Research Topics
| John KurhanewiczSummaryAffiliation: University of California Country: USA Publications
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Publications
Multiparametric magnetic resonance imaging in prostate cancer: present and futureJohn Kurhanewicz
Department of Radiology, University of California, San Francisco, California, USA
Curr Opin Urol 18:71-7. 2008..The purpose of this article is to review the current status of advanced MRI techniques based on anatomic, metabolic and physiologic properties of prostate cancer with a focus on their impact in managing prostate cancer patients...- Current and potential applications of clinical 13C MR spectroscopyJohn Kurhanewicz
University of California San Francisco, San Francisco, California 94158 2330, USA
J Nucl Med 49:341-4. 2008..Preliminary preclinical studies in a model of prostate cancer have demonstrated the potential clinical utility of hyperpolarized (13)C MRS... - Advances in MR spectroscopy of the prostateJohn Kurhanewicz
University of California, San Francisco, San Francisco, CA 94158, USA
Magn Reson Imaging Clin N Am 16:697-710, ix-x. 2008..Accuracy can be improved by performing MR imaging/MRSI at higher magnetic field strengths, using more sensitive hyperpolarized (13)C MRSI techniques and through the addition of other functional MR techniques... - Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical researchJohn Kurhanewicz
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94158 2330, USA
Neoplasia 13:81-97. 2011..Nevertheless, there are no fundamental barriers to rapid translation of this exciting technology to clinical research and perhaps clinical care... 
Feasibility of MR imaging/MR spectroscopy-planned focal partial salvage permanent prostate implant (PPI) for localized recurrence after initial PPI for prostate cancerCharles C Hsu
Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94115, USA
Int J Radiat Oncol Biol Phys 85:370-7. 2013..To assess the feasibility of magnetic resonance imaging (MRI)-planned partial salvage permanent prostate implant (psPPI) among patients with biopsy-proven local recurrence after initial PPI without evidence of distant disease...- Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP miceMatthew L Zierhut
UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94143 2532, USA
J Magn Reson 202:85-92. 2010.... - Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSIPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
Magn Reson Med 63:582-91. 2010..The results of this study demonstrated the potential of this new hyperpolarized MR dynamic method for improved cancer detection and characterization... - Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and gradingMark J Albers
Department of Bioengineering, University of California San Francisco, San Francisco, California 94158 2330, USA
Cancer Res 68:8607-15. 2008.... - In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvateSimon Hu
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
Mol Imaging Biol 11:399-407. 2009.... 
Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopyMark G Swanson
Department of Radiology, University of California San Francisco, 94107, USA
Magn Reson Med 55:1257-64. 2006..7, P < 0.01; [PAs](mean) = 5.28 +/- 5.44, P < 0.01). Serial spectra acquired over 12 hr indicated that the degradation of Cho-containing metabolites was minimized by acquiring HR-MAS data at 1 degree C compared to 20 degrees C...- Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivoDavid M Wilson
Department of Radiology, University of California San Francisco UCSF, San Francisco, CA, United States
J Magn Reson 205:141-7. 2010.... - Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissuesMay Britt Tessem
Department of Radiology, University of California San Francisco, San Francisco, California 94158 2330, USA
Magn Reson Med 60:510-6. 2008..The significant increase in the concentration of both lactate and alanine in biopsy tissue containing as little as 5% cancer could be exploited in hyperpolarized (13)C spectroscopic imaging (SI) studies of prostate cancer patients... - Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imagingPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
IEEE Trans Med Imaging 31:265-75. 2012.... - Three-dimensional conformal external beam radiotherapy compared with permanent prostate implantation in low-risk prostate cancer based on endorectal magnetic resonance spectroscopy imaging and prostate-specific antigen levelBarby Pickett
Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143, USA
Int J Radiat Oncol Biol Phys 65:65-72. 2006..Recent studies have suggested that the treatment of low-risk prostate cancer yields similar results for patients treated with 3D-CRT or PPI... - High-resolution 3D MR spectroscopic imaging of the prostate at 3 T with the MLEV-PRESS sequenceAlbert P Chen
