Sanjay Kumar

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Cell-matrix mechanobiology: applications to brain tumors and design of tissue engineering scaffolds
    Sanjay Kumar
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3350-2. 2009
  2. pmc Contractility dominates adhesive ligand density in regulating cellular de-adhesion and retraction kinetics
    Shamik Sen
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Ann Biomed Eng 39:1163-73. 2011
  3. pmc From molecular signal activation to locomotion: an integrated, multiscale analysis of cell motility on defined matrices
    Amit Pathak
    Department of Bioengineering, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e18423. 2011
  4. pmc Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology
    Shamik Sen
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 4:e8427. 2009
  5. pmc Imaging and manipulating the structural machinery of living cells on the micro- and nanoscale
    Matthew G Chown
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Int J Nanomedicine 2:333-44. 2007
  6. pmc Mechanics, malignancy, and metastasis: the force journey of a tumor cell
    Sanjay Kumar
    Department of Bioengineering, University of California, Berkeley, USA
    Cancer Metastasis Rev 28:113-27. 2009
  7. pmc Biophysical mechanisms of single-cell interactions with microtopographical cues
    Anuj A Patel
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Biomed Microdevices 12:287-96. 2010
  8. pmc The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells
    Theresa A Ulrich
    Department of Bioengineering, University of California Berkeley and University of California San Francisco University of California Berkeley Joint Graduate Group in Bioengineering, Berkeley, CA 94720 1762, USA
    Cancer Res 69:4167-74. 2009
  9. doi request reprint Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices
    Theresa A Ulrich
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Biomaterials 31:1875-84. 2010
  10. pmc Vinculin tension distributions of individual stress fibers within cell-matrix adhesions
    Ching Wei Chang
    Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    J Cell Sci 126:3021-30. 2013

