Research Topics
| D J KupferSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
The interaction of drug- and psychotherapy in the long-term treatment of depressionD J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Affect Disord 62:131-7. 2001..This paper reviews key findings in recurrent depression with respect to long-term treatment. Particular attention is paid to the combination treatment of psychotherapy and antidepressant drugs...- Demographic and clinical characteristics of individuals in a bipolar disorder case registryDavid J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Clin Psychiatry 63:120-5. 2002.... - Recruiting and retaining future generations of physician scientists in mental healthDavid J Kupfer
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Arch Gen Psychiatry 59:657-60. 2002..quot; A coalition of stakeholders--federal, academic, foundational, and in the pharmaceutical industry--is needed to meet these challenges... - Adolescent development and the regulation of behavior and emotion: comments on part VIIIDavid J Kupfer
Western Psychiatric Institute and Clinic, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Ann N Y Acad Sci 1021:320-2. 2004 - Citalopram as adjunctive therapy in bipolar depressionD J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Clin Psychiatry 62:985-90. 2001..The treatment of bipolar depression remains a major clinical challenge. The effectiveness and safety of adjunctive citalopram were evaluated in DSM-IV-diagnosed bipolar depressed patients in a 5-site study... - High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depressionC F Reynolds
Mental Health Clinical Research Center for the Study of Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Am J Psychiatry 153:1418-22. 1996..Twenty-eight patients (17.7%) received inpatient care at some point during acute-phase treatment... - Influence of panic-agoraphobic spectrum symptoms on treatment response in patients with recurrent major depressionE Frank
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Psychiatry 157:1101-7. 2000..The authors tested the hypothesis that a lifetime history of panic-agoraphobic spectrum symptoms predicts a poorer response to depression treatment... - Temporal profiles of the course of depression during treatment. Predictors of pathways toward recovery in the elderlyM A Dew
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
Arch Gen Psychiatry 54:1016-24. 1997..Whether patients vary in their pathways toward those outcomes--and the extent to which such variation can be anticipated by patient characteristics prior to treatment--has not been empirically examined... - Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?C F Reynolds
Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
Am J Psychiatry 154:958-62. 1997..This study was conducted to identify which elderly patients with remitted recurrent major depression remain well with maintenance interpersonal psychotherapy after discontinuation of active antidepressant medication (nortriptyline)... - Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapyC F Reynolds
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
Am J Psychiatry 156:202-8. 1999..The authors tested the hypothesis that nortriptyline and interpersonal psychotherapy, alone and in combination, are superior to placebo in achieving remission of bereavement-related major depressive episodes... - Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 yearsC F Reynolds
The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
JAMA 281:39-45. 1999..Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability... - Latent structure of EEG sleep variables in depressed and control subjects: descriptions and clinical correlatesD J Buysse
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Psychiatry Res 79:105-22. 1998..Multivariate statistical techniques decrease the risk of Type I and Type II errors when using a large number of collinear sleep measures, and can clarify conceptual issues related to sleep and depression... - Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depressionG S Smith
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Psychiatry 156:683-9. 1999.... - Initial recovery patterns may predict which maintenance therapies for depression will keep older adults wellM A Dew
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Affect Disord 65:155-66. 2001..Patients' temporal patterns of acute treatment response may predict who requires which maintenance therapy to remain well... - Sleep and treatment response in depression: new findings using power spectral analysisD J Buysse
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, E 1127 WPIC, Pittsburgh, PA 15213, USA
Psychiatry Res 103:51-67. 2001..Quantitative REMs may provide a more direct measure of brainstem function and dysfunction during REM sleep than quantitative sleep EEG measures... 
