Lakshmi P Kunju

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Lymphovascular invasion of urothelial cancer in matched transurethral bladder tumor resection and radical cystectomy specimens
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    J Urol 180:1928-32; discussion 1932. 2008
  2. doi request reprint Nephrogenic adenoma: report of a case and review of morphologic mimics
    Lakshmi P Kunju
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 134:1455-9. 2010
  3. pmc Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer
    Irfan A Asangani
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Cell 49:80-93. 2013
  4. pmc Correlation of urine TMPRSS2:ERG and PCA3 to ERG+ and total prostate cancer burden
    Allison Young
    Dept of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Clin Pathol 138:685-96. 2012
  5. doi request reprint Prostate cancer with aberrant diffuse p63 expression: report of a case and review of the literature and morphologic mimics
    Angela Wu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, USA
    Arch Pathol Lab Med 137:1179-84. 2013
  6. pmc Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104 5054, USA
    Am J Clin Pathol 139:771-9. 2013
  7. doi request reprint Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Pathol Int 58:620-5. 2008
  8. pmc Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma
    Ritu Bhalla
    Michigan Center for Translational Pathology, Ann Arbor, MI, USA
    Mod Pathol 26:835-48. 2013
  9. pmc The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
    John R Prensner
    1 Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA 2
    Nat Genet 45:1392-8. 2013
  10. doi request reprint Activating ESR1 mutations in hormone-resistant metastatic breast cancer
    Dan R Robinson
    1 Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA 2 Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA 3
    Nat Genet 45:1446-51. 2013

