R Kurlan

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint "Levodopa phobia": a new iatrogenic cause of disability in Parkinson disease
    Roger Kurlan
    Department of Neurology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Neurology 64:923-4. 2005
  2. ncbi request reprint Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome
    Thomas J Spencer
    Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    J Atten Disord 11:470-81. 2008
  3. ncbi request reprint "Fear of falling" gait: a potentially reversible psychogenic gait disorder
    Roger Kurlan
    University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, New York 14620, USA
    Cogn Behav Neurol 18:171-2. 2005
  4. ncbi request reprint Disabling repetitive behaviors in Parkinson's disease
    Roger Kurlan
    Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642 8673, USA
    Mov Disord 19:433-7. 2004
  5. ncbi request reprint The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician
    Roger Kurlan
    Cognitive and Behavioral Neurology Unit, Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642 8673, USA
    Pediatrics 113:883-6. 2004
  6. ncbi request reprint Tourette's syndrome: are stimulants safe?
    Roger Kurlan
    Department of Neurology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8673, USA
    Curr Neurol Neurosci Rep 3:285-8. 2003
  7. ncbi request reprint Quetiapine for agitation or psychosis in patients with dementia and parkinsonism
    Roger Kurlan
    Mt Hope Professional Building, Rochester, NY 14620, USA
    Neurology 68:1356-63. 2007
  8. ncbi request reprint Prevalence of tics in schoolchildren and association with placement in special education
    R Kurlan
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Neurology 57:1383-8. 2001
  9. ncbi request reprint Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study
    Roger Kurlan
    University of Rochester School of Medicine, Mt Hope Professional Building, 1351 Mt Hope Ave, Suite 100, Rochester, NY 14620, USA
    Pediatrics 121:1188-97. 2008
  10. pmc A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease
    I H Richard
    University of Rochester, Rochester, NY, USA
    Neurology 78:1229-36. 2012

