T Kutateladze

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Molecular mechanism of membrane docking by the Vam7p PX domain
    Stephanie A Lee
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 281:37091-101. 2006
  2. ncbi request reprint Structural mechanism of endosome docking by the FYVE domain
    T Kutateladze
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 291:1793-6. 2001
  3. pmc Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain
    Tatiana G Kutateladze
    Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Biochim Biophys Acta 1761:868-77. 2006
  4. pmc Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes
    Tatiana G Kutateladze
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Prog Lipid Res 46:315-27. 2007
  5. ncbi request reprint Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures
    M K Storey
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 276:48539-48. 2001
  6. pmc pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers
    Robert A Hom
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Mol Biol 373:412-23. 2007
  7. pmc Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate
    Joanna Gajewiak
    Department of Medicinal Chemistry, The University of Utah, Salt Lake City, 84108 1257, USA
    Org Lett 8:2811-3. 2006
  8. pmc Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2
    Pedro V Peña
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Nature 442:100-3. 2006
  9. pmc Molecular mechanism of membrane targeting by the GRP1 PH domain
    Ju He
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO, USA
    J Lipid Res 49:1807-15. 2008
  10. pmc Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate
    Matthew L Cheever
    Molecular Biology Program, University of Colorado Health Sciences Center, Aurora, 80045, USA
    Protein Sci 15:1873-82. 2006

Research Grants

  1. STRUCTURE AND FUNCTION OF FYVE DOMAINS
    TATIANA KUTATELADZE; Fiscal Year: 2004
  2. Structure and Function of the Phox Domain
    TATIANA KUTATELADZE; Fiscal Year: 2004

Collaborators

  • M Overduin
  • R C Murphy
  • Yong Xu
  • Vladislav V Verkhusha
  • Dmitri Ivanov
  • Colin G Ferguson
  • W Cho
  • Rui Zhao
  • A Shisheva
  • W Yang
  • Janet M Wood
  • Robert Hodges
  • Shaodong Dai
  • Mark Bedford
  • Christopher Burd
  • Xiaobing Shi
  • Or Gozani
  • Foteini Davrazou
  • Stephanie A Lee
  • Kay L Walter
  • Matthew L Cheever
  • Robert V Stahelin
  • Yang Shi
  • Glenn D Prestwich
  • Daniel G S Capelluto
  • Ju He
  • Mohsin Vora
  • Adam G W Matthews
  • Paul J Utz
  • Robert A Hom
  • Wei Huang
  • Dylan Carney
  • Etienne Tokonzaba
  • Zhongzhou Chen
  • Pedro V Peña
  • Joanna Gajewiak
  • Roman Brunecky
  • David L Zoetewey
  • M K Storey
  • Rachel M Haney
  • Sunmi Han
  • Peggie Cheung
  • LeAnn Howe
  • Aimee Lake
  • Oksana M Subach
  • Karen S Champagne
  • Mercedes Gallardo
  • Honglu Zhang
  • Ian M Fingerman
  • Santiago Ramon-Maiques
  • Alex J Kuo
  • Alexey A Lugovskoy
  • David G E Martin
  • Ioulia Kachirskaia
  • Marjorie A Oettinger
  • Steve M Chan
  • Jen Hao A Kuo
  • David N Ciccone
  • MaryAnn Regner
  • Scott D Briggs
  • Nicolas Lacoste
  • Donald E Ayer
  • Xia Hong
  • Qilong Mao
  • Mark Ewalt
  • Michael Simpson
  • Tao Hong
  • Gongyi Zhang
  • Katrin F Chua
  • Fei Lan
  • Eriko Michishita
  • Johnathan Whetstine
  • Thanuja Gangi Setty
  • Jianye Zang
  • Tiffany Hung
  • Mohan R Kaadige
  • PEDRO PENA
  • Jacques Cote
  • Cheol Ho Pan
  • James Kovacs
  • James Hagman
  • Kirk Hansen
  • Anjanabha Saha
  • Bradley R Cairns
  • Christelle Cayrou
  • Jinming Geng
  • Stephanie Lee
  • Rosemary Eyeson
  • Piotr W Rzepecki
  • Andrei G Kutateladze

