John Kurhanewicz

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Multiparametric magnetic resonance imaging in prostate cancer: present and future
    John Kurhanewicz
    Department of Radiology, University of California, San Francisco, California, USA
    Curr Opin Urol 18:71-7. 2008
  2. pmc Current and potential applications of clinical 13C MR spectroscopy
    John Kurhanewicz
    University of California San Francisco, San Francisco, California 94158 2330, USA
    J Nucl Med 49:341-4. 2008
  3. pmc Advances in MR spectroscopy of the prostate
    John Kurhanewicz
    University of California, San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging Clin N Am 16:697-710, ix-x. 2008
  4. pmc Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research
    John Kurhanewicz
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94158 2330, USA
    Neoplasia 13:81-97. 2011
  5. doi request reprint Feasibility of MR imaging/MR spectroscopy-planned focal partial salvage permanent prostate implant (PPI) for localized recurrence after initial PPI for prostate cancer
    Charles C Hsu
    Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94115, USA
    Int J Radiat Oncol Biol Phys 85:370-7. 2013
  6. pmc Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice
    Matthew L Zierhut
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94143 2532, USA
    J Magn Reson 202:85-92. 2010
  7. pmc Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:582-91. 2010
  8. ncbi request reprint Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy
    Mark G Swanson
    Department of Radiology, University of California San Francisco, 94107, USA
    Magn Reson Med 55:1257-64. 2006
  9. pmc Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues
    May Britt Tessem
    Department of Radiology, University of California San Francisco, San Francisco, California 94158 2330, USA
    Magn Reson Med 60:510-6. 2008
  10. pmc Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading
    Mark J Albers
    Department of Bioengineering, University of California San Francisco, San Francisco, California 94158 2330, USA
    Cancer Res 68:8607-15. 2008

Research Grants

  1. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 1999
  2. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2009
  3. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2007
  4. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2007
  5. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2006
  6. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2006
  7. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2005
  8. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2005
  9. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2004
  10. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2003

Detail Information

Publications99

  1. pmc Multiparametric magnetic resonance imaging in prostate cancer: present and future
    John Kurhanewicz
    Department of Radiology, University of California, San Francisco, California, USA
    Curr Opin Urol 18:71-7. 2008
    ..The purpose of this article is to review the current status of advanced MRI techniques based on anatomic, metabolic and physiologic properties of prostate cancer with a focus on their impact in managing prostate cancer patients...
  2. pmc Current and potential applications of clinical 13C MR spectroscopy
    John Kurhanewicz
    University of California San Francisco, San Francisco, California 94158 2330, USA
    J Nucl Med 49:341-4. 2008
    ..Preliminary preclinical studies in a model of prostate cancer have demonstrated the potential clinical utility of hyperpolarized (13)C MRS...
  3. pmc Advances in MR spectroscopy of the prostate
    John Kurhanewicz
    University of California, San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging Clin N Am 16:697-710, ix-x. 2008
    ..Accuracy can be improved by performing MR imaging/MRSI at higher magnetic field strengths, using more sensitive hyperpolarized (13)C MRSI techniques and through the addition of other functional MR techniques...
  4. pmc Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research
    John Kurhanewicz
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94158 2330, USA
    Neoplasia 13:81-97. 2011
    ..Nevertheless, there are no fundamental barriers to rapid translation of this exciting technology to clinical research and perhaps clinical care...
  5. doi request reprint Feasibility of MR imaging/MR spectroscopy-planned focal partial salvage permanent prostate implant (PPI) for localized recurrence after initial PPI for prostate cancer
    Charles C Hsu
    Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94115, USA
    Int J Radiat Oncol Biol Phys 85:370-7. 2013
    ..To assess the feasibility of magnetic resonance imaging (MRI)-planned partial salvage permanent prostate implant (psPPI) among patients with biopsy-proven local recurrence after initial PPI without evidence of distant disease...
  6. pmc Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice
    Matthew L Zierhut
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94143 2532, USA
    J Magn Reson 202:85-92. 2010
    ....
  7. pmc Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:582-91. 2010
    ..The results of this study demonstrated the potential of this new hyperpolarized MR dynamic method for improved cancer detection and characterization...
