Bonnie Ky

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Biomarker approach to the detection and cardioprotective strategies during anthracycline chemotherapy
    Bonnie Ky
    Division of Cardiovascular Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Heart Fail Clin 7:323-31. 2011
  2. ncbi request reprint Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab
    Bonnie Ky
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    J Am Coll Cardiol 63:809-16. 2014
  3. pmc Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    J Am Coll Cardiol 62:1165-72. 2013
  4. doi request reprint Left ventricular remodeling in human heart failure: quantitative echocardiographic assessment of 1,794 patients
    Bonnie Ky
    Division of Cardiovascular Medicine Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Echocardiography 29:758-65. 2012
  5. pmc Multiple biomarkers for risk prediction in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circ Heart Fail 5:183-90. 2012
  6. ncbi request reprint The effects of statin therapy on plasma markers of inflammation in patients without vascular disease
    Bonnie Ky
    University of Pennsylvania Medical Center, Division of Cardiovascular Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Clin Cardiol 28:67-70. 2005
  7. pmc The vascular marker soluble fms-like tyrosine kinase 1 is associated with disease severity and adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 58:386-94. 2011
  8. pmc High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circ Heart Fail 4:180-7. 2011
  9. doi request reprint Gender differences in cardiac remodeling and clinical outcomes in chronic stable angina pectoris (from the ACTION Trial)
    Bonnie Ky
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 105:943-7. 2010
  10. pmc Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 120:310-7. 2009