Predictors and moderators of time to remission of major depression with interpersonal psychotherapy and SSRI pharmacotherapyE Frank
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Psychol Med 41:151-62. 2011..We sought to determine whether measures of spectrum psychopathology are useful in deciding which patients with unipolar depression should receive pharmacotherapy versus depression-specific psychotherapy...- Controlled comparison of electrophysiological sleep in families of probands with unipolar depressionD E Giles
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
Am J Psychiatry 155:192-9. 1998..This study presents polysomnographic data and psychiatric history for parents and siblings of probands with unipolar depression and short REM latency, probands with unipolar depression and normal REM latency, and normal comparison probands... - Symptoms of stress and depression as correlates of sleep in primary insomniaM Hall
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
Psychosom Med 62:227-30. 2000..In the preliminary study described here, we evaluated the extent to which symptoms of stress and depression are associated with subjective sleep complaints and quantitative measures of sleep in individuals with chronic insomnia... - Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot studyJ C Soares
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Psychopharmacology (Berl) 149:12-6. 2000..In vitro and in vivo animal studies suggest that the intracellular phosphatidylinositol (PI) pathway is an important target for the effects of lithium... - The Pittsburgh study of normal sleep in young adults: focus on the relationship between waking and sleeping EEG spectral patternsC L Ehlers
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
Electroencephalogr Clin Neurophysiol 106:199-205. 1998..Significant correlations between waking and sleep EEG suggest that the spectral signature of an individual's EEG may be found across sleep/wake states... - Effects of diagnosis on treatment recommendations in chronic insomnia--a report from the APA/NIMH DSM-IV field trialD J Buysse
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
Sleep 20:542-52. 1997..Site-related differences suggest a lack of consensus in how these disorders are conceptualized and treated... - Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary studyJ C Soares
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
Psychiatry Res 95:109-18. 2000..These preliminary findings suggest that chronic lithium treatment may decrease the levels of both cytosolic PKC alpha isozyme and membrane PIP(2) in platelets of bipolar disorder patients... - Tolerability of combined treatment with lithium and paroxetine in patients with bipolar disorder and depressionA Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
J Clin Psychopharmacol 21:474-8. 2001..Clinicians should be aware of the possible development of a serotonin syndrome among patients in whom paroxetine is added to ongoing lithium treatment... - Differential effects of age on brain gray matter in bipolar patients and healthy individualsP Brambilla
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neuropsychobiology 43:242-7. 2001.... - Changes in forebrain function from waking to REM sleep in depression: preliminary analyses of [18F]FDG PET studiesE A Nofzinger
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Psychiatry Res 91:59-78. 1999..These observations indicate that changes in limbic and paralimbic function from waking to REM sleep differ significantly from normal in depressed patients... - A longitudinal study of laboratory- and diary-based sleep measures in healthy "old old" and "young old" volunteersC C Hoch
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
Sleep 17:489-96. 1994..To our knowledge, this is the first longitudinal data set on sleep in the healthy old old... - Psychotropic drug prescription patterns among patients with bipolar I disorderJ Levine
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
Bipolar Disord 2:120-30. 2000..We evaluated prescription patterns and the influence of demographic variables on these patterns in a voluntary registry of subjects with bipolar disorder... - Decreased pituitary volume in patients with bipolar disorderR B Sassi
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 50:271-80. 2001..Our findings suggest that detectable abnormalities in pituitary size are present in patients with bipolar disorder, which may reflect a dysfunctional HPA axis... - Anatomical MRI study of basal ganglia in bipolar disorder patientsP Brambilla
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
Psychiatry Res 106:65-80. 2001.... - MRI study of posterior fossa structures and brain ventricles in bipolar patientsP Brambilla
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Psychiatr Res 35:313-22. 2001..However, there were suggestions that abnormalities in cerebellum, vermis, and lateral ventricle sizes may be present in familial cases of the disorder, which should be further examined in future studies with larger patient samples... - Influence of traumatic grief on suicidal ideation among young adultsH G Prigerson
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
Am J Psychiatry 156:1994-5. 1999..The purpose of this study was to examine the influence of traumatic grief on suicidal ideation... - Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modalityE Frank
Department of Psychiatry, University of Pittsburgh 15213, USA