Collaborators

Detail Information

Publications34

  1. doi request reprint Lymphovascular invasion of urothelial cancer in matched transurethral bladder tumor resection and radical cystectomy specimens
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    J Urol 180:1928-32; discussion 1932. 2008
    ..We examined the agreement of lymphovascular invasion status in matched transurethral bladder tumor resection and cystectomy specimens...
  2. doi request reprint Nephrogenic adenoma: report of a case and review of morphologic mimics
    Lakshmi P Kunju
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 134:1455-9. 2010
    ..Herein, I report a case of nephrogenic adenoma with some worrisome histologic features and review the diagnostic criteria as well as pertinent morphologic malignant mimics of nephrogenic adenoma...
  3. pmc Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer
    Irfan A Asangani
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Cell 49:80-93. 2013
    ..Together, these results suggest that the EZH2-MMSET HMTase axis coordinately functions as a master regulator of transcriptional repression, activation, and oncogenesis and may represent an attractive therapeutic target in cancer...
  4. pmc Correlation of urine TMPRSS2:ERG and PCA3 to ERG+ and total prostate cancer burden
    Allison Young
    Dept of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Clin Pathol 138:685-96. 2012
    ..03) and summed linear tumor dimension (r(s) = 0.26, P = .10). In summary, we demonstrate a strong correlation between urine T2:ERG score and total ERG+ prostate cancer burden at prostatectomy, consistent with high tumor specificity...
  5. doi request reprint Prostate cancer with aberrant diffuse p63 expression: report of a case and review of the literature and morphologic mimics
    Angela Wu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, USA
    Arch Pathol Lab Med 137:1179-84. 2013
    ..Current controversies regarding the grading, prognosis, and molecular profile of p63-positive prostatic adenocarcinomas are also discussed...
  6. pmc Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104 5054, USA
    Am J Clin Pathol 139:771-9. 2013
    ..In summary, EPR3864 may be useful in detecting EWSR1:FLI1 and EWSR1:ERG rearranged EFTs in addition to prostate carcinomas...
  7. doi request reprint Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Pathol Int 58:620-5. 2008
    ..Despite matching for tumor size, grade 1 IDC have a higher incidence of lymph node metastasis and may have Her-2-neu overexpression compared to TC...
  8. pmc Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma
    Ritu Bhalla
    Michigan Center for Translational Pathology, Ann Arbor, MI, USA
    Mod Pathol 26:835-48. 2013
    ..Automated dual ERG-PTEN and ERG-SPINK1 immunohistochemisty assays are simple, reliable and portable across study sites for the simultaneous assessment of these proteins in prostate cancer...
  9. pmc The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
    John R Prensner
    1 Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA 2
    Nat Genet 45:1392-8. 2013
    ..These results suggest that SChLAP1 contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex...
  10. doi request reprint Activating ESR1 mutations in hormone-resistant metastatic breast cancer
    Dan R Robinson
    1 Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA 2 Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA 3
    Nat Genet 45:1446-51. 2013
    ..Taken together, these studies suggest that activating mutations in ESR1 are a key mechanism in acquired endocrine resistance in breast cancer therapy. ..
  11. doi request reprint p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0602, USA
    Histopathology 60:597-608. 2012
    ..Accurate classification, especially the distinction of UC from RCC, is critical, as therapeutic approaches differ...
  12. pmc Identification of targetable FGFR gene fusions in diverse cancers
    Yi Mi Wu
    Michigan Center for Translational Pathology, University of Michigan Medical School, 1400 E Medical Center Drive 5316 CCGC, Ann Arbor, MI 48109 5940, USA
    Cancer Discov 3:636-47. 2013
    ....
  13. ncbi request reprint Partial atrophy in prostate needle biopsies: a detailed analysis of its morphology, immunophenotype, and cellular kinetics
    Christopher G Przybycin
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Surg Pathol 32:58-64. 2008
    ..PA foci do not represent a spectrum of proliferative inflammatory atrophy, justifying its term...
  14. ncbi request reprint Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34betaE12), and/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Clin Pathol 125:675-81. 2006
    ..This panel was used on 26 diagnostically challenging cases and resolved 81% of cases as UCa vs PCa. The majority of PCa cases retain PSA. Negative PSA with positive HMWCK and/or p63 establishes a diagnosis of UCa...
  15. ncbi request reprint Expression of renal cell carcinoma antigen (RCC) in renal epithelial and nonrenal tumors: diagnostic Implications
    Nasir Bakshi
    Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA
    Appl Immunohistochem Mol Morphol 15:310-5. 2007
    ..RCC also does not reliably differentiate subtypes of renal epithelial neoplasms...
  16. ncbi request reprint Usefulness of basal cell cocktail (34betaE12 + p63) in the diagnosis of atypical prostate glandular proliferations
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Am J Clin Pathol 122:517-23. 2004
    ..The cocktail provides a simple, cost-effective improvement in basal cell immunohistochemical analysis of difficult prostate lesions...
  17. pmc Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing
    Dan R Robinson
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Genet 45:180-5. 2013
    ..These studies establish NAB2-STAT6 as the defining driver mutation of SFT and provide an example of how neoplasia can be initiated by converting a transcriptional repressor of mitogenic pathways into a transcriptional activator...
  18. doi request reprint High-grade carcinomas involving the renal sinus: report of a case and review of the differential diagnosis and immunohistochemical expression
    Allison Young
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 136:907-10. 2012
    ..A panel consisting of p63, paired box gene 8 (PAX8), and INI-1 is most optimal in distinguishing UC from CDC and RMC. A subset of urothelial carcinoma of upper urinary tract may be positive with PAX8...