Detail Information

Publications28

  1. doi request reprint Biomarker approach to the detection and cardioprotective strategies during anthracycline chemotherapy
    Bonnie Ky
    Division of Cardiovascular Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Heart Fail Clin 7:323-31. 2011
    ..This review highlights the current evidence regarding the use of biomarkers in anthracycline-treated patients and presents the available literature on prophylactic cardioprotective strategies...
  2. ncbi request reprint Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab
    Bonnie Ky
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    J Am Coll Cardiol 63:809-16. 2014
    ..The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy...
  3. pmc Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    J Am Coll Cardiol 62:1165-72. 2013
    ....
  4. doi request reprint Left ventricular remodeling in human heart failure: quantitative echocardiographic assessment of 1,794 patients
    Bonnie Ky
    Division of Cardiovascular Medicine Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Echocardiography 29:758-65. 2012
    ..We sought to define the adaptive remodeling that occurs in chronic human HF through the detailed analyses of a large quantitative echocardiography database...
  5. pmc Multiple biomarkers for risk prediction in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circ Heart Fail 5:183-90. 2012
    ..Prior studies have suggested using a panel of biomarkers that measure diverse biological processes as a prognostic tool in chronic heart failure. Whether this approach improves risk prediction beyond clinical evaluation is unknown...
  6. ncbi request reprint The effects of statin therapy on plasma markers of inflammation in patients without vascular disease
    Bonnie Ky
    University of Pennsylvania Medical Center, Division of Cardiovascular Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Clin Cardiol 28:67-70. 2005
    ..This article will review the relationship between inflammatory markers and cardiovascular disease risk and the effects of statins on these markers in subjects without a known history of coronary disease...
  7. pmc The vascular marker soluble fms-like tyrosine kinase 1 is associated with disease severity and adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 58:386-94. 2011
    ..We sought to evaluate placental growth factor (PlGF) and soluble Fms-like tyrosine kinase 1 (sFlt-1) as clinical biomarkers in chronic heart failure (HF)...
  8. pmc High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circ Heart Fail 4:180-7. 2011
    ..The use of ST2 in chronic heart failure has not been well defined. Our objective was to determine whether plasma ST2 levels predict adverse outcomes in chronic heart failure in the context of current approaches...
  9. doi request reprint Gender differences in cardiac remodeling and clinical outcomes in chronic stable angina pectoris (from the ACTION Trial)
    Bonnie Ky
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 105:943-7. 2010
    ..These findings may reflect inherent gender-based differences in ischemic heart disease and cardiac remodeling and might help to identify women at high risk...
  10. pmc Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 120:310-7. 2009
    ..However, circulating NRG-1 has not been studied in human heart disease. We used a novel immunoassay to test whether circulating NRG-1beta is associated with disease severity and clinical outcomes in chronic heart failure...
  11. doi request reprint Simultaneous assessment of unprocessed ProBNP1-108 in addition to processed BNP32 improves identification of high-risk ambulatory patients with heart failure
    Daniel L Dries
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA PA 19104, USA
    Circ Heart Fail 3:220-7. 2010
    ..We hypothesized that simultaneous assessment of proBNP(1-108) and active BNP32, as an index of natriuretic peptide processing efficiency, would improve risk stratification in patients with chronic systolic heart failure...
  12. ncbi request reprint Clinical utility of automated assessment of left ventricular ejection fraction using artificial intelligence-assisted border detection
    Hind W Rahmouni
    Department of Medicine, Cardiovascular Division, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Am Heart J 155:562-70. 2008
    ..We tested Siemens AutoEF software (Siemens Medical Solutions, Erlangen, Germany) to determine whether it correlated with visual estimates of EF, manual planimetry, and cardiac magnetic resonance (CMR)...
  13. pmc Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure
    Kathleen W Zhang
    Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    J Am Heart Assoc 3:e000550. 2014
    ..The utility of longitudinal, circumferential, and radial strain and strain rate in determining prognosis in chronic heart failure is not well established...
  14. ncbi request reprint The utility of prescreening transesophageal echocardiograms: a prospective study
    Jeffrey Ogbara
    Department of Medicine, Cardiovascular Division, Echocardiography Laboratory University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Echocardiography 28:767-73. 2011
    ..However, the intersection of the AUC with the safety and clinical use of transesophageal echocardiography (TEE) is not well established...
  15. pmc Short-term treatment with high-dose atorvastatin reduces LDL cholesterol but shows no anti-inflammatory effects in normolipidemic subjects with normal CRP levels
    John S Millar
    The Institute for Translational Medicine and Therapeutics, The University of Pennsylvania, Philadelphia, USA
    Clin Transl Sci 3:140-6. 2010
    ....
  16. pmc Application of appropriateness criteria in outpatient transthoracic echocardiography
    James N Kirkpatrick
    Department of Medicine, Cardiovascular Division, Echocardiography Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Soc Echocardiogr 22:53-9. 2009
    ..Appropriateness criteria were applied to outpatient transthoracic echocardiographic (TTE) studies...
  17. ncbi request reprint Transthoracic and transesophageal echocardiography for the indication of suspected infective endocarditis: vegetations, blood cultures and imaging
    Vinay Kini
    Hospital of the University of Pennsylvania, Department of Medicine, Cardiovascular Division, Philadelphia, Pennsylvania, USA
    J Am Soc Echocardiogr 23:396-402. 2010
    ..The aim of this study was to investigate the ability of transthoracic echocardiography (TTE) to detect vegetations and the relationship between blood cultures and transesophageal echocardiography (TEE)...
  18. doi request reprint Hand-carried echocardiography for assessment of left ventricular filling and ejection fraction in the surgical intensive care unit
    Dustin G Mark
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Crit Care 24:470.e1-7. 2009
    ....
  19. ncbi request reprint Biomarker predictors of cardiac hospitalization in chronic heart failure: a recurrent event analysis
    Esther Vorovich
    Penn Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
    J Card Fail 20:569-76. 2014
    ..Identification of heart failure (HF) patients at risk for hospitalization may improve care and reduce costs. We evaluated 9 biomarkers as predictors of cardiac hospitalization in chronic HF...
  20. pmc Asymptomatic cardiac toxicity in long-term cancer survivors: defining the population and recommendations for surveillance
    Joseph R Carver
    Cardio oncology in the Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Oncol 40:229-38. 2013
    ..Screening strategies, including the use of biomarkers, echocardiography, and expert opinion surveillance and treatment recommendations, are presented...
  21. pmc FGF23 modifies the relationship between vitamin D and cardiac remodeling
    Bonnie Ky
    Renal Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circ Heart Fail 6:817-24. 2013
    ..Our objective was to determine the relationships between vitamin D and cardiac remodeling in chronic kidney disease and the effects of parathyroid hormone and FGF23 on these associations...
  22. pmc Emerging paradigms in cardiomyopathies associated with cancer therapies
    Bonnie Ky
    Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circ Res 113:754-64. 2013
    ..And therein lies the catch-22. Nevertheless, cardio-oncology has the potential to be transformative as the human cardiomyopathies that arise from targeted therapies can provide insights into the normal function of the heart. ..
  23. doi request reprint Longitudinal strain in friedreich ataxia: a potential marker for early left ventricular dysfunction
    Martin St John Sutton
    Department of Cardiology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    Echocardiography 31:50-7. 2014
    ..However, the relationship between remodeling and novel measures of cardiac function such as strain, and the time-dependent changes in these measures are poorly defined...
  24. pmc Physical performance and frailty in chronic kidney disease
    PETER P REESE
    Renal Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA
    Am J Nephrol 38:307-15. 2013
    ..Chronic kidney disease (CKD) is also strongly associated with these outcomes. The risks of poor physical performance and frailty among CKD patients, however, are not well established...
  25. doi request reprint Heart failure associated with sunitinib: lessons learned from animal models
    Colin F Greineder
    Department of Pharmacology, Institute for Translational Medicine and Therapeutics, Department of Emergency Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Hypertens Rep 13:436-41. 2011
    ....
  26. ncbi request reprint The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans
    Bonnie Ky
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Am Coll Cardiol 51:1653-62. 2008
    ..The aim of this study was to determine the effects of pravastatin and atorvastatin on markers of oxidative stress in plasma...
  27. doi request reprint Differentiation syndrome in non-M3 acute myeloid leukemia treated with the retinoid X receptor agonist bexarotene
    Courtney D DiNardo
    Department of Internal Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Med Oncol 25:299-302. 2008
    ..This case emphasizes the importance of monitoring for differentiation syndrome among patients receiving retinoid therapies and demonstrates the ability of bexarotene to stimulate differentiation of leukemic blasts...
  28. pmc Common variants in HSPB7 and FRMD4B associated with advanced heart failure
    Thomas P Cappola
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Circ Cardiovasc Genet 3:147-54. 2010
    ..We tested the hypothesis that inherited variation in genes of known importance to cardiovascular biology would thus contribute to heart failure risk...