D J Kupfer

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The interaction of drug- and psychotherapy in the long-term treatment of depression
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 62:131-7. 2001
  2. ncbi request reprint Demographic and clinical characteristics of individuals in a bipolar disorder case registry
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:120-5. 2002
  3. ncbi request reprint Recruiting and retaining future generations of physician scientists in mental health
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 59:657-60. 2002
  4. ncbi request reprint Adolescent development and the regulation of behavior and emotion: comments on part VIII
    David J Kupfer
    Western Psychiatric Institute and Clinic, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:320-2. 2004
  5. ncbi request reprint Citalopram as adjunctive therapy in bipolar depression
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 62:985-90. 2001
  6. ncbi request reprint High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 153:1418-22. 1996
  7. ncbi request reprint Influence of panic-agoraphobic spectrum symptoms on treatment response in patients with recurrent major depression
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 157:1101-7. 2000
  8. ncbi request reprint Temporal profiles of the course of depression during treatment. Predictors of pathways toward recovery in the elderly
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
    Arch Gen Psychiatry 54:1016-24. 1997
  9. ncbi request reprint Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 154:958-62. 1997
  10. ncbi request reprint Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 156:202-8. 1999

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint The interaction of drug- and psychotherapy in the long-term treatment of depression
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 62:131-7. 2001
    ..This paper reviews key findings in recurrent depression with respect to long-term treatment. Particular attention is paid to the combination treatment of psychotherapy and antidepressant drugs...
  2. ncbi request reprint Demographic and clinical characteristics of individuals in a bipolar disorder case registry
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:120-5. 2002
    ....
  3. ncbi request reprint Recruiting and retaining future generations of physician scientists in mental health
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 59:657-60. 2002
    ..quot; A coalition of stakeholders--federal, academic, foundational, and in the pharmaceutical industry--is needed to meet these challenges...
  4. ncbi request reprint Adolescent development and the regulation of behavior and emotion: comments on part VIII
    David J Kupfer
    Western Psychiatric Institute and Clinic, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:320-2. 2004
  5. ncbi request reprint Citalopram as adjunctive therapy in bipolar depression
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 62:985-90. 2001
    ..The treatment of bipolar depression remains a major clinical challenge. The effectiveness and safety of adjunctive citalopram were evaluated in DSM-IV-diagnosed bipolar depressed patients in a 5-site study...
  6. ncbi request reprint High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 153:1418-22. 1996
    ..Twenty-eight patients (17.7%) received inpatient care at some point during acute-phase treatment...
  7. ncbi request reprint Influence of panic-agoraphobic spectrum symptoms on treatment response in patients with recurrent major depression
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 157:1101-7. 2000
    ..The authors tested the hypothesis that a lifetime history of panic-agoraphobic spectrum symptoms predicts a poorer response to depression treatment...
  8. ncbi request reprint Temporal profiles of the course of depression during treatment. Predictors of pathways toward recovery in the elderly
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
    Arch Gen Psychiatry 54:1016-24. 1997
    ..Whether patients vary in their pathways toward those outcomes--and the extent to which such variation can be anticipated by patient characteristics prior to treatment--has not been empirically examined...
  9. ncbi request reprint Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 154:958-62. 1997
    ..This study was conducted to identify which elderly patients with remitted recurrent major depression remain well with maintenance interpersonal psychotherapy after discontinuation of active antidepressant medication (nortriptyline)...
  10. ncbi request reprint Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 156:202-8. 1999
    ..The authors tested the hypothesis that nortriptyline and interpersonal psychotherapy, alone and in combination, are superior to placebo in achieving remission of bereavement-related major depressive episodes...
  11. ncbi request reprint Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years
    C F Reynolds
    The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 281:39-45. 1999
    ..Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability...
  12. ncbi request reprint Latent structure of EEG sleep variables in depressed and control subjects: descriptions and clinical correlates
    D J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Psychiatry Res 79:105-22. 1998
    ..Multivariate statistical techniques decrease the risk of Type I and Type II errors when using a large number of collinear sleep measures, and can clarify conceptual issues related to sleep and depression...
