Natasha Kyprianou

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Emerging biomarkers of prostate cancer (Review)
    Sarah K Martin
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Oncol Rep 28:409-17. 2012
  2. pmc Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction
    J V Partin
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Br J Cancer 88:1615-21. 2003
  3. ncbi request reprint Therapeutic value of quinazoline-based compounds in prostate cancer
    Johnathan Bilbro
    Combs Res Bldg, Rm 306, University of Kentucky Medical Center, Lexington, KY 40536, U S A
    Anticancer Res 33:4695-700. 2013
  4. pmc Molecular signatures in urologic tumors
    Spencer Larkin
    Departments of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, KY 40536, USA
    Int J Mol Sci 14:18421-36. 2013
  5. pmc Growth factor signalling in prostatic growth: significance in tumour development and therapeutic targeting
    Arich Ryan Reynolds
    Department of Surgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Br J Pharmacol 147:S144-52. 2006
  6. doi request reprint Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells
    Sowmyalakshmi Srinivasan
    Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Int J Cancer 125:961-7. 2009
  7. pmc Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells
    Meng Lei Zhu
    Combs Res Bldg, Rm 306, University of Kentucky Medical Center, Lexington, KY 40536, USA
    FASEB J 24:769-77. 2010
  8. pmc Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity
    Jason B Garrison
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Cancer Res 67:11344-52. 2007
  9. pmc Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance
    Shinichi Sakamoto
    Department of Surgery Urology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Cancer Res 70:1885-95. 2010
  10. pmc EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer
    Haining Zhu
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    Prostate 72:72-81. 2012

Research Grants

Collaborators

Detail Information

Publications59

  1. pmc Emerging biomarkers of prostate cancer (Review)
    Sarah K Martin
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Oncol Rep 28:409-17. 2012
    ....
  2. pmc Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction
    J V Partin
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Br J Cancer 88:1615-21. 2003
    ..The present study provides an initial insight into the molecular targets of the apoptotic action of quinazolines against prostate cancer cells...
  3. ncbi request reprint Therapeutic value of quinazoline-based compounds in prostate cancer
    Johnathan Bilbro
    Combs Res Bldg, Rm 306, University of Kentucky Medical Center, Lexington, KY 40536, U S A
    Anticancer Res 33:4695-700. 2013
    ....
  4. pmc Molecular signatures in urologic tumors
    Spencer Larkin
    Departments of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, KY 40536, USA
    Int J Mol Sci 14:18421-36. 2013
    ....
  5. pmc Growth factor signalling in prostatic growth: significance in tumour development and therapeutic targeting
    Arich Ryan Reynolds
    Department of Surgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Br J Pharmacol 147:S144-52. 2006
    ....
  6. doi request reprint Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells
    Sowmyalakshmi Srinivasan
    Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Int J Cancer 125:961-7. 2009
    ..Thus, these results suggest that diosgenin might prove to be a potential chemotherapeutic agent for the treatment of BCa...
  7. pmc Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells
    Meng Lei Zhu
    Combs Res Bldg, Rm 306, University of Kentucky Medical Center, Lexington, KY 40536, USA
    FASEB J 24:769-77. 2010
    ..Zhum, M.-L., Kyprianou, N. Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells...
  8. pmc Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity
    Jason B Garrison
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Cancer Res 67:11344-52. 2007
    ..This new class of quinazoline-based compounds provides considerable promise as antitumor drugs for the treatment of advanced prostate cancer...
  9. pmc Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance
    Shinichi Sakamoto
    Department of Surgery Urology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Cancer Res 70:1885-95. 2010
    ..These findings suggest (a) a therapeutic significance of disrupting talin1 signaling/focal adhesion interactions in targeting metastatic prostate cancer and (b) a potential value for talin1 as a marker of tumor progression to metastasis...
