David J Kupfer

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Major depressive disorder: new clinical, neurobiological, and treatment perspectives
    David J Kupfer
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA, USA
    Lancet 379:1045-55. 2012
  2. ncbi Psychiatry's Integration with Medicine: The Role of DSM-5
    David J Kupfer
    University of Pittsburgh Medical Center and Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213 email
    Annu Rev Med 64:385-92. 2013
  3. ncbi Advances in bipolar disorder: selected sessions from the 2011 International Conference on Bipolar Disorder
    David J Kupfer
    University of Pittsburgh, Pennsylvania, USA
    Ann N Y Acad Sci 1242:1-25. 2011
  4. ncbi On the road to DSM-V and ICD-11
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Eur Arch Psychiatry Clin Neurosci 258:2-6. 2008
  5. ncbi The increasing medical burden in bipolar disorder
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    JAMA 293:2528-30. 2005
  6. ncbi Achieving adequate outcomes in geriatric depression: standardized criteria for remission
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S24-8. 2005
  7. ncbi The pharmacological management of depression
    David J Kupfer
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Dialogues Clin Neurosci 7:191-205. 2005
  8. ncbi Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
  9. ncbi The Career Development Institute for Psychiatry: an innovative, longitudinal program for physician-scientists
    David J Kupfer
    Department of Psychiatry at the University of Pittsburgh Medical Center, WPIC, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Acad Psychiatry 33:313-8. 2009
  10. ncbi African-American participants in a bipolar disorder registry: clinical and treatment characteristics
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Bipolar Disord 7:82-8. 2005

Research Grants

  1. Reducing Medical Risks in Individuals with Bipolar Disorder
    David Kupfer; Fiscal Year: 2009
  2. Research Career Development Institute for Bipolar Disorder
    David Kupfer; Fiscal Year: 2007
  3. Research Career Development Institute for Psychiatry
    David Kupfer; Fiscal Year: 2007
  4. Medical Comorbidity, Medical Burden and Biopolar Disorder
    David Kupfer; Fiscal Year: 2006
  5. SEROTONIN 1A RECEPTOR & METABOLIC IMAGING IN DEPRESSION
    David Kupfer; Fiscal Year: 2002
  6. Reducing Medical Risks in Individuals with Bipolar Disorder
    David J Kupfer; Fiscal Year: 2010

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. ncbi Major depressive disorder: new clinical, neurobiological, and treatment perspectives
    David J Kupfer
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA, USA
    Lancet 379:1045-55. 2012
    ..Although clear advances have been made, no fully satisfactory treatments for major depression are available...
  2. ncbi Psychiatry's Integration with Medicine: The Role of DSM-5
    David J Kupfer
    University of Pittsburgh Medical Center and Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213 email
    Annu Rev Med 64:385-92. 2013
    ..Furthermore, revisions to DSM-5 will inform development of the primary care version of DSM-5. The goal is to publish a manual that enhances clinical utility in a manner that is concise and more amenable to use in primary care...
  3. ncbi Advances in bipolar disorder: selected sessions from the 2011 International Conference on Bipolar Disorder
    David J Kupfer
    University of Pittsburgh, Pennsylvania, USA
    Ann N Y Acad Sci 1242:1-25. 2011
    ....
  4. ncbi On the road to DSM-V and ICD-11
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Eur Arch Psychiatry Clin Neurosci 258:2-6. 2008
    ..The road to DSM-V and ICD-11 has been challenging, but members continue to work diligently in their goal of constructing the most harmonious, scientifically sound, and clinically relevant DSM to date...
  5. ncbi The increasing medical burden in bipolar disorder
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    JAMA 293:2528-30. 2005
  6. ncbi Achieving adequate outcomes in geriatric depression: standardized criteria for remission
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S24-8. 2005
    ..Finally, there is growing recognition that standardized remission criteria can be valuable for establishing treatment guidelines for late-life depression, as well as for educating clinicians and consumers...
  7. ncbi The pharmacological management of depression
    David J Kupfer
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Dialogues Clin Neurosci 7:191-205. 2005
    ..It is expected that the next generation of antidepressants would be associated with more specific disease and outcome biomarkers...
  8. ncbi Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
    ..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
  9. ncbi The Career Development Institute for Psychiatry: an innovative, longitudinal program for physician-scientists
    David J Kupfer
    Department of Psychiatry at the University of Pittsburgh Medical Center, WPIC, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Acad Psychiatry 33:313-8. 2009
    ....
