SAMUEL KUNA

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Agreement in computer-assisted manual scoring of polysomnograms across sleep centers
    Samuel T Kuna
    Department of Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, USA
    Sleep 36:583-9. 2013
  2. pmc Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes
    Samuel T Kuna
    University of Pennsylvania, Philadelphia, PA, USA
    Sleep 36:641-649A. 2013
  3. pmc Heritability of performance deficit accumulation during acute sleep deprivation in twins
    Samuel T Kuna
    Department of Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, USA
    Sleep 35:1223-33. 2012
  4. ncbi request reprint Portable-monitor testing: an alternative strategy for managing patients with obstructive sleep apnea
    Samuel T Kuna
    Pulmonary, Allergy, Critical Care, and Sleep Section, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Respir Care 55:1196-215. 2010
  5. pmc Effect of progressive mandibular advancement on pharyngeal airway size in anesthetized adults
    Samuel T Kuna
    Department of Medicine, University of Pennsylvania and Pulmonary, Philadelphia Veterans Administration Medical Center 111P, 3900 Woodland Avenue, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 109:605-12. 2008
  6. ncbi request reprint Evaluation of an oral mandibular advancement titration appliance
    Samuel T Kuna
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:593-603. 2006
  7. ncbi request reprint Respiratory-related activation and mechanical effects of the pharyngeal constrictor muscles
    S T Kuna
    Pulmonary, Critical Care and Sleep Section, Department of Internal Medicine, Philadelphia Veterans Affairs Medical Center 111P, University of Pennsylvania, University and Woodland Avenue, Philadelphia, PA, USA
    Respir Physiol 119:155-61. 2000
  8. ncbi request reprint A 54-year-old man with obstructive sleep apnea
    Samuel T Kuna
    Pulmonary, Critical Care, Sleep Section, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    JAMA 288:2032-9. 2002
  9. ncbi request reprint Effects of pharyngeal muscle activation on airway pressure-area relationships
    Samuel T Kuna
    Pulmonary, Allergy, and Critical Care Division, Department of Internal Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA, USA
    Am J Respir Crit Care Med 166:972-7. 2002
  10. ncbi request reprint Regional effects of selective pharyngeal muscle activation on airway shape
    Samuel T Kuna
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 169:1063-9. 2004

