Mei-Ping Kung

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Novel styrylpyridines as probes for SPECT imaging of amyloid plaques
    Wenchao Qu
    Department of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:2157-65. 2007
  2. ncbi request reprint Characterization of a novel iodinated ligand, IPMPP, for human dopamine D4 receptors expressed in CHO cells
    M P Kung
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Life Sci 60:91-100. 1997
  3. ncbi request reprint Development and evaluation of iodinated tracers targeting amyloid plaques for SPECT imaging
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Mol Neurosci 24:49-53. 2004
  4. ncbi request reprint Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Mol Neurosci 20:15-24. 2003
  5. ncbi request reprint Characterization of radioiodinated ligand binding to amyloid beta plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19014, USA
    J Mol Neurosci 20:249-54. 2003
  6. ncbi request reprint Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305 Philadelphia, PA 19104, United States
    Brain Res 1025:98-105. 2004
  7. ncbi request reprint IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Brain Res 956:202-10. 2002
  8. ncbi request reprint Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Mol Neurosci 19:7-10. 2002
  9. ncbi request reprint Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Eur J Nucl Med Mol Imaging 31:1136-45. 2004
  10. ncbi request reprint 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent
    Hank F Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Med Chem 47:5258-64. 2004

Research Grants

  1. SPECT Imaging of Abeta Plaques in Brain
    Mei Ping Kung; Fiscal Year: 2006

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Novel styrylpyridines as probes for SPECT imaging of amyloid plaques
    Wenchao Qu
    Department of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:2157-65. 2007
    ..Taken together, these results strongly suggest that these styrylpyridines are useful for imaging Abeta plaques in the living human brain...
  2. ncbi request reprint Characterization of a novel iodinated ligand, IPMPP, for human dopamine D4 receptors expressed in CHO cells
    M P Kung
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Life Sci 60:91-100. 1997
    ..In addition, measuring D4 receptor stimulation of [35S]GTPgammaS binding further demonstrated the antagonist property of IPMPP...
  3. ncbi request reprint Development and evaluation of iodinated tracers targeting amyloid plaques for SPECT imaging
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Mol Neurosci 24:49-53. 2004
    ..Only ligands with the promising in vitro and in vivo characteristics such as IMPY will likely warrant their success to be potential imaging agents mapping amyloid plaques in living human brain...
  4. ncbi request reprint Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Mol Neurosci 20:15-24. 2003
    ..Further structural modifications of TZDM to lower the background labeling will be needed to optimize the plaque-labeling property...
  5. ncbi request reprint Characterization of radioiodinated ligand binding to amyloid beta plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19014, USA
    J Mol Neurosci 20:249-54. 2003
    ....
  6. ncbi request reprint Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305 Philadelphia, PA 19104, United States
    Brain Res 1025:98-105. 2004
    ..These properties suggest that when labeled with I-123 or C-11, these two ligands may be useful to quantitate amyloid plaque burdens in the living AD patients...
  7. ncbi request reprint IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Brain Res 956:202-10. 2002
    ....
  8. ncbi request reprint Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Mol Neurosci 19:7-10. 2002
    ..11%.ID at 4 h p.i). Taken together, these data suggest that [125I]3 is useful for in vitro plaque detection, it may not be suitable for in vivo monitoring of A beta progression and deposition...
  9. ncbi request reprint Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Eur J Nucl Med Mol Imaging 31:1136-45. 2004
    ..Taken together, these data indicate that [123I]IMPY is a potentially useful SPECT imaging agent for in vivo labeling of Abeta plaques in the living brain...
  10. ncbi request reprint 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent
    Hank F Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Med Chem 47:5258-64. 2004
    ..These data suggest that [(123)I]4 may be useful for imaging SERT binding sites in the brain by single photon emission computed tomography (SPECT)...
  11. ncbi request reprint New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques
    Rajesh Chandra
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:2415-23. 2007
    ..These preliminary results suggest that the novel diphenylacetylenes may be potentially useful for imaging of Abeta plaques in the brain of patients with Alzheimer's disease...
  12. ncbi request reprint 18F-labeled styrylpyridines as PET agents for amyloid plaque imaging
    Wei Zhang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:89-97. 2007
    ..These preliminary results suggest that novel PET tracers may be potentially useful for the imaging of Abeta plaques in the living human brain...
  13. ncbi request reprint F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Abeta aggregates in the brain
    Wei Zhang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 32:799-809. 2005
    ..In conclusion, the preliminary results strongly suggest these fluorinated PEG stilbene derivatives are suitable candidates as Abeta plaque imaging agents for studying patients with Alzheimer's disease...
  14. pmc Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:239-46. 2007
    ..From these findings, we conclude that [(18)F]FP-(+)-DTBZ is a sensitive and selective tracer for VMAT2 binding sites and it may be useful for in vivo evaluation of diseases relating to changes of monoamine neuronal integrity...
  15. pmc 2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents
    Ajit K Parhi
