John Kurhanewicz

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Diffusion MR of hyperpolarized 13C molecules in solution
    Bertram L Koelsch
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
    Analyst 138:1011-4. 2013
  2. pmc A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    J Magn Reson 217:41-7. 2012
  3. pmc Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    IEEE Trans Med Imaging 31:265-75. 2012
  4. doi request reprint Feasibility of MR imaging/MR spectroscopy-planned focal partial salvage permanent prostate implant (PPI) for localized recurrence after initial PPI for prostate cancer
    Charles C Hsu
    Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94115, USA
    Int J Radiat Oncol Biol Phys 85:370-7. 2013
  5. pmc Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:18606-11. 2011
  6. pmc In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine
    Simon Hu
    Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 29:1035-40. 2011
  7. pmc In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Mol Imaging Biol 11:399-407. 2009
  8. pmc Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 65:610-9. 2011
  9. doi request reprint 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Cell Metab 14:131-42. 2011
  10. pmc Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
    J Magn Reson Imaging 33:692-7. 2011

Collaborators

Detail Information

Publications37

  1. pmc Diffusion MR of hyperpolarized 13C molecules in solution
    Bertram L Koelsch
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
    Analyst 138:1011-4. 2013
    ..Potential applications include rapidly measuring molecular binding, cellular membrane transport, in vivo metabolite distribution and establishing a magnetic field independent hyperpolarized parameter...
  2. pmc A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    J Magn Reson 217:41-7. 2012
    ..Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed...
  3. pmc Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    IEEE Trans Med Imaging 31:265-75. 2012
    ....
  4. doi request reprint Feasibility of MR imaging/MR spectroscopy-planned focal partial salvage permanent prostate implant (PPI) for localized recurrence after initial PPI for prostate cancer
    Charles C Hsu
    Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94115, USA
    Int J Radiat Oncol Biol Phys 85:370-7. 2013
    ..To assess the feasibility of magnetic resonance imaging (MRI)-planned partial salvage permanent prostate implant (psPPI) among patients with biopsy-proven local recurrence after initial PPI without evidence of distant disease...
  5. pmc Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:18606-11. 2011
    ..More broadly, these findings suggest a prognostic role for this new redox sensor in determining vulnerability of both normal and abnormal tissues to ROS...
  6. pmc In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine
    Simon Hu
    Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 29:1035-40. 2011
    ..The intracellular lactate-to-pyruvate ratio of normal rat tissue measured with hyperpolarized [1-(13)C]alanine was 4.89±0.61 (mean±S.E.) as opposed to a ratio of 0.41±0.03 when hyperpolarized [1-(13)C]pyruvate was injected...
  7. pmc In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Mol Imaging Biol 11:399-407. 2009
    ....
  8. pmc Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 65:610-9. 2011
    ..This approach has enabled the monitoring of perfusion and uptake of the pyruvate, and the conversion dynamics to lactate and alanine throughout a volume with high spatial and temporal resolution...
  9. doi request reprint 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Cell Metab 14:131-42. 2011
    ..These results demonstrate that metabolic changes precede tumor formation and regression and are directly linked to the activity of a single oncogene...
  10. pmc Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
    J Magn Reson Imaging 33:692-7. 2011
    ..To demonstrate dynamic imaging of a diffusible perfusion tracer, hyperpolarized [(13)C]urea, for regional measurement of blood flow in preclinical cancer models...
  11. pmc Local staging of prostate cancer: comparative accuracy of T2-weighted endorectal MR imaging and transrectal ultrasound
    Adam J Jung
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Clin Imaging 36:547-52. 2012
    ..The objective of this study was to compare the accuracy of T2-weighted magnetic resonance (MR) imaging and transrectal ultrasound (TRUS) for staging of prostate cancer...