J Abnorm Psychol 108:579-87. 1999..This finding, consistent with the authors' philosophy that bipolar patients benefit from stable routines, suggests that disruptions in the psychosocial treatment plan contribute to worse outcomes... - Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI)D J Buysse
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
Sleep 14:331-8. 1991..Extremely healthy elderly subjects appear to adapt in their perception of objectively disturbed sleep... - Longitudinal changes in diary- and laboratory-based sleep measures in healthy "old old" and "young old" subjects: a three-year follow-upC C Hoch
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Sleep 20:192-202. 1997..The current results are representative of healthy elderly; sleep would probably deteriorate earlier and more quickly in elderly with more serious health problems and heavier medication use... - Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levelsC F Reynolds
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Psychiatry 156:1177-81. 1999..This study compared the long-term efficacy of two fixed plasma levels of nortriptyline in preventing or delaying recurrence of major depression in elderly patients and in minimizing residual depressive symptoms and somatic complaints... - Simultaneous evaluation of the harms and benefits of treatments in randomized clinical trials: demonstration of a new approachE Frank
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Psychol Med 42:865-73. 2012..Particularly in mental health, however, there is a lack of a single objective, reliable measure of outcome that is sensitive to crucial individual differences among patients... - PET imaging of serotonin 1A receptor binding in depressionW C Drevets
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
Biol Psychiatry 46:1375-87. 1999..PET imaging using the 5HT1A receptor radioligand, [11C]WAY-100635, may clarify the clinical conditions under which 5HT1A receptor binding potential (BP) is abnormal in depression... - Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 TJ C Soares
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 49:437-43. 2001..Future studies should examine a possible role for this methodology in investigations of lithium refractoriness and prediction of treatment outcome in bipolar patients... - Patterns of sleep episodes in young and elderly adults during a 36-hour constant routineD J Buysse
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
Sleep 16:632-7. 1993..They also confirm the presence of sex differences in sleep patterns among the elderly and support the distinction between objective and subjective measures of sleepiness... - Response to placebo among bipolar I disorder patients experiencing their first manic episodeK N Chengappa
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Special Studies Center at Mayview State Hospital, PA 15213 2593, USA
Bipolar Disord 2:332-5. 2000..Olanzapine versus placebo in the treatment of acute mania. Am J Psychiatry 1999; 156: 702-709)... - Panic-agoraphobic spectrum: reliability and validity of assessment instrumentsM K Shear
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Psychiatr Res 35:59-66. 2001..We conclude that PAS can be reliably assessed, and that it describes a valid, coherent constellation of features associated with DSM IV Panic Disorder, but providing additional important clinical information... - Concordance between habitual sleep times and laboratory recording schedulesC F Reynolds
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
Sleep 15:571-5. 1992..We strongly recommend a policy of routinely including data on laboratory versus habitual sleep times in peer-reviewed publications... - EEG sleep in African-American patients with major depression: a historical case control studyD E Giles
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
Depress Anxiety 8:58-64. 1998..The pathological implications of these differences remained to be explored in careful prospective studies of African-American depressed patients and in well-characterized, racially matched normal control comparisons... - Nocturnal penile tumescence in healthy 20- to 59-year-olds: a revisitC F Reynolds
Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
Sleep 12:368-73. 1989..Maximum buckling force and maximum erectile fullness showed stability across the four decades of the Pittsburgh sample... - Diagnostic certainty of a voluntary bipolar disorder case registryP A Cluss
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Affect Disord 52:93-9. 1999..The development and implementation of a bipolar disorder case registry and the assessment of diagnostic certainty of the resulting sample are described... - Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleepE A Nofzinger
Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
Psychiatry Res 98:71-91. 2000.... - The effects of age and gender on sleep EEG power spectral density in the middle years of life (ages 20-60 years old)J Carrier
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
Psychophysiology 38:232-42. 2001..Increasing age was associated with higher power in the beta range. These results suggest that increasing age may be related to an attenuation of homeostatic sleep pressure and to an increase in cortical activation during sleep... - Comparison of sleep-disordered breathing among healthy elderly in the seventh, eighth, and ninth decades of lifeC C Hoch
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