  19. doi request reprint Multiple prostate cancer cores with different Gleason grades submitted in the same specimen container without specific site designation: should each core be assigned an individual Gleason score?
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 40:558-64. 2009
    ..When multiple intact cores are submitted in the same container without specific identifiers, individual cores with cancer should be graded and/or the Worst Gleason score should be recorded...
  20. ncbi request reprint Significance of flat epithelial atypia on mammotome core needle biopsy: Should it be excised?
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48331, USA
    Hum Pathol 38:35-41. 2007
    ..Chronic inflammation and stromal changes are present in a subset of cases. Flat epithelial atypia shows a risk of upgrade to carcinoma similar to that of ADH and, hence, should be recognized and warrants a follow-up excision...
  21. pmc EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Mod Pathol 24:786-93. 2011
    ..049, respectively). Our study provides first evidence that EZH2 and epithelial and stromal ALDH-1 detection in benign breast biopsies may predict increased risk for breast cancer, with implications for breast cancer prevention...
  22. ncbi request reprint Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 39:96-101. 2008
    ..Morphologic spectrum of these PRCCs emphasizes that the future prognostic model of PRCC may need to be based primarily on the nuclear characteristics, irrespective of the cytoplasmic features...
  23. pmc Antibody-based detection of ERG rearrangements in prostate core biopsies, including diagnostically challenging cases: ERG staining in prostate core biopsies
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48104 5054, USA
    Arch Pathol Lab Med 136:935-46. 2012
    ....
  24. doi request reprint Cluster analysis of immunohistochemical profiles delineates CK7, vimentin, S100A1 and C-kit (CD117) as an optimal panel in the differential diagnosis of renal oncocytoma from its mimics
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA
    Histopathology 58:169-79. 2011
    ....
  25. doi request reprint Accuracy of determining small renal mass management with risk stratified biopsies: confirmation by final pathology
    Schuyler J Halverson
    Medical School, University of Michigan Health System, Ann Arbor, Michigan, USA
    J Urol 189:441-6. 2013
    ..We assess the accuracy of a biopsy directed treatment algorithm in correctly assigning active surveillance vs treatment in patients with small renal masses by comparing biopsy results with final surgical pathology...
  26. doi request reprint The potential impact of reproducibility of Gleason grading in men with early stage prostate cancer managed by active surveillance: a multi-institutional study
    Jesse K McKenney
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    J Urol 186:465-9. 2011
    ..We evaluated the reproducibility of Gleason grading as relevant to the clinical treatment of men on active surveillance...
  27. doi request reprint Funding anatomic pathology research: a retrospective analysis of an intramural funding mechanism
    Andrew McDaniel
    Department of Pathology, University of Michigan Health System, Ann Arbor, 48109, USA
    Arch Pathol Lab Med 137:1270-3. 2013
    ..A review committee consisting of faculty members with diverse academic interests evaluated applications; proposals were eligible for a maximum award amount of $30 000 per project with a maximum program cost of $150 000 annually...
  28. pmc Role of transcriptional corepressor CtBP1 in prostate cancer progression
    Rui Wang
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Neoplasia 14:905-14. 2012
    ..Taken together, our studies demonstrated that dysregulated expression of CtBP1 plays an important role in prostate cancer progression and may serve as a viable therapeutic target...
  29. doi request reprint Utility of PAX8 and PAX2 immunohistochemistry in the identification of renal cell carcinoma in diagnostic cytology
    Stewart M Knoepp
    Department of Pathology, University of Michigan Medical School, 1500E Medical Center Drive, Ann Arbor, MI 48109, USA
    Diagn Cytopathol 40:667-72. 2012
    ..Overall, the results indicate that PAX8 and PAX2 are diagnostically useful adjuncts in confirming the diagnosis of RCC in cytology specimens...
  30. ncbi request reprint Image-guided biopsy in the evaluation of renal mass lesions in contemporary urological practice: indications, adequacy, clinical impact, and limitations of the pathological diagnosis
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 36:1309-15. 2005
    ..Most biopsies can be classified into clinically relevant categories; however, caution is advised while interpreting oncocytic neoplasms because sampling and tumor heterogeneity may adversely affect interpretation...
  31. pmc Challenges in accurate registration of 3-D medical imaging and histopathology in primary prostate cancer
    Charles Meyer
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    Eur J Nucl Med Mol Imaging 40:S72-8. 2013
    ..Specific registration techniques that facilitate the most difficult part of the registration process--the mapping of pathology onto high-resolution imaging, preferably aided by the ex vivo prostate specimen--are discussed...
  32. ncbi request reprint Utility of cytokeratin 20 and Ki-67 as markers of urothelial dysplasia
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Pathol Int 55:248-54. 2005
    ..In summary, abnormal CK20 is a useful adjunct to morphology for confirming dysplasia. Ki-67 by itself is a less reliable marker of dysplasia. E-Cad is not a useful marker in this setting...
  33. pmc The mutational landscape of lethal castration-resistant prostate cancer
    Catherine S Grasso
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 487:239-43. 2012
    ..In summary, we describe the mutational landscape of a heavily treated metastatic cancer, identify novel mechanisms of AR signalling deregulated in prostate cancer, and prioritize candidates for future study...
  34. ncbi request reprint Diagnostic usefulness of monoclonal antibody P504S in the workup of atypical prostatic glandular proliferations
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Am J Clin Pathol 120:737-45. 2003
    ..Most HGPINs show diffuse moderate P504S staining. AAH may show focal P504S staining. We recommend using P504S along with morphologic examination and conventional basal cell markers...