  12. pmc Prostate cancer: prediction of biochemical failure after external-beam radiation therapy--Kattan nomogram and endorectal MR imaging estimation of tumor volume
    Antonio C Westphalen
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, Box 0628, Room M 372, San Francisco, CA 94143 0628, USA
    Radiology 261:477-86. 2011
    ..To determine whether magnetic resonance (MR) imaging and MR spectroscopic imaging findings can improve predictions made with the Kattan nomogram for radiation therapy...
  13. doi request reprint Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluid
    Brad R Cohn
    Department of Radiology, School of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Am J Obstet Gynecol 203:76.e1-76.e10. 2010
    ....
  14. pmc Does local recurrence of prostate cancer after radiation therapy occur at the site of primary tumor? Results of a longitudinal MRI and MRSI study
    Elnasif Arrayeh
    Department of Radiology and Biomedical Imaging, University of California San Francisco, California, USA
    Int J Radiat Oncol Biol Phys 82:e787-93. 2012
    ....
  15. pmc Endorectal MRI after radiation therapy: questioning the sextant analysis
    Shilpa R Kumbhani
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94143 0628, USA
    J Magn Reson Imaging 33:1086-90. 2011
    ..Despite its known limitations, sextant is the generally accepted standard for magnetic resonance imaging (MRI) and biopsy coregistration; nevertheless, depending on the magnitude of localization errors, other options may be adequate...
  16. pmc Prostate cancer managed with active surveillance: role of anatomic MR imaging and MR spectroscopic imaging
    Vincent Fradet
    Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, Calif, USA
    Radiology 256:176-83. 2010
    ....
  17. pmc Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 31:163-70. 2013
    ..1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer...
  18. pmc Magnetic resonance spectroscopic imaging of benign prostatic tissue: findings at 3.0 T compared to 1.5 T-initial experience
    Munish Chitkara
    Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    Clin Imaging 35:288-93. 2011
    ..5 T using a Wilcoxon ranked-sum test; awareness of this selective amplification of these metabolic signals at high field strength may help avoid overdiagnosis of prostate cancer...
  19. pmc Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors
    Ilwoo Park
    Joint Graduate Group in Bioengineering, Surbeck Laboratory of Advanced Imaging, University of California San Francisco Berkeley, 1700 4th Street, Byers Hall, Room BH 303, San Francisco, CA 94158 2532, USA
    Neuro Oncol 12:133-44. 2010
    ..These results suggest that hyperpolarized MR metabolic imaging may be valuable for assessing prognosis and monitoring response to therapy for patients with brain tumors...
  20. pmc Toward adaptive stereotactic robotic brachytherapy for prostate cancer: demonstration of an adaptive workflow incorporating inverse planning and an MR stealth robot
    J Adam Cunha
    Department of Radiation Oncology, University of California, San Francisco, CA, USA
    Minim Invasive Ther Allied Technol 19:189-202. 2010
    ..Demonstration of this workflow is a key element of a successful translation to the clinic of the MRI stealth robotic delivery system, MRBot...
  21. pmc Multiparametric 3T endorectal mri after external beam radiation therapy for prostate cancer
    Antonio C Westphalen
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Magn Reson Imaging 36:430-7. 2012
    ..To determine the best combination of magnetic resonance imaging (MRI) parameters for the detection of locally recurrent prostate cancer after external beam radiation therapy...
  22. pmc Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy
    Christopher S Ward
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:1296-305. 2010
    ....
  23. pmc Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research
    John Kurhanewicz
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94158 2330, USA
    Neoplasia 13:81-97. 2011
    ..Nevertheless, there are no fundamental barriers to rapid translation of this exciting technology to clinical research and perhaps clinical care...
  24. pmc Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 30:1367-72. 2012
    ..004), acetoacetate (+504±281%, P=.009) and acetylcarnitine (+377±157%, P=.003) were detected when [2-(13)C]pyruvate was used...
  25. pmc Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer
    Janine M Lupo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 28:153-62. 2010
    ..The MLS was significantly higher in TRAMP mice that had advanced disease...