  8. ncbi request reprint Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy
    Mark G Swanson
    Department of Radiology, University of California San Francisco, 94107, USA
    Magn Reson Med 55:1257-64. 2006
    ..7, P < 0.01; [PAs](mean) = 5.28 +/- 5.44, P < 0.01). Serial spectra acquired over 12 hr indicated that the degradation of Cho-containing metabolites was minimized by acquiring HR-MAS data at 1 degree C compared to 20 degrees C...
  9. pmc Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues
    May Britt Tessem
    Department of Radiology, University of California San Francisco, San Francisco, California 94158 2330, USA
    Magn Reson Med 60:510-6. 2008
    ..The significant increase in the concentration of both lactate and alanine in biopsy tissue containing as little as 5% cancer could be exploited in hyperpolarized (13)C spectroscopic imaging (SI) studies of prostate cancer patients...
  10. pmc Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading
    Mark J Albers
    Department of Bioengineering, University of California San Francisco, San Francisco, California 94158 2330, USA
    Cancer Res 68:8607-15. 2008
    ....
  11. pmc In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Mol Imaging Biol 11:399-407. 2009
    ....
  12. pmc Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo
    David M Wilson
    Department of Radiology, University of California San Francisco UCSF, San Francisco, CA, United States
    J Magn Reson 205:141-7. 2010
    ....
  13. pmc Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    IEEE Trans Med Imaging 31:265-75. 2012
    ....
  14. ncbi request reprint Prostate depiction at endorectal MR spectroscopic imaging: investigation of a standardized evaluation system
    Juyoung A Jung
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143, USA
    Radiology 233:701-8. 2004
    ..To investigate the accuracy and interobserver variability of a standardized evaluation system for endorectal three-dimensional (3D) magnetic resonance (MR) spectroscopic imaging of the prostate...
  15. pmc 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158 2512, USA
    Magn Reson Med 63:312-21. 2010
    ....
  16. ncbi request reprint High-resolution 3D MR spectroscopic imaging of the prostate at 3 T with the MLEV-PRESS sequence
    Albert P Chen
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143 2512, USA
    Magn Reson Imaging 24:825-32. 2006
    ..5 t mrsi...
  17. ncbi request reprint High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features--initial experience
    Jeffrey J Hom
    Department of Radiology, University of California, San Francisco, Box 0628, M 372, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Radiology 242:483-9. 2007
    ..To retrospectively determine the magnetic resonance (MR) and MR spectroscopic imaging features of high-grade prostatic intraepithelial neoplasia (HGPIN) in patients with prostate cancer...
  18. pmc Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer
    Janine M Lupo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 28:153-62. 2010
    ..The MLS was significantly higher in TRAMP mice that had advanced disease...
  19. ncbi request reprint Three-dimensional conformal external beam radiotherapy compared with permanent prostate implantation in low-risk prostate cancer based on endorectal magnetic resonance spectroscopy imaging and prostate-specific antigen level
    Barby Pickett
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 65:65-72. 2006
    ..Recent studies have suggested that the treatment of low-risk prostate cancer yields similar results for patients treated with 3D-CRT or PPI...
  20. ncbi request reprint High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding
    Albert P Chen
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Magn Reson Imaging 25:1288-92. 2007
    ..The short acquisition time provided by this method reduces the 3T prostate MRI/MRSI exam time, allows longer repetition times, and/or allows the acquisition of additional MR acquisitions within the same exam...
  21. pmc A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    J Magn Reson 217:41-7. 2012
    ..Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed...
  22. pmc Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:18606-11. 2011
    ..More broadly, these findings suggest a prognostic role for this new redox sensor in determining vulnerability of both normal and abnormal tissues to ROS...
  23. pmc Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI
    Simon Hu
    Department of Radiology, University of California, Box 2512, 1700 4th Street, QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
    J Magn Reson 192:258-64. 2008
    ..Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility...
  24. pmc Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
    J Magn Reson Imaging 33:692-7. 2011
    ..To demonstrate dynamic imaging of a diffusible perfusion tracer, hyperpolarized [(13)C]urea, for regional measurement of blood flow in preclinical cancer models...
  25. pmc Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco UCSF, 1700 fourth St, Byers Hall 203, San Francisco, California 94158, USA
    J Am Chem Soc 131:17591-6. 2009
    ..Thus, this study demonstrates the first hyperpolarization of a carbohydrate carbon with a sufficient T(1) and solution state polarization for ex vivo spectroscopy and in vivo spectroscopic imaging studies...