Research Grants

Detail Information

Publications35

  1. ncbi request reprint "Levodopa phobia": a new iatrogenic cause of disability in Parkinson disease
    Roger Kurlan
    Department of Neurology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Neurology 64:923-4. 2005
  2. ncbi request reprint Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome
    Thomas J Spencer
    Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    J Atten Disord 11:470-81. 2008
    ..This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS)...
  3. ncbi request reprint "Fear of falling" gait: a potentially reversible psychogenic gait disorder
    Roger Kurlan
    University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, New York 14620, USA
    Cogn Behav Neurol 18:171-2. 2005
    ..To describe "fear of falling" gait...
  4. ncbi request reprint Disabling repetitive behaviors in Parkinson's disease
    Roger Kurlan
    Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642 8673, USA
    Mov Disord 19:433-7. 2004
    ..The repetitive behavior responded poorly to serotonin reuptake inhibitors. Certain atypical antipsychotics may be of benefit...
  5. ncbi request reprint The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician
    Roger Kurlan
    Cognitive and Behavioral Neurology Unit, Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642 8673, USA
    Pediatrics 113:883-6. 2004
    ..The optimum diagnostic and therapeutic approach awaits the results of additional research studies...
  6. ncbi request reprint Tourette's syndrome: are stimulants safe?
    Roger Kurlan
    Department of Neurology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8673, USA
    Curr Neurol Neurosci Rep 3:285-8. 2003
    ..Methylphenidate appears to be the best-tolerated stimulant compound, with tics often lessening during treatment...
  7. ncbi request reprint Quetiapine for agitation or psychosis in patients with dementia and parkinsonism
    Roger Kurlan
    Mt Hope Professional Building, Rochester, NY 14620, USA
    Neurology 68:1356-63. 2007
    ..To assess the efficacy and tolerability of quetiapine for agitation or psychosis in patients with dementia and parkinsonism...
  8. ncbi request reprint Prevalence of tics in schoolchildren and association with placement in special education
    R Kurlan
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Neurology 57:1383-8. 2001
    ....
  9. ncbi request reprint Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study
    Roger Kurlan
    University of Rochester School of Medicine, Mt Hope Professional Building, 1351 Mt Hope Ave, Suite 100, Rochester, NY 14620, USA
    Pediatrics 121:1188-97. 2008
    ....
  10. pmc A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease
    I H Richard
    University of Rochester, Rochester, NY, USA
    Neurology 78:1229-36. 2012
    ..To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI) in the treatment of depression in Parkinson disease (PD)...
  11. ncbi request reprint The behavioral spectrum of tic disorders: a community-based study
    R Kurlan
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8673, USA
    Neurology 59:414-20. 2002
    ....
  12. doi request reprint Study of istradefylline in patients with Parkinson's disease on levodopa with motor fluctuations
    Robert A Hauser
    Department of Neurology, University of South Florida, Tampa, Florida 33606, USA
    Mov Disord 23:2177-85. 2008
    ..We conclude that istradefylline is well tolerated and significantly reduces OFF time as an adjunct to levodopa in PD subjects with motor fluctuations...
  13. doi request reprint Istradefylline as monotherapy for Parkinson disease: results of the 6002-US-051 trial
    H H Fernandez
    Department of Neurology, University of Florida Movement Disorders Center, PO Box 100236, 100 South Newell Dr, L3 100, Gainesville, FL 32610 0236, USA
    Parkinsonism Relat Disord 16:16-20. 2010
    ..6002-US-051 was a 12-week, double-blind study evaluating the safety and efficacy of istradefylline, a selective A(2A) adenosine receptor antagonist, as monotherapy in patients with Parkinson's disease (PD)...
  14. pmc The management of tics
    David Shprecher
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Mov Disord 24:15-24. 2009
    ..A comprehensive evaluation accounting for secondary causes, psychosocial factors, and comorbid neuropsychiatric conditions is essential to successful treatment of tic disorders...
  15. pmc Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease
    David K Simon
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 11:53. 2010
    ..We investigated the potential contribution of mtDNA variants or mutations to the risk of PD...
  16. pmc Fatigue in levodopa-naive subjects with Parkinson disease
    G Schifitto
    University of Rochester, NY, USA
    Neurology 71:481-5. 2008
    ..Fatigue is a common complaint in Parkinson disease (PD). We investigated fatigue in a cohort of previously untreated patients with early PD enrolled in the Earlier vs Later Levodopa (ELLDOPA) clinical trial...
  17. pmc Normal pressure hydrocephalus: diagnosis and treatment
    David Shprecher
    University of Rochester School of Medicine, 1351 Mt Hope Avenue, Suite 100, Rochester, NY 14620, USA
    Curr Neurol Neurosci Rep 8:371-6. 2008
    ....
  18. ncbi request reprint Parkinson's disease and dementia with Lewy bodies: one disease or two?
    Irene Hegeman Richard
    University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, New York 14642, USA
    Mov Disord 17:1161-5. 2002
    ..The mechanisms responsible for the different clinical presentations are not known, and the issue of whether PD and DLB represent two distinct diseases remains unsettled...
  19. ncbi request reprint Worsening of motor function and mood in a patient with Parkinson's disease after pharmacologic challenge with oral rivastigmine
    Irene Hegeman Richard
    Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Clin Neuropharmacol 25:296-9. 2002
    ..We conclude that further studies should be done to evaluate the efficacy and tolerability of these agents in this illness but that caution should be exercised when using acetylcholinesterase inhibitors in patients with PD...
  20. ncbi request reprint The ups and downs of Parkinson disease: a prospective study of mood and anxiety fluctuations
    Irene H Richard
    University of Rochester, Rochester, New York, USA
    Cogn Behav Neurol 17:201-7. 2004
    ..Parkinson disease (PD) patients with motor fluctuations experience mood fluctuations, but studies have been limited in number and methodology...
  21. ncbi request reprint Gabapentin's effects on hot flashes in postmenopausal women: a randomized controlled trial
    Thomas Guttuso
    Department of Neurology, University of Rochester, Rochester, New York 14642, USA
    Obstet Gynecol 101:337-45. 2003
    ..To evaluate whether treatment with the anticonvulsant gabapentin may be effective in reducing hot flash frequency and severity...
  22. doi request reprint Cancer incidence in a trial of an antiapoptotic agent for Parkinson's disease
    Steven R Schwid
    Department of Neurology, University of Rochester, Rochester, New York, USA
    Mov Disord 25:1801-8. 2010
    ..Melanoma occurrence in our PD patients was greater than predicted compared with the general population and was unrelated to dopaminergic therapy. Clinical surveillance of PD patients for melanoma may be warranted...
  23. ncbi request reprint A longitudinal program for biomarker development in Parkinson's disease: a feasibility study
    Bernard Ravina
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mov Disord 24:2081-90. 2009
    ..The PostCEPT cohort and associated studies strongly support the feasibility of the LABS-PD approach of retaining and repurposing clinical trial cohorts to collect longitudinal clinical and biomarker data...
  24. ncbi request reprint Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial
    Robert G Holloway
    Department of Neurology, University of Rochester, 1351 Mt Hope Avenue, Suite 220, Rochester, NY 14620, USA
    Arch Neurol 61:1044-53. 2004
    ..The best way to initiate dopaminergic therapy for early Parkinson disease remains unclear...
  25. ncbi request reprint Tics and its disorders
    D Marcus
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642-8673, USA
    Neurol Clin 19:735-58, viii. 2001
    ..Tourette syndrome and its differential diagnosis are discussed in this article with a focus on new developments in classification, etiology, epidemiology, genetics, pathophysiology, and clinical management...
  26. ncbi request reprint Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers
    C W Hess
    Department of Neurology, PACC, Beth Israel Medical Center, Suite 5J, 10 Union Square East, New York, NY 10003, USA
    Neurology 68:522-4. 2007
    ....
  27. ncbi request reprint Relationship between mood and motor fluctuations in Parkinson's disease
    I H Richard
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Neuropsychiatry Clin Neurosci 13:35-41. 2001
    ..Motor and emotional states were not, however, consistently correlated. When they were correlated, the most frequent pattern was the common occurrence of decreased mood, increased anxiety, and reduced motor function...
  28. ncbi request reprint Levodopa responsiveness in disorders with parkinsonism: a review of the literature
    Radu Constantinescu
    Department of Neurology, University of Rochester School of Medicine, Rochester, New York, USA
    Mov Disord 22:2141-8; quiz 2295. 2007
    ..Efforts should be directed toward better defining LR when used for diagnostic purposes and in scientific publications...
  29. ncbi request reprint A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
    Paul Coleman
    Center for Aging and Developmental Biology, University of Rochester School of Medicine, Rochester, NY 14642 8673, USA
    Neurology 63:1155-62. 2004
    ..e., "synaptoprotection") in AD. Such "synaptoprotective" therapy will probably need to be administered at a critical early time point, perhaps years before onset of clinical symptoms...
  30. pmc Medication tolerance and augmentation in restless legs syndrome: the need for drug class rotation
    Roger Kurlan
    Movement Disorders Unit, Department of Neurology, University of Rochester School of Medicine, Rochester, NY, USA
    J Gen Intern Med 21:C1-4. 2006
    ..We discuss the optimal management of RLS and propose strategies to overcome tolerance and augmentation such as a rotational approach among agents from different classes...
  31. ncbi request reprint Assistive devices for gait in Parkinson's disease
    Radu Constantinescu
    Department of Neurology, University of Rochester School of Medicine, 1351 Mt Hope Avenue, Suite 100, Rochester, NY 14620 3917, USA
    Parkinsonism Relat Disord 13:133-8. 2007
    ..We review the available literature and provide practical information about available mobility assistive devices for patients with PD...
  32. ncbi request reprint Syncope in children with Tourette's syndrome treated with guanfacine
    Allison King
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14620, USA
    Mov Disord 21:419-20. 2006
    ..Syncope appears to be an uncommon side effect of guanfacine and is probably due to drug-induced hypotension or bradycardia...
  33. ncbi request reprint A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5
    Paul Coleman
    Department of Neurology, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, P O Box 645, NY 14642, USA
    Neurosci Lett 364:139-40. 2004
    ..We conclude that the cause of Alzheimer's disease in this patient is an authentic PS1 gene abnormality responsible for the patient's early onset Alzheimer's disease...
  34. ncbi request reprint Future and alternative therapies in Tourette syndrome
    Roger Kurlan
    Department of Neurology, University of Rochester, Rochester, New York, USA
    Adv Neurol 99:248-53. 2006