  10. ncbi African-American participants in a bipolar disorder registry: clinical and treatment characteristics
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Bipolar Disord 7:82-8. 2005
    ..The goal of this paper was to compare clinical characteristics and treatment history of African-American and Caucasian participants in a bipolar disorder registry...
  11. ncbi Dimensional models for research and diagnosis: a current dilemma
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Abnorm Psychol 114:557-9. 2005
    ..These refinements will be vital in determining the extent and reality of co-occurrence of disorder and the determination of boundaries across specific disorders...
  12. ncbi Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
    ..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness...
  13. ncbi Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulation
    Anne Germain
    University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara St, E 1116, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1856-63. 2004
    ..The goal of this study was to investigate the functional neuroanatomical correlates of non-REM sleep relative to presleep wakefulness in depressed patients and healthy subjects...
  14. ncbi Randomized, placebo-controlled trial of fluoxetine for acute treatment of minor depressive disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Am J Psychiatry 161:1864-71. 2004
    ..Minor depressive disorder is both common and associated with significant psychosocial impairment. This study examined antidepressant treatment efficacy in a large group of patients with minor depressive disorder...
  15. ncbi Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:761-7. 2007
    ..The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment...
  16. ncbi Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
    ..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death...
  17. ncbi Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load
    Stefanie Hassel
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 10:916-27. 2008
    ..We examined potential confounding effects of total psychotropic medication load and illness variables upon neural abnormalities...
  18. ncbi Suicide attempts and ideation in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:509-14. 2004
    ..Suicidal thinking and behavior are common in individuals with bipolar disorder...
  19. ncbi Prefrontal cortical and striatal activity to happy and fear faces in bipolar disorder is associated with comorbid substance abuse and eating disorder
    Stefanie Hassel
    University of Pittsburgh, School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    J Affect Disord 118:19-27. 2009
    ....
  20. ncbi Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:905-11. 2002
    ..We hypothesized that lifetime panic spectrum features would be associated with higher levels of suicidal ideation and a poorer response to acute treatment of the index mood episode in this patient population...
  21. ncbi Pain predicts longer time to remission during treatment of recurrent depression
    Jordan F Karp
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 66:591-7. 2005
    ..We hypothesized that greater pain and somatic scores prior to treatment with imipramine and interpersonal psychotherapy would predict a slowed time to remission from depression...
  22. ncbi Relationship of variability in residual symptoms with recurrence of major depressive disorder during maintenance treatment
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1877-84. 2004
    ....
  23. ncbi Diurnal variation in regional brain glucose metabolism in depression
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 62:438-45. 2007
    ..This study compared diurnal variation in mood and regional cerebral metabolic rate of glucose (rCMRglc) in depressed and healthy subjects...
  24. ncbi Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:996-1004. 2005
    ..Recent investigations have demonstrated benefits from the addition of psychoeducation or psychotherapy to pharmacotherapy in this population...
  25. ncbi Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Am J Psychiatry 163:1905-17. 2006
    ..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  26. ncbi Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder
    Amelia Versace
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 67:422-31. 2010
    ..Amygdala-orbitofrontal cortical (OFC) functional connectivity (FC) to emotional stimuli and relationships with white matter remain little examined in bipolar disorder individuals (BD)...
  27. ncbi Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder
    Jorge R C Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 174:195-201. 2009
    ....
  28. ncbi A placebo-controlled, random-assignment, parallel-group pilot study of adjunctive topiramate for patients with schizoaffective disorder, bipolar type
    Kn Roy Chengappa
    Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, and Mayview State Hospital, Pittsburgh, PA, USA
    Bipolar Disord 9:609-17. 2007
    ..This pilot study evaluated the efficacy and safety of adjunctive topiramate compared with placebo in the treatment of patients with a diagnosis of schizoaffective disorder, bipolar type (SAD-BT)...
  29. ncbi EEG spectral analysis in primary insomnia: NREM period effects and sex differences
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center and Sleep Medicine Institute, University ofPittsburgh School ofMedicine, Pittsburgh, PA, USA
    Sleep 31:1673-82. 2008
    ..To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep...
  30. ncbi Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Trials 5:253-61. 2008
    ..A multi-site clinical trial that includes psychotherapy as one of the treatments presents numerous challenges related to cross-site consistency and communication...
