Makoto Kuro-o

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism
    Makoto Kuro-o
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9072, USA
    Nat Rev Nephrol 9:650-60. 2013
  2. pmc Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi, 329 0498, Japan
    BMC Nephrol 13:155. 2012
  3. doi request reprint Klotho in health and disease
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9072, USA
    Curr Opin Nephrol Hypertens 21:362-8. 2012
  4. doi request reprint Klotho and βKlotho
    Makoto Kuro-o
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Adv Exp Med Biol 728:25-40. 2012
  5. doi request reprint Overview of the FGF23-Klotho axis
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    Pediatr Nephrol 25:583-90. 2010
  6. doi request reprint Klotho
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    Pflugers Arch 459:333-43. 2010
  7. pmc A potential link between phosphate and aging--lessons from Klotho-deficient mice
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Mech Ageing Dev 131:270-5. 2010
  8. pmc Klotho and aging
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Biochim Biophys Acta 1790:1049-58. 2009
  9. ncbi request reprint Endocrine FGFs and Klothos: emerging concepts
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Trends Endocrinol Metab 19:239-45. 2008
  10. pmc Klotho and the aging process
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Korean J Intern Med 26:113-22. 2011

Research Grants

Collaborators

Detail Information

Publications55

  1. doi request reprint Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism
    Makoto Kuro-o
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9072, USA
    Nat Rev Nephrol 9:650-60. 2013
    ..These observations raise the possibility that calciprotein particles contribute to the pathogenesis of CKD. This theory, if verified, is expected to provide novel diagnostic markers and therapeutic targets in CKD. ..
  2. pmc Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi, 329 0498, Japan
    BMC Nephrol 13:155. 2012
    ..The purpose of the present study was to characterize the relationship between the soluble Klotho level and renal function in patients with various degrees of chronic kidney disease (CKD)...
  3. doi request reprint Klotho in health and disease
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9072, USA
    Curr Opin Nephrol Hypertens 21:362-8. 2012
    ....
  4. doi request reprint Klotho and βKlotho
    Makoto Kuro-o
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Adv Exp Med Biol 728:25-40. 2012
    ..This chapter overviews function of Klotho family proteins as obligate coreceptors for endocrine FGFs and discusses potential link between Klothos and age-related diseases...
  5. doi request reprint Overview of the FGF23-Klotho axis
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    Pediatr Nephrol 25:583-90. 2010
    ..Thus, the bone-kidney endocrine axis mediated by FGF23 and Klotho has emerged as a novel target of therapeutic interventions in CKD...
  6. doi request reprint Klotho
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    Pflugers Arch 459:333-43. 2010
    ..Potential contribution of these multiple activities of Klotho protein to aging processes is discussed...
  7. pmc A potential link between phosphate and aging--lessons from Klotho-deficient mice
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Mech Ageing Dev 131:270-5. 2010
    ..These findings suggest an unexpected link between inorganic phosphate and aging in mammals...
  8. pmc Klotho and aging
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Biochim Biophys Acta 1790:1049-58. 2009
    ..Thus, the transmembrane and secreted forms of Klotho protein have distinct functions, which may collectively affect aging processes in mammals...
  9. ncbi request reprint Endocrine FGFs and Klothos: emerging concepts
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Trends Endocrinol Metab 19:239-45. 2008
    ..This review covers roles of Klotho family proteins in the regulation of activity and expression of endocrine FGFs...
  10. pmc Klotho and the aging process
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Korean J Intern Med 26:113-22. 2011
    ..The purposes of this review were to overview recent progress on Klotho research and to discuss a novel aging mechanism...
  11. ncbi request reprint Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9072, USA
    Curr Opin Nephrol Hypertens 15:437-41. 2006
    ..This review summarizes the most recent findings on Klotho in the regulation of fibroblast growth factor-23 (FGF23) signaling and phosphate/calcium homeostasis...
  12. pmc Suppression of aging in mice by the hormone Klotho
    Hiroshi Kurosu
    Department of Pathology, University of Texas UT Southwestern Medical Center at Dallas, 5323 Harry Hines Bouleuvard, Dallas, TX 75390 9072, USA
    Science 309:1829-33. 2005
    ..Klotho protein may function as an anti-aging hormone in mammals...
  13. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
    ..Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD...
  14. ncbi request reprint Klotho and chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Contrib Nephrol 180:47-63. 2013
    ..Therefore, Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease...
  15. pmc BetaKlotho is required for metabolic activity of fibroblast growth factor 21
    Yasushi Ogawa
    Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7432-7. 2007
    ..Importantly, administration of FGF21 into mice induces MAP kinase phosphorylation in white adipose tissue and not in tissues without betaKlotho expression. Thus, betaKlotho functions as a cofactor essential for FGF21 activity...
  16. pmc Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    FASEB J 24:3438-50. 2010
    ....
  17. pmc Regulation of oxidative stress by the anti-aging hormone klotho
    Masaya Yamamoto
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Biol Chem 280:38029-34. 2005
    ..Thus, Klotho-induced inhibition of insulin/IGF-1 signaling is associated with increased resistance to oxidative stress, which potentially contributes to the anti-aging properties of klotho...
  18. pmc Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    Shigehiro Doi