  13. ncbi request reprint Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression
    G S Smith
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:683-9. 1999
    ....
  14. ncbi request reprint Initial recovery patterns may predict which maintenance therapies for depression will keep older adults well
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 65:155-66. 2001
    ..Patients' temporal patterns of acute treatment response may predict who requires which maintenance therapy to remain well...
  15. ncbi request reprint Sleep and treatment response in depression: new findings using power spectral analysis
    D J Buysse
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, E 1127 WPIC, Pittsburgh, PA 15213, USA
    Psychiatry Res 103:51-67. 2001
    ..Quantitative REMs may provide a more direct measure of brainstem function and dysfunction during REM sleep than quantitative sleep EEG measures...
  16. pmc Predictors and moderators of time to remission of major depression with interpersonal psychotherapy and SSRI pharmacotherapy
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychol Med 41:151-62. 2011
    ..We sought to determine whether measures of spectrum psychopathology are useful in deciding which patients with unipolar depression should receive pharmacotherapy versus depression-specific psychotherapy...
  17. ncbi request reprint Controlled comparison of electrophysiological sleep in families of probands with unipolar depression
    D E Giles
    Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
    Am J Psychiatry 155:192-9. 1998
    ..This study presents polysomnographic data and psychiatric history for parents and siblings of probands with unipolar depression and short REM latency, probands with unipolar depression and normal REM latency, and normal comparison probands...
  18. ncbi request reprint Symptoms of stress and depression as correlates of sleep in primary insomnia
    M Hall
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychosom Med 62:227-30. 2000
    ..In the preliminary study described here, we evaluated the extent to which symptoms of stress and depression are associated with subjective sleep complaints and quantitative measures of sleep in individuals with chronic insomnia...
  19. ncbi request reprint Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Psychopharmacology (Berl) 149:12-6. 2000
    ..In vitro and in vivo animal studies suggest that the intracellular phosphatidylinositol (PI) pathway is an important target for the effects of lithium...
  20. ncbi request reprint The Pittsburgh study of normal sleep in young adults: focus on the relationship between waking and sleeping EEG spectral patterns
    C L Ehlers
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
    Electroencephalogr Clin Neurophysiol 106:199-205. 1998
    ..Significant correlations between waking and sleep EEG suggest that the spectral signature of an individual's EEG may be found across sleep/wake states...
  21. ncbi request reprint Effects of diagnosis on treatment recommendations in chronic insomnia--a report from the APA/NIMH DSM-IV field trial
    D J Buysse
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Sleep 20:542-52. 1997
    ..Site-related differences suggest a lack of consensus in how these disorders are conceptualized and treated...
  22. ncbi request reprint Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Psychiatry Res 95:109-18. 2000
    ..These preliminary findings suggest that chronic lithium treatment may decrease the levels of both cytosolic PKC alpha isozyme and membrane PIP(2) in platelets of bipolar disorder patients...
  23. ncbi request reprint Tolerability of combined treatment with lithium and paroxetine in patients with bipolar disorder and depression
    A Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
    J Clin Psychopharmacol 21:474-8. 2001
    ..Clinicians should be aware of the possible development of a serotonin syndrome among patients in whom paroxetine is added to ongoing lithium treatment...
  24. ncbi request reprint Differential effects of age on brain gray matter in bipolar patients and healthy individuals
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychobiology 43:242-7. 2001
    ....
  25. ncbi request reprint Changes in forebrain function from waking to REM sleep in depression: preliminary analyses of [18F]FDG PET studies
    E A Nofzinger
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychiatry Res 91:59-78. 1999
    ..These observations indicate that changes in limbic and paralimbic function from waking to REM sleep differ significantly from normal in depressed patients...