  26. pmc Pretreatment endorectal magnetic resonance imaging and magnetic resonance spectroscopic imaging features of prostate cancer as predictors of response to external beam radiotherapy
    Tim Joseph
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Int J Radiat Oncol Biol Phys 73:665-71. 2009
    ....
  27. pmc In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine
    Simon Hu
    Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 29:1035-40. 2011
    ..The intracellular lactate-to-pyruvate ratio of normal rat tissue measured with hyperpolarized [1-(13)C]alanine was 4.89±0.61 (mean±S.E.) as opposed to a ratio of 0.41±0.03 when hyperpolarized [1-(13)C]pyruvate was injected...
  28. doi request reprint (1)H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: inter- and intraobserver reproducibility study
    Bonnie N Joe
    Department of Radiology, University of California San Francisco, 1600 Divisadero St, Room C250, Box 1667, San Francisco, CA 94115, USA
    J Magn Reson Imaging 28:1540-5. 2008
    ..To determine the intra- and interobserver reproducibility of human amniotic fluid metabolite concentration measurements (including potential markers of fetal lung maturity) detectable by MR spectroscopy...
  29. pmc Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 65:610-9. 2011
    ..This approach has enabled the monitoring of perfusion and uptake of the pyruvate, and the conversion dynamics to lactate and alanine throughout a volume with high spatial and temporal resolution...
  30. doi request reprint Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy
    Brad R Cohn
    Department of Radiology and Biomedical Imaging, University of California, 1600 Divisadero Street, Room C 250, Box 1667, San Francisco, CA 94115, USA
    MAGMA 22:343-52. 2009
    ..To establish and compare normative metabolite concentrations in 2nd and 3rd trimester human amniotic fluid samples in an effort to reveal metabolic biomarkers of fetal health and development...
  31. pmc Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 31:635-42. 2013
    ..This was shown in STEAM images that highlighted abnormal cancer cell metabolism and suppressed vascular (13)C metabolite signals...
  32. pmc Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer
    Simon Hu
    Dept of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, 1700 4th St QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 31:490-6. 2013
    ..Dramatic increases in (13)C-bicarbonate were detected just 1 min (as well as 6 min) after DCA administration...
  33. pmc Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Prostate 73:1171-81. 2013
    ..In this study, we investigate the glucose reprogramming using HP (13) C pyruvate MR in a patient-derived prostate tissue slice culture (TSC) model...
  34. pmc Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 31:163-70. 2013
    ..1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer...
  35. pmc Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy
    Mark G Swanson
    Department of Radiology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    Magn Reson Med 60:33-40. 2008
    ..7 +/- 2.2%, while Cho+mI and Eth increased 18% in 1 hr at 1 degrees C and a 2250 Hz spin rate...
  36. pmc Toward adaptive stereotactic robotic brachytherapy for prostate cancer: demonstration of an adaptive workflow incorporating inverse planning and an MR stealth robot
    J Adam Cunha
    Department of Radiation Oncology, University of California, San Francisco, CA, USA
    Minim Invasive Ther Allied Technol 19:189-202. 2010
    ..Demonstration of this workflow is a key element of a successful translation to the clinic of the MRI stealth robotic delivery system, MRBot...
  37. ncbi request reprint Endorectal MR imaging and MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: preliminary experience
    Fergus V Coakley
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 233:441-8. 2004
    ..To evaluate endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging for the depiction of locally recurrent prostate cancer after external beam radiation therapy...
  38. pmc Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies
    Albert P Chen
    Department of Radiology, University of California, Box 2512, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 26:721-6. 2008
    ..This study also demonstrated the potential value of this hyperpolarized agent to investigate in vivo lactate uptake and metabolism in preclinical animal models...
  39. pmc 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Cell Metab 14:131-42. 2011
    ..These results demonstrate that metabolic changes precede tumor formation and regression and are directly linked to the activity of a single oncogene...
  40. pmc Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI)
    Michael A Ohliger
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    J Magn Reson Imaging 38:701-13. 2013
    ..Human applications additionally require rapid imaging to permit breath-holding and to minimize the effects of physiologic motion...