Detail Information

Publications27

  1. pmc Agreement in computer-assisted manual scoring of polysomnograms across sleep centers
    Samuel T Kuna
    Department of Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, USA
    Sleep 36:583-9. 2013
    ..To determine intersite agreement in respiratory event scoring of polysomnograms (PSGs) using different hypopnea definitions...
  2. pmc Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes
    Samuel T Kuna
    University of Pennsylvania, Philadelphia, PA, USA
    Sleep 36:641-649A. 2013
    ..To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years...
  3. pmc Heritability of performance deficit accumulation during acute sleep deprivation in twins
    Samuel T Kuna
    Department of Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, USA
    Sleep 35:1223-33. 2012
    ....
  4. ncbi request reprint Portable-monitor testing: an alternative strategy for managing patients with obstructive sleep apnea
    Samuel T Kuna
    Pulmonary, Allergy, Critical Care, and Sleep Section, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Respir Care 55:1196-215. 2010
    ..The cost-effectiveness of portable-monitor testing and its potential to improve patient access to diagnosis and treatment requires further investigation...
  5. pmc Effect of progressive mandibular advancement on pharyngeal airway size in anesthetized adults
    Samuel T Kuna
    Department of Medicine, University of Pennsylvania and Pulmonary, Philadelphia Veterans Administration Medical Center 111P, 3900 Woodland Avenue, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 109:605-12. 2008
    ..The purpose of this study was to determine the effect of progressive mandibular advancement on pharyngeal airway size in normal adults during intravenous infusion of propofol for anesthesia...
  6. ncbi request reprint Evaluation of an oral mandibular advancement titration appliance
    Samuel T Kuna
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:593-603. 2006
    ..To determine whether a manually adjustable oral mandibular advancement titration appliance (EMA-T) predicts successful long-term treatment with an oral mandibular advancement appliance (MAA)...
  7. ncbi request reprint Respiratory-related activation and mechanical effects of the pharyngeal constrictor muscles
    S T Kuna
    Pulmonary, Critical Care and Sleep Section, Department of Internal Medicine, Philadelphia Veterans Affairs Medical Center 111P, University of Pennsylvania, University and Woodland Avenue, Philadelphia, PA, USA
    Respir Physiol 119:155-61. 2000
    ..These results suggest that PC muscle activation at the end of an apneic episode, when airway volume is relatively low, may help restore airway patency in patients with obstructive sleep apnea...
  8. ncbi request reprint A 54-year-old man with obstructive sleep apnea
    Samuel T Kuna
    Pulmonary, Critical Care, Sleep Section, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    JAMA 288:2032-9. 2002
  9. ncbi request reprint Effects of pharyngeal muscle activation on airway pressure-area relationships
    Samuel T Kuna
    Pulmonary, Allergy, and Critical Care Division, Department of Internal Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA, USA
    Am J Respir Crit Care Med 166:972-7. 2002
    ..The results indicate that the mechanical effects of pharyngeal muscle activation depend not only on the region and muscles activated but also on the intraluminal pressure...
  10. ncbi request reprint Regional effects of selective pharyngeal muscle activation on airway shape
    Samuel T Kuna
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 169:1063-9. 2004
    ....
  11. ncbi request reprint Effects of pharyngeal muscle activation on airway size and configuration
    S T Kuna
    Department of Internal Medicine, University of Pennsylvania and Philadelphia VAMC, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 164:1236-41. 2001
    ..The results indicate that the mechanical effects of pharyngeal muscle contraction depend on the airway level and the specific muscles that are activated...
  12. pmc Phasic respiratory pharyngeal mechanics by magnetic resonance imaging in lean and obese zucker rats
    Michael J Brennick
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 173:1031-7. 2006
    ..Although obstructive sleep apnea is strongly associated with obesity, we have little understanding of how obesity may alter the mechanical properties of the pharynx and the role of obesity in the pathogenesis of sleep apnea...
  13. pmc Respiratory modulation of the pharyngeal airway in lean and obese mice
    Michael J Brennick
    Department of Medicine, School of Medicine, University of Pennsylvania, 3624 Market St, Philadelphia, PA, United States
    Respir Physiol Neurobiol 175:296-302. 2011
    ..The data support an hypothesis that pharyngeal airway patency in obesity is dependent on inspiratory dilation and may be vulnerable to loss of neuromuscular pharyngeal activation...
  14. pmc Pharyngeal airway wall mechanics using tagged magnetic resonance imaging during medial hypoglossal nerve stimulation in rats
    Michael J Brennick
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Physiol 561:597-610. 2004
    ..The results reveal that the increase in pharyngeal airway size resulting from stimulation of the medial branch of the hypoglossal nerve is predominantly due to ventral displacement of the ventral and lateral pharyngeal walls...
  15. pmc Covariates of craving in actively drinking alcoholics