  26. ncbi request reprint A longitudinal study of laboratory- and diary-based sleep measures in healthy "old old" and "young old" volunteers
    C C Hoch
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 17:489-96. 1994
    ..To our knowledge, this is the first longitudinal data set on sleep in the healthy old old...
  27. ncbi request reprint Psychotropic drug prescription patterns among patients with bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Bipolar Disord 2:120-30. 2000
    ..We evaluated prescription patterns and the influence of demographic variables on these patterns in a voluntary registry of subjects with bipolar disorder...
  28. ncbi request reprint Decreased pituitary volume in patients with bipolar disorder
    R B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 50:271-80. 2001
    ..Our findings suggest that detectable abnormalities in pituitary size are present in patients with bipolar disorder, which may reflect a dysfunctional HPA axis...
  29. ncbi request reprint Anatomical MRI study of basal ganglia in bipolar disorder patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:65-80. 2001
    ....
  30. ncbi request reprint MRI study of posterior fossa structures and brain ventricles in bipolar patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:313-22. 2001
    ..However, there were suggestions that abnormalities in cerebellum, vermis, and lateral ventricle sizes may be present in familial cases of the disorder, which should be further examined in future studies with larger patient samples...
  31. ncbi request reprint Influence of traumatic grief on suicidal ideation among young adults
    H G Prigerson
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 156:1994-5. 1999
    ..The purpose of this study was to examine the influence of traumatic grief on suicidal ideation...
  32. ncbi request reprint Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modality
    E Frank
    Department of Psychiatry, University of Pittsburgh 15213, USA
    J Abnorm Psychol 108:579-87. 1999
    ..This finding, consistent with the authors' philosophy that bipolar patients benefit from stable routines, suggests that disruptions in the psychosocial treatment plan contribute to worse outcomes...
  33. ncbi request reprint Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI)
    D J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
    Sleep 14:331-8. 1991
    ..Extremely healthy elderly subjects appear to adapt in their perception of objectively disturbed sleep...
  34. ncbi request reprint Longitudinal changes in diary- and laboratory-based sleep measures in healthy "old old" and "young old" subjects: a three-year follow-up
    C C Hoch
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Sleep 20:192-202. 1997
    ..The current results are representative of healthy elderly; sleep would probably deteriorate earlier and more quickly in elderly with more serious health problems and heavier medication use...
  35. ncbi request reprint Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:1177-81. 1999
    ..This study compared the long-term efficacy of two fixed plasma levels of nortriptyline in preventing or delaying recurrence of major depression in elderly patients and in minimizing residual depressive symptoms and somatic complaints...
  36. pmc Simultaneous evaluation of the harms and benefits of treatments in randomized clinical trials: demonstration of a new approach
    E Frank
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychol Med 42:865-73. 2012
    ..Particularly in mental health, however, there is a lack of a single objective, reliable measure of outcome that is sensitive to crucial individual differences among patients...
  37. ncbi request reprint PET imaging of serotonin 1A receptor binding in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Biol Psychiatry 46:1375-87. 1999
    ..PET imaging using the 5HT1A receptor radioligand, [11C]WAY-100635, may clarify the clinical conditions under which 5HT1A receptor binding potential (BP) is abnormal in depression...
  38. ncbi request reprint Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:437-43. 2001
    ..Future studies should examine a possible role for this methodology in investigations of lithium refractoriness and prediction of treatment outcome in bipolar patients...
  39. ncbi request reprint Patterns of sleep episodes in young and elderly adults during a 36-hour constant routine
    D J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
    Sleep 16:632-7. 1993
    ..They also confirm the presence of sex differences in sleep patterns among the elderly and support the distinction between objective and subjective measures of sleepiness...
  40. ncbi request reprint Response to placebo among bipolar I disorder patients experiencing their first manic episode
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Special Studies Center at Mayview State Hospital, PA 15213 2593, USA
    Bipolar Disord 2:332-5. 2000
    ..Olanzapine versus placebo in the treatment of acute mania. Am J Psychiatry 1999; 156: 702-709)...