  41. pmc Local staging of prostate cancer: comparative accuracy of T2-weighted endorectal MR imaging and transrectal ultrasound
    Adam J Jung
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Clin Imaging 36:547-52. 2012
    ..The objective of this study was to compare the accuracy of T2-weighted magnetic resonance (MR) imaging and transrectal ultrasound (TRUS) for staging of prostate cancer...
  42. pmc Prostate cancer: prediction of biochemical failure after external-beam radiation therapy--Kattan nomogram and endorectal MR imaging estimation of tumor volume
    Antonio C Westphalen
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, Box 0628, Room M 372, San Francisco, CA 94143 0628, USA
    Radiology 261:477-86. 2011
    ..To determine whether magnetic resonance (MR) imaging and MR spectroscopic imaging findings can improve predictions made with the Kattan nomogram for radiation therapy...
  43. ncbi request reprint Prostate cancer: endorectal MR imaging and MR spectroscopic imaging--distinction of true-positive results from chance-detected lesions
    Jeffrey J Hom
    Department of Radiology, University of California, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 238:192-9. 2006
    ..To retrospectively investigate size criteria for the identification of chance-detected lesions at endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging of prostate cancer...
  44. ncbi request reprint T2-Weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy
    Antonio C Westphalen
    Department of Radiology, Abdominal Imaging Section, University of California San Francisco, San Francisco, California 94143 0628, USA
    Int Braz J Urol 35:171-80; discussion 181-2. 2009
    ..To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy...
  45. pmc Prostate MRI and 3D MR spectroscopy: how we do it
    Sadhna Verma
    Department of Radiology, University of Cincinnati Medical Center, Cincinnati, OH 45267 0761, USA
    AJR Am J Roentgenol 194:1414-26. 2010
    ..This review is a primer on the technical aspects of performing a high-quality MRI and MR spectroscopic imaging examination of the prostate...
  46. ncbi request reprint Class solution in inverse planned HDR prostate brachytherapy for dose escalation of DIL defined by combined MRI/MRSI
    Yongbok Kim
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Radiother Oncol 88:148-55. 2008
    ..To establish an inverse planning set of parameters (class solution) to boost dominant intra-prostatic lesion (DIL) defined by MRI/MRSI...
  47. pmc Prostate cancer: role of pretreatment MR in predicting outcome after external-beam radiation therapy--initial experience
    David A McKenna
    Department of Radiology, University of California, San Francisco, M 372, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Radiology 247:141-6. 2008
    ..To retrospectively determine if pretreatment endorectal magnetic resonance (MR) imaging findings are predictive of outcome in patients who undergo external-beam radiation therapy for prostate cancer...
  48. ncbi request reprint Prostate cancer localization with endorectal MR imaging and MR spectroscopic imaging: effect of clinical data on reader accuracy
    Rajpal Dhingsa
    Departments of Radiology, Pathology, and Urology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    Radiology 230:215-20. 2004
    ....
  49. ncbi request reprint Diagnosis of prostate cancer in patients with an elevated prostate-specific antigen level: role of endorectal MRI and MR spectroscopic imaging
    Nick G Costouros
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Rm M 372, Box 0628, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 188:812-6. 2007
    ..The objective of our study was to determine the accuracy of endorectal MRI and MR spectroscopic imaging (MRSI) in the diagnosis of prostate cancer in patients with an elevated serum prostate-specific antigen (PSA) level...
  50. pmc Prostate cancer: is inapparent tumor at endorectal MR and MR spectroscopic imaging a favorable prognostic finding in patients who select active surveillance?
    Alvin R Cabrera
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Radiology 247:444-50. 2008
    ..To retrospectively determine whether inapparent tumor at endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging is a favorable prognostic finding in prostate cancer patients who select active surveillance for management...
  51. ncbi request reprint Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience
    Albert P Chen
    Department of Radiology, University of California San Francisco, San Francisco, California, USA
    Magn Reson Med 58:1099-106. 2007
    ..135 cm(3) nominal spatial resolution. Elevated (13)C lactate (lac) was observed in both primary and metastatic tumors, demonstrating the feasibility of studying cellular bioenergetics in vivo with DNP hyperpolarized (13)C MRSI...
