Ashok Kumar

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice
    Ashwani Mittal
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cell Biol 188:833-49. 2010
  2. pmc Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice
    Pradyut K Paul
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cell Biol 191:1395-411. 2010
  3. pmc Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells
    Shephali Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 5:e13262. 2010
  4. pmc Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice
    Siva K Panguluri
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 5:e8760. 2010
  5. pmc Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program
    Sajedah M Hindi
    2Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston St, Louisville, KY 40202, USA
    FASEB J 28:1398-411. 2014
  6. pmc TWEAK and TRAF6 regulate skeletal muscle atrophy
    Ashok Kumar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Curr Opin Clin Nutr Metab Care 15:233-9. 2012
  7. pmc The TWEAK-Fn14 system: breaking the silence of cytokine-induced skeletal muscle wasting
    S Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Curr Mol Med 12:3-13. 2012
  8. pmc Genetic ablation of TWEAK augments regeneration and post-injury growth of skeletal muscle in mice
    Ashwani Mittal
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 177:1732-42. 2010
  9. pmc TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1
    Mukesh Kumar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 182:2439-48. 2009
  10. pmc Matrix metalloproteinase inhibitor batimastat alleviates pathology and improves skeletal muscle function in dystrophin-deficient mdx mice
    Akhilesh Kumar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Am J Pathol 177:248-60. 2010

Research Grants

  1. Role of TWEAK in Skeletal Muscle Metabolism
    Ashok Kumar; Fiscal Year: 2007
  2. Role of TWEAK in Skeletal Muscle Metabolism
    Ashok Kumar; Fiscal Year: 2009
  3. Role of TWEAK in Skeletal Muscle Metabolism
    Ashok Kumar; Fiscal Year: 2010

