S Kunwar

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies
    S Kunwar
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Acta Neurochir Suppl 88:105-11. 2003
  2. ncbi request reprint Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies
    Sandeep Kunwar
    Department of Neurosurgery, University of California, San Francisco, California 94143 0350, USA
    Neurosurg Focus 20:E15. 2006
  3. ncbi request reprint Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group
    Sandeep Kunwar
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94143 0350, USA
    J Clin Oncol 25:837-44. 2007
  4. ncbi request reprint Endoscopic adjuncts to intraventricular surgery
    Sandeep Kunwar
    Department of Neurosurgery, University of California, San Francisco School of Medicine, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 14:547-57. 2003
  5. ncbi request reprint Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma
    Ian F Parney
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, California 94143 0350, USA
    J Neurosurg 102:267-75. 2005
  6. pmc Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization
    Joanna J Phillips
    Neuropathology Unit, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0102, USA
    Arch Pathol Lab Med 134:1063-9. 2010
  7. ncbi request reprint Complications of lumboperitoneal shunts
    Vincent Y Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 60:1045-8; discussion 1049. 2007
  8. ncbi request reprint Safety and efficacy of the direct endonasal transsphenoidal approach for challenging sellar tumors
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, P O Box 0112, San Francisco, CA 94143, USA
    J Neurooncol 87:317-25. 2008
  9. doi request reprint Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas
    Edward F Chang
    Department of Neurological Surgery, Division of Endocrinology, University of California, San Francisco, California 94143, USA
    J Neurosurg 108:736-45. 2008
  10. doi request reprint Pre-operative dopamine agonist therapy improves post-operative tumor control following prolactinoma resection
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA
    Pituitary 12:158-64. 2009

Detail Information

Publications31

  1. ncbi request reprint Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies
    S Kunwar
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Acta Neurochir Suppl 88:105-11. 2003
    ..The preclinical data and details and preliminary results of the three clinical trials are reviewed...
  2. ncbi request reprint Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies
    Sandeep Kunwar
    Department of Neurosurgery, University of California, San Francisco, California 94143 0350, USA
    Neurosurg Focus 20:E15. 2006
    ..Cintredekin besudotox (also known as IL13- PE38QQR) is a recombinant chimeric cytotoxin consisting of interleukin-13 and a truncated exotoxin produced by the Pseudomonas aeruginosa bacterium, which targets malignant glioma cells...
  3. ncbi request reprint Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group
    Sandeep Kunwar
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94143 0350, USA
    J Clin Oncol 25:837-44. 2007
    ..We assessed the use of intracerebral CED to deliver CB in patients with recurrent malignant glioma (MG)...
  4. ncbi request reprint Endoscopic adjuncts to intraventricular surgery
    Sandeep Kunwar
    Department of Neurosurgery, University of California, San Francisco School of Medicine, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 14:547-57. 2003
    ..Its further use in the management of intraventricular cysts and tumors is dependent on long-term follow-up and the development of even better instrumentation...
  5. ncbi request reprint Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma
    Ian F Parney
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, California 94143 0350, USA
    J Neurosurg 102:267-75. 2005
    ..Serial neuroradiographic changes were assessed in this cohort of patients...
  6. pmc Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization
    Joanna J Phillips
    Neuropathology Unit, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0102, USA
    Arch Pathol Lab Med 134:1063-9. 2010
    ..This pattern of genetic changes only partially overlaps with the genomic alterations reported in pituitary adenomas. In summary, our data suggest that pituicytomas are a unique subset of tumors of the sellar region...
  7. ncbi request reprint Complications of lumboperitoneal shunts
    Vincent Y Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 60:1045-8; discussion 1049. 2007
    ..These shunts can be placed with or without valves. We sought to review the complications associated with the use of LP shunts with the increasing use of horizontal-vertical (HV) valve systems...