Department of Radiology, University of California at San Francisco, San Francisco, CA 94143-2512, USA
Magn Reson Imaging 24:825-32. 2006..5 t mrsi... - High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features--initial experienceJeffrey J Hom
Department of Radiology, University of California, San Francisco, Box 0628, M 372, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
Radiology 242:483-9. 2007..To retrospectively determine the magnetic resonance (MR) and MR spectroscopic imaging features of high-grade prostatic intraepithelial neoplasia (HGPIN) in patients with prostate cancer... - Prostate depiction at endorectal MR spectroscopic imaging: investigation of a standardized evaluation systemJuyoung A Jung
Department of Radiology, University of California-San Francisco, San Francisco, CA 94143, USA
Radiology 233:701-8. 2004.... - 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancerSimon Hu
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158 2512, USA
Magn Reson Med 63:312-21. 2010.... - Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancerJanine M Lupo
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
Magn Reson Imaging 28:153-62. 2010..The MLS was significantly higher in TRAMP mice that had advanced disease... - A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactateGalen D Reed
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
J Magn Reson 217:41-7. 2012..Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed... - Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imagingKayvan R Keshari
Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:18606-11. 2011..More broadly, these findings suggest a prognostic role for this new redox sensor in determining vulnerability of both normal and abnormal tissues to ROS... - Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSISimon Hu
Department of Radiology, University of California, Box 2512, 1700 4th Street, QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
J Magn Reson 192:258-64. 2008..Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility... - Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imagingKayvan R Keshari
Department of Radiology and Biomedical Imaging, University of California San Francisco UCSF, 1700 fourth St, Byers Hall 203, San Francisco, California 94158, USA
J Am Chem Soc 131:17591-6. 2009..Thus, this study demonstrates the first hyperpolarization of a carbohydrate carbon with a sufficient T(1) and solution state polarization for ex vivo spectroscopy and in vivo spectroscopic imaging studies... - Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopyBrad R Cohn
Department of Radiology and Biomedical Imaging, University of California, 1600 Divisadero Street, Room C 250, Box 1667, San Francisco, CA 94115, USA
MAGMA 22:343-52. 2009..To establish and compare normative metabolite concentrations in 2nd and 3rd trimester human amniotic fluid samples in an effort to reveal metabolic biomarkers of fetal health and development... - Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer modelsCornelius Von Morze
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
J Magn Reson Imaging 33:692-7. 2011..To demonstrate dynamic imaging of a diffusible perfusion tracer, hyperpolarized [(13)C]urea, for regional measurement of blood flow in preclinical cancer models... - Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studiesPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
Magn Reson Med 65:610-9. 2011..This approach has enabled the monitoring of perfusion and uptake of the pyruvate, and the conversion dynamics to lactate and alanine throughout a volume with high spatial and temporal resolution... - (1)H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: inter- and intraobserver reproducibility studyBonnie N Joe
Department of Radiology, University of California San Francisco, 1600 Divisadero St, Room C250, Box 1667, San Francisco, CA 94115, USA
J Magn Reson Imaging 28:1540-5. 2008..To determine the intra- and interobserver reproducibility of human amniotic fluid metabolite concentration measurements (including potential markers of fetal lung maturity) detectable by MR spectroscopy... - In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanineSimon Hu
Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
Magn Reson Imaging 29:1035-40. 2011..The intracellular lactate-to-pyruvate ratio of normal rat tissue measured with hyperpolarized [1-(13)C]alanine was 4.89±0.61 (mean±S.E.) as opposed to a ratio of 0.41±0.03 when hyperpolarized [1-(13)C]pyruvate was injected... - Pretreatment endorectal magnetic resonance imaging and magnetic resonance spectroscopic imaging features of prostate cancer as predictors of response to external beam radiotherapyTim Joseph
Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Int J Radiat Oncol Biol Phys 73:665-71. 2009.... - Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studiesAlbert P Chen