  31. ncbi Regional brain glucose metabolism during morning and evening wakefulness in humans: preliminary findings
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Sleep 27:1245-54. 2004
    ..The goal of this pilot study was to examine regional relative brain glucose metabolism during morning and evening wakefulness in healthy humans...
  32. ncbi Effect of age, weight, and CYP2C19 genotype on escitalopram exposure
    Yuyan Jin
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Pharmacol 50:62-72. 2010
    ..These variables may affect patient tolerance of this antidepressant and may provide important information in the effort to tailor treatments to patients' individual needs...
  33. ncbi Interpersonal psychotherapy for depression with panic spectrum symptoms: a pilot study
    Jill M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Depress Anxiety 21:140-2. 2005
    ..A newly adapted psychosocial treatment for depression with lifetime panic spectrum symptoms was evaluated in an open pilot study...
  34. ncbi Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Arch Gen Psychiatry 61:695-702. 2004
    ....
  35. ncbi Smaller cingulate volumes in unipolar depressed patients
    Sheila C Caetano
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Biol Psychiatry 59:702-6. 2006
    ..Smaller cingulate volumes in currently depressed patients support the hypothesis that cingulate cortex abnormalities are state dependent, whereas changes in left anterior cingulate might be trait related...
  36. ncbi Prevalence and clinical correlates of medical comorbidities in patients with bipolar I disorder: analysis of acute-phase data from a randomized controlled trial
    Wesley K Thompson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15260, USA
    J Clin Psychiatry 67:783-8. 2006
    ..We studied the relationship between number of medical comorbidities in patients with bipolar I disorder and their demographic and clinical characteristics...
  37. ncbi Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 160:1636-42. 2003
    ..Utilizing data from a previously characterized registry of subjects with bipolar illness, the authors examined age at onset of the first illness episode in cohorts of subjects born from 1900 through 1939 and from 1940 through 1959...
  38. ncbi Insomnia and objectively measured sleep disturbances predict treatment outcome in depressed patients treated with psychotherapy or psychotherapy-pharmacotherapy combinations
    Wendy M Troxel
    Department of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 73:478-85. 2012
    ..The present study is a secondary analysis that examines the degree to which insomnia, objective sleep disturbances, or their combination predicts depression remission following pharmacotherapy and/or psychotherapy treatment...
  39. ncbi The longitudinal course of cognition in older adults with bipolar disorder
    Ariel G Gildengers
    Intervention Research Center for Late life Mood Disorders and the Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:744-52. 2009
    ....
  40. ncbi Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?
    Cecile D Ladouceur
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 47:532-9. 2008
    ..The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD...
  41. ncbi Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:382-90. 2009
    ..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder...
  42. ncbi The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorder
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States University Center for Social and Urban Research, Pittsburgh, PA, United States
    Psychiatry Res 168:67-77. 2009
    ..It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics...
  43. ncbi Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  44. ncbi Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
    Sheila C Caetano
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, TX, USA
    Psychiatry Res 132:141-7. 2004
    ..A smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients...
  45. ncbi Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 15:174-9. 2007
    ..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder...
  46. ncbi Functional neuroimaging evidence for hyperarousal in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 161:2126-8. 2004
    ..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia...
  47. ncbi Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Control Clin Trials 25:119-42. 2004
    ..Participants with an adequate symptomatic response may enter the 12-month naturalistic follow-up phase with brief monthly and more complete quarterly assessments...
  48. ncbi Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..Future studies examining the relationship between specific symptomatic dimensions of MDD and OFC volumes could be especially informative...
  49. ncbi Exploring risk factors for the emergence of children's mental health problems
    Marilyn J Essex
    Department of Psychiatry, University of Wisconsin Madison 53719, USA
    Arch Gen Psychiatry 63:1246-56. 2006
    ..Exploratory studies that generate testable models of how risk factors for childhood mental health problems work together over time are critical for developing effective prevention and treatment strategies...
  50. ncbi The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1559-65. 2008
    ..The authors describe the effect of acute treatment with interpersonal and social rhythm therapy on occupational functioning over a period of approximately 2.5 years...
  51. ncbi Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 9:462-7. 2007
    ..We examine the structure of mood and anxiety spectrum features in patients with BD I to identify subtypes with similar profiles...
  52. ncbi Daytime symptoms in primary insomnia: a prospective analysis using ecological momentary assessment
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center, Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Sleep Med 8:198-208. 2007
    ....