  41. ncbi request reprint Panic-agoraphobic spectrum: reliability and validity of assessment instruments
    M K Shear
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:59-66. 2001
    ..We conclude that PAS can be reliably assessed, and that it describes a valid, coherent constellation of features associated with DSM IV Panic Disorder, but providing additional important clinical information...
  42. ncbi request reprint Concordance between habitual sleep times and laboratory recording schedules
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
    Sleep 15:571-5. 1992
    ..We strongly recommend a policy of routinely including data on laboratory versus habitual sleep times in peer-reviewed publications...
  43. ncbi request reprint EEG sleep in African-American patients with major depression: a historical case control study
    D E Giles
    Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
    Depress Anxiety 8:58-64. 1998
    ..The pathological implications of these differences remained to be explored in careful prospective studies of African-American depressed patients and in well-characterized, racially matched normal control comparisons...
  44. ncbi request reprint Nocturnal penile tumescence in healthy 20- to 59-year-olds: a revisit
    C F Reynolds
    Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 12:368-73. 1989
    ..Maximum buckling force and maximum erectile fullness showed stability across the four decades of the Pittsburgh sample...
  45. ncbi request reprint Diagnostic certainty of a voluntary bipolar disorder case registry
    P A Cluss
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    J Affect Disord 52:93-9. 1999
    ..The development and implementation of a bipolar disorder case registry and the assessment of diagnostic certainty of the resulting sample are described...
  46. ncbi request reprint Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep
    E A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 98:71-91. 2000
    ....
  47. ncbi request reprint The effects of age and gender on sleep EEG power spectral density in the middle years of life (ages 20-60 years old)
    J Carrier
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Psychophysiology 38:232-42. 2001
    ..Increasing age was associated with higher power in the beta range. These results suggest that increasing age may be related to an attenuation of homeostatic sleep pressure and to an increase in cortical activation during sleep...
  48. ncbi request reprint Comparison of sleep-disordered breathing among healthy elderly in the seventh, eighth, and ninth decades of life
    C C Hoch
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 13:502-11. 1990
    ..4% of men versus 5.4% of women (chi 2 = 4.25, p less than 0.05). These data suggest that SDB increases with advancing age even in the healthy elderly and may be more marked in healthy men than women...
  49. ncbi request reprint Lifetime prevalence of substance or alcohol abuse and dependence among subjects with bipolar I and II disorders in a voluntary registry
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, School of Medicine, PA 15213 2593, USA
    Bipolar Disord 2:191-5. 2000
    ..To evaluate the prevalence of substance abuse dependence and/or alcohol abuse dependence among subjects with bipolar I versus bipolar II disorder in a voluntary registry...
  50. ncbi request reprint Illness characteristics and their association with prescription patterns for bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213-2593, USA
    Bipolar Disord 3:41-9. 2001
    ..CONCLUSIONS: Our results suggest that subjects with bipolar I disorder have high rate of suicidal attempts and may have serious functional impairments...
  51. ncbi request reprint Inositol as an add-on treatment for bipolar depression
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Bipolar Disord 2:47-55. 2000
    ..Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot study evaluated its potential efficacy and safety in bipolar depression...
  52. ncbi request reprint Are buckling force measurements reliable in nocturnal penile tumescence studies?
    E A Nofzinger
    Sleep and Chronobiology Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 16:156-62. 1993
    ....
  53. ncbi request reprint Do nocturnal penile tumescence recordings alter electroencephalographic sleep?
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 10:486-90. 1987
    ....
  54. ncbi request reprint Personality pathology and outcome in recurrently depressed women over 2 years of maintenance interpersonal psychotherapy
    J M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychol Med 34:659-69. 2004
    ..By maintenance treatment we refer to long-term treatment provided to prevent depression recurrence among remitted patients...
  55. ncbi request reprint Adjunctive antipsychotic use in bipolar patients: an open 6-month prospective study following an acute episode
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Affect Disord 56:1-8. 1999
    ..We examined the use of adjunctive antipsychotics in the treatment of bipolar patients...