Department of Radiology, University of California, Box 2512, San Francisco, CA 94158 2512, USA
Magn Reson Imaging 26:721-6. 2008..This study also demonstrated the potential value of this hyperpolarized agent to investigate in vivo lactate uptake and metabolism in preclinical animal models... - Endorectal MR imaging and MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: preliminary experienceFergus V Coakley
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
Radiology 233:441-8. 2004..To evaluate endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging for the depiction of locally recurrent prostate cancer after external beam radiation therapy... - Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopyMark G Swanson
Department of Radiology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
Magn Reson Med 60:33-40. 2008..7 +/- 2.2%, while Cho+mI and Eth increased 18% in 1 hr at 1 degrees C and a 2250 Hz spin rate... - 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regressionSimon Hu
Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
Cell Metab 14:131-42. 2011..These results demonstrate that metabolic changes precede tumor formation and regression and are directly linked to the activity of a single oncogene... - Toward adaptive stereotactic robotic brachytherapy for prostate cancer: demonstration of an adaptive workflow incorporating inverse planning and an MR stealth robotJ Adam Cunha
Department of Radiation Oncology, University of California, San Francisco, CA, USA
Minim Invasive Ther Allied Technol 19:189-202. 2010..Demonstration of this workflow is a key element of a successful translation to the clinic of the MRI stealth robotic delivery system, MRBot... - High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encodingAlbert P Chen
Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA
J Magn Reson Imaging 25:1288-92. 2007..The short acquisition time provided by this method reduces the 3T prostate MRI/MRSI exam time, allows longer repetition times, and/or allows the acquisition of additional MR acquisitions within the same exam... - Local staging of prostate cancer: comparative accuracy of T2-weighted endorectal MR imaging and transrectal ultrasoundAdam J Jung
Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
Clin Imaging 36:547-52. 2012..The objective of this study was to compare the accuracy of T2-weighted magnetic resonance (MR) imaging and transrectal ultrasound (TRUS) for staging of prostate cancer... - Prostate cancer: endorectal MR imaging and MR spectroscopic imaging--distinction of true-positive results from chance-detected lesionsJeffrey J Hom
Department of Radiology, University of California, Box 0628, M-372, San Francisco, CA 94143-0628, USA
Radiology 238:192-9. 2006.... - Prostate cancer: is inapparent tumor at endorectal MR and MR spectroscopic imaging a favorable prognostic finding in patients who select active surveillance?Alvin R Cabrera
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
Radiology 247:444-50. 2008..To retrospectively determine whether inapparent tumor at endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging is a favorable prognostic finding in prostate cancer patients who select active surveillance for management... - Prostate cancer: prediction of biochemical failure after external-beam radiation therapy--Kattan nomogram and endorectal MR imaging estimation of tumor volumeAntonio C Westphalen
Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, Box 0628, Room M 372, San Francisco, CA 94143 0628, USA
Radiology 261:477-86. 2011..To determine whether magnetic resonance (MR) imaging and MR spectroscopic imaging findings can improve predictions made with the Kattan nomogram for radiation therapy... - Prostate MRI and 3D MR spectroscopy: how we do itSadhna Verma
Department of Radiology, University of Cincinnati Medical Center, Cincinnati, OH 45267 0761, USA
AJR Am J Roentgenol 194:1414-26. 2010..Performing a high-quality MR spectroscopic examination requires understanding of the technical aspects and limitations of spectral acquisition, postprocessing techniques, and spectral evaluation... - Diagnosis of prostate cancer in patients with an elevated prostate-specific antigen level: role of endorectal MRI and MR spectroscopic imagingNick G Costouros
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Rm M 372, Box 0628, San Francisco, CA 94143 0628, USA
AJR Am J Roentgenol 188:812-6. 2007..The objective of our study was to determine the accuracy of endorectal MRI and MR spectroscopic imaging (MRSI) in the diagnosis of prostate cancer in patients with an elevated serum prostate-specific antigen (PSA) level... - Prostate cancer: role of pretreatment MR in predicting outcome after external-beam radiation therapy--initial experienceDavid A McKenna