  53. ncbi A pilot study of standardized treatment in geriatric bipolar disorder
    Ariel G Gildengers
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, the Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine 15213, USA
    Am J Geriatr Psychiatry 13:319-23. 2005
    ..CONCLUSIONS: Treating older adults with bipolar disorder under standardized treatment is feasible and is associated with low symptom levels. However, most older adults with bipolar disorder do not experience sustained recovery...
  54. ncbi Sensitivity to change and predictive validity of the MOODS-SR questionnaire, last-month version
    Mario Miniati
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychother Psychosom 78:116-24. 2009
    ....
  55. ncbi Recovery and functional outcomes following olanzapine treatment for bipolar I mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
    Bipolar Disord 7:68-76. 2005
    ..Typical experimental categorizations of treatment responses in bipolar disorder (BPD) patients may have limited relationship to clinical recovery or functional status, and there is inadequate research on such clinically important outcomes...
  56. ncbi Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:701-10. 2009
    ..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
  57. ncbi Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 27:792-9. 2002
    ..05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial...
  58. ncbi Report by the ACNP Task Force on response and remission in major depressive disorder
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 31:1841-53. 2006
    ..Research to evaluate these recommendations empirically is needed...
  59. ncbi White matter hyperintensities in bipolar and unipolar patients with relatively mild-to-moderate illness severity
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 77:237-45. 2003
    ..We examined the rates of hyperintense lesions in adult, non-elderly bipolar and unipolar patients, with a relatively mild-to-moderate illness severity, and in matched healthy controls...
  60. ncbi Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapy
    Paola Rucci
    Department of Psychiatry, Western Psychiatric Institite and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 159:1160-4. 2002
    ..CONCLUSIONS: A treatment program in a maximally supportive clinical environment can significantly reduce suicidal behavior in high-risk patients with bipolar I disorder...
  61. ncbi Prevalence of obesity and weight change during treatment in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:528-33. 2002
    ....
  62. ncbi Replicable differences in preferred circadian phase between bipolar disorder patients and control individuals
    Joel Wood
    Departments of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, Pittsburgh, PA, United States
    Psychiatry Res 166:201-9. 2009
    ..Individuals with elevated depressive mood scores are more likely to be evening types. Our results suggest a replicable relationship between circadian phase and morbid mood states...
  63. ncbi 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients
    Paolo Brambilla
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
    Psychiatry Res 138:131-9. 2005
    ..Future 1H MRS investigations should longitudinally examine the role of illness chronicity on DLPFC abnormalities and their relationship with the symptoms of unipolar disorder...
  64. ncbi Altered development of white matter in youth at high familial risk for bipolar disorder: a diffusion tensor imaging study
    Amelia Versace
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 49:1249-59, 1259.e1. 2010
    ..Age-related changes in WM microstructure using diffusion tensor imaging with tract-based spatial statistics in healthy offspring having a parent with BD were compared with those in healthy controls...
  65. ncbi The phenomenology of bipolar disorder: what drives the high rate of medical burden and determines long-term prognosis?
    Isabella Soreca
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Depress Anxiety 26:73-82. 2009
    ....
  66. ncbi Cross-cultural validity of the structured clinical interview for panic-agoraphobic spectrum
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Soc Psychiatry Psychiatr Epidemiol 40:283-90. 2005
    ....
  67. ncbi Reduced left anterior cingulate volumes in untreated bipolar patients
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 56:467-75. 2004
    ..Furthermore, our results suggest that lithium treatment might influence cingulate volumes in bipolar patients, which could possibly reflect postulated neuroprotective effects of lithium...
  68. ncbi The prevalence of the metabolic syndrome in patients with schizoaffective disorder--bipolar subtype
    Ranita Basu
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2593, USA
    Bipolar Disord 6:314-8. 2004
    ....
  69. ncbi Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Psychiatry 159:466-8. 2002
    ..CONCLUSIONS: Treatment of late-life depression with nortriptyline and psychotherapy is more likely to maintain social adjustment than treatment with either alone. Combination therapy improves not only duration but quality of wellness...
  70. ncbi A pilot study of subjective daytime alertness and mood in primary insomnia participants using ecological momentary assessment
    Helena Levitt
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Sleep Med 2:113-31. 2004
    ..Coefficients of variation for DSD domains were greater in the insomnia group. Frequent measures of daytime symptoms may be useful outcomes in insomnia studies...