  56. ncbi request reprint The development of study exit criteria for evaluating antimanic compounds
    E Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 62:421-5. 2001
    ..We sought a method that would be safer, more economical, and less sensitive to nonspecific factors in the clinical environment while still allowing unambiguous assessment of efficacy...
  57. ncbi request reprint Clinical indicators for the use of antidepressants in the treatment of bipolar I depression
    A Fagiolini
    Department of Psychiatry University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 4:277-82. 2002
    ..Our objective was to evaluate the clinical and demographic differences between patients who remitted on a mood stabilizer alone and patients who subsequently required an adjunctive antidepressant to achieve stabilization...
  58. ncbi request reprint Narrowing the gap in treatment of depression
    J S Harman
    University of Pittsburgh School of Medicine, Pennsylvania, USA
    Int J Psychiatry Med 31:239-53. 2001
    ..The purpose of this study is to assess treatment rates in 1993-1994 and 1996-1997...
  59. ncbi request reprint Increased platelet membrane phosphatidylinositol-4,5-bisphosphate in drug-free depressed bipolar patients
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Neurosci Lett 299:150-2. 2001
    ....
  60. ncbi request reprint Anxiety as a predictor of response to interpersonal psychotherapy for recurrent major depression: an exploratory investigation
    U Feske
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pennsylvania, USA
    Depress Anxiety 8:135-41. 1998
    ..Our findings strengthen existing evidence that concomitant anxiety can adversely affect the outcome of interpersonal therapy for depression...
  61. ncbi request reprint Forebrain activation in REM sleep: an FDG PET study
    E A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    Brain Res 770:192-201. 1997
    ..This is in accordance with views that alterations in REM sleep in psychiatric disorders, such as depression, may reflect dysregulation in limbic and paralimbic structures...
  62. ncbi request reprint Inducing jet-lag in older people: directional asymmetry
    T H Monk
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, USA
    J Sleep Res 9:101-16. 2000
    ..Subjective alertness suffered more disruption after the phase advance than after the phase delay...
  63. pmc A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  64. ncbi request reprint Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    B G Pollock
    Intervention Research Center for Late Life Mood Disorders and the Geriatric Psychopharmacology Program, Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 23:587-90. 2000
    ..Onset of response to nortriptyline was not affected. Allelic variation of 5-HTTLPR may contribute to the variable initial response of patients treated with a selective serotonin reuptake inhibitor...
  65. pmc Self-reported cognitive problems predict employment trajectory in patients with bipolar I disorder
    A M Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States
    J Affect Disord 124:324-8. 2010
    ..Cognitive impairment in bipolar disorder has been associated with poor functional outcomes. We examined the relation of self-reported cognitive problems to employment trajectory in patients diagnosed with bipolar I disorder...
  66. ncbi request reprint The sleep of healthy people--a diary study
    T H Monk
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA, USA
    Chronobiol Int 17:49-60. 2000
    ....
  67. ncbi request reprint Electroencephalographic sleep of healthy children. Part II: Findings using automated delta and REM sleep measurement methods
    P A Coble
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213
    Sleep 10:551-62. 1987
    ..Findings are discussed relative to those obtained in the same children using standard measurement methods...
  68. ncbi request reprint Serotonin type-1A receptor imaging in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nucl Med Biol 27:499-507. 2000
    ....
  69. ncbi request reprint Depression and aging: a look to the future
    C F Reynolds
    Department of Psychiatry at the University of Pittsburgh School of Medicine, Pennsylvania, USA
    Psychiatr Serv 50:1167-72. 1999
    ....
  70. ncbi request reprint Circadian rhythms in healthy aging--effects downstream from the pacemaker
    T H Monk
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
    Chronobiol Int 17:355-68. 2000
    ....