  8. ncbi request reprint Safety and efficacy of the direct endonasal transsphenoidal approach for challenging sellar tumors
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, P O Box 0112, San Francisco, CA 94143, USA
    J Neurooncol 87:317-25. 2008
    ..Large macroadenomas (3-4 cm) can still be addressed with this simple, unmodified direct endonasal approach. We present our experience with this unique and challenging patient population...
  9. doi request reprint Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas
    Edward F Chang
    Department of Neurological Surgery, Division of Endocrinology, University of California, San Francisco, California 94143, USA
    J Neurosurg 108:736-45. 2008
    ..The authors' aim was to determine predictors of recurrence and overall survival and to define patient subgroups that may benefit from radiotherapy...
  10. doi request reprint Pre-operative dopamine agonist therapy improves post-operative tumor control following prolactinoma resection
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA
    Pituitary 12:158-64. 2009
    ..We sought to determine whether preoperative treatment with dopamine agonists alters the outcome of surgical intervention...
  11. doi request reprint Surgical resection and permanent iodine-125 brachytherapy for brain metastases
    Kim Huang
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, Room L 08, San Francisco, CA, 94143 0226, USA
    J Neurooncol 91:83-93. 2009
    ..To evaluate the efficacy and toxicity of surgical resection and permanent iodine-125 brachytherapy without adjuvant whole brain radiation therapy (WBRT) for brain metastases...
  12. pmc An approach to the management of patients with residual Cushing's disease
    Lewis S Blevins
    California Center for Pituitary Disorders, University of California at San Francisco, Room A 808, San Francisco, CA 94143 0350, USA
    J Neurooncol 94:313-9. 2009
    ....
  13. pmc Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma
    Sandeep Kunwar
    Division of Neuro Oncology, Department of Neurological Surgery, University of California, 400 Parnassus Avenue, A 808, San Francisco, CA 94143 0350, USA
    Neuro Oncol 12:871-81. 2010
    ..There was no survival difference between CB administered via CED and GW. Drug distribution was not assessed and may be crucial for evaluating future CED-based therapeutics...
  14. pmc Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study
    Sabine Mueller
    Department of Neurology, University of San Francisco, 350 Parnassus Ave, Suite 609, San Francisco, CA 94117, USA
    J Neurooncol 101:267-77. 2011
    ..55; PFS: P = 0.35) or imaging changes on day 43 MRI (P = 0.88). Catheter positioning scores and overall catheter placement scores were not associated with clinical outcome in this large prospective trial...
  15. ncbi request reprint GNOSIS: guidelines for neuro-oncology: standards for investigational studies--reporting of surgically based therapeutic clinical trials
    Susan Chang
    Neuro Oncology Service, Department of Neurological Surgery, University of California San Francisco, 400 Parnassus Avenue, A 808, San Francisco, CA 94143 0350, USA
    J Neurooncol 82:211-20. 2007
    ....
  16. ncbi request reprint Extended bifrontal craniotomy for midline anterior fossa meningiomas: minimization of retraction-related edema and surgical outcomes
    John H Chi
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 59:ONS426-33; discussion ONS433-4. 2006
    ..The authors have attempted to quantitate retraction-related edema occurring after surgery to determine whether the extra bone removal limits retraction and reduces the chance of brain injury...
  17. ncbi request reprint Phase II study of high central dose Gamma Knife radiosurgery and marimastat in patients with recurrent malignant glioma
    David A Larson
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 54:1397-404. 2002
    ..To assess the outcome of high central dose Gamma Knife radiosurgery plus marimastat in patients with recurrent malignant glioma...
  18. ncbi request reprint Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    Nader Sanai
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 427:740-4. 2004
    ..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain...
  19. ncbi request reprint Stereotactic radiosurgery and interstitial brachytherapy for glial neoplasms
    M W McDermott
    Department of Neurosurgery, University of California, San Francisco, CA, USA
    J Neurooncol 69:83-100. 2004
    ..This paper reviews the recent literature and results of the use of brachytherapy and radiosurgery in the management of newly diagnosed and recurrent malignant gliomas...