Department of Radiology, University of California, San Francisco, M 372, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
Radiology 247:141-6. 2008..To retrospectively determine if pretreatment endorectal magnetic resonance (MR) imaging findings are predictive of outcome in patients who undergo external-beam radiation therapy for prostate cancer... - Prostate cancer localization with endorectal MR imaging and MR spectroscopic imaging: effect of clinical data on reader accuracyRajpal Dhingsa
Departments of Radiology, Pathology, and Urology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA
Radiology 230:215-20. 2004..A stricter definition of a true-positive result is associated with reduced sensitivity for prostate cancer nodule detection... - Class solution in inverse planned HDR prostate brachytherapy for dose escalation of DIL defined by combined MRI/MRSIYongbok Kim
Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
Radiother Oncol 88:148-55. 2008..To establish an inverse planning set of parameters (class solution) to boost dominant intra-prostatic lesion (DIL) defined by MRI/MRSI... - T2-Weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapyAntonio C Westphalen
Department of Radiology, Abdominal Imaging Section, University of California San Francisco, San Francisco, California 94143 0628, USA
Int Braz J Urol 35:171-80; discussion 181-2. 2009..To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy... - Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomasKayvan R Keshari
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
Cancer Res 73:529-38. 2013..We show that such differential cellular transporter expression and associated metabolic phenotype can be noninvasively assessed via real-time monitoring of hyperpolarized (13)C-pyruvate-to-lactate flux... - Use of MRI and spectroscopy in evaluation of external beam radiotherapy for prostate cancerBarby Pickett
Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
Int J Radiat Oncol Biol Phys 60:1047-55. 2004.... - Organ-confined prostate cancer: effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imagingAliya Qayyum
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA
AJR Am J Roentgenol 183:1079-83. 2004..MRI staging criteria and guidelines for scheduling studies after biopsy may require appropriate modification... - Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopyCarissa F Santos
Department of Radiology, University of California, San Francisco, CA, USA
NMR Biomed 23:391-8. 2010..This study demonstrates that histopathologic and genetic microarray analysis can be successfully performed on prostate surgical and biopsy tissues following HR-MAS analysis; however, biopsy tissues are more fragile than surgical tissues... - Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluidBrad R Cohn
Department of Radiology, School of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Am J Obstet Gynecol 203:76.e1-76.e10. 2010.... - Magnetic resonance spectroscopic imaging of benign prostatic tissue: findings at 3.0 T compared to 1.5 T-initial experienceMunish Chitkara
Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
Clin Imaging 35:288-93. 2011..5 T using a Wilcoxon ranked-sum test; awareness of this selective amplification of these metabolic signals at high field strength may help avoid overdiagnosis of prostate cancer... - Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imagingPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, Byers Hall, Suite 102, 1700 4th Street, San Francisco, CA 94158, USA
J Magn Reson 194:121-7. 2008..The metabolic products are observable for a longer window because the low pyruvate flip angle preserves magnetization, allowing for improved observation of spatially varying metabolic reactions... - Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imagingAntonio C Westphalen
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
Radiology 246:177-84. 2008.... - Endorectal MRI after radiation therapy: questioning the sextant analysisShilpa R Kumbhani
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94143 0628, USA
J Magn Reson Imaging 33:1086-90. 2011..Despite its known limitations, sextant is the generally accepted standard for magnetic resonance imaging (MRI) and biopsy coregistration; nevertheless, depending on the magnitude of localization errors, other options may be adequate... - Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostateSusan M Noworolski
The Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, The University of California, San Francisco, California 94107, USA
J Magn Reson Imaging 32:654-62. 2010..To develop and validate a post-processing correction algorithm to remove the effect of the inhomogeneous reception profile of the endorectal coil on MR spectroscopic imaging (MRSI) data... - A clinical comparison of rigid and inflatable endorectal-coil probes for MRI and 3D MR spectroscopic imaging (MRSI) of the prostateSusan M Noworolski