  71. ncbi request reprint The effect of GRF on the EEG sleep of normal males
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh, School of Medicine, PA 15213
    Sleep 14:87-8. 1991
    ..These increases were not associated with major alterations in sleep including slow-wave sleep...
  72. ncbi request reprint Competence of depressed patients for consent to research
    P S Appelbaum
    Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Psychiatry 156:1380-4. 1999
    ..This study used a new instrument for assessing depressed patients' capacities to consent to research and examined their performance, including the relation between severity of depression and extent of impairment...
  73. ncbi request reprint Antidepressant-induced weight gain: a comparison study of four medications
    M H Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA
    Psychiatry Res 26:265-71. 1988
    ..Weight change during treatment was not associated with age, sex, severity of depression, obesity, weight loss during depression, or clinical response...
  74. ncbi request reprint Can clinical features of bipolar-I disorder be assessed reliably on the telephone?
    L K Brar
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    J Affect Disord 71:221-7. 2002
    ..The reliability of telephone interviews for rating 25 selected individual items of the Diagnostic Interview for Genetic Studies (DIGS) was assessed among persons with remitted bipolar disorder I (BPD I, n = 20)...
  75. ncbi request reprint MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals
    S C Caetano
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-3282, USA
    Psychiatry Res 108:161-8. 2001
    ..Although functional abnormalities in the thalamus are likely to be implicated in the pathophysiology of mood disorders, no abnormalities in thalamic size appear present in bipolar or unipolar individuals...
  76. ncbi request reprint Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Bipolar Disord 7:424-30. 2005
    ..This study sought to evaluate the presence of the metabolic syndrome in a group of 171 patients with bipolar disorder who were consecutively recruited in the Bipolar Disorder Center for Pennsylvanians...
  77. pmc Antidepressants and psychotherapy: a clinical research review
    Ellen Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic PA 15213, USA
    Dialogues Clin Neurosci 7:263-72. 2005
    ..There is a clear need for more information about the relative efficacy of pharmacotherapy-psychotherapy combinations or sequences versus either pharmacotherapy or psychotherapy provided as monotherapies...
  78. ncbi request reprint Circadian phase variation in bipolar I disorder
    Hader A Mansour
    Department of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Chronobiol Int 22:571-84. 2005
    ..Thus, distinct patterns of M/E were noted among BD1 patients and among BD1 subgroups. The impact of medication, mood state, and chronicity on CS scores needs to be considered...
  79. ncbi request reprint Dimensional models for research and diagnosis: a current dilemma
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Abnorm Psychol 114:557-9. 2005
    ..These refinements will be vital in determining the extent and reality of co-occurrence of disorder and the determination of boundaries across specific disorders...
  80. ncbi request reprint Presenting characteristics of depressed outpatients as a function of recurrence: preliminary findings from the STAR*D clinical trial
    Steven D Hollon
    Department of Psychology, Vanderbilt University, 306 Wilson Hall, Nashville, TN 37203, United States
    J Psychiatr Res 40:59-69. 2006
    ..Recurrent depression predicts risk for subsequent episodes, but it is unclear how it relates to demographic features, course of illness, and clinical presentation...
  81. ncbi request reprint Achieving adequate outcomes in geriatric depression: standardized criteria for remission
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S24-8. 2005
    ..Finally, there is growing recognition that standardized remission criteria can be valuable for establishing treatment guidelines for late-life depression, as well as for educating clinicians and consumers...
  82. ncbi request reprint Interpersonal psychotherapy for depression with panic spectrum symptoms: a pilot study
    Jill M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Depress Anxiety 21:140-2. 2005
    ..A newly adapted psychosocial treatment for depression with lifetime panic spectrum symptoms was evaluated in an open pilot study...
  83. ncbi request reprint A pilot study of standardized treatment in geriatric bipolar disorder
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, the Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine 15213, USA
    Am J Geriatr Psychiatry 13:319-23. 2005
    ..The authors sought to determine the feasibility of treating elderly adults with bipolar disorder under standardized-treatment conditions...