  10. pmc EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer
    Haining Zhu
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    Prostate 72:72-81. 2012
    ..Proteins on cell surface play important roles during cancer progression and metastasis via their ability to mediate cell-to-cell interactions and navigate the communication between cells and the microenvironment...
  11. pmc Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model
    Hong Pu
    Department of Surgery Urology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Cancer Res 69:7366-74. 2009
    ..The study also suggests that a dysfunctional TGF beta RII augments androgen receptor expression and promotes inflammation in early stage tumor growth, thus conferring a significant contribution by TGF-beta to prostate cancer progression...
  12. pmc Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway
    Jason B Garrison
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Cancer Res 66:464-72. 2006
    ..These results show that doxazosin exerts its apoptotic effects against benign and malignant prostate cells via a death receptor-mediated mechanism with a potential integrin contribution towards cell survival outcomes...
  13. doi request reprint TGF-beta signaling and androgen receptor status determine apoptotic cross-talk in human prostate cancer cells
    Meng Lei Zhu
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Prostate 68:287-95. 2008
    ....
  14. pmc The role of alpha-blockers in the management of prostate cancer
    Anastasios Tahmatzopoulos
    University of Kentucky Medical Center, 800 Rose Street, MS 283, Lexington, KY 40536 0298, USA
    Expert Opin Pharmacother 5:1279-85. 2004
    ....
  15. pmc Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer
    Meng Lei Zhu
    Departments of Toxicology, Pathology, Molecular Biochemistry, and Urology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Cancer Res 70:7992-8002. 2010
    ..Our findings show that in addition to blocking cell division, docetaxel impairs AR signaling, evidence that enables new insights into the therapeutic efficacy of microtubule-targeting drugs in prostate cancer...
  16. pmc Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling
    Brian Zhu
    Department of Surgery, Division of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Prostate 70:17-26. 2010
    ..shRNA PHB loss of function in prostate cancer cells led to enhanced apoptotic response to TGF-beta via Smad-dependent mechanism...
  17. doi request reprint Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma
    Shinichi Sakamoto
    Department of Surgery, University of Kentucky College of Medicine, Lexington, KY, USA
    Eur Urol 59:734-44. 2011
    ..Quinazoline-based α1-adrenoceptor antagonists suppress tumor growth by inducing apoptosis via an α1-adrenoceptor-independent action. Anoikis is a unique mode of apoptosis consequential to insufficient cell-matrix interactions...
  18. ncbi request reprint Finasteride targets prostate vascularity by inducing apoptosis and inhibiting cell adhesion of benign and malignant prostate cells
    M Tandy Sutton
    Division of Urology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Prostate 66:1194-202. 2006
    ..This study investigated the effects of finasteride, a 5alpha-reductase inhibitor, clinically used for the treatment of benign prostatic hyperplasia (BPH) on prostate tumor vascularity, apoptosis, and cell adhesion in situ and in vitro...
  19. pmc Effect of terazosin on tissue vascularity and apoptosis in transitional cell carcinoma of bladder
    Anastasios Tahmatzopoulos
    Department of Surgery, Markey Cancer Center, University of Kentucky Medical Center, Lexington, Kentucky, USA
    Urology 65:1019-23. 2005
    ..The alpha1-adrenoceptor antagonist terazosin has recently been shown to induce apoptosis in prostate cancer cells both in vitro and in vivo and to reduce prostatic tissue vascularity by potentially affecting endothelial cell adhesion...
  20. pmc Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis
    Anastasios Tahmatzopoulos
    Department of Surgery, Division of Urology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Oncogene 24:5375-83. 2005
    ..These findings may have therapeutic significance in the development of antiangiogenic targeting by doxazosin and derivative agents for advanced prostate cancer...