  52. pmc Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Cancer Res 73:529-38. 2013
    ..We show that such differential cellular transporter expression and associated metabolic phenotype can be noninvasively assessed via real-time monitoring of hyperpolarized (13)C-pyruvate-to-lactate flux...
  53. pmc Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostate
    Susan M Noworolski
    The Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, The University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 32:654-62. 2010
    ..To develop and validate a post-processing correction algorithm to remove the effect of the inhomogeneous reception profile of the endorectal coil on MR spectroscopic imaging (MRSI) data...
  54. ncbi request reprint Organ-confined prostate cancer: effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging
    Aliya Qayyum
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 183:1079-83. 2004
    ..Our aim was to determine the effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging findings in patients with organ-confined prostate cancer...
  55. pmc Magnetic resonance spectroscopic imaging of benign prostatic tissue: findings at 3.0 T compared to 1.5 T-initial experience
    Munish Chitkara
    Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    Clin Imaging 35:288-93. 2011
    ..5 T using a Wilcoxon ranked-sum test; awareness of this selective amplification of these metabolic signals at high field strength may help avoid overdiagnosis of prostate cancer...
  56. doi request reprint Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluid
    Brad R Cohn
    Department of Radiology, School of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Am J Obstet Gynecol 203:76.e1-76.e10. 2010
    ....
  57. pmc Locally recurrent prostate cancer after external beam radiation therapy: diagnostic performance of 1.5-T endorectal MR imaging and MR spectroscopic imaging for detection
    Antonio C Westphalen
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 256:485-92. 2010
    ..To determine if performing magnetic resonance (MR) spectroscopic imaging, compared with performing T2-weighted MR imaging alone, improves the detection of locally recurrent prostate cancer after definitive external beam radiation therapy...
  58. pmc Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy
    Carissa F Santos
    Department of Radiology, University of California, San Francisco, CA, USA
    NMR Biomed 23:391-8. 2010
    ..This study demonstrates that histopathologic and genetic microarray analysis can be successfully performed on prostate surgical and biopsy tissues following HR-MAS analysis; however, biopsy tissues are more fragile than surgical tissues...
  59. pmc Endorectal MRI after radiation therapy: questioning the sextant analysis
    Shilpa R Kumbhani
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94143 0628, USA
    J Magn Reson Imaging 33:1086-90. 2011
    ..Despite its known limitations, sextant is the generally accepted standard for magnetic resonance imaging (MRI) and biopsy coregistration; nevertheless, depending on the magnitude of localization errors, other options may be adequate...
  60. ncbi request reprint Use of MRI and spectroscopy in evaluation of external beam radiotherapy for prostate cancer
    Barby Pickett
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 60:1047-55. 2004
    ....
  61. pmc Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, Byers Hall, Suite 102, 1700 4th Street, San Francisco, CA 94158, USA
    J Magn Reson 194:121-7. 2008
    ..The metabolic products are observable for a longer window because the low pyruvate flip angle preserves magnetization, allowing for improved observation of spatially varying metabolic reactions...
  62. pmc A clinical comparison of rigid and inflatable endorectal-coil probes for MRI and 3D MR spectroscopic imaging (MRSI) of the prostate
    Susan M Noworolski
    Department of Radiology, University of California, San Francisco, San Francisco, California 94107, USA
    J Magn Reson Imaging 27:1077-82. 2008
    ..To compare the data quality and ease of use of four endorectal-coil probe setups for prostate MRI...
  63. ncbi request reprint Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imaging
    Antonio C Westphalen
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 246:177-84. 2008
    ....
  64. pmc Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 30:1367-72. 2012
    ..004), acetoacetate (+504±281%, P=.009) and acetylcarnitine (+377±157%, P=.003) were detected when [2-(13)C]pyruvate was used...
  65. pmc Does local recurrence of prostate cancer after radiation therapy occur at the site of primary tumor? Results of a longitudinal MRI and MRSI study
    Elnasif Arrayeh
    Department of Radiology and Biomedical Imaging, University of California San Francisco, California, USA
    Int J Radiat Oncol Biol Phys 82:e787-93. 2012
    ....
  66. pmc Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism
    Kayvan R Keshari
    Department of Radiology, University of California San Francisco, SanFrancisco, California, USA
    Magn Reson Med 63:322-9. 2010
    ..Although this preliminary study involved immortalized cells, this combination of technologies can be extended to the real-time metabolic exploration of primary benign and cancerous cells and tissues prior to and after therapy...