Collaborators

Detail Information

Publications30

  1. pmc The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice
    Ashwani Mittal
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cell Biol 188:833-49. 2010
    ..This study reveals a novel mediator of skeletal muscle atrophy and indicates that the TWEAK-Fn14 system is an important target for preventing skeletal muscle wasting...
  2. pmc Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice
    Pradyut K Paul
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cell Biol 191:1395-411. 2010
    ..This study unveils a novel mechanism of skeletal muscle atrophy and suggests that TRAF6 is an important therapeutic target to prevent skeletal muscle wasting...
  3. pmc Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells
    Shephali Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 5:e13262. 2010
    ..However, the underpinning molecular mechanisms by which TNF-α causes skeletal muscle wasting are less well-understood...
  4. pmc Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice
    Siva K Panguluri
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 5:e8760. 2010
    ..However, the role of miRs in skeletal muscle wasting is unknown...
  5. pmc Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program
    Sajedah M Hindi
    2Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston St, Louisville, KY 40202, USA
    FASEB J 28:1398-411. 2014
    ..Overexpression of PGC-1α not only blocks the TWEAK-induced atrophy program but also diminishes the expression of Fn14 in denervated skeletal muscle...
  6. pmc TWEAK and TRAF6 regulate skeletal muscle atrophy
    Ashok Kumar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Curr Opin Clin Nutr Metab Care 15:233-9. 2012
    ..To discuss the roles and mechanisms of action of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in skeletal muscle atrophy...
  7. pmc The TWEAK-Fn14 system: breaking the silence of cytokine-induced skeletal muscle wasting
    S Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Curr Mol Med 12:3-13. 2012
    ....
  8. pmc Genetic ablation of TWEAK augments regeneration and post-injury growth of skeletal muscle in mice
    Ashwani Mittal
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 177:1732-42. 2010
    ..Collectively, our study suggests that TWEAK negatively regulates muscle regeneration and that TWEAK is a potential therapeutic target to enhance skeletal muscle regeneration in vivo...
  9. pmc TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1
    Mukesh Kumar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 182:2439-48. 2009
    ..Collectively, our study demonstrates that TAK1 and Akt are the important components of TWEAK-induced proinflammatory signaling and gene expression...
  10. pmc Matrix metalloproteinase inhibitor batimastat alleviates pathology and improves skeletal muscle function in dystrophin-deficient mdx mice
    Akhilesh Kumar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Am J Pathol 177:248-60. 2010
    ..Our study provides the novel evidence that the expression of MMPs is atypically increased in DMD, that their inhibition ameliorates pathogenesis, and that batimastat could prove to be a significant candidate for DMD therapy...
  11. pmc Reciprocal interaction between TRAF6 and notch signaling regulates adult myofiber regeneration upon injury
    Sajedah M Hindi
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Mol Cell Biol 32:4833-45. 2012
    ..Collectively, our study demonstrates that specific inhibition of TRAF6 improves satellite cell activation and skeletal muscle regeneration through upregulation of Notch signaling and reducing the inflammatory repertoire...
  12. pmc Transforming growth factor-beta-activated kinase 1 is an essential regulator of myogenic differentiation
    Shephali Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Biol Chem 285:6401-11. 2010
    ..Insulin growth factor 1-induced myogenic differentiation was also found to involve TAK1. Collectively, our results suggest that TAK1 is an important upstream regulator of skeletal muscle cell differentiation...
  13. doi request reprint TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases
    Shephali Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Physiol 227:1042-51. 2012
    ..Collectively, the present study provides novel insight into the mechanisms of action of TWEAK in skeletal muscle...
  14. pmc Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of
    Hong Li
    Departments of Anatomical Sciences and Neurobiology and Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Biol Chem 284:4439-50. 2009
    ..The study unveils a novel mechanism of skeletal muscle tissue destruction in pathological conditions...
  15. pmc The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms
    Pradyut K Paul
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Mol Cell Biol 32:1248-59. 2012
    ..Finally, our results also identify lysine 63-linked autoubiquitination of TRAF6 as a process essential for its regulatory role in starvation-induced muscle atrophy...
  16. pmc The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle
    Marjan M Tajrishi
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, United States
    Biochem Biophys Res Commun 446:1219-24. 2014
    ..Collectively, our study suggests that the TWEAK-Fn14 signaling axis contributes to age-associated muscle atrophy and fibrosis potentially through its local activation of proteolytic systems and inflammatory pathways. ..
  17. pmc Proinflammatory cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) suppresses satellite cell self-renewal through inversely modulating Notch and NF-κB signaling pathways
    Yuji Ogura
    From the Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202 and
    J Biol Chem 288:35159-69. 2013
    ..Collectively, our study demonstrates that TWEAK suppresses satellite cell self-renewal through activating NF-κB and repressing Notch signaling. ..
  18. pmc Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice
    Saurabh Dahiya
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Hum Mol Genet 20:4345-59. 2011
    ..Collectively, our study suggests that elevated levels of active MMP-9 protein cause hypertrophy in skeletal muscle and that the modulation of MMP-9 levels may have therapeutic value in various muscular disorders including DMD...
  19. pmc Matrix metalloproteinase-9 inhibition improves proliferation and engraftment of myogenic cells in dystrophic muscle of mdx mice
    Sajedah M Hindi
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 8:e72121. 2013
    ..Collectively, our study suggests that the inhibition of MMP-9 is a promising approach to stimulate myofiber regeneration and improving engraftment of muscle progenitor cells in dystrophic muscle. ..
  20. pmc Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy
    Hong Li
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Hum Mol Genet 18:2584-98. 2009
    ..Collectively, our study suggests that the increased production of MMP-9 exacerbates dystrophinopathy and MMP-9 represents as one of the most promising therapeutic targets for the prevention of disease progression in DMD...
  21. pmc Osteopontin-stimulated expression of matrix metalloproteinase-9 causes cardiomyopathy in the mdx model of Duchenne muscular dystrophy
    Saurabh Dahiya
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 187:2723-31. 2011
    ..This study provides a novel mechanism for development of cardiac dysfunction and suggests that MMP-9 and OPN are important therapeutic targets to mitigating cardiac abnormalities in patients with DMD...
  22. pmc Gene profiling studies in skeletal muscle by quantitative real-time polymerase chain reaction assay
    Shephali Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA
    Methods Mol Biol 798:311-24. 2012
    ..Here, we describe, the qRT-PCR technique, in detail, for -successful gene expression studies in skeletal muscle cells and tissues...
  23. pmc Therapeutic targeting of signaling pathways in muscular dystrophy
    Shephali Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY, 40202, USA
    J Mol Med (Berl) 88:155-66. 2010
    ....
  24. pmc TRAF6 coordinates the activation of autophagy and ubiquitin-proteasome systems in atrophying skeletal muscle
    Pradyut K Paul
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA
    Autophagy 7:555-6. 2011
    ....
  25. pmc Wasting mechanisms in muscular dystrophy
    Jonghyun Shin
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Int J Biochem Cell Biol 45:2266-79. 2013
    ..In this article, we have reviewed major cellular and molecular mechanisms leading to muscle wasting in muscular dystrophy. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  26. pmc Nuclear factor-kappa B signaling in skeletal muscle atrophy
    Hong Li
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Mol Med (Berl) 86:1113-26. 2008
    ..In this article, we have outlined the current understanding regarding the role of NF-kappaB in skeletal muscle with particular reference to different models of muscle wasting and the development of novel therapy...
  27. pmc Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy
    Sajedah M Hindi
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA and
    Hum Mol Genet 23:1492-505. 2014
    ....
  28. pmc Signaling mechanisms in mammalian myoblast fusion
    Sajedah M Hindi
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Sci Signal 6:re2. 2013
    ..Here, we review the roles of the major signaling pathways in mammalian myoblast fusion...
  29. pmc The TWEAK-Fn14 pathway: a potent regulator of skeletal muscle biology in health and disease
    Marjan M Tajrishi
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, United States
    Cytokine Growth Factor Rev 25:215-25. 2014
    ..This review article highlights recent advancements toward understanding how the TWEAK-Fn14 pathway regulates the response to various skeletal muscle insults and, more broadly, engages multiple mechanisms to drive tissue fibrosis. ..

Research Grants4

  1. Role of TWEAK in Skeletal Muscle Metabolism
    Ashok Kumar; Fiscal Year: 2007
    ....
  2. Role of TWEAK in Skeletal Muscle Metabolism
    Ashok Kumar; Fiscal Year: 2009
    ....
  3. Role of TWEAK in Skeletal Muscle Metabolism
    Ashok Kumar; Fiscal Year: 2010
    ....