Sleep 13:502-11. 1990..4% of men versus 5.4% of women (chi 2 = 4.25, p less than 0.05). These data suggest that SDB increases with advancing age even in the healthy elderly and may be more marked in healthy men than women... - Lifetime prevalence of substance or alcohol abuse and dependence among subjects with bipolar I and II disorders in a voluntary registryK N Chengappa
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, School of Medicine, PA 15213 2593, USA
Bipolar Disord 2:191-5. 2000..To evaluate the prevalence of substance abuse dependence and/or alcohol abuse dependence among subjects with bipolar I versus bipolar II disorder in a voluntary registry... - Illness characteristics and their association with prescription patterns for bipolar I disorderJ Levine
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213-2593, USA
Bipolar Disord 3:41-9. 2001..CONCLUSIONS: Our results suggest that subjects with bipolar I disorder have high rate of suicidal attempts and may have serious functional impairments... - Inositol as an add-on treatment for bipolar depressionK N Chengappa
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
Bipolar Disord 2:47-55. 2000..Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot study evaluated its potential efficacy and safety in bipolar depression... - Are buckling force measurements reliable in nocturnal penile tumescence studies?E A Nofzinger
Sleep and Chronobiology Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
Sleep 16:156-62. 1993.... - Do nocturnal penile tumescence recordings alter electroencephalographic sleep?M E Thase
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
Sleep 10:486-90. 1987.... - Personality pathology and outcome in recurrently depressed women over 2 years of maintenance interpersonal psychotherapyJ M Cyranowski
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
Psychol Med 34:659-69. 2004..Future maintenance treatment trials are needed to clarify the relationship between episodic mood disorder and personality function over time... - Adjunctive antipsychotic use in bipolar patients: an open 6-month prospective study following an acute episodeJ C Soares
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
J Affect Disord 56:1-8. 1999..We examined the use of adjunctive antipsychotics in the treatment of bipolar patients... - The development of study exit criteria for evaluating antimanic compoundsE Frank
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Clin Psychiatry 62:421-5. 2001..We sought a method that would be safer, more economical, and less sensitive to nonspecific factors in the clinical environment while still allowing unambiguous assessment of efficacy... - Clinical indicators for the use of antidepressants in the treatment of bipolar I depressionA Fagiolini
Department of Psychiatry University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 4:277-82. 2002..Larger, prospective, and controlled studies are needed to verify our results and to identify additional indicators for a mood stabilizer and antidepressant combination treatment strategy... - Narrowing the gap in treatment of depressionJ S Harman
University of Pittsburgh School of Medicine, Pennsylvania, USA
Int J Psychiatry Med 31:239-53. 2001..The purpose of this study is to assess treatment rates in 1993-1994 and 1996-1997... - Increased platelet membrane phosphatidylinositol-4,5-bisphosphate in drug-free depressed bipolar patientsJ C Soares
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Neurosci Lett 299:150-2. 2001.... - Anxiety as a predictor of response to interpersonal psychotherapy for recurrent major depression: an exploratory investigationU Feske
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pennsylvania, USA
Depress Anxiety 8:135-41. 1998..Our findings strengthen existing evidence that concomitant anxiety can adversely affect the outcome of interpersonal therapy for depression... - Forebrain activation in REM sleep: an FDG PET studyE A Nofzinger
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
Brain Res 770:192-201. 1997..This is in accordance with views that alterations in REM sleep in psychiatric disorders, such as depression, may reflect dysregulation in limbic and paralimbic structures... - Inducing jet-lag in older people: directional asymmetryT H Monk
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, USA
J Sleep Res 9:101-16. 2000..Subjective alertness suffered more disruption after the phase advance than after the phase delay... - A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)Barnett S Meyers
Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
Arch Gen Psychiatry 66:838-47. 2009..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features... - Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depressionB G Pollock
Intervention Research Center for Late Life Mood Disorders and the Geriatric Psychopharmacology Program, Graduate School of Public Health, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 23:587-90. 2000..Onset of response to nortriptyline was not affected. Allelic variation of 5-HTTLPR may contribute to the variable initial response of patients treated with a selective serotonin reuptake inhibitor... - Self-reported cognitive problems predict employment trajectory in patients with bipolar I disorderA M Gilbert
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States
J Affect Disord 124:324-8. 2010..Cognitive impairment in bipolar disorder has been associated with poor functional outcomes. We examined the relation of self-reported cognitive problems to employment trajectory in patients diagnosed with bipolar I disorder... - The sleep of healthy people--a diary studyT H Monk