  84. ncbi request reprint Cross-cultural validity of the structured clinical interview for panic-agoraphobic spectrum
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Soc Psychiatry Psychiatr Epidemiol 40:283-90. 2005
    ....
  85. ncbi request reprint Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
    ..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness...
  86. ncbi request reprint Body pain and treatment response in late-life depression
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:188-94. 2005
    ..They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation...
  87. ncbi request reprint Prevalence and clinical correlates of medical comorbidities in patients with bipolar I disorder: analysis of acute-phase data from a randomized controlled trial
    Wesley K Thompson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15260, USA
    J Clin Psychiatry 67:783-8. 2006
    ..We studied the relationship between number of medical comorbidities in patients with bipolar I disorder and their demographic and clinical characteristics...
  88. ncbi request reprint Hypothyroidism in patients with bipolar I disorder treated primarily with lithium
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Epidemiol Psichiatr Soc 15:123-7. 2006
    ..This study evaluated the frequency and clinical significance of abnormal Thyroid Stimulating Hormone (TSH) and Free Thyroxine Index (FTI) in patients with bipolar I disorder treated primarily with lithium...
  89. ncbi request reprint Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group Report
    Karina W Davidson
    Department of Medicine, Columbia University College of Physicians and Surgeons, 622 W 168th St, PH9 Center, Room 941, New York, NY 10032, USA
    Psychosom Med 68:645-50. 2006
    ..The National Heart, Lung, and Blood Institute convened an interdisciplinary working group of experts to develop recommendations for the assessment and treatment of depression in patients with coronary heart disease (CHD)...
  90. pmc Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Trials 5:253-61. 2008
    ..A multi-site clinical trial that includes psychotherapy as one of the treatments presents numerous challenges related to cross-site consistency and communication...
  91. pmc Using computerized adaptive testing to reduce the burden of mental health assessment
    Robert D Gibbons
    Center for Health Statistics, University of Illinois at Chicago, Psychiatric Institute 457, M C 912, Chicago, IL 60680 6998, USA
    Psychiatr Serv 59:361-8. 2008
    ..This study investigated the combination of item response theory and computerized adaptive testing (CAT) for psychiatric measurement as a means of reducing the burden of research and clinical assessments...
  92. pmc Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?
    Cecile D Ladouceur
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 47:532-9. 2008
    ..The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD...
  93. pmc Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  94. pmc Medication effects in neuroimaging studies of bipolar disorder
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:313-20. 2008
    ..Withdrawing all individuals from medication and examining only unmedicated individuals may be clinically unfeasible, and examining only unmedicated individuals may render findings less generalizable...
  95. ncbi request reprint Sleep quality and architecture in quetiapine, risperidone, or never-treated schizophrenia patients
    Matcheri S Keshavan
    J Clin Psychopharmacol 27:703-5. 2007
  96. pmc Serotonin-1A receptor imaging in recurrent depression: replication and literature review
    Wayne C Drevets
    Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
    Nucl Med Biol 34:865-77. 2007
    ..In the current study, we attempted to replicate our previous findings in an independent sample of subjects selected according to the criteria for primary recurrent depression applied in our prior study...
  97. pmc Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 9:462-7. 2007
    ..We examine the structure of mood and anxiety spectrum features in patients with BD I to identify subtypes with similar profiles...
  98. pmc Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:761-7. 2007
    ..The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment...
  99. ncbi request reprint Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 15:174-9. 2007
    ..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder...
  100. pmc Greater cortical gray matter density in lithium-treated patients with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 62:7-16. 2007
    ..Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures...
  101. ncbi request reprint Exploring risk factors for the emergence of children's mental health problems
    Marilyn J Essex
    Department of Psychiatry, University of Wisconsin Madison 53719, USA
    Arch Gen Psychiatry 63:1246-56. 2006
    ..Exploratory studies that generate testable models of how risk factors for childhood mental health problems work together over time are critical for developing effective prevention and treatment strategies...