Department of Radiology, University of California, San Francisco, San Francisco, California 94107, USA
J Magn Reson Imaging 27:1077-82. 2008..To compare the data quality and ease of use of four endorectal-coil probe setups for prostate MRI... - Locally recurrent prostate cancer after external beam radiation therapy: diagnostic performance of 1.5-T endorectal MR imaging and MR spectroscopic imaging for detectionAntonio C Westphalen
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
Radiology 256:485-92. 2010..To determine if performing magnetic resonance (MR) spectroscopic imaging, compared with performing T2-weighted MR imaging alone, improves the detection of locally recurrent prostate cancer after definitive external beam radiation therapy... - Does local recurrence of prostate cancer after radiation therapy occur at the site of primary tumor? Results of a longitudinal MRI and MRSI studyElnasif Arrayeh
Department of Radiology and Biomedical Imaging, University of California San Francisco, California, USA
Int J Radiat Oncol Biol Phys 82:e787-93. 2012.... - Prostate cancer managed with active surveillance: role of anatomic MR imaging and MR spectroscopic imagingVincent Fradet
Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, Calif, USA
Radiology 256:176-83. 2010.... - Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolismKayvan R Keshari
Department of Radiology, University of California San Francisco, SanFrancisco, California, USA
Magn Reson Med 63:322-9. 2010..Although this preliminary study involved immortalized cells, this combination of technologies can be extended to the real-time metabolic exploration of primary benign and cancerous cells and tissues prior to and after therapy... - Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experienceAlbert P Chen
Department of Radiology, University of California San Francisco, San Francisco, California, USA
Magn Reson Med 58:1099-106. 2007..135 cm(3) nominal spatial resolution. Elevated (13)C lactate (lac) was observed in both primary and metastatic tumors, demonstrating the feasibility of studying cellular bioenergetics in vivo with DNP hyperpolarized (13)C MRSI... - Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumorsIlwoo Park
Joint Graduate Group in Bioengineering, Surbeck Laboratory of Advanced Imaging, University of California San Francisco Berkeley, 1700 4th Street, Byers Hall, Room BH 303, San Francisco, CA 94158 2532, USA
Neuro Oncol 12:133-44. 2010..These results suggest that hyperpolarized MR metabolic imaging may be valuable for assessing prognosis and monitoring response to therapy for patients with brain tumors... - Diagnostic tools and imaging methods in intervertebral disk degenerationSharmila Majumdar
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
Orthop Clin North Am 42:501-11, viii. 2011..With the potential for morphologic and biochemical characterization of the intervertebral disk, MRI shows promise as a tool to quantitatively assess disk health... - Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopyChristopher S Ward
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
Cancer Res 70:1296-305. 2010.... - Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registrationYongbok Kim
Department of Radiation Oncology, University of California, San Francisco, Comprehensive Cancer Center 1600 Divisadero Street, Suite H1031, San Francisco, California 94143 1708, USA
Med Phys 32:3569-78. 2005..941 +/- 0.008 vs 0.899 +/- 0.033, for the rigid and expandable coils, respectively). In conclusion, the manual rigid-body alignment of prostate MR images acquired with and without the ERC can be improved through the use of a rigid ERC... - Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturityMatthew S Clifton
Department of Surgery, University of California-San Francisco, San Francisco, CA 94143-0570, USA
J Pediatr Surg 41:768-73. 2006..Magnetic resonance spectroscopy shows a trend toward an increased quantity of choline in third- vs second-trimester amniocentesis... - Validity of prostate-specific antigen as a tumour marker in men with prostate cancer managed by watchful-waiting: correlation with findings at serial endorectal magnetic resonance imaging and spectroscopic imagingFergus V Coakley
Department of Urology, The University of California at San Francisco, San Francisco, CA, USA
BJU Int 99:41-5. 2007.... - Lactic acid and proteoglycans as metabolic markers for discogenic back painKayvan R Keshari
Department of Radiology, University of California, San Francisco, CA 94158 2330, USA
Spine (Phila Pa 1976) 33:312-7. 2008..These samples were then analyzed using ex vivo proton high resolution magic angle spinning (HR-MAS) NMR spectroscopy to produce metabolic profiles for comparison between the 2 patient groups... - Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissuesSusan Moyher Noworolski