Research Grants9

  1. PANDAS and Strep Infection: Are they Linked?
    Roger Kurlan; Fiscal Year: 2004
    ..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients. ..
  2. PANDAS and Strep Infection: Are they Linked?
    Roger Kurlan; Fiscal Year: 2001
    ..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients. ..
  3. Treating Agitation/Psychosis in Dementia/Parkinsonism
    Roger Kurlan; Fiscal Year: 2002
    ..This study will provide important information regarding the optimal treatment of psychosis and agitation for patients with the commonly encountered combination of primary dementia and parkinsonism. ..
  4. PANDAS and Strep Infection: Are they Linked?
    Roger Kurlan; Fiscal Year: 2002
    ..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients. ..
  5. Treating Agitation/Psychosis in Dementia/Parkinsonism
    Roger Kurlan; Fiscal Year: 2003
    ..This study will provide important information regarding the optimal treatment of psychosis and agitation for patients with the commonly encountered combination of primary dementia and parkinsonism. ..
  6. PANDAS and Strep Infection: Are they Linked?
    Roger Kurlan; Fiscal Year: 2003
    ..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients. ..
  7. Treating Agitation/Psychosis in Dementia/Parkinsonism
    Roger Kurlan; Fiscal Year: 2004
    ..This study will provide important information regarding the optimal treatment of psychosis and agitation for patients with the commonly encountered combination of primary dementia and parkinsonism. ..
  8. Parkinson's Disease Data Organizing Center
    Roger Kurlan; Fiscal Year: 2008
    ..The University of Rochester has extensive expertise and resources which will facilitate the development of a highly successful PD-DOC. The PD-DOC will be a critical force in advancing collaborative research in PD. ..
  9. Parkinson's Disease Data Organizing Center
    Roger Kurlan; Fiscal Year: 2007
    ..The University of Rochester has extensive expertise and resources which will facilitate the development of a highly successful PD-DOC. The PD-DOC will be a critical force in advancing collaborative research in PD. ..