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:8655-65. 2011
    ..These results have raised the possibility that secreted Klotho may function as an endogenous anti-EMT factor by inhibiting multiple growth factor signaling pathways simultaneously...
  19. pmc Regulation of fibroblast growth factor-23 signaling by klotho
    Hiroshi Kurosu
    Department of Pathology, Pediatrics, and Internal Medicine and Applied Genomics, Genzyme Corporation, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:6120-3. 2006
    ..Thus, Klotho functions as a cofactor essential for activation of FGF signaling by FGF23...
  20. pmc Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Annu Rev Physiol 75:503-33. 2013
    ....
  21. pmc Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
    Seung Kuy Cha
    Departments of Medicine and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:9805-10. 2008
    ..This action of Klotho represents a novel mechanism for regulation of the activity of cell-surface glycoproteins and likely contributes to maintenance of calcium balance by Klotho...
  22. pmc Secreted klotho and chronic kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Adv Exp Med Biol 728:126-57. 2012
    ..Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease...
  23. ncbi request reprint Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice
    Hiroaki Masuda
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Mech Ageing Dev 126:1274-83. 2005
    ..Our data indicate that Klotho may be effective in the treatment of multiple age-related disorders and is essential for maintaining animals free of these disorders...
  24. pmc Pin1 null mice exhibit low bone mass and attenuation of BMP signaling
    Zhong Jian Shen
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e63565. 2013
    ..Our results thus uncover a novel aspect of the molecular underpinning of osteoblast function and identify a new therapeutic target for bone diseases...
  25. pmc Role of Klotho in aging, phosphate metabolism, and CKD
    George B John
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    Am J Kidney Dis 58:127-34. 2011
    ..This review focuses on the current understanding of Klotho protein function, with emphasis on its potential involvement in the pathophysiologic process of CKD...
  26. pmc Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system
    Chung Yi Cheng
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Adv Chronic Kidney Dis 18:91-7. 2011
    ..This article will briefly summarize how delicate interactions of the FGF23-klotho system can regulate systemic phosphate homeostasis...
  27. pmc Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    Hiroshi Kurosu
    Departments of Pathology and Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Biol Chem 282:26687-95. 2007
    ..We conclude that the expression of betaKlotho, in combination with particular FGFR isoforms, determines the tissue-specific metabolic activities of FGF19 and FGF21...
  28. ncbi request reprint [A potential link between phosphate and aging]
    Kazuhiro Shiizaki
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Clin Calcium 22:1493-8. 2012
    ..Further clinical studies are required to verify the link between phosphate and aging and to apply this novel concept to anti-aging medicine...
  29. pmc Klotho and kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 7390 8855, USA
    J Nephrol 23:S136-44. 2010
    ..In summary, Klotho is a critical molecule in a wide variety of renal diseases and bears great potential as a diagnostic and prognostic biomarker as well as for therapeutic replacement therapy...
  30. pmc Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
    Jian Xie
    Department of Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Commun 3:1238. 2012
    ..These results provide a new perspective on the pathogenesis of cardiomyopathies and open new avenues for treatment of the disease...
  31. pmc Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 78:1240-51. 2010
    ..Thus, endogenous Klotho not only serves as an early biomarker for AKI but also functions as a renoprotective factor with therapeutic potential...
  32. pmc Renal and extrarenal actions of Klotho
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Semin Nephrol 33:118-29. 2013
    ....
  33. pmc Nuclear localization of Klotho in brain: an anti-aging protein
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas Texas, USA
    Neurobiol Aging 33:1483.e25-30. 2012
    ..This new finding suggests that in addition to Klotho being secreted from cells in brain, it also has a nuclear function...
  34. pmc Ultra-short echo time (UTE) MR imaging of the lung: comparison between normal and emphysematous lungs in mutant mice
    Masaya Takahashi
    Advanced Imaging Research Center, UT Southwestern Medical Center, 2201 Inwood Rd, Dallas, Texas 75390 8542, USA
    J Magn Reson Imaging 32:326-33. 2010
    ..To investigate the utility of ultra-short echo time (UTE) sequence as pulmonary MRI to detect non-uniform disruption of lung architecture that is typical of emphysema...
  35. pmc Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
    Klementina Fon Tacer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Endocrinol 24:2050-64. 2010
    ..This FGF atlas provides an important resource for guiding future studies to elucidate the physiological functions of FGFs in adult animals...
  36. ncbi request reprint Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *
    Orhan K Oz
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9153, USA
    J Bone Miner Res 22:1893-902. 2007
    ..ArKO mice have hypercalciuria and lower levels of calcium transport proteins, whereas levels of the klotho protein are elevated. Thus, estrogen deficiency is sufficient to cause altered renal calcium handling...
  37. doi request reprint Klotho as a regulator of oxidative stress and senescence
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Biol Chem 389:233-41. 2008
    ..Thus, understanding of Klotho protein function is expected to provide new insights into the molecular basis for aging, phosphate/vitamin D metabolism, cancer and stem cell biology...
