Research Topics
| Igor B KuznetsovSummaryAffiliation: University at Albany Country: USA Publications
| Collaborators
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Detail Information
Publications
Protein sequence alignment with family-specific amino acid similarity matricesIgor B Kuznetsov
Cancer Research Center, Department of Epidemiology and Biostatistics, University at Albany, State University of New York, One Discovery Drive, Rensselaer, NY, USA 12144
BMC Res Notes 4:296. 2011..abstract:..
Simplified computational methods for the analysis of protein flexibilityIgor B Kuznetsov
Gen NY Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA
Curr Protein Pept Sci 10:607-13. 2009....- A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotypeIgor B Kuznetsov
Gen NY Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA
Bioinformatics 25:1185-6. 2009..AVAILABILITY: Freely available at http://nat2pred.rit.albany.edu. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online... 
ProBias: a web-server for the identification of user-specified types of compositionally biased segments in protein sequencesIgor B Kuznetsov
Gen NY Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, One Discovery Drive, University at Albany, Rensselaer, NY 12144, USA
Bioinformatics 24:1534-5. 2008..AVAILABILITY: Freely available at http://lcg.rit.albany.edu/ProBias. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online...- Ordered conformational change in the protein backbone: prediction of conformationally variable positions from sequence and low-resolution structural dataIgor B Kuznetsov
Department of Epidemiology and Biostatistics, Gen NY Sis Center for Excellence in Cancer Genomics, University at Albany, Rensselaer, New York 12144, USA
Proteins 72:74-87. 2008..Application of the present methodology to the prion protein (PrP) shows that conformationally variable positions predicted in its ordered C-terminal domain are located within segments presumed to be involved in refolding of PrP... - Using evolutionary and structural information to predict DNA-binding sites on DNA-binding proteinsIgor B Kuznetsov
Gen NY Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, Rensselaer, NewYork 12144, USA
Proteins 64:19-27. 2006..A web-server implementation of the predictors is freely available online at http://lcg.rit.albany.edu/dp-bind/... - A novel sensitive method for the detection of user-defined compositional bias in biological sequencesIgor B Kuznetsov
Gen NY Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, State University of New York One Discovery Drive, Rensselaer, NY 12144, USA
Bioinformatics 22:1055-63. 2006..BIAS is benchmarked against SEG, SAPS and CAST programs. We also use BIAS to show that groups of proteins with the same biological function are significantly associated with particular types of compositionally biased segments... - Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease-promoting mutationsIgor B Kuznetsov
Department of Biomathematical Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
Protein Sci 13:3230-44. 2004..We suggest that the observed increase in hydrophobicity may facilitate PrP-to-PrP or/and PrP-to-cofactor interactions, and thus promote structural conversion... - DP-Bind: a web server for sequence-based prediction of DNA-binding residues in DNA-binding proteinsSeungwoo Hwang
Gen NY Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, One Discovery Drive, University at Albany, Rensselaer, NY 12144, USA
Bioinformatics 23:634-6. 2007..AVAILABILITY: Freely available at http://lcg.rit.albany.edu/dp-bind. SUPPLEMENTARY INFORMATION: http://lcg.rit.albany.edu/dp-bind/dpbind_supplement.html... - Class-specific correlations between protein folding rate, structure-derived, and sequence-derived descriptorsIgor B Kuznetsov
Department of Biomathematical Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
Proteins 54:333-41. 2004..These results suggest that intrinsic structural propensities may be an important determinant of the rate of folding in small two-state proteins... - On the properties and sequence context of structurally ambivalent fragments in proteinsIgor B Kuznetsov
Department of Biomathematical Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
Protein Sci 12:2420-33. 2003..These results have implications for protein design and structure prediction... - Similarity between the C-terminal domain of the prion protein and chimpanzee cytomegalovirus glycoprotein UL9Igor B Kuznetsov
Department of Biomathematical Sciences, Mount Sinai School of Medicine, Box 1023, One Gustave L Levy Place, New York, NY 10029, USA
Protein Eng 16:861-3. 2003.... - Discriminative ability with respect to amino acid types: assessing the performance of knowledge-based potentials without threadingIgor B Kuznetsov
Department of Biomathematical Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
Proteins 49:266-84. 2002..For each potential, our methodology is able to identify a potential-specific amino acid distance matrix and a reduced amino acid alphabet of any specified size, which may have implications for sequence alignment and multibody models...