  21. ncbi request reprint Cofilin drives cell-invasive and metastatic responses to TGF-β in prostate cancer
    Joanne Collazo
    Authors Affiliations Departments of Toxicology, Urology, Molecular and Cellular Biochemistry, and Pathology, University of Kentucky College of Medicine, Lexington, Kentucky and Departments of Cancer Genetics and Urology, Roswell Park Cancer Institute, Buffalo, New York
    Cancer Res 74:2362-73. 2014
    ..Our findings show that the actin-severing protein CFL coordinates responses to TGF-β that are needed for invasive cancer migration and metastasis...
  22. ncbi request reprint Prohibitin and cofilin are intracellular effectors of transforming growth factor beta signaling in human prostate cancer cells
    Beibei Zhu
    Division of Urology, College of Medicine, University of Kentucky, Lexington, KY 40536 0298, USA
    Cancer Res 66:8640-7. 2006
    ..Silencing Smad4 showed that the cellular localization changes associated with prohibitin and cofilin action in response to TGF-beta are independent of Smad4 intracellular signaling...
  23. ncbi request reprint Effect of permixon on human prostate cell growth: lack of apoptotic action
    Brian Hill
    Division of Urology, University of Maryland School of Medicine, Baltimore, MD, USA
    Prostate 61:73-80. 2004
    ..In this study, we investigated the magnitude and specificity of the effect of Permixon on cell proliferation and apoptosis in human prostate cancer cells...
  24. ncbi request reprint Apoptotic impact of alpha1-blockers on prostate cancer growth: a myth or an inviting reality?
    Anastasios Tahmatzopoulos
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Prostate 59:91-100. 2004
    ..This action alone however does not fully account for the long-term clinical response to these drugs in BPH patients...
  25. pmc Targeting anoikis resistance in prostate cancer metastasis
    Shinichi Sakamoto
    Department of Surgery Urology, University of Kentucky College of Medicine, Lexington, KY, USA
    Mol Aspects Med 31:205-14. 2010
    ..Potential combination strategies targeting tumor vascularity (via anoikis) and impairing tumor initiation (via "classic" apoptosis), provide strong therapeutic promise for metastatic prostate cancer by preventing the onset of metastasis...
  26. pmc Androgen receptor and growth factor signaling cross-talk in prostate cancer cells
    Meng Lei Zhu
    Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA
    Endocr Relat Cancer 15:841-9. 2008
    ..The significance of this derailed cross-talk between androgens and key signaling networks in prostate cancer progression and its value as a therapeutic forum targeting androgen-independent metastatic prostate cancer is discussed...
  27. ncbi request reprint Alpha1-adrenoceptor antagonists radiosensitize prostate cancer cells via apoptosis induction
    David C Cuellar
    Division of Urology, The University of Maryland School of Medicine, Baltimore, USA
    Anticancer Res 22:1673-9. 2002
    ..In this study, we evaluated the potential additive/synergistic apoptotic effect of alpha1-adrenoceptor antagonists with ionizing radiation against human prostate cancer cells in vitro...
  28. pmc Targeting vasculature in urologic tumors: mechanistic and therapeutic significance
    Shinichi Sakamoto
    Division of Urology and Department of Molecular Biochemistry, and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Cell Biochem 103:691-708. 2008
    ....
  29. pmc Effect of alpha1-adrenoceptor antagonist exposure on prostate cancer incidence: an observational cohort study
    Andrew M Harris
    Division of Urology, Department of Surgery, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    J Urol 178:2176-80. 2007
    ..To assess the effect of alpha1-blocker exposure on the incidence of prostate cancer we performed an exploratory, observational cohort study...
  30. doi request reprint Detection of microRNAs in prostate cancer cells by microRNA array
    Xiaoqing Tang
    Department of Plant and Soil Sciences and KTRDC, University of Kentucky, Lexington, KY, USA
    Methods Mol Biol 732:69-88. 2011
    ..This comprehensive and easy-to-follow protocol will be useful for studying miRNAs in various cancers and can be readily adapted for miRNA analysis in a variety of human diseases...
