Charles Kunos

Summary

Affiliation: University Hospitals Case Medical Center
Country: USA

Publications

  1. ncbi request reprint Cyberknife radiosurgery for squamous cell carcinoma of vulva after prior pelvic radiation therapy
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Technol Cancer Res Treat 7:375-80. 2008
  2. pmc Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Radiat Res 174:574-81. 2010
  3. pmc Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Int J Gynecol Cancer 22:1463-9. 2012
  4. doi request reprint Hematological toxicity after robotic stereotactic body radiosurgery for treatment of metastatic gynecologic malignancies
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Int J Radiat Oncol Biol Phys 84:e35-41. 2012
  5. pmc Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Transl Med 10:79. 2012
  6. pmc Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia
    Charles A Kunos
    Department of Epidemiology and Biostatistics, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Future Oncol 8:145-50. 2012
  7. pmc Posttherapy residual disease associates with long-term survival after chemoradiation for bulky stage 1B cervical carcinoma: a Gynecologic Oncology Group study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106 5000, USA
    Am J Obstet Gynecol 203:351.e1-8. 2010
  8. pmc Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: enhanced radiation response at low-dose rates
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Int J Radiat Oncol Biol Phys 80:1198-204. 2011
  9. pmc Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Radiat Res 176:425-33. 2011
  10. doi request reprint 18F-fluoro-2-deoxy-D-glucose positron emission tomography standard uptake value ratio as an indicator of cervical cancer chemoradiation therapeutic response
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Int J Gynecol Cancer 21:1117-23. 2011