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA, USA
Chronobiol Int 17:49-60. 2000.... - Electroencephalographic sleep of healthy children. Part II: Findings using automated delta and REM sleep measurement methodsP A Coble
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213
Sleep 10:551-62. 1987..Findings are discussed relative to those obtained in the same children using standard measurement methods... - Serotonin type-1A receptor imaging in depressionW C Drevets
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Nucl Med Biol 27:499-507. 2000.... - Depression and aging: a look to the futureC F Reynolds
Department of Psychiatry at the University of Pittsburgh School of Medicine, Pennsylvania, USA
Psychiatr Serv 50:1167-72. 1999.... - Circadian rhythms in healthy aging--effects downstream from the pacemakerT H Monk
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
Chronobiol Int 17:355-68. 2000.... - The effect of GRF on the EEG sleep of normal malesD J Kupfer
Department of Psychiatry, University of Pittsburgh, School of Medicine, PA 15213
Sleep 14:87-8. 1991..These increases were not associated with major alterations in sleep including slow-wave sleep... - Competence of depressed patients for consent to researchP S Appelbaum
Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
Am J Psychiatry 156:1380-4. 1999..This study used a new instrument for assessing depressed patients' capacities to consent to research and examined their performance, including the relation between severity of depression and extent of impairment... - Antidepressant-induced weight gain: a comparison study of four medicationsM H Fernstrom
Department of Psychiatry, University of Pittsburgh School of Medicine, PA
Psychiatry Res 26:265-71. 1988..Weight change during treatment was not associated with age, sex, severity of depression, obesity, weight loss during depression, or clinical response... - Can clinical features of bipolar-I disorder be assessed reliably on the telephone?L K Brar
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
J Affect Disord 71:221-7. 2002..The reliability of telephone interviews for rating 25 selected individual items of the Diagnostic Interview for Genetic Studies (DIGS) was assessed among persons with remitted bipolar disorder I (BPD I, n = 20)... - MRI study of thalamic volumes in bipolar and unipolar patients and healthy individualsS C Caetano
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-3282, USA
Psychiatry Res 108:161-8. 2001..Although functional abnormalities in the thalamus are likely to be implicated in the pathophysiology of mood disorders, no abnormalities in thalamic size appear present in bipolar or unipolar individuals... - Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for PennsylvaniansAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
Bipolar Disord 7:424-30. 2005..This study sought to evaluate the presence of the metabolic syndrome in a group of 171 patients with bipolar disorder who were consecutively recruited in the Bipolar Disorder Center for Pennsylvanians... - Antidepressants and psychotherapy: a clinical research reviewEllen Frank
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic PA 15213, USA
Dialogues Clin Neurosci 7:263-72. 2005..There is a clear need for more information about the relative efficacy of pharmacotherapy-psychotherapy combinations or sequences versus either pharmacotherapy or psychotherapy provided as monotherapies... - Circadian phase variation in bipolar I disorderHader A Mansour
Department of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
Chronobiol Int 22:571-84. 2005..Thus, distinct patterns of M/E were noted among BD1 patients and among BD1 subgroups. The impact of medication, mood state, and chronicity on CS scores needs to be considered... - Dimensional models for research and diagnosis: a current dilemmaDavid J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Abnorm Psychol 114:557-9. 2005..These refinements will be vital in determining the extent and reality of co-occurrence of disorder and the determination of boundaries across specific disorders... - Presenting characteristics of depressed outpatients as a function of recurrence: preliminary findings from the STAR*D clinical trialSteven D Hollon
Department of Psychology, Vanderbilt University, 306 Wilson Hall, Nashville, TN 37203, United States
J Psychiatr Res 40:59-69. 2006..Recurrent depression predicts risk for subsequent episodes, but it is unclear how it relates to demographic features, course of illness, and clinical presentation... - Achieving adequate outcomes in geriatric depression: standardized criteria for remissionDavid J Kupfer
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Clin Psychopharmacol 25:S24-8. 2005..Finally, there is growing recognition that standardized remission criteria can be valuable for establishing treatment guidelines for late-life depression, as well as for educating clinicians and consumers... - Interpersonal psychotherapy for depression with panic spectrum symptoms: a pilot studyJill M Cyranowski
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Depress Anxiety 21:140-2. 2005..A newly adapted psychosocial treatment for depression with lifetime panic spectrum symptoms was evaluated in an open pilot study... - A pilot study of standardized treatment in geriatric bipolar disorderAriel G Gildengers
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, the Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine 15213, USA
