Research Topics
| T KutateladzeSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
Molecular mechanism of membrane docking by the Vam7p PX domainStephanie A Lee
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
J Biol Chem 281:37091-101. 2006..The affinities of the PX domain for PtdIns(3)P and other lipids reveal a remarkable synergy within the multivalent complex that stably anchors Vam7p at the vacuolar membrane...
Structural mechanism of endosome docking by the FYVE domainT Kutateladze
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Science 291:1793-6. 2001..Specific recognition of the 3-phosphate was determined indirectly and directly by two clusters of conserved arginines...- Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domainTatiana G Kutateladze
Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
Biochim Biophys Acta 1761:868-77. 2006..Contributions of each component to the FYVE domain specificity and affinity for PtdIns(3)P-containing membranes are discussed... - Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranesTatiana G Kutateladze
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Prog Lipid Res 46:315-27. 2007..Here, structural and functional aspects and current mechanisms of the multivalent membrane anchoring by the FYVE and PX domains are reviewed and compared... - Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structuresM K Storey
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Biol Chem 276:48539-48. 2001..The essential function of the PtdEtn in the presence of propanolamine does not appear to be the formation of hexagonal phase lipid, insofar as PtdPrn readily forms hexagonal phase structures detectable by (31)P NMR... - pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayersRobert A Hom
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
J Mol Biol 373:412-23. 2007..The pH sensitivity of the ENTH and ANTH domains is reminiscent to the pH dependency of the FYVE domain suggesting a common regulatory mechanism of membrane anchoring by a subset of the PI-binding domains... - Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphateJoanna Gajewiak
Department of Medicinal Chemistry, The University of Utah, Salt Lake City, 84108-1257, USA
Org Lett 8:2811-3. 2006..NMR studies of PtdIns(3)MP bound to the (15)N-labeled FYVE domain showed significant (1)H and (15)N chemical shift changes relative to the unliganded protein... - Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2Pedro V Peña
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Nature 442:100-3. 2006..Elucidation of the mechanisms underlying this novel function of PHD fingers provides a basis for deciphering the role of the ING family of tumour suppressors in chromatin regulation and signalling... - Molecular mechanism of membrane targeting by the GRP1 PH domainJu He
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO, USA
J Lipid Res 49:1807-15. 2008..Together, our results provide new insight into the multivalent mechanism of the membrane targeting and regulation of the GRP1 PH domain... - Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphateMatthew L Cheever
Molecular Biology Program, University of Colorado Health Sciences Center, Aurora, 80045, USA
Protein Sci 15:1873-82. 2006..Thus, the induced dynamic and structural effects are transduced from the buried heart of the binding pocket in the helical lobe through the beta-sheet lobe to the exposed surface of the bilayer-inserted protein... - The DIX domain targets dishevelled to actin stress fibres and vesicular membranesDaniel G S Capelluto
Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
Nature 419:726-9. 2002..We propose that partitioning of Dvl into cytoskeletal and vesicular pools by the DIX domain represents a point of divergence in Wnt signalling... - Investigation of the binding geometry of a peripheral membrane proteinRoman Brunecky
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Biochemistry 44:16064-71. 2005.... - Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switchStephanie A Lee
Department of Pharmacology and Molecular Biology Program, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 102:13052-7. 2005..The presented mode of FYVE regulation establishes the unique function of FYVE proteins as low pH sensors of PtdIns3P and reveals the critical role of the histidine switch in targeting of these proteins to endosomal membranes... - Multivalent mechanism of membrane insertion by the FYVE domainTatiana G Kutateladze
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 279:3050-7. 2004..Thus, the FYVE domain is targeted to endosomes through the synergistic action of stereospecific PtdIns(3)P head group ligation, hydrophobic insertion and electrostatic interactions with acidic phospholipids... - Structural insights into histone demethylation by JMJD2 family membersZhongzhou Chen
Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
Cell 125:691-702. 2006..Sited-directed mutagenesis in conjunction with demethylase activity assays allowed us to propose a molecular model for substrate selection by the JMJD2 histone demethylase family... - RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombinationAdam G W Matthews
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 450:1106-10. 2007..Furthermore, our results provide the first evidence indicating that disrupting the read-out of histone modifications can cause an inherited human disease... - Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modelingWei Huang
Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Salt Lake City, UT 84108 1257, USA
J Am Chem Soc 129:6498-506. 2007.... - Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36Xiaobing Shi
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
J Biol Chem 282:2450-5. 2007..Together, our study suggests that a common function for PHD fingers is to transduce methyl-lysine events and sheds light on how a single histone modification can be linked to multiple biological outcomes... - Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProPDavid L Zoetewey
Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Mol Biol 334:1063-76. 2003..The coiled-coil and its possible importance for osmosensing are discussed... - Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphateYong Xu
Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108-1257, USA
J Am Chem Soc 128:885-97. 2006..In addition, the PtdIns(3)P analogues with dioleoyl and dipalmitoyl chains were substrates for the 5-kinase enzyme PIKfyve; the corresponding phosphorylated ms-PI(3,5)P2 products were detected by radio-TLC analysis... - Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domainEtienne Tokonzaba
Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
Chem Biol Drug Des 67:230-7. 2006..Thus the Src homology 2 domain of Abl, a myristoylated and membrane-localized protein, is able to interact directly with phosphoinositides through a multifunctional basic site that overlaps the phosphotyrosine pocket... - ING2 PHD domain links histone H3 lysine 4 methylation to active gene repressionXiaobing Shi
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Nature 442:96-9. 2006..Together, our findings establish a pivotal role for trimethylation of H3K4 in gene repression and, potentially, tumour suppressor mechanisms...
Research Grants
- STRUCTURE AND FUNCTION OF FYVE DOMAINSTATIANA KUTATELADZE; Fiscal Year: 2004..Zinc's structural importance is demonstrated by FYVE domain refolding experiments, and is related to other zinc binding domains such as RING fingers. ..
- Structure and Function of the Phox DomainTATIANA KUTATELADZE; Fiscal Year: 2004....