  38. ncbi request reprint αKlotho and vascular calcification: an evolving paradigm
    Ming Chang Hu
    aDepartment of Internal Medicine bThe Charles and Jane Pak Center of Mineral Metabolism and Clinical Research cDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA dCenter for Molecular Medicine, Jichi Medical University Tochigi, Japan eDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Nephrol Hypertens 23:331-9. 2014
    ..Although the molecular mechanism of action of αKlotho is not well understood, the downstream targets and biologic functions of αKlotho are astonishingly pleiotropic. An emerging body of literature links αKlotho to uremic vasculopathy...
  39. pmc FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
    Yan G Ni
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Proc Natl Acad Sci U S A 104:20517-22. 2007
    ....
  40. pmc Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells
    Jinyong Kim
    Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Biol Chem 286:43294-300. 2011
    ..Together, these data suggest that KLB is an important regulator in the immortalization of HCECs by facilitating FGF19 growth factor signaling...
  41. pmc Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions
    Xiaoyu Wang
    Harold C, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Proteome Sci 9:53. 2011
    ..Software is developed to facilitate the quantitative readouts of signaling network activities. Kinetics of EGFRvIII mutant signaling was analyzed to quantify cross-talks between EGFR and other signaling pathways...
  42. ncbi request reprint Fibroblast growth factor 23 and uremic vascular calcification: is it time to escalate from biomarker status to pathogenic agent?
    Orson W Moe
    1 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA 2 Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA 3 Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 85:1022-3. 2014
    ..used animal and cell-culture models to query whether FGF23 is a direct 'vasculotoxin.' We discuss the interpretation of their findings. At this juncture, much remains unanswered about the significance of FGF23 elevation in CKD. ..
  43. pmc Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction
    Osamu Togao
    Advanced Imaging Research Center, UT Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390 8542, USA
    Radiology 255:772-80. 2010
    ....
  44. pmc Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho
    Seung Kuy Cha
    Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Mol Pharmacol 76:38-46. 2009
    ..Intravenous administration of KLe increases the level of Klotho in urine and increases urinary excretion of K(+). These results suggest that Klotho may have a broader function in the regulation of ion transport in the kidney...
  45. pmc Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
    Regina Goetz
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Biol 27:3417-28. 2007
    ..Klotho/betaKlotho have evolved as a compensatory mechanism for the poor ability of heparin/heparan sulfate to promote binding of FGF19, -21, and -23 to their cognate receptors...
  46. doi request reprint The Klotho gene family and the endocrine fibroblast growth factors
    Hiroshi Kurosu
    Department of Hygiene and Public Health I, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Curr Opin Nephrol Hypertens 17:368-72. 2008
    ..This review summarizes recent progress in understanding of Klotho and betaKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23)...
  47. ncbi request reprint Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes
    Koji Wakimoto
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 3 16 89 Kashima, Yodogawa ku, Osaka 532 8505, Japan
    Comp Biochem Physiol B Biochem Mol Biol 135:9-15. 2003
    ..Although NCX1 protein levels were decreased in heterozygous mice, there were no changes in NCX2 and NCX3 protein levels between wild type and heterozygous mice...
  48. pmc The parathyroid is a target organ for FGF23 in rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 117:4003-8. 2007
    ..These data indicate that FGF23 acts directly on the parathyroid through the MAPK pathway to decrease serum PTH. This bone-parathyroid endocrine axis adds a new dimension to the understanding of mineral homeostasis...
  49. ncbi request reprint Klotho gene polymorphisms associated with bone density of aged postmenopausal women
    Ken ichi Kawano
    Department of Orthopedic Surgery, University of Tokyo, Japan
    J Bone Miner Res 17:1744-51. 2002
    ..These results indicate that the klotho gene may be involved in the pathophysiology of bone loss with aging in humans...
  50. ncbi request reprint Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells
    Yorito Anamizu
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, 183 8526, Tokyo, Japan
    Acta Neuropathol 109:457-66. 2005
    ..The kl/kl is a new animal model of AHC degeneration, and may provide clues to understanding the etiology of classic ALS...
  51. pmc Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
    Dullei Min
    Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University, CA 94304, USA
    Blood 109:2529-37. 2007
    ..The result suggests that TEC damage is pathophysiologically important in thymic aging, and KGF therapy may be clinically useful in improving thymopoiesis and immune function in the elderly...
  52. ncbi request reprint [Recent progress in Klotho research]
    Makoto Kuro-o
    Nihon Ronen Igakkai Zasshi 43:674-81. 2006
  53. ncbi request reprint Production of nitric oxide, but not prostacyclin, is reduced in klotho mice
    Tetsuya Nakamura
    The Second Department of Internal Medicine, Gunma University School of Medicine, Maebaeshi, Japan
    Jpn J Pharmacol 89:149-56. 2002
    ..No immunostaining for NO synthase was noted in the aorta of kl/kl mice. The expression of the klotho gene product may have a role in the regulation of VEGF expression and is tightly linked to endothelial release of NO...
  54. pmc FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis
    Damian Medici
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Cell Biol 182:459-65. 2008
    ..These data provide new insights into the physiological roles of FGF-23 and Klotho...