  67. pmc Prostate cancer managed with active surveillance: role of anatomic MR imaging and MR spectroscopic imaging
    Vincent Fradet
    Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, Calif, USA
    Radiology 256:176-83. 2010
    ....
  68. pmc Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors
    Ilwoo Park
    Joint Graduate Group in Bioengineering, Surbeck Laboratory of Advanced Imaging, University of California San Francisco Berkeley, 1700 4th Street, Byers Hall, Room BH 303, San Francisco, CA 94158 2532, USA
    Neuro Oncol 12:133-44. 2010
    ..These results suggest that hyperpolarized MR metabolic imaging may be valuable for assessing prognosis and monitoring response to therapy for patients with brain tumors...
  69. ncbi request reprint Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity
    Matthew S Clifton
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 41:768-73. 2006
    ..The purpose of this study was to test the feasibility of assessing fetal lung maturity in vivo and ex vivo using MR spectroscopy to determine differences in amniotic fluid choline concentrations between the second and third trimesters...
  70. ncbi request reprint Validity of prostate-specific antigen as a tumour marker in men with prostate cancer managed by watchful-waiting: correlation with findings at serial endorectal magnetic resonance imaging and spectroscopic imaging
    Fergus V Coakley
    Department of Urology, The University of California at San Francisco, San Francisco, CA, USA
    BJU Int 99:41-5. 2007
    ....
  71. ncbi request reprint Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration
    Yongbok Kim
    Department of Radiation Oncology, University of California, San Francisco, Comprehensive Cancer Center 1600 Divisadero Street, Suite H1031, San Francisco, California 94143 1708, USA
    Med Phys 32:3569-78. 2005
    ..941 +/- 0.008 vs 0.899 +/- 0.033, for the rigid and expandable coils, respectively). In conclusion, the manual rigid-body alignment of prostate MR images acquired with and without the ERC can be improved through the use of a rigid ERC...
  72. pmc Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy
    Christopher S Ward
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:1296-305. 2010
    ....
  73. pmc Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues
    Susan Moyher Noworolski
    Department of Radiology and Biomedical Imaging, The University of California, San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 26:1071-80. 2008
    ....
  74. ncbi request reprint Lactic acid and proteoglycans as metabolic markers for discogenic back pain
    Kayvan R Keshari
    Department of Radiology, University of California, San Francisco, CA 94158 2330, USA
    Spine (Phila Pa 1976) 33:312-7. 2008
    ..These samples were then analyzed using ex vivo proton high resolution magic angle spinning (HR-MAS) NMR spectroscopy to produce metabolic profiles for comparison between the 2 patient groups...
  75. doi request reprint Diagnostic tools and imaging methods in intervertebral disk degeneration
    Sharmila Majumdar
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Orthop Clin North Am 42:501-11, viii. 2011
    ..With the potential for morphologic and biochemical characterization of the intervertebral disk, MRI shows promise as a tool to quantitatively assess disk health...
  76. pmc Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate
    Yakir S Levin
    Department of Radiology, Stanford University, Stanford, California 94158, USA
    Magn Reson Med 62:1091-8. 2009
    ..These methods will allow further characterization of metabolic properties of prostate cancer cells in the future. Magn Reson Med, 2009. (c) 2009 Wiley-Liss, Inc...
  77. ncbi request reprint Inverse planning for HDR prostate brachytherapy used to boost dominant intraprostatic lesions defined by magnetic resonance spectroscopy imaging
    Jean Pouliot
    Department of Radiation Oncology, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 59:1196-207. 2004
    ..To dose escalate selected regions inside the prostate without compromising the dose coverage of the prostate and the protection to the urethra, rectum, and bladder for prostate cancer patients treated with high-dose-rate brachytherapy...
  78. pmc Role of magnetic resonance imaging and magnetic resonance spectroscopic imaging before and after radiotherapy for prostate cancer
    Antonio C Westphalen
    Department of Radiology, University of California, San Francisco, San Francisco, California 94143, USA
    J Endourol 22:789-94. 2008
    ....