  31. ncbi request reprint Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance
    Natasha Kyprianou
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, USA
    J Urol 169:1520-5. 2003
    ..This action alone however does not fully account for the long-term clinical responses exerted by these drugs in the treatment of patients with benign prostatic hyperplasia (BPH)...
  32. doi request reprint Significance of talin in cancer progression and metastasis
    Andreas Desiniotis
    Department of Surgery Urology, and Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, USA
    Int Rev Cell Mol Biol 289:117-47. 2011
    ....
  33. pmc Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group
    Wang Xia Wang
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    Cancer Res 70:9137-42. 2010
    ..These findings indicate for the first time that the mitogen and growth factor GRN is dysregulated via the miR-15/107 gene group in multiple human cancers, which may provide a potential common therapeutic target...
  34. pmc Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells
    Raj Kumar
    Department of Clinical Laboratory Sciences, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA
    Cancer Prev Res (Phila) 2:234-43. 2009
    ....
  35. ncbi request reprint Targeting TGF-beta in prostate cancer: therapeutic possibilities during tumor progression
    Elisabeth Jones
    University of Kentucky, Surgery Urology and Markey Cancer Center, 306 Combs Building, 800 Rose Street, Lexington, KY 40536, USA
    Expert Opin Ther Targets 13:227-34. 2009
    ..Increased production of TGF-beta causes immunosuppression, extracellular matrix degradation, epithelia to mesenchymal transition and angiogenesis that promotes tumor cell invasion and metastasis...
  36. ncbi request reprint Apoptosis induction by doxazosin and other quinazoline alpha1-adrenoceptor antagonists: a new mechanism for cancer treatment?
    Natasha Kyprianou
    Naunyn Schmiedebergs Arch Pharmacol 380:473-7. 2009
    ....
  37. ncbi request reprint Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action
    Cynthia M Benning
    Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 62:597-602. 2002
    ....
  38. pmc Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance
    Shaun McKenzie
    Department of Surgery Urology, University of Kentucky Medical Center, Lexington, KY, USA
    J Cell Biochem 97:18-32. 2006
    ..The challenges in the development of effective treatment modalities for advanced prostate cancer represent a classic paradigm of the functional significance of anti-apoptotic pathways in the development of therapeutic resistance...
  39. pmc Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells
    Patrick J Hensley
    Department of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America Department of Pathology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 9:e86238. 2014
    ....
  40. ncbi request reprint Bcl-2 antagonizes the combined apoptotic effect of transforming growth factor-beta and dihydrotestosterone in prostate cancer cells
    Elizabeth M Bruckheimer
    Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, USA
    Prostate 53:133-42. 2002
    ..We previously demonstrated that dihydrotestosterone (DHT) enhances transforming growth factor-beta (TGF-beta) -induced apoptosis in human prostate cancer cells (Endocrinology 2001;142:2419-2426)...
  41. pmc Proteasomal regulation of caspase-8 in cancer cell apoptosis
    Michael V Fiandalo
    Department of Molecular and Cellular Biochemistry and the Markey Cancer Center, University of Kentucky College of Medicine, Combs Cancer Research Building, 306, 800 Rose Street, Lexington, KY 40536, USA
    Apoptosis 18:766-76. 2013
    ..Inhibition of this E3 ligase in combination with TRAIL towards restoring apoptosis signaling activation may have potential therapeutic significance in resistant tumors...
  42. pmc Targeting caspases in cancer therapeutics
    Patrick Hensley
    Department of Urology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
    Biol Chem 394:831-43. 2013
    ....
  43. pmc Advances in the design and synthesis of prazosin derivatives over the last ten years
    Andreas Desiniotis
    University of Kentucky Medical Center, University of Kentucky, College of Medicine, Department of Surgery, Combs Cancer Research Building, Room 306, Lexington, KY 40536, USA
    Expert Opin Ther Targets 15:1405-18. 2011
    ....