  71. ncbi Electroencephalographic sleep profiles in single-episode and recurrent unipolar forms of major depression: II. Comparison during remission
    Ripu D Jindal
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 51:230-6. 2002
    ..Resolution of this issue requires longitudinal and family studies...
  72. ncbi Utility of sparse concentration sampling for citalopram in elderly clinical trial subjects
    Robert R Bies
    Department of Psychiatry and Pharmaceutical Sciences, University of Pittsburgh, 805 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15213, USA
    J Clin Pharmacol 44:1352-9. 2004
    ..This is particularly valuable for populations such as the elderly, who are not typically available for pharmacokinetic studies...
  73. ncbi Psychophysiological reactivity and coping styles influence the effects of acute stress exposure on rapid eye movement sleep
    Anne Germain
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Psychosom Med 65:857-64. 2003
    ..Mediation and moderation models are more informative than traditional bivariate approaches to investigating the relation between stress exposure and sleep alterations...
  74. ncbi Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychiatr Clin North Am 26:457-94, x. 2003
    ..This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study...
  75. ncbi Elevated amygdala activity to sad facial expressions: a state marker of bipolar but not unipolar depression
    Jorge R C Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 67:414-21. 2010
    ....
  76. ncbi A descriptive analysis of minor depression
    Mark Hyman Rapaport
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, 92037, USA
    Am J Psychiatry 159:637-43. 2002
    ..The authors provide a detailed clinical description of minor depression: its symptoms, level of disability, stability, and relationship to patient and family history of major depressive disorder...
  77. ncbi Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late-Life and Mid-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..RESULTS: Older-old patients responded as quickly and successfully as the young- and middle-old. CONCLUSIONS: Major depression in the very old can be treated as successfully as in early old age...
  78. ncbi The relationship between lifestyle regularity and subjective sleep quality
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Chronobiol Int 20:97-107. 2003
    ..Thus, there appears to be an association between lifestyle regularity and good sleep, though the direction of causality remains to be tested...
  79. ncbi The future of psychiatry as clinical neuroscience
    Charles F Reynolds
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Acad Med 84:446-50. 2009
    ....
  80. ncbi Demographic and clinical characteristics of individuals in a bipolar disorder case registry
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:120-5. 2002
    ....
  81. ncbi Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, Mayview State Hospital, University of Pittsburgh Medical Center, PA 15213 2593, USA
    Bipolar Disord 5:1-5. 2003
    ....
  82. ncbi Obesity as a correlate of outcome in patients with bipolar I disorder
    Andrea Fagiolini
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 160:112-7. 2003
    ....
  83. ncbi Reduced gray matter volume in ventral prefrontal cortex but not amygdala in bipolar disorder: significant effects of gender and trait anxiety
    Jorge R C Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 171:54-68. 2009
    ..PMRG is part of medial prefrontal network implicated in visceromotor and emotion regulation...
  84. ncbi Chronotype and body composition in bipolar disorder
    Isabella Soreca
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Chronobiol Int 26:780-8. 2009
    ..Evening chronotype could be a proxy for as yet unknown specific causes of the high rate of obesity and obesity-related diseases in bipolar disorder...
  85. ncbi The effect of reporting methods for dosing times on the estimation of pharmacokinetic parameters of escitalopram
    Yuyan Jin
    University of Pittsburgh Medical Center, Department of Pharmaceutical Sciences and Psychiatry, 805 Salk Hall, Pittsburgh, PA 15261, USA
    J Clin Pharmacol 49:176-84. 2009
    ..Furthermore, the parameters estimated from the MEMS method were similar to literature reported values for V/F ( approximately 1100 L) and K(a) ( approximately 0.8-0.9 h(-1)) arising from traditional pharmacokinetic approaches...
  86. ncbi Medication effects in neuroimaging studies of bipolar disorder
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:313-20. 2008
    ..Withdrawing all individuals from medication and examining only unmedicated individuals may be clinically unfeasible, and examining only unmedicated individuals may render findings less generalizable...
  87. ncbi Body pain and treatment response in late-life depression
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:188-94. 2005
    ..They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation...
  88. ncbi Cognitive functioning in late-life bipolar disorder
    Ariel G Gildengers
    Information Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 161:736-8. 2004
    ..This study characterized cognitive functioning in elderly patients with bipolar disorder...
  89. ncbi Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Brain 125:1105-15. 2002
    ....