Am J Geriatr Psychiatry 13:319-23. 2005..CONCLUSIONS: Treating older adults with bipolar disorder under standardized treatment is feasible and is associated with low symptom levels. However, most older adults with bipolar disorder do not experience sustained recovery... - Cross-cultural validity of the structured clinical interview for panic-agoraphobic spectrumEllen Frank
Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Soc Psychiatry Psychiatr Epidemiol 40:283-90. 2005.... - Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depressionEric A Nofzinger
Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:387-96. 2005..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness... - Body pain and treatment response in late-life depressionJordan F Karp
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 13:188-94. 2005..They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation... - Prevalence and clinical correlates of medical comorbidities in patients with bipolar I disorder: analysis of acute-phase data from a randomized controlled trialWesley K Thompson
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15260, USA
J Clin Psychiatry 67:783-8. 2006..We studied the relationship between number of medical comorbidities in patients with bipolar I disorder and their demographic and clinical characteristics... - Hypothyroidism in patients with bipolar I disorder treated primarily with lithiumAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Epidemiol Psichiatr Soc 15:123-7. 2006..This study evaluated the frequency and clinical significance of abnormal Thyroid Stimulating Hormone (TSH) and Free Thyroxine Index (FTI) in patients with bipolar I disorder treated primarily with lithium... - Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group ReportKarina W Davidson
Department of Medicine, Columbia University College of Physicians and Surgeons, 622 W 168th St, PH9 Center, Room 941, New York, NY 10032, USA
Psychosom Med 68:645-50. 2006..The National Heart, Lung, and Blood Institute convened an interdisciplinary working group of experts to develop recommendations for the assessment and treatment of depression in patients with coronary heart disease (CHD)... - Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depressionEllen Frank
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Clin Trials 5:253-61. 2008..A multi-site clinical trial that includes psychotherapy as one of the treatments presents numerous challenges related to cross-site consistency and communication... - Using computerized adaptive testing to reduce the burden of mental health assessmentRobert D Gibbons
Center for Health Statistics, University of Illinois at Chicago, Psychiatric Institute 457, M C 912, Chicago, IL 60680 6998, USA
Psychiatr Serv 59:361-8. 2008..This study investigated the combination of item response theory and computerized adaptive testing (CAT) for psychiatric measurement as a means of reducing the burden of research and clinical assessments... - Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?Cecile D Ladouceur
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:532-9. 2008..The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD... - Medical burden in late-life bipolar and major depressive disordersAriel G Gildengers
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:194-200. 2008..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder... - Medication effects in neuroimaging studies of bipolar disorderMary L Phillips
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Am J Psychiatry 165:313-20. 2008..Withdrawing all individuals from medication and examining only unmedicated individuals may be clinically unfeasible, and examining only unmedicated individuals may render findings less generalizable... - Sleep quality and architecture in quetiapine, risperidone, or never-treated schizophrenia patientsMatcheri S Keshavan
J Clin Psychopharmacol 27:703-5. 2007 - Serotonin-1A receptor imaging in recurrent depression: replication and literature reviewWayne C Drevets
Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
Nucl Med Biol 34:865-77. 2007..In the current study, we attempted to replicate our previous findings in an independent sample of subjects selected according to the criteria for primary recurrent depression applied in our prior study... - Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorderAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 9:462-7. 2007..We examine the structure of mood and anxiety spectrum features in patients with BD I to identify subtypes with similar profiles... - Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depressionEllen Frank
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:761-7. 2007..The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment... - Cognitive functioning and instrumental activities of daily living in late-life bipolar disorderAriel G Gildengers
Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 15:174-9. 2007..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder... - Greater cortical gray matter density in lithium-treated patients with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Biol Psychiatry 62:7-16. 2007..Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures... - Exploring risk factors for the emergence of children's mental health problemsMarilyn J Essex
Department of Psychiatry, University of Wisconsin Madison 53719, USA
Arch Gen Psychiatry 63:1246-56. 2006..Exploratory studies that generate testable models of how risk factors for childhood mental health problems work together over time are critical for developing effective prevention and treatment strategies...