Detail Information

Publications27

  1. ncbi request reprint Cyberknife radiosurgery for squamous cell carcinoma of vulva after prior pelvic radiation therapy
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Technol Cancer Res Treat 7:375-80. 2008
    ..This study describes the first reported use of cyberknife radiosurgery for the treatment of recurrent vulvar cancer in three women...
  2. pmc Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Radiat Res 174:574-81. 2010
    ..We conclude that blockage of RNR activity by 3-AP impairs DNA damage responses that rely on deoxyribonucleotide production and thereby may substantially increase chemoradiosensitivity of human cervical cancers...
  3. pmc Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Int J Gynecol Cancer 22:1463-9. 2012
    ..Here, we investigate the impact of pretherapy RNR M1, M2, and M2b (p53R3) subunit level upon human cervical cancer radiochemosensitivity...
  4. doi request reprint Hematological toxicity after robotic stereotactic body radiosurgery for treatment of metastatic gynecologic malignancies
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Int J Radiat Oncol Biol Phys 84:e35-41. 2012
    ..To evaluate hematological toxicity after robotic stereotactic body radiosurgery (SBRT) for treatment of women with metastatic abdominopelvic gynecologic malignancies...
  5. pmc Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Transl Med 10:79. 2012
    ..The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer...
  6. pmc Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia
    Charles A Kunos
    Department of Epidemiology and Biostatistics, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Future Oncol 8:145-50. 2012
    ..Management of methemoglobinemia includes supplemental oxygen, ascorbate and, most importantly, intravenously administered methylene blue as a therapeutic antidote...
  7. pmc Posttherapy residual disease associates with long-term survival after chemoradiation for bulky stage 1B cervical carcinoma: a Gynecologic Oncology Group study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106 5000, USA
    Am J Obstet Gynecol 203:351.e1-8. 2010
    ..The objective of the study was to study posttherapy chemoradiation hysterectomy histology with long-term survival in bulky stage 1(B) cervical cancer patients...
  8. pmc Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: enhanced radiation response at low-dose rates
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Int J Radiat Oncol Biol Phys 80:1198-204. 2011
    ....
  9. pmc Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Radiat Res 176:425-33. 2011
    ..Cell survival was assessed by colony formation. We found that deoxyribonucleotide salvage facilitates DNA repair during RNR inhibition by 3-AP and that salvage reduces the radiochemosensitivity of human cervical cancer cells...
  10. doi request reprint 18F-fluoro-2-deoxy-D-glucose positron emission tomography standard uptake value ratio as an indicator of cervical cancer chemoradiation therapeutic response
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Int J Gynecol Cancer 21:1117-23. 2011
    ....
  11. ncbi request reprint Helical tomotherapy versus conventional radiation to deliver abdominopelvic radiation
    J Choe
    Department of Radiation Oncology and Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Technol Cancer Res Treat 11:49-56. 2012
    ..Novel chemoradiosensitizing agent clinical trials incorporating our TOMO abdominopelvic radiation technique for treatment of patients with recurrent ovarian cancer are under development...
  12. pmc Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein
    Charles A Kunos
    Departments of Radiation Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Radiat Res 172:666-76. 2009
    ....
  13. doi request reprint Retrospective analysis of concomitant Cisplatin during radiation in patients aged 55 years or older for treatment of advanced cervical cancer: a gynecologic oncology group study
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center and University Hospitals of Cleveland Case Medical Center, Cleveland, Ohio, USA
    Int J Gynecol Cancer 19:1258-63. 2009
    ....
  14. ncbi request reprint Stereotactic body radiosurgery for pelvic relapse of gynecologic malignancies
    Charles Kunos
    Department of Radiation Oncology, Hospital of Cleveland MAILSTOP LTR 6068 Case Medical Center and Case Western Reserve University Cleveland, OH 44106, USA
    Technol Cancer Res Treat 8:393-400. 2009
    ..This study details our clinical experience with stereotactic body radiosurgery for treatment of patients with pelvic relapses of gynecologic malignancies after prior pelvic radiation...
  15. ncbi request reprint Comparison of helical tomotherapy versus conventional radiation to deliver craniospinal radiation
    Charles A Kunos
    Department of Radiation Oncology, CASE Comprehensive Cancer Center and Case Western Reserve University, Cleveland, OH 44106 6068, USA
    Technol Cancer Res Treat 7:227-33. 2008
    ..However, the long-term effects of tomotherapy dose avoidance on spine growth and large volume low dose radiation in children are not yet known...
  16. doi request reprint Concurrent cisplatin-based chemoradiation International Federation of Gynecology and Obstetrics stage IB2 cervical carcinoma
    Behiye P C Goksedef
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Obstet Gynecol 200:175.e1-5. 2009
    ..The objective of the study was to assess the effectiveness of primary chemoradiation for stage IB(2) cervical carcinoma...
  17. doi request reprint Radiation therapy compared with pelvic node resection for node-positive vulvar cancer: a randomized controlled trial
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Obstet Gynecol 114:537-46. 2009
    ..To report long-term survival and toxicity of radiation compared with pelvic node resection for patients with groin node-positive vulvar cancer...
  18. doi request reprint Patterns of recurrence in stage I endometrioid endometrial adenocarcinoma with lymphovascular space invasion
    Fiona Simpkins
    Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Int J Gynecol Cancer 23:98-104. 2013
    ..The objective of this study was to determine the patterns of recurrence of stage IB-IIA endometrioid endometrial adenocarcinoma (EMCA) with lymphovascular invasion (LVSI)...
  19. doi request reprint Stereotactic body radiation therapy for nonresectable tumors of the pancreas
    Kush Goyal
    Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Surg Res 174:319-25. 2012
    ..We report on our experience with SBRT in patients with pancreatic adenocarcinoma who were found not to be candidates for surgical resection...
  20. doi request reprint Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence
    Nabila Rasool
    Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Gynecol Oncol 116:10-4. 2010
    ..To study patterns of recurrence and survival outcomes in patients with surgical stage I, grade 3 endometrioid adenocarcinoma of the endometrium (EA) treated with various treatment modalities...
  21. pmc Phase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer
    Charles A Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    Clin Cancer Res 16:1298-306. 2010
    ..v. cisplatin and daily pelvic radiation in patients with gynecologic malignancies. 3-AP is a novel small-molecule inhibitor of ribonucleotide reductase (RNR) and is being tested as a potential radiosensitizer and chemosensitizer...
  22. doi request reprint Emerging application of stereotactic body radiation therapy for gynecologic malignancies
    Nina A Mayr
    Arthur G James Cancer Hospital and Solove Research Institute Ohio State University, OH, USA
    Expert Rev Anticancer Ther 11:1069-75. 2011
    ..This article will consider indications for SBRT application in gynecological cancer management, will reflect on outcomes from key SBRT clinical trials and will discuss new therapeutic roles of SBRT for gynecological cancers...
  23. ncbi request reprint Intraoperative electron radiotherapy for extremity sarcomas does not increase acute or late morbidity
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106 5000, USA
    Clin Orthop Relat Res 446:247-52. 2006
    ..Level of Evidence: Prognostic Study, Level II (retrospective study). See the Guidelines for Authors for a complete description of levels of evidence...
  24. ncbi request reprint Breast conservation surgery achieving>or=2 mm tumor-free margins results in decreased local-regional recurrence rates
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, Ohio 44106 5000, USA
    Breast J 12:28-36. 2006
    ..Based on our findings, cosmetically acceptable tumor-free (>or=2 mm) surgical margins significantly reduce local in-breast and regional lymph node recurrences with fractionated radiation therapy, chemotherapy, and hormonal therapy...
  25. pmc Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair
    Lauren Shunkwiler
    Department of Radiation Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Int J Mol Sci 14:3773-85. 2013
    ..Overall, our findings support enhanced radiochemotherapy toxicity in cancers proficient in DNA double-strand break repair when PARP is inhibited by ABT-888...
  26. pmc Chemotherapy Administration during Pelvic Radiation for Cervical Cancer Patients Aged >/=55 Years in the SEER-Medicare Population
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center and University Hospitals of Cleveland Case Medical Center, Cleveland, OH 44106, USA
    J Oncol 2008:931532. 2008
    ..04). While SEER-Medicare data indicated an increasing trend for chemoradiation after the 1999 NCI clinical alert, chemoradiation was less frequent in elderly women with cervical cancer...
  27. ncbi request reprint Migration of implanted free radioactive seeds for adenocarcinoma of the prostate using a Mick applicator
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH, USA
    Brachytherapy 3:71-7. 2004
    ..This study investigates the rate of free seed migration and associated seed-related sequelae after using a radioimmunoguided Mick applicator technique to place radioactive seeds within the prostate...