  20. ncbi request reprint Chromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme
    Anjan Misra
    Brain Tumor Research Center, Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Genes Chromosomes Cancer 45:20-30. 2006
    ..We identified three candidate regions on chromosome 7 that conferred radiation resistance in our model system...
  21. ncbi request reprint Brain metastases of breast cancer
    Michelle E Melisko
    Division of Hematology Oncology, University of California at San Francisco, San Francisco, CA 94115, USA
    Expert Rev Anticancer Ther 5:253-68. 2005
    ..New approaches include chemotherapy combinations, biologic therapies and novel drug-delivery strategies...
  22. ncbi request reprint The "yo-yo" technique to prevent cerebrospinal fluid rhinorrhea after anterior clinoidectomy for proximal internal carotid artery aneurysms
    John H Chi
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 59:ONS101-7; discussion ONS101-7. 2006
    ..We present a technique for repairing this defect and preventing CSF rhinorrhea...
  23. ncbi request reprint Genetic subgroups of anaplastic astrocytomas correlate with patient age and survival
    S Kunwar
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Cancer Res 61:7683-8. 2001
    ..Our results indicate that genetic events underlie the well-known effects of age on survival in grade III astrocytoma and demonstrate the importance of molecular classification in astrocytic tumors...
  24. ncbi request reprint Cavernous and inferior petrosal sinus sampling in the evaluation of ACTH-dependent Cushing's syndrome
    Chienying Liu
    Department of Medicine, University of California, San Francisco 94117, USA
    Clin Endocrinol (Oxf) 61:478-86. 2004
    ..inferior petrosal sinus) and the use of lateralization data in tumour localization. We have analysed our experience with CVS to address these controversies...
  25. pmc Long term outcome following repeat transsphenoidal surgery for recurrent endocrine-inactive pituitary adenomas
    Edward F Chang
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA
    Pituitary 13:223-9. 2010
    ..Our data suggest that when performed by experienced transsphenoidal surgeons, durable tumor control can be obtained in these frequently locally aggressive tumors with acceptable rates of post-operative morbidity...
  26. ncbi request reprint Protein biomarker identification in the CSF of patients with CNS lymphoma
    Sushmita Roy
    PPD Biomarker Discovery Sciences, LLC, Menlo Park, CA, USA
    J Clin Oncol 26:96-105. 2008
    ..Elucidation of the CSF proteome may yield insights into the pathogenesis of CNS disease. We tested the hypothesis that individual CSF proteins distinguish CNS lymphoma from benign focal brain lesions...
  27. ncbi request reprint Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results
    Michael A Vogelbaum
    Brain Tumor and Neuro Oncology Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurosurgery 61:1031-7; discussion 1037-8. 2007
    ....
  28. ncbi request reprint Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy
    Mitomu Kioi
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892, USA
    Technol Cancer Res Treat 5:239-50. 2006
    ..Most recently, a randomized controlled Phase 3 clinical trial (PRECISE) with intraparenchymal IL-13 cytotoxin administration was completed and subjects are being monitored for safety and survival...
  29. ncbi request reprint Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant b
    John H Sampson
    Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    J Neurooncol 65:27-35. 2003
    ..9 weeks. Overall, 3 of 15 patients, with residual disease at the time of therapy, have demonstrated radiographic responses and one patient with a complete response and has survived greater than 83 weeks...
  30. ncbi request reprint Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies
    John H Sampson
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurosurg Focus 20:E14. 2006
    ..The purpose of this study was to determine if CED would provide a larger volume of distribution (Vd) of a radiolabeled monoclonal antibody (mAb) than a bolus injection...
  31. pmc Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors
    John H Sampson
    Division of Neurosurgery, Department of Surgery, Box 3050, Room 220 Sands Building, Duke University Medical Center, Durham, NC 27710, USA
    Neuro Oncol 10:320-9. 2008
    ..However, the potential efficacy of drugs delivered by this technique may be severely constrained by ineffective infusion in many patients...