Research Grants15

  1. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2002
    ..In addition, it promises to promote better understanding of the Klotho protein function and verify its role as an anti-aging hormone, which would have a significant impact on basic research and medical practice of aging. ..
  2. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2009
    ..If successful, this project would justify Klotho replacement therapy as a rational therapeutic intervention in aging and chronic kidney disease, which would have profound impacts on medical practice in general. ..
  3. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2010
    ..These studies will promote better understanding of Klotho protein function, which may eventually contribute to understanding of molecular mechanisms of aging. ..
  4. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2009
    ..These studies will promote better understanding of Klotho protein function, which may eventually contribute to understanding of molecular mechanisms of aging. ..
  5. Proteomics of mouse models for aging and longevity
    Makoto Kuro O; Fiscal Year: 2007
    ..These studies are expected to provide critical information that promotes a better understanding of the molecular mechanisms of aging and longevity. ..
  6. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2007
    ..These studies will promote better understanding of Klotho protein function, which may eventually contribute to understanding of molecular mechanisms of aging. ..
  7. Proteomics of mouse models for aging and longevity
    Makoto Kuro O; Fiscal Year: 2006
    ..These studies are expected to provide critical information that promotes a better understanding of the molecular mechanisms of aging and longevity. ..
  8. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2006
    ..In addition, it promises to promote better understanding of the Klotho protein function and verify its role as an anti-aging hormone, which would have a significant impact on basic research and medical practice of aging. ..
  9. Proteomics of mouse models for aging and longevity
    Makoto Kuro O; Fiscal Year: 2005
    ..These studies are expected to provide critical information that promotes a better understanding of the molecular mechanisms of aging and longevity. ..
  10. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2005
    ..In addition, it promises to promote better understanding of the Klotho protein function and verify its role as an anti-aging hormone, which would have a significant impact on basic research and medical practice of aging. ..
  11. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2004
    ..In addition, it promises to promote better understanding of the Klotho protein function and verify its role as an anti-aging hormone, which would have a significant impact on basic research and medical practice of aging. ..
  12. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2003
    ..In addition, it promises to promote better understanding of the Klotho protein function and verify its role as an anti-aging hormone, which would have a significant impact on basic research and medical practice of aging. ..
  13. Effects of Klotho Protein on Aging and Metabolism
    Makoto Kuro O; Fiscal Year: 2009
    ..These studies will promote better understanding of Klotho protein function, which may eventually contribute to understanding of molecular mechanisms of aging. ..