Department of Radiology and Biomedical Imaging, The University of California, San Francisco, San Francisco, CA, USA
Magn Reson Imaging 26:1071-80. 2008.... - Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrateYakir S Levin
Department of Radiology, Stanford University, Stanford, California 94158, USA
Magn Reson Med 62:1091-8. 2009..These methods will allow further characterization of metabolic properties of prostate cancer cells in the future. Magn Reson Med, 2009. (c) 2009 Wiley-Liss, Inc... - Time to metabolic atrophy after permanent prostate seed implantation based on magnetic resonance spectroscopic imagingBarby Pickett
Department of Radiation Oncology, University of California, San Francisco, School of Medicine, 94143 1708, USA
Int J Radiat Oncol Biol Phys 59:665-73. 2004..To characterize the time to metabolic atrophy (TMA) after permanent prostate implantation (PPI) using combined MRI and magnetic resonance spectroscopic imaging (MRSI) compared with the time to prostate-specific antigen (PSA) nadir... - Inverse planning for HDR prostate brachytherapy used to boost dominant intraprostatic lesions defined by magnetic resonance spectroscopy imagingJean Pouliot
Department of Radiation Oncology, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143 1708, USA
Int J Radiat Oncol Biol Phys 59:1196-207. 2004..To dose escalate selected regions inside the prostate without compromising the dose coverage of the prostate and the protection to the urethra, rectum, and bladder for prostate cancer patients treated with high-dose-rate brachytherapy... - Magnetic resonance imaging and spectroscopic imaging of prostate cancerFergus V Coakley
Department of Radiology, University of California San Fransisco, 94143 0628, USA
J Urol 170:S69-75; discussion S75-6. 2003.... - Registration of MR prostate images with biomechanical modeling and nonlinear parameter estimationRon Alterovitz
Department of Industrial Engineering and Operations Research, University of California, Berkeley, 4141 Etcheverry Hall, Berkeley, California 94720 1777, USA
Med Phys 33:446-54. 2006..5% for the balloon probe cases and 98.1% for the rigid probe cases. The method improves significantly over previous methods (P < 0.05) with greater improvement for balloon probe cases with larger tissue deformations... - Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative discKayvan R Keshari
Department of Radiology, University of California, San Francisco, CA 94107, USA
Spine (Phila Pa 1976) 30:2683-8. 2005..A quantitative high-resolution magic angle spinning (HR-MAS) NMR study of human lumbar discs was conducted to determine biomarkers of disc degeneration... - Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissuesMark G Swanson
Department of Radiology, University of California San Francisco, San Francisco, California 94143 1290, USA
Magn Reson Med 50:944-54. 2003.... - Quantification of prostate MRSI data by model-based time domain fitting and frequency domain analysisPieter Pels
ESAT SCD, Katholieke Universiteit Leuven, Leuven Heverlee, Belgium
NMR Biomed 19:188-97. 2006..Comparing the ratios estimated by the TDF and the FDA, the methods predicted the same spectrum type in 17 out of 18 voxels of the in vivo case study (94.4%)... - Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopyJin Zuo
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA
Magn Reson Med 62:1140-6. 2009..0039). This study demonstrates for the first time that short-echo PRESS on a clinical 3T MR scanner can be used to noninvasively and can reproducibly quantify metabolic changes associated with degeneration of intervertebral discs... - Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancerJohn Kurhanewicz
Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, San Francisco, California 94143 1290, USA
J Magn Reson Imaging 16:451-63. 2002.... - A novel application of 1H magnetic resonance spectroscopy: non-invasive identification of spermatogenesis in men with non-obstructive azoospermiaDavid S Aaronson
Department of Urology, University of California San Francisco, Ambulatory Care Center, Suite A633, San Francisco, CA 94117, USA
Hum Reprod 25:847-52. 2010..This study sought to identify metabolic signatures associated with various histological states of spermatogenesis in infertile men... - Mucinous adenocarcinoma of the prostate: MRI and MR spectroscopy featuresAntonio C Westphalen
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, M 372, Box 0628, San Francisco, CA 94143 0628, USA
AJR Am J Roentgenol 193:W238-43. 2009..CONCLUSION: MRI and MR spectroscopy do not appear to provide the ability to reliably detect the lakes of extracellular mucin seen in mucinous adenocarcinoma of the prostate... - Role of magnetic resonance imaging and magnetic resonance spectroscopic imaging before and after radiotherapy for prostate cancerAntonio C Westphalen