  79. ncbi request reprint Time to metabolic atrophy after permanent prostate seed implantation based on magnetic resonance spectroscopic imaging
    Barby Pickett
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, 94143 1708, USA
    Int J Radiat Oncol Biol Phys 59:665-73. 2004
    ..To characterize the time to metabolic atrophy (TMA) after permanent prostate implantation (PPI) using combined MRI and magnetic resonance spectroscopic imaging (MRSI) compared with the time to prostate-specific antigen (PSA) nadir...
  80. pmc Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer
    John Kurhanewicz
    Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, San Francisco, California 94143 1290, USA
    J Magn Reson Imaging 16:451-63. 2002
    ....
  81. ncbi request reprint Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissues
    Mark G Swanson
    Department of Radiology, University of California San Francisco, San Francisco, California 94143 1290, USA
    Magn Reson Med 50:944-54. 2003
    ....
  82. doi request reprint A novel application of 1H magnetic resonance spectroscopy: non-invasive identification of spermatogenesis in men with non-obstructive azoospermia
    David S Aaronson
    Department of Urology, University of California San Francisco, Ambulatory Care Center, Suite A633, San Francisco, CA 94117, USA
    Hum Reprod 25:847-52. 2010
    ..This study sought to identify metabolic signatures associated with various histological states of spermatogenesis in infertile men...
  83. ncbi request reprint Magnetic resonance imaging and spectroscopic imaging of prostate cancer
    Fergus V Coakley
    Department of Radiology, University of California San Fransisco, 94143 0628, USA
    J Urol 170:S69-75; discussion S75-6. 2003
    ....
  84. ncbi request reprint Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy
    Jin Zuo
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA
    Magn Reson Med 62:1140-6. 2009
    ..0039). This study demonstrates for the first time that short-echo PRESS on a clinical 3T MR scanner can be used to noninvasively and can reproducibly quantify metabolic changes associated with degeneration of intervertebral discs...
  85. ncbi request reprint Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc
    Kayvan R Keshari
    Department of Radiology, University of California, San Francisco, CA 94107, USA
    Spine (Phila Pa 1976) 30:2683-8. 2005
    ..A quantitative high-resolution magic angle spinning (HR-MAS) NMR study of human lumbar discs was conducted to determine biomarkers of disc degeneration...
  86. ncbi request reprint Quantification of prostate MRSI data by model-based time domain fitting and frequency domain analysis
    Pieter Pels
    ESAT SCD, Katholieke Universiteit Leuven, Leuven Heverlee, Belgium
    NMR Biomed 19:188-97. 2006
    ..Comparing the ratios estimated by the TDF and the FDA, the methods predicted the same spectrum type in 17 out of 18 voxels of the in vivo case study (94.4%)...
  87. pmc Mucinous adenocarcinoma of the prostate: MRI and MR spectroscopy features
    Antonio C Westphalen
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, M 372, Box 0628, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 193:W238-43. 2009
    ..The purpose of this study was to investigate the MRI and MR spectroscopy features of mucinous adenocarcinoma of the prostate...
  88. ncbi request reprint Registration of MR prostate images with biomechanical modeling and nonlinear parameter estimation
    Ron Alterovitz
    Department of Industrial Engineering and Operations Research, University of California, Berkeley, 4141 Etcheverry Hall, Berkeley, California 94720 1777, USA
    Med Phys 33:446-54. 2006
    ..5% for the balloon probe cases and 98.1% for the rigid probe cases. The method improves significantly over previous methods (P < 0.05) with greater improvement for balloon probe cases with larger tissue deformations...
  89. ncbi request reprint Prostate cancer tumor volume: measurement with endorectal MR and MR spectroscopic imaging
    Fergus V Coakley
    Department of Radiology, University of California San Francisco, Box 0628, L 308, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Radiology 223:91-7. 2002
    ..To determine accuracy of magnetic resonance (MR) and three-dimensional (3D) MR spectroscopic imaging in prostate cancer tumor volume measurement...
  90. ncbi request reprint Sequence design for magnetic resonance spectroscopic imaging of prostate cancer at 3 T
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, California, USA
    Magn Reson Med 53:1033-9. 2005
    ..Studies in a human subject verified that this behavior is reproduced in vivo and demonstrated that the water and lipid suppression of the new pulse sequence are sufficient for application in prostate cancer patients...