  26. pmc Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Cancer Res 73:529-38. 2013
    ..We show that such differential cellular transporter expression and associated metabolic phenotype can be noninvasively assessed via real-time monitoring of hyperpolarized (13)C-pyruvate-to-lactate flux...
  27. pmc Locally recurrent prostate cancer after external beam radiation therapy: diagnostic performance of 1.5-T endorectal MR imaging and MR spectroscopic imaging for detection
    Antonio C Westphalen
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 256:485-92. 2010
    ..To determine if performing magnetic resonance (MR) spectroscopic imaging, compared with performing T2-weighted MR imaging alone, improves the detection of locally recurrent prostate cancer after definitive external beam radiation therapy...
  28. pmc Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions
    Kayvan R Keshari
    Department of Radiology, University of California San Francisco, San Francisco, USA
    Analyst 137:3427-9. 2012
    ..Differences in β-cyclodextrin concentration were easily visualized. These results suggest that hyperpolarized (13)C MR could be used in vivo to determine the presence and density of receptors for a given ligand-receptor pair...
  29. doi request reprint Diagnostic tools and imaging methods in intervertebral disk degeneration
    Sharmila Majumdar
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Orthop Clin North Am 42:501-11, viii. 2011
    ..With the potential for morphologic and biochemical characterization of the intervertebral disk, MRI shows promise as a tool to quantitatively assess disk health...
  30. pmc Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA
    Am J Physiol Renal Physiol 302:F1658-62. 2012
    ..More rapid medullary enhancement was observed under antidiuresis, consistent with known upregulation of UT-A1...
  31. pmc Management of prostate cancer patients with lymph node involvement: a rapidly evolving paradigm
    Gilles Crehange
    Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1600 Divisadero Street, CA 94143, San Francisco, United States
    Cancer Treat Rev 38:956-67. 2012
    ..This review highlights advances in imaging and reports how they may help to define a new paradigm to manage node-positive prostate cancer patients with a curative-intent...
  32. pmc Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostate
    Susan M Noworolski
    The Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, The University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 32:654-62. 2010
    ..To develop and validate a post-processing correction algorithm to remove the effect of the inhomogeneous reception profile of the endorectal coil on MR spectroscopic imaging (MRSI) data...
  33. pmc Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy
    Carissa F Santos
    Department of Radiology, University of California, San Francisco, CA, USA
    NMR Biomed 23:391-8. 2010
    ..This study demonstrates that histopathologic and genetic microarray analysis can be successfully performed on prostate surgical and biopsy tissues following HR-MAS analysis; however, biopsy tissues are more fragile than surgical tissues...
  34. pmc High-resolution magic angle spinning NMR spectroscopy of human osteoarthritic cartilage
    Keerthi Shet
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    NMR Biomed 25:538-44. 2012
    ....
  35. doi request reprint Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy
    Jin Zuo
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA
    Magn Reson Med 62:1140-6. 2009
    ..0039). This study demonstrates for the first time that short-echo PRESS on a clinical 3T MR scanner can be used to noninvasively and can reproducibly quantify metabolic changes associated with degeneration of intervertebral discs...
  36. pmc Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco UCSF, 1700 fourth St, Byers Hall 203, San Francisco, California 94158, USA
    J Am Chem Soc 131:17591-6. 2009
    ..Thus, this study demonstrates the first hyperpolarization of a carbohydrate carbon with a sufficient T(1) and solution state polarization for ex vivo spectroscopy and in vivo spectroscopic imaging studies...
  37. doi request reprint Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy
    Brad R Cohn
    Department of Radiology and Biomedical Imaging, University of California, 1600 Divisadero Street, Room C 250, Box 1667, San Francisco, CA 94115, USA
    MAGMA 22:343-52. 2009
    ..To establish and compare normative metabolite concentrations in 2nd and 3rd trimester human amniotic fluid samples in an effort to reveal metabolic biomarkers of fetal health and development...