Department of Radiology, University of California, San Francisco, San Francisco, California 94143, USA
J Endourol 22:789-94. 2008.... - Prostate cancer tumor volume: measurement with endorectal MR and MR spectroscopic imagingFergus V Coakley
Department of Radiology, University of California San Francisco, Box 0628, L-308, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA
Radiology 223:91-7. 2002.... - Sequence design for magnetic resonance spectroscopic imaging of prostate cancer at 3 TCharles H Cunningham
Department of Electrical Engineering, Stanford University, California, USA
Magn Reson Med 53:1033-9. 2005..Studies in a human subject verified that this behavior is reproduced in vivo and demonstrated that the water and lipid suppression of the new pulse sequence are sufficient for application in prostate cancer patients... - Magnetic resonance spectroscopy in patients with locally confined prostate cancer: association of prostatic citrate and metabolic atrophy with time on hormone deprivation therapy, PSA level, and biopsy Gleason scoreUllrich G Mueller-Lisse
Institut fur Klinische Radiologie, Klinikum der Ludwig Maximilians Universitaet, Muenchen Innenstadt, Ziemssenstrasse 1, 80336 Muenchen, Germany
Eur Radiol 17:371-8. 2007..MRS detects prostate metabolism in patients with PSA exceeding 0.20 ng/ml after hormone-deprivation therapy... - Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13CCharles H Cunningham
Department of Medical Biophysics, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
J Magn Reson 187:357-62. 2007..Experiments in vivo showed three-dimensional coverage with excellent spectral quality and SNR... - Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic productsCharles H Cunningham
Department of Medical Biophysics and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ont, Canada M4N 3M5
J Magn Reson 193:139-46. 2008..5s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer... - Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CTClaudia Testa
Department of Clinical Medicine and Applied Biotechnology D Campanacci, Diagnostic Imaging Section V Bollini, Pathologic Anatomy Unit, Institute of Oncology F Addarii, P E T Center, Policlinico S Orsola Malpighi, University of Bologna, Italy
Radiology 244:797-806. 2007.... - Preliminary assessment of magnetic resonance spectroscopic imaging in predicting treatment outcome in patients with prostate cancer at high risk for relapseDarko Pucar
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Clin Prostate Cancer 3:174-81. 2004..Although MRSI did not provide added prognostic value to MRI in this small number of patients, MRSI might increase the confidence of the clinician in assessing risk on MRI by contributing supporting metabolic data... - Prostatic biopsy directed with endorectal MR spectroscopic imaging findings in patients with elevated prostate specific antigen levels and prior negative biopsy findings: early experienceAdilson Prando
Department of Radiology, Vera Cruz Hospital, Av Andrade Neves 707, Campinas SP, 13013 161, Brazil
Radiology 236:903-10. 2005.... - Improved signal to noise in high-resolution magic angle spinning total correlation spectroscopy studies of prostate tissues using rotor-synchronized adiabatic pulsesAndrew S Zektzer
Center for Molecular and Functional Imaging, Department of Radiology, University of California, 185 Berry Street, San Francisco, CA 94017, USA
Magn Reson Med 53:41-8. 2005.... - Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopyKayvan R Keshari
Department of Radiology, University of California-San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
Magn Reson Med 53:519-27. 2005..The results of this study support the feasibility of using in vivo spectroscopy for detecting chemical changes associated with disc degeneration... - Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cellsYun Ge Zhao
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4390, USA
J Biol Chem 278:15056-64. 2003..Moreover, MMP-26 and MMP-9 proteins were both expressed in the same human prostate carcinoma tissue samples examined. These results indicate that MMP-26 may be a physiological and pathological activator of pro-MMP-9...
Research Grants
- MR Based Molecular Imaging of Prostate CancerJohn Kurhanewicz; Fiscal Year: 2009....
- MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSIJohn Kurhanewicz; Fiscal Year: 2007..This is a translational project intended to provide new biochemical information about prostate cancer before and after radiation therapy and to aid in the translation of this technology into clinical practice. ..
- MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSIJohn Kurhanewicz; Fiscal Year: 2003....
- Translation and Evaluation of a Multiparametric Prostate Cancer 3T ExamDaniel B Vigneron; Fiscal Year: 2010....