  90. ncbi Antidepressants and psychotherapy: a clinical research review
    Ellen Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic PA 15213, USA
    Dialogues Clin Neurosci 7:263-72. 2005
    ..There is a clear need for more information about the relative efficacy of pharmacotherapy-psychotherapy combinations or sequences versus either pharmacotherapy or psychotherapy provided as monotherapies...
  91. ncbi Anger attacks in bipolar depression: predictors and response to citalopram added to mood stabilizers
    Oommen K Mammen
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:627-33. 2004
    ..We hypothesized that if anger attacks were related to hypomanic symptoms they would respond unfavorably to citalopram, whereas if they were related to trait anger or depressive symptoms they would respond favorably...
  92. ncbi Circadian phase variation in bipolar I disorder
    Hader A Mansour
    Department of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Chronobiol Int 22:571-84. 2005
    ..Thus, distinct patterns of M/E were noted among BD1 patients and among BD1 subgroups. The impact of medication, mood state, and chronicity on CS scores needs to be considered...
  93. ncbi Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Bipolar Disord 7:424-30. 2005
    ..This study sought to evaluate the presence of the metabolic syndrome in a group of 171 patients with bipolar disorder who were consecutively recruited in the Bipolar Disorder Center for Pennsylvanians...
  94. ncbi Hypothyroidism in patients with bipolar I disorder treated primarily with lithium
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Epidemiol Psichiatr Soc 15:123-7. 2006
    ..This study evaluated the frequency and clinical significance of abnormal Thyroid Stimulating Hormone (TSH) and Free Thyroxine Index (FTI) in patients with bipolar I disorder treated primarily with lithium...
  95. ncbi Behavioral circadian regularity at age 1 month predicts anxiety levels during school-age years
    Timothy H Monk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 178:370-3. 2010
    ..Baby SRM score at age 1 month significantly predicted the child's school (K-9, 5 time points) anxiety level (more regular=less anxious), and may be mediated through sociability and directed-attention pathways...
  96. ncbi Adolescent development and the regulation of behavior and emotion: comments on part VIII
    David J Kupfer
    Western Psychiatric Institute and Clinic, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:320-2. 2004
  97. ncbi Functional impairment in the remission phase of bipolar disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 7:281-5. 2005
    ....
  98. ncbi Recruiting and retaining future generations of physician scientists in mental health
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 59:657-60. 2002
    ..quot; A coalition of stakeholders--federal, academic, foundational, and in the pharmaceutical industry--is needed to meet these challenges...
  99. ncbi Morningness-eveningness and lifestyle regularity
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Chronobiol Int 21:435-43. 2004
    ..Thus it appears that morning types appear to be more regular in their daily lifestyle than are evening types, suggesting a relationship between these two aspects of human circadian behavior...
  100. ncbi A pilot study of community mental health care for depression in a supermarket setting
    Holly A Swartz
    Department of Psychiatry, University of Pittsburg School of Medicine and Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
    Psychiatr Serv 53:1132-7. 2002
    ..A pilot project was undertaken to test the feasibility of providing psychotherapy for depressed women in a supermarket, a novel setting that may minimize barriers to care such as stigma associated with visiting a mental health clinic...
  101. ncbi Prospective assessment of sexual function in women treated for recurrent major depression
    Jill M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Psychiatr Res 38:267-73. 2004
    ....

Research Grants11

  1. Reducing Medical Risks in Individuals with Bipolar Disorder
    David Kupfer; Fiscal Year: 2009
    ....
  2. Research Career Development Institute for Bipolar Disorder
    David Kupfer; Fiscal Year: 2007
    ..We believe that the Research CDI for Bipolar Disorder will become a national resource to help reverse the decline in the number of dedicated clinical and basic scientists in this area of research. ..
  3. Research Career Development Institute for Psychiatry
    David Kupfer; Fiscal Year: 2007
    ....
  4. Medical Comorbidity, Medical Burden and Biopolar Disorder
    David Kupfer; Fiscal Year: 2006
    ..This investigation is directed toward reducing the impact of medical burden on psychiatric outcomes as expressed in levels of functioning, extent of symptomatic remission, and degree of suicidality. ..
  5. SEROTONIN 1A RECEPTOR & METABOLIC IMAGING IN DEPRESSION
    David Kupfer; Fiscal Year: 2002
    ..abstract_text> ..
  6. Reducing Medical Risks in Individuals with Bipolar Disorder
    David J Kupfer; Fiscal Year: 2010
    ....