  44. pmc Modeling prostate cancer in mice: limitations and opportunities
    Patrick J Hensley
    Department of Surgery Urology, University of Kentucky, Lexington, KY 40536, USA
    J Androl 33:133-44. 2012
    ....
  45. ncbi request reprint Apoptosis incidence and protein expression of p53, TGF-beta receptor II, p27Kip1, and Smad4 in benign, premalignant, and malignant human prostate
    Li Zeng
    Division of Urology, Department of Surgery, Lexington, KY 40536, USA
    Hum Pathol 35:290-7. 2004
    ..Identification of apoptotic regulators in precursor premalignant lesions may have prognostic significance in disease progression as well as therapeutic value for targeting prostate cancer...
  46. ncbi request reprint Sequencing hormonal ablation and radiotherapy in prostate cancer: a molecular and therapeutic prespective (Review)
    Brian Hill
    Division of Urology, Department of Surgery, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Oncol Rep 9:1151-6. 2002
    ....
  47. pmc Autophagy and oxidative stress in gliomas with IDH1 mutations
    Misty R Gilbert
    Department of Pathology and Laboratory Medicine, University of Kentucky, 307 Combs Building, Lexington, KY, 40536, USA
    Acta Neuropathol 127:221-33. 2014
    ..These data indicate that mutant IDH1 and 2-HG can induce oxidative stress, autophagy, and apoptosis, but these effects vary greatly according to cell type. ..
  48. ncbi request reprint Novel targeting of apoptosis pathways for prostate cancer therapy
    Jason B Garrison
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Curr Cancer Drug Targets 4:85-95. 2004
    ....
  49. pmc Intracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis
    Steven R Schwarze
    Department of Molecular Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Prostate 68:1615-23. 2008
    ..In this review, we focus on linking ER stress-induced apoptosis to therapeutic targeting of prostate tumors and dissect its cross-talk with the intrinsic and extrinsic apoptotic pathways...
  50. ncbi request reprint Transforming growth factor beta and prostate cancer
    Brian Zhu
    Division of Urology, Department of Surgery, University of Kentucky, Lexington, KY, USA
    Cancer Treat Res 126:157-73. 2005
    ....
  51. pmc Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis?
    Gabriela Rennebeck
    Department of Surgery Urology and Molecular, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, 40536, USA
    Cancer Res 65:11230-5. 2005
    ....
  52. ncbi request reprint Gene fusions find an ERG-way to tumor inflammation
    Sarah K Martin
    University of Kentucky College of Medicine, Lexington, KY
    Cancer Biol Ther 11:418-20. 2011
    ..Mohamed, Shyh-Han Tan, Chen Sun, Syed Shaheduzzaman, Ying Hu, Gyorgy Petrovics, Yongmei Chen, Isabell A. Sesterhenn, Hua Li, Taduru Sreenath, David G. McLeod, Albert Dobi and Shiv Srivastava...
  53. pmc Live free or die: tales of homeless (cells) in cancer
    Craig Horbinski
    Department of Pathology, University of Kentucky, Lexington, Kentucky, USA
    Am J Pathol 177:1044-52. 2010
    ..Dissecting the mechanistic players in the cellular response may be of high clinical significance in identifying effective approaches in reversing anoikis resistance in primary tumor cells and, consequently, impairing metastasis...
  54. pmc Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract
    Gretchen E Garcia
    Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neoplasia 8:523-33. 2006
    ..Further, Akt kinase activity was reduced in cells treated with Nexrutine, and ectopic expression of myristoylated Akt protected from Nexrutine induced inhibition of proliferation, implicating a role for Akt signaling...
  55. ncbi request reprint Anoikis induction by quinazoline based alpha 1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2
    Kasapr Keledjian
    Divisionof Urology, University of Maryland, Baltimore, USA
    J Urol 169:1150-6. 2003
    ..In this study we investigated the effect of the 2 piperazidinyl quinazoline based alpha1-adrenoceptor antagonists and the methoxybenzene sulfonamide alpha1-antagonist tamsulosin on human prostate cancer cell adhesion...