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    J Med Chem 50:6673-84. 2007
    ....
  16. pmc 2-(2'-((Dimethylamino)methyl)-4'-(3-[(18)F]fluoropropoxy)-phenylthio)benzenamine for positron emission tomography imaging of serotonin transporters
    Julie L Wang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nucl Med Biol 35:447-58. 2008
    ..A new (18)F ligand, 2-(2'-((dimethylamino)methyl)-4'-(3-[(18)F]fluoropropoxy)-phenylthio)benzenamine ([(18)F]1), for positron emission tomography (PET) imaging of serotonin transporters (SERT) was evaluated...
  17. pmc Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 17:3581-4. 2007
    ..Taken together, these preliminary results strongly suggest that these novel iodinated aza-diphenylacetylenes may be potentially useful for imaging Abeta plaques in the living human brain...
  18. ncbi request reprint Dimethylamino-fluorenes: ligands for detecting beta-amyloid plaques in the brain
    Chi Wan Lee
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 30:573-80. 2003
    ..When [(125)I]2f was injected intravenously into normal mice, it exhibited an excellent brain uptake. Taken together the data suggest that [(125)I]2f may be useful as an in vivo imaging agent to detect Abeta plaques in the brain...
  19. doi request reprint In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 49:1171-6. 2008
    ..In this article, 9-fluoropropyl-(+)-dihydrotetrabenazine (FP-(+)-DTBZ), which is a VMAT2 imaging agent, was evaluated as a PET agent for estimating BCM in vivo...
  20. pmc F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain
    Wei Zhang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 48:5980-8. 2005
    ..In conclusion, the preliminary results strongly suggest that these fluorinated stilbene derivatives, [18F]3e and [18F]4e, are suitable candidates as Abeta plaque imaging agents for studying patients with AD...
  21. pmc Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for beta-amyloid plaques
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 18:4823-7. 2008
    ..These preliminary results identified that indolylphenylacetylene, 14, may be a good lead for further structural modification to develop a useful Abeta plaque imaging agent...
  22. pmc Fluoro-pegylated (FPEG) imaging agents targeting Abeta aggregates
    Karin A Stephenson
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, Pennsylvania 19104, USA
    Bioconjug Chem 18:238-46. 2007
    ..This approach appears to be effective in some core structures, but it cannot be uniformly applied to all structures...
  23. ncbi request reprint 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease
    Masahiro Ono
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 30:565-71. 2003
    ....
  24. ncbi request reprint Biphenyls labeled with technetium 99m for imaging beta-amyloid plaques in the brain
    Zhi Ping Zhuang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 32:171-84. 2005
    ..Caution should be taken when comparing these 99mTc complexes with the corresponding surrogates--the Re complexes...
  25. ncbi request reprint Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain
    Zhi Ping Zhuang
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 46:237-43. 2003
    ..Taken together, the data suggests that [123I]16(IMPY) may be useful for imaging A beta aggregates in patients with Alzheimer's disease...
  26. ncbi request reprint Occupancy of dopamine D2 receptors in the mouse brain measured using ultra-high-resolution single-photon emission tomography and [123]IBF
    Paul D Acton
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia 19104, USA
    Eur J Nucl Med Mol Imaging 29:1507-15. 2002
    ..03 mg/kg using a single receptor site saturation model. This study has demonstrated clearly that ultra-high-resolution SPET of small animals is capable of measuring displacement and occupancy of dopamine D2 receptors by competing ligands...
  27. pmc 5-Chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine: a new serotonin transporter ligand
    Shunichi Oya
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:129-39. 2007
    ..The excellent selective uptake and retention in the hypothalamus region suggest that [(123)I]7 is a potential lead compound for developing new imaging agents targeting SERT-binding sites with single-photon emission computed tomography...
  28. pmc Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain
    Michael R Kilbourn
    Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA
    Nucl Med Biol 34:233-7. 2007
    ....
  29. pmc (R)-N-Methyl-3-(3-(125)I-pyridin-2-yloxy)-3-phenylpropan-1-amine: a novel probe for norepinephrine transporters
    Balagopal Lakshmi
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 35:43-52. 2008
    ..Preliminary results suggest that this improved iodinated ligand, when labeled with (123)I, may be useful for mapping NET-binding sites with single photon emission computed tomography in the living human brain...
  30. ncbi request reprint Safety, biodistribution, and dosimetry of 123I-IMPY: a novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Nucl Med 47:748-54. 2006
    ..The pharmacologic safety profile of the compound was simultaneously assessed...
  31. pmc A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent
    Karl Plossl
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 35:83-90. 2008
    ..In conclusion, the new N(2)S(2) ligand was readily prepared and labeled with radioactive (67)Ga. Biodistribution in rats revealed high initial heart uptake and relatively high retention reflecting regional myocardial perfusion...
  32. pmc Quick assembly of 1,4-diphenyltriazoles as probes targeting beta-amyloid aggregates in Alzheimer's disease
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:3380-7. 2007
    ....
  33. pmc Synthesis of biphenyltrienes as probes for beta-amyloid plaques
    Zhi Ping Zhuang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 49:2841-4. 2006
    ..When labeled with suitable radionuclides, they are useful as in vivo imaging agents for detecting Abeta plaques in the brains of Alzheimer's patients...