  91. ncbi request reprint Prostatic biopsy directed with endorectal MR spectroscopic imaging findings in patients with elevated prostate specific antigen levels and prior negative biopsy findings: early experience
    Adilson Prando
    Department of Radiology, Vera Cruz Hospital, Av Andrade Neves 707, Campinas SP, 13013 161, Brazil
    Radiology 236:903-10. 2005
    ....
  92. ncbi request reprint Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT
    Claudia Testa
    Department of Clinical Medicine and Applied Biotechnology D Campanacci, Diagnostic Imaging Section V Bollini, Pathologic Anatomy Unit, Institute of Oncology F Addarii, P E T Center, Policlinico S Orsola Malpighi, University of Bologna, Italy
    Radiology 244:797-806. 2007
    ....
  93. pmc Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products
    Charles H Cunningham
    Department of Medical Biophysics and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ont, Canada M4N 3M5
    J Magn Reson 193:139-46. 2008
    ..5s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer...
  94. ncbi request reprint Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C
    Charles H Cunningham
    Department of Medical Biophysics, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
    J Magn Reson 187:357-62. 2007
    ..Experiments in vivo showed three-dimensional coverage with excellent spectral quality and SNR...
  95. ncbi request reprint Improved signal to noise in high-resolution magic angle spinning total correlation spectroscopy studies of prostate tissues using rotor-synchronized adiabatic pulses
    Andrew S Zektzer
    Center for Molecular and Functional Imaging, Department of Radiology, University of California, 185 Berry Street, San Francisco, CA 94017, USA
    Magn Reson Med 53:41-8. 2005
    ....
  96. ncbi request reprint Preliminary assessment of magnetic resonance spectroscopic imaging in predicting treatment outcome in patients with prostate cancer at high risk for relapse
    Darko Pucar
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Prostate Cancer 3:174-81. 2004
    ..Although MRSI did not provide added prognostic value to MRI in this small number of patients, MRSI might increase the confidence of the clinician in assessing risk on MRI by contributing supporting metabolic data...
  97. ncbi request reprint Magnetic resonance spectroscopy in patients with locally confined prostate cancer: association of prostatic citrate and metabolic atrophy with time on hormone deprivation therapy, PSA level, and biopsy Gleason score
    Ullrich G Mueller-Lisse
    Institut fur Klinische Radiologie, Klinikum der Ludwig Maximilians Universitaet, Muenchen Innenstadt, Ziemssenstrasse 1, 80336 Muenchen, Germany
    Eur Radiol 17:371-8. 2007
    ..MRS detects prostate metabolism in patients with PSA exceeding 0.20 ng/ml after hormone-deprivation therapy...
  98. ncbi request reprint Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Biol Chem 278:15056-64. 2003
    ..Moreover, MMP-26 and MMP-9 proteins were both expressed in the same human prostate carcinoma tissue samples examined. These results indicate that MMP-26 may be a physiological and pathological activator of pro-MMP-9...
  99. ncbi request reprint Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy
    Kayvan R Keshari
    Department of Radiology, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    Magn Reson Med 53:519-27. 2005
    ..The results of this study support the feasibility of using in vivo spectroscopy for detecting chemical changes associated with disc degeneration...

Research Grants18

  1. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 1999
    ....
  2. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2009
    ....
  3. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2007
    ..This is a translational project intended to provide new biochemical information about prostate cancer before and after radiation therapy and to aid in the translation of this technology into clinical practice. ..
  4. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2007
    ....
  5. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2006
    ..This is a translational project intended to provide new biochemical information about prostate cancer before and after radiation therapy and to aid in the translation of this technology into clinical practice. ..
  6. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2006
    ....
  7. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2005
    ..This is a translational project intended to provide new biochemical information about prostate cancer before and after radiation therapy and to aid in the translation of this technology into clinical practice. ..
  8. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2005
    ....
  9. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2004
    ..This is a translational project intended to provide new biochemical information about prostate cancer before and after radiation therapy and to aid in the translation of this technology into clinical practice. ..
  10. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2003
    ....
  11. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2002
    ....
  12. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2001
    ....
  13. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2000
    ....
  14. Translation and Evaluation of a Multiparametric Prostate Cancer 3T Exam
    Daniel B Vigneron; Fiscal Year: 2010
    ....