    Subhajit Chakravorty
    Veterans Integrated Service Network, Mental Illness Research, Education and Clinical Center, Philadelphia V A Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Addict 19:450-7. 2010
    ..The results from this study suggest that alcohol craving is a complex phenomenon influenced by multiple factors...
  16. doi request reprint Ambulatory management of patients with sleep apnea: is there a place for portable monitor testing?
    Bernie Sunwoo
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, 844 West Gates, Philadelphia, PA 19104, USA
    Clin Chest Med 31:299-308. 2010
    ..Whether ambulatory management is cost-effective and will improve patient access to diagnosis and treatment requires further investigation...
  17. pmc Differences in perceptions of the diagnosis and treatment of obstructive sleep apnea and continuous positive airway pressure therapy among adherers and nonadherers
    Amy M Sawyer
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Qual Health Res 20:873-92. 2010
    ..Our findings suggest opportunities for developing and testing tailored interventions to promote CPAP use...
  18. pmc Neighborhood of residence is associated with daily adherence to CPAP therapy
    Alec B Platt
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center Philadelphia, PA, USA
    Sleep 32:799-806. 2009
    ..Risk factors for nonadherence are not well understood but may reflect individual or neighborhood socioeconomic factors. We sought to determine the association of socioeconomic status and initial CPAP adherence...
  19. pmc A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study
    Gary D Foster
    Center for Obesity Research and Education, Temple University, 3223 N Broad St, Ste 175, Philadelphia, PA 19140, USA
    Arch Intern Med 169:1619-26. 2009
    ..The belief that weight loss improves obstructive sleep apnea (OSA) has limited empirical support. The purpose of this 4-center study was to assess the effects of weight loss on OSA over a 1-year period...
  20. pmc Adherence to sleep apnea therapy and use of lipid-lowering drugs: a study of the healthy-user effect
    Alec B Platt
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Chest 137:102-8. 2010
    ..This association may be confounded if CPAP adherents are healthier in ways not measured by investigators. We assessed whether patients adhering to lipid-lowering medications were more adherent to CPAP...
  21. pmc Obstructive sleep apnea among obese patients with type 2 diabetes
    Gary D Foster
    Temple University, Philadelphia, Pennsylvania, USA
    Diabetes Care 32:1017-9. 2009
    ..To assess the risk factors for the presence and severity of obstructive sleep apnea (OSA) among obese patients with type 2 diabetes...
  22. pmc Validation of a novel device to objectively measure adherence to long-term oxygen therapy
    Sun Kai V Lin
    Department of Bioengineering, University of Pennsylvania, Philadelphia 19104, USA
    Int J Chron Obstruct Pulmon Dis 3:435-42. 2008
    ..We have developed a novel oxygen adherence monitor that objectively measures patient use of long-term oxygen therapy. The monitor attaches to the oxygen source and detects whether or not the patient is wearing the nasal cannula...
  23. ncbi request reprint A novel device for measuring long-term oxygen therapy adherence: a preliminary validation
    Sun Kai V Lin
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Respir Care 51:266-71. 2006
    ..We have developed a novel oxygen-adherence monitor to address these limitations, and this report introduces the monitor and provides preliminary data validating its use...
  24. ncbi request reprint Can continuous positive airway pressure be self-titrated?
    Samuel T Kuna
    Am J Respir Crit Care Med 167:674-5. 2003
  25. ncbi request reprint Cognitive impairment in patients with traumatic brain injury and obstructive sleep apnea
    Mark C Wilde
    University of Texas Health Science Center, Houston, TX 77030, USA
    Arch Phys Med Rehabil 88:1284-8. 2007
    ..To examine the impact of comorbid obstructive sleep apnea (OSA) on the cognitive functioning of traumatic brain injury (TBI) patients...
  26. pmc Prevalence and consequences of sleep disorders in traumatic brain injury
    Richard J Castriotta
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Texas Health Science Center at Houston, TX 77030, USA
    J Clin Sleep Med 3:349-56. 2007
    ..Determine prevalence and consequences of sleepiness and sleep disorders after traumatic brain injury (TBI)...
  27. ncbi request reprint Access to diagnosis and treatment of patients with suspected sleep apnea
    W Ward Flemons
    Faculty of Medicine, University of Calgary, Alberta, Canada
    Am J Respir Crit Care Med 169:668-72. 2004

Research Grants11

  1. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 2003
    ..This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania. ..
  2. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2003
    ....
  3. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 1999
    ..This close correlation in responses will allow an exploration in animal experiments of the possible mechanisms underlying observations made in humans. ..
  4. Research Priorities in Ambulatory Management of Obstructive Sleep Apnea Workshop
    SAMUEL KUNA; Fiscal Year: 2007
    ..We submit that this workshop is an essential ?next step? to ensuring that there is substantive advancement of scientific knowledge in this important field. ..