  34. ncbi request reprint Selective binding of 2-[125I]iodo-nisoxetine to norepinephrine transporters in the brain
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 31:533-41. 2004
    ..The specific brain localization was significantly reduced by a dose of nisoxetine pretreatment. Taken together, the data suggest that [(123)I]2-INXT may be useful for mapping NET binding sites in the brain...
  35. ncbi request reprint Benzofuran derivatives as Abeta-aggregate-specific imaging agents for Alzheimer's disease
    Masahiro Ono
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 29:633-42. 2002
    ..Additional modifications are necessary to improve the in vivo imaging properties for plaque detection...
  36. ncbi request reprint Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker
    Catherine Hou
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 33:203-9. 2006
    ..Further modification of the ligand and the imaging parameters will be needed to improve the signal for in vivo detection...
  37. ncbi request reprint Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters
    Rajesh Goswami
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 33:685-94. 2006
    ..Further studies are warranted to assess the utility of these (18)F-labeled DTBZ derivatives as PET tracers for the diagnosis of various neurodegenerative diseases...
  38. ncbi request reprint Mass effect of injected dose in small rodent imaging by SPECT and PET
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, 19104, USA
    Nucl Med Biol 32:673-8. 2005
    ..When using small animal imaging for studying drug occupancy (either by a pretreatment, coinjection or chasing dose), the mass effects on imaging outcome are important factors for consideration...
  39. ncbi request reprint Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging
    Rajesh Chandra
    Department of Radiology, University of Pennsylvania, Room 305, 3700 Market Street, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 16:1350-2. 2006
    ..These compounds may be useful for the development of novel PET tracers for the imaging of beta-amyloid plaques in the brain of patients with Alzheimer's disease...
  40. ncbi request reprint A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114
    Adam S Crystal
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurochem 86:1359-68. 2003
    ....
  41. ncbi request reprint Radiopharmaceuticals for single-photon emission computed tomography brain imaging
    Hank F Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Nucl Med 33:2-13. 2003
    ..Development of (99m)Tc agents will likely extend the application of site-specific brain radiopharmaceuticals for routine applications in aiding the diagnosis and monitoring treatments of various neurologic and psychiatric disorders...
  42. ncbi request reprint Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT
    Hank F Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:787-9. 2007
    ..The trials and tribulations of developing [99mTc]TRODAT for routine clinical use in Taiwan provide an interesting case study in how to (critics may say, how not to) develop a molecular imaging agent...
  43. ncbi request reprint Ultra-high resolution single photon emission tomography imaging of the mouse striatum
    Paul D Acton
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Nucl Med Mol Imaging 29:446. 2002
  44. ncbi request reprint Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains
    Masahiro Ono
    Department of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Med Chem 49:2725-30. 2006
    ..Taken together, the data suggest that a relatively simple benzofuran derivative, [(11)C]8, may be a useful candidate PET tracer for detecting amyloid plaques in the brains of patients with Alzheimer's disease...
  45. doi request reprint Synthesis and screening of a library of Re/Tc-based amyloid probes derived from beta-breaker peptides
    Karin A Stephenson
    Department of Chemistry, McMaster University, Hamilton, ON, Canada
    Bioconjug Chem 19:1087-94. 2008
    ..For one of these leads, the (99m)Tc analogue was synthesized and the product showed high stability toward histidine and cysteine challenges, making it a viable candidate for in vivo biodistribution studies...
  46. doi request reprint IMPY, a potential beta-amyloid imaging probe for detection of prion deposits in scrapie-infected mice
    Pu Jiao Song
    INSERM, U619, F 37000 Tours, France
    Nucl Med Biol 35:197-201. 2008
    ....
  47. ncbi request reprint In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
    Nicolaas P L G Verhoeff
    Vivian Rakoff PET Centre, Centre for Addiction and Mental Health, Ontario, Canada
    Am J Geriatr Psychiatry 12:584-95. 2004
    ..The authors' aim was to develop a novel Abeta-specific positron-emission tomography (PET) tracer...
  48. ncbi request reprint Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Med Chem 47:2208-18. 2004
    ....
  49. ncbi request reprint Congo red and thioflavin-T analogs detect Abeta oligomers
    Izumi Maezawa
    M I N D Institute and Department of Pathology, University of California Davis, Sacramento, California 95817, USA
    J Neurochem 104:457-68. 2008
    ..We propose that by improving the binding affinity of current ligands, in vivo imaging of AbetaO is feasible by a 'signal subtraction' procedure. This approach may facilitate the identification of individuals with early AD...
  50. ncbi request reprint Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease
    Masahiro Ono
    Department of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8521, Japan
    Nucl Med Biol 32:329-35. 2005
    ..Taken together, the data suggest that the new radio tracer, [125I], may be useful as a radioiodinated imaging agent for mapping A beta plaques in the brains of patients with AD...

Research Grants1

  1. SPECT Imaging of Abeta Plaques in Brain
    Mei Ping Kung; Fiscal Year: 2006
    ..The At3-plaque-specific imaging agents will be useful for early detection or monitoring the progression and effectiveness of treatment of AD. ..