Research Grants

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Cell-matrix mechanobiology: applications to brain tumors and design of tissue engineering scaffolds
    Sanjay Kumar
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3350-2. 2009
    ....
  2. pmc Contractility dominates adhesive ligand density in regulating cellular de-adhesion and retraction kinetics
    Shamik Sen
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Ann Biomed Eng 39:1163-73. 2011
    ..These results support the use of cellular de-adhesion measurements to track cellular mechanical properties...
  3. pmc From molecular signal activation to locomotion: an integrated, multiscale analysis of cell motility on defined matrices
    Amit Pathak
    Department of Bioengineering, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e18423. 2011
    ....
  4. pmc Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology
    Shamik Sen
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 4:e8427. 2009
    ....
  5. pmc Imaging and manipulating the structural machinery of living cells on the micro- and nanoscale
    Matthew G Chown
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Int J Nanomedicine 2:333-44. 2007
    ....
  6. pmc Mechanics, malignancy, and metastasis: the force journey of a tumor cell
    Sanjay Kumar
    Department of Bioengineering, University of California, Berkeley, USA
    Cancer Metastasis Rev 28:113-27. 2009
    ....
  7. pmc Biophysical mechanisms of single-cell interactions with microtopographical cues
    Anuj A Patel
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Biomed Microdevices 12:287-96. 2010
    ..Together, our data support a model in which microtopographical cues alter the local mechanical microenvironment of cells by modulating adhesion and adhesion-dependent mechanotransductive signaling...
  8. pmc The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells
    Theresa A Ulrich
    Department of Bioengineering, University of California Berkeley and University of California San Francisco University of California Berkeley Joint Graduate Group in Bioengineering, Berkeley, CA 94720 1762, USA
    Cancer Res 69:4167-74. 2009
    ..Collectively, our results provide support for a novel model in which ECM rigidity provides a transformative, microenvironmental cue that acts through actomyosin contractility to regulate the invasive properties of GBM tumor cells...
  9. doi request reprint Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices
    Theresa A Ulrich
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Biomaterials 31:1875-84. 2010
    ..Our results are consistent with a model in which agarose shifts ECM dissipation of cell-induced stresses from non-affine deformation of individual collagen fibers to bulk-affine deformation of a continuum network...
  10. pmc Vinculin tension distributions of individual stress fibers within cell-matrix adhesions
    Ching Wei Chang
    Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    J Cell Sci 126:3021-30. 2013
    ....
  11. pmc Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform
    Badriprasad Ananthanarayanan
    Department of Bioengineering and California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA
    Biomaterials 32:7913-23. 2011
    ..This material system represents a brain-mimetic model ECM with tunable ligand density and stiffness amenable to investigations of the mechanobiological regulation of brain tumor progression...
  12. pmc Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery
    Kandice Tanner
    Lawrence Berkeley National Laboratory, University of California, Berkeley, California, USA
    Biophys J 99:2775-83. 2010
    ..They also suggest that some fibers can absorb components and assume mechanical roles of other fibers to stabilize cell shape...
  13. pmc Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration
    Amit Pathak
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Integr Biol (Camb) 5:1067-75. 2013
    ..These results demonstrate that oncogenic lesions and ECM biophysical properties can synergistically interact to drive invasive migration, and that both inputs may act through common molecular mechanisms to enhance migration speed. ..
  14. pmc Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells
    Albert J Keung
    Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA
    Integr Biol (Camb) 4:1049-58. 2012
    ..These findings further highlight important differences between mESCs and hPSCs and have implications for both the design of future biomaterials as well as our understanding of early embryonic development...
  15. ncbi request reprint Biophysics and dynamics of natural and engineered stem cell microenvironments
    Albert J Keung
    Department of Chemical Engineering, University of California, Berkeley, CA, USA
    Wiley Interdiscip Rev Syst Biol Med 2:49-64. 2010
    ....
  16. pmc A genetic strategy for the dynamic and graded control of cell mechanics, motility, and matrix remodeling
    Joanna L MacKay
    Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, USA
    Biophys J 102:434-42. 2012
    ....
  17. pmc Combining mechanical and optical approaches to dissect cellular mechanobiology
    Shamik Sen
    Department of Bioengineering, 274A Stanley Hall 1762, University of California, Berkeley, CA 94720 1762, USA
    J Biomech 43:45-54. 2010
    ..Together, these studies demonstrate how single-cell biomechanical tools can be effectively combined with molecular imaging technologies for elucidating mechanotransduction processes and identifying mechanosensitive proteins...
  18. pmc Independent regulation of tumor cell migration by matrix stiffness and confinement
    Amit Pathak
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Proc Natl Acad Sci U S A 109:10334-9. 2012
    ..These studies represent a paradigm for investigating matrix regulation of invasion and demonstrate that matrix confinement alters the relationship between cell migration speed and ECM stiffness...
  19. doi request reprint Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells
    Albert J Keung
    Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720 3220, USA
    Stem Cells 29:1886-97. 2011
    ..These results establish Rho GTPase-based mechanotransduction and cellular stiffness as biophysical regulators of NSC fate in vitro and RhoA as an important regulatory protein in the hippocampal stem cell niche...
  20. pmc Contributions of talin-1 to glioma cell-matrix tensional homeostasis
    Shamik Sen
    Department of Bioengineering, University of California, 274A Stanley Hall no 1762, Berkeley, CA 94720, USA
    J R Soc Interface 9:1311-7. 2012
    ..Together, these data support a role for talin-1 in the maintenance of tensional homeostasis in GBM and suggest a functional role for enriched talin expression in this tumour...
  21. pmc Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression
    Wilbur A Lam
    Department of Bioengineering, University of California, Berkeley, CA, USA
    Mol Cancer 9:35. 2010
    ....
  22. doi request reprint Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues
    Albert J Keung
    Department of Chemical Engineering, University of California, Berkeley, California, 94720, USA
    Annu Rev Cell Dev Biol 26:533-56. 2010
    ....
  23. ncbi request reprint Contractility-dependent modulation of cell proliferation and adhesion by microscale topographical cues
    Rahul G Thakar
    Department of Physiology, University of California, San Francisco 203C Byers Hall Box 2520, 1700 4th Street San Francisco, CA 94158 2330, USA
    Small 4:1416-24. 2008
    ..Together, our results support a model in which cell fate decisions may be directly manipulated within tissue engineering scaffolds by the inclusion of microtopographical structures that alter cellular mechanics...
  24. doi request reprint Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness
    Amit Pathak
    Department of Bioengineering, University of California, Berkeley, CA, USA
    Integr Biol (Camb) 3:267-78. 2011
    ....
  25. pmc Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive
    Albert J Keung
    Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA
    Sci Rep 3:1817. 2013
    ....
  26. pmc Microscale mechanisms of agarose-induced disruption of collagen remodeling
    Theresa A Ulrich
    Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Biomaterials 32:5633-42. 2011
    ..These findings provide new mechanistic insights into the regulatory function of agarose and bear general implications for cell adhesion and motility in fibrous ECMs...
  27. pmc Microenvironmental stiffness enhances glioma cell proliferation by stimulating epidermal growth factor receptor signaling
    Vaibhavi Umesh
    Department of Bioengineering, University of California, Berkeley, California, United States of America
    PLoS ONE 9:e101771. 2014
    ..Our findings collectively support a model in which tissue stiffening promotes GBM proliferation by spatially and biochemically amplifying EGFR signaling. ..
  28. doi request reprint Measuring the elastic properties of living cells with atomic force microscopy indentation
    Joanna L MacKay
    Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA
    Methods Mol Biol 931:313-29. 2013
    ..Our protocol is written specifically for the BioScopeâ„¢ Catalystâ„¢ AFM system (Bruker AXS Inc.); however, most of the general concepts can be readily translated to other commercial systems...
  29. ncbi request reprint A composite hydrogel platform for the dissection of tumor cell migration at tissue interfaces
    Andrew D Rape
    Department of Bioengineering, University of California, Berkeley, United States
    Biomaterials 35:8846-53. 2014
    ....
  30. pmc Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility
    Joanna L MacKay
    Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, California 94720, USA
    Soft Matter 10:2372-80. 2014
    ....
  31. ncbi request reprint Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors
    Fanny A Pelissier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA Center for Cancer Biomarkers, Department of Biomedicine, University of Bergen, Bergen 5009, Norway
    Cell Rep 7:1926-39. 2014
    ..Thus, aging phenotypes of mammary epithelia may arise partly because alterations in Hippo pathway activation impair microenvironment-directed differentiation and lineage specificity...
  32. pmc A fluorescent peroxidase probe increases the sensitivity of commercial ELISAs by two orders of magnitude
    Abhinav P Acharya
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Chem Commun (Camb) 49:10379-81. 2013
    ....
  33. doi request reprint Ordered and disordered proteins as nanomaterial building blocks
    Nithya Srinivasan
    Department of Bioengineering, University of California, Berkeley, CA, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:204-18. 2012
    ..A key theme throughout the review is that specific environmental stimuli can trigger protein conformational changes, which in turn can alter macroscopic material properties and function...

Research Grants1

  1. Intermediate filament control of neuronal mechanics
    Sanjay Kumar; Fiscal Year: 2005
    ..abstract_text> ..