecular basis of polyglutamine neurodegeneration from studies of a spinocerebellar ataxia type 7 mouse model
    S K Grote
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA 98195 7110, USA
    Cytogenet Genome Res 100:164-74. 2003
  4. ncbi request reprint Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7
    A R La Spada
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA 98195, USA
    Neuron 31:913-27. 2001
  5. ncbi request reprint Genomic organization, chromosome location, and expression analysis of mouse beta-synuclein, a candidate for involvement in neurodegeneration
    B L Sopher
    Department of Laboratory Medicine, University of Washington Medical Center, Room NW 120, Seattle, WA 98995 7110, USA
    Cytogenet Cell Genet 93:117-23. 2001
  6. pmc Beta-synuclein gene alterations in dementia with Lewy bodies
    H Ohtake
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Neurology 63:805-11. 2004
  7. ncbi request reprint Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 34:155-68. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Trinucleotide repeat instability: genetic features and molecular mechanisms
    A R La Spada
    Department of Laboratory Medicine and Pharmacology, University of Washington Medical Center, Seattle 98195, USA
    Brain Pathol 7:943-63. 1997
    ..There are many reasons to suspect that this uniquely human phenomenon will significantly impact upon our understanding of development, differentiation and neurobiology...
  2. ncbi request reprint Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability
    A R La Spada
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 7:959-67. 1998
    ....
  3. ncbi request reprint Insights into the molecular basis of polyglutamine neurodegeneration from studies of a spinocerebellar ataxia type 7 mouse model
    S K Grote
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA 98195 7110, USA
    Cytogenet Genome Res 100:164-74. 2003
    ....
  4. ncbi request reprint Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7
    A R La Spada
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA 98195, USA
    Neuron 31:913-27. 2001
    ..Our results suggest that CRX transcription interference accounts for the retinal degeneration in SCA7 and thus may provide an explanation for how cell-type specificity is achieved in this polyglutamine repeat disease...
  5. ncbi request reprint Genomic organization, chromosome location, and expression analysis of mouse beta-synuclein, a candidate for involvement in neurodegeneration
    B L Sopher
    Department of Laboratory Medicine, University of Washington Medical Center, Room NW 120, Seattle, WA 98995 7110, USA
    Cytogenet Cell Genet 93:117-23. 2001
    ..Knowledge of the genomic organization and expression pattern of Sncb will allow functional studies of its potential role in neurodegeneration to commence in the mouse...
  6. pmc Beta-synuclein gene alterations in dementia with Lewy bodies
    H Ohtake
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Neurology 63:805-11. 2004
    ..To determine whether mutations in the genes for alpha-synuclein or beta-synuclein are responsible for dementia with Lewy bodies (DLB), a disorder closely related to Parkinson disease (PD)...
  7. ncbi request reprint Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 34:155-68. 2008
    ....