  56. ncbi request reprint Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation
    Yeng Jeng Shaw
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Med Chem 47:4453-62. 2004
    ..2 and 1.5 microM, respectively. Together, these in vitro efficacy data suggest the translational potential of these agents in prostate cancer treatment...
  57. ncbi request reprint Caspase-1 enhances the apoptotic response of prostate cancer cells to ionizing radiation
    Rachel N Winter
    Department of Biochemistry and Molecular Biology and Division of Urology, University of Maryland School of Medicine, Baltimore, MD, USA
    Anticancer Res 24:1377-86. 2004
    ..In this study, we investigated the role of caspase-1 in radiation-induced apoptosis in order to identify the significance of this apoptotic initiator in radiation resistance...
  58. ncbi request reprint Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion
    Kaspar Keledjian
    Division of Surgery, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    J Cell Biochem 94:374-88. 2005
    ..This evidence may have potential therapeutic significance in using this quinazoline-based compound as an antiangiogenic agent for the treatment of advanced prostate cancer...
  59. ncbi request reprint Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer
    John T Isaacs
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 66:1768-78. 2006
    ..MS clinical trials were discontinued because of unacceptable toxicity, due to dose-dependent induction of proinflammation...

Research Grants11

  1. Anoikis Effect by Quinazolines on Prostate Growth
    Natasha Kyprianou; Fiscal Year: 2005
    ..Potential results will establish the apoptotic/anoikis effect by the quinazolines as a significant phenomenon with clinical relevance in development and progression of benign prostatic hyperplasia (BPH) prostate cancer. ..
  2. TGF-Beta Signaling Pathways in Prostate Tumorigenesis
    Natasha Kyprianou; Fiscal Year: 2005
    ..abstract_text> ..
  3. Anoikis Effect by Quinazolines on Prostate Growth
    Natasha Kyprianou; Fiscal Year: 2007
    ..Potential results will establish the apoptotic/anoikis effect by the quinazolines as a significant phenomenon with clinical relevance in development and progression of benign prostatic hyperplasia (BPH) prostate cancer. ..
  4. Anoikis Effect by Quinazolines on Prostate Growth
    Natasha Kyprianou; Fiscal Year: 2006
    ..Potential results will establish the apoptotic/anoikis effect by the quinazolines as a significant phenomenon with clinical relevance in development and progression of benign prostatic hyperplasia (BPH) prostate cancer. ..
  5. Symposium:Men's Health Issues in Basic Urologic Research
    Natasha Kyprianou; Fiscal Year: 2002
    ..Funding is requested to partially defray the travel and lodging costs fore the invited speakers and to partially cover the costs of travel awards to young investigators. ..
  6. Anoikis Effect by Quinazolines on Prostate Growth
    Natasha Kyprianou; Fiscal Year: 2004
    ..Potential results will establish the apoptotic/anoikis effect by the quinazolines as a significant phenomenon with clinical relevance in development and progression of benign prostatic hyperplasia (BPH) prostate cancer. ..
  7. TGF-Beta Signaling Pathways in Prostate Tumorigenesis
    Natasha Kyprianou; Fiscal Year: 2004
    ..abstract_text> ..
  8. TGF-Beta Signaling Pathways in Prostate Tumorigenesis
    Natasha Kyprianou; Fiscal Year: 2003
    ..abstract_text> ..
  9. TGF-Beta Signaling Pathways in Prostate Tumorigenesis
    Natasha Kyprianou; Fiscal Year: 2002
    ..abstract_text> ..
  10. Novel Effectors of TGF-beta Signaling in Prostate Growth Regulation and Tumor Pro
    Natasha Kyprianou; Fiscal Year: 2010
    ..The application will also pursue the mechanism converting TGF- from a tumor suppressor in normal and benign prostate growth, to a tumor promoter in advanced metastatic cancer. ..