Detail Information

Publications22

  1. pmc Molecular mechanism of membrane docking by the Vam7p PX domain
    Stephanie A Lee
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 281:37091-101. 2006
    ..The affinities of the PX domain for PtdIns(3)P and other lipids reveal a remarkable synergy within the multivalent complex that stably anchors Vam7p at the vacuolar membrane...
  2. ncbi request reprint Structural mechanism of endosome docking by the FYVE domain
    T Kutateladze
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 291:1793-6. 2001
    ..Specific recognition of the 3-phosphate was determined indirectly and directly by two clusters of conserved arginines...
  3. pmc Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain
    Tatiana G Kutateladze
    Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Biochim Biophys Acta 1761:868-77. 2006
    ..Contributions of each component to the FYVE domain specificity and affinity for PtdIns(3)P-containing membranes are discussed...
  4. pmc Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes
    Tatiana G Kutateladze
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Prog Lipid Res 46:315-27. 2007
    ..Here, structural and functional aspects and current mechanisms of the multivalent membrane anchoring by the FYVE and PX domains are reviewed and compared...
  5. ncbi request reprint Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures
    M K Storey
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 276:48539-48. 2001
    ..The essential function of the PtdEtn in the presence of propanolamine does not appear to be the formation of hexagonal phase lipid, insofar as PtdPrn readily forms hexagonal phase structures detectable by (31)P NMR...
  6. pmc pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers
    Robert A Hom
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Mol Biol 373:412-23. 2007
    ..The pH sensitivity of the ENTH and ANTH domains is reminiscent to the pH dependency of the FYVE domain suggesting a common regulatory mechanism of membrane anchoring by a subset of the PI-binding domains...
  7. pmc Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate
    Joanna Gajewiak
    Department of Medicinal Chemistry, The University of Utah, Salt Lake City, 84108 1257, USA
    Org Lett 8:2811-3. 2006
    ..NMR studies of PtdIns(3)MP bound to the (15)N-labeled FYVE domain showed significant (1)H and (15)N chemical shift changes relative to the unliganded protein...
  8. pmc Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2
    Pedro V Peña
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Nature 442:100-3. 2006
    ..Elucidation of the mechanisms underlying this novel function of PHD fingers provides a basis for deciphering the role of the ING family of tumour suppressors in chromatin regulation and signalling...
  9. pmc Molecular mechanism of membrane targeting by the GRP1 PH domain
    Ju He
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO, USA
    J Lipid Res 49:1807-15. 2008
    ..Together, our results provide new insight into the multivalent mechanism of the membrane targeting and regulation of the GRP1 PH domain...
  10. pmc Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate
    Matthew L Cheever
    Molecular Biology Program, University of Colorado Health Sciences Center, Aurora, 80045, USA
    Protein Sci 15:1873-82. 2006
    ..Thus, the induced dynamic and structural effects are transduced from the buried heart of the binding pocket in the helical lobe through the beta-sheet lobe to the exposed surface of the bilayer-inserted protein...
  11. ncbi request reprint The DIX domain targets dishevelled to actin stress fibres and vesicular membranes
    Daniel G S Capelluto
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nature 419:726-9. 2002
    ..We propose that partitioning of Dvl into cytoskeletal and vesicular pools by the DIX domain represents a point of divergence in Wnt signalling...
  12. pmc Investigation of the binding geometry of a peripheral membrane protein
    Roman Brunecky
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Biochemistry 44:16064-71. 2005
    ....
  13. pmc Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch
    Stephanie A Lee
    Department of Pharmacology and Molecular Biology Program, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 102:13052-7. 2005
    ..The presented mode of FYVE regulation establishes the unique function of FYVE proteins as low pH sensors of PtdIns3P and reveals the critical role of the histidine switch in targeting of these proteins to endosomal membranes...
  14. ncbi request reprint Multivalent mechanism of membrane insertion by the FYVE domain
    Tatiana G Kutateladze
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:3050-7. 2004
    ..Thus, the FYVE domain is targeted to endosomes through the synergistic action of stereospecific PtdIns(3)P head group ligation, hydrophobic insertion and electrostatic interactions with acidic phospholipids...
  15. ncbi request reprint Structural insights into histone demethylation by JMJD2 family members
    Zhongzhou Chen
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Cell 125:691-702. 2006
    ..Sited-directed mutagenesis in conjunction with demethylase activity assays allowed us to propose a molecular model for substrate selection by the JMJD2 histone demethylase family...
  16. pmc RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
    Adam G W Matthews
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 450:1106-10. 2007
    ..Furthermore, our results provide the first evidence indicating that disrupting the read-out of histone modifications can cause an inherited human disease...
  17. pmc Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling
    Wei Huang
    Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Salt Lake City, UT 84108 1257, USA
    J Am Chem Soc 129:6498-506. 2007
    ....
  18. pmc Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36
    Xiaobing Shi
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Biol Chem 282:2450-5. 2007
    ..Together, our study suggests that a common function for PHD fingers is to transduce methyl-lysine events and sheds light on how a single histone modification can be linked to multiple biological outcomes...
  19. ncbi request reprint Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP
    David L Zoetewey
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Mol Biol 334:1063-76. 2003
    ..The coiled-coil and its possible importance for osmosensing are discussed...
  20. pmc Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate
    Yong Xu
    Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108 1257, USA
    J Am Chem Soc 128:885-97. 2006
    ..In addition, the PtdIns(3)P analogues with dioleoyl and dipalmitoyl chains were substrates for the 5-kinase enzyme PIKfyve; the corresponding phosphorylated ms-PI(3,5)P2 products were detected by radio-TLC analysis...
  21. pmc Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain
    Etienne Tokonzaba
    Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Chem Biol Drug Des 67:230-7. 2006
    ..Thus the Src homology 2 domain of Abl, a myristoylated and membrane-localized protein, is able to interact directly with phosphoinositides through a multifunctional basic site that overlaps the phosphotyrosine pocket...
  22. pmc ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression
    Xiaobing Shi
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nature 442:96-9. 2006
    ..Together, our findings establish a pivotal role for trimethylation of H3K4 in gene repression and, potentially, tumour suppressor mechanisms...

Research Grants2

  1. STRUCTURE AND FUNCTION OF FYVE DOMAINS
    TATIANA KUTATELADZE; Fiscal Year: 2004
    ..Zinc's structural importance is demonstrated by FYVE domain refolding experiments, and is related to other zinc binding domains such as RING fingers. ..
  2. Structure and Function of the Phox Domain
    TATIANA KUTATELADZE; Fiscal Year: 2004
    ....