Anil Kumar

Summary

Affiliation: University of Missouri-Kansas City
Country: USA

Publications

  1. pmc HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA
    Ankit Shah
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, United States of America
    PLoS ONE 6:e21261. 2011
  2. pmc Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes
    Ankit Shah
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, USA
    PLoS ONE 7:e52060. 2012
  3. pmc HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors
    Xun Liu
    Division of Pharmacology and Toxicology, School of Pharmacy
    Sci Rep 4:4450. 2014
  4. pmc HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1
    A Shah
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO, USA
    Cell Death Dis 4:e850. 2013
  5. pmc Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways
    Mohitkumar R Gangwani
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
    J Neuroinflammation 10:136. 2013
  6. pmc Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
    Rajkumar Tulsawani
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68 198, USA
    BMC Neurosci 11:125. 2010
  7. pmc Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration
    Anil Kumar
    Division of Pharmacology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
    Virology 371:238-45. 2008
  8. pmc New approaches to the inhibition of replication of viral pathogens
    Anil Kumar
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, 2464 Charlotte Street, Kansas City, MO 64108, USA
    Expert Rev Anti Infect Ther 9:975-7. 2011
  9. pmc Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes
    Santosh Kumar
    University of Missouri Kansas City, School of Pharmacy, 2464 Charlotte St, Kansas City, MO 64108, USA
    Expert Opin Drug Metab Toxicol 8:1363-75. 2012
  10. pmc An LC-MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes
    Anusha Ande
    Pharmacology and Toxicology, School of Pharmacy, 3253 Health Sciences Building, University of Missouri Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA
    Drug Alcohol Depend 125:49-59. 2012

Collaborators

Detail Information

Publications55

  1. pmc HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA
    Ankit Shah
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, United States of America
    PLoS ONE 6:e21261. 2011
    ..These results demonstrate that HIV-1 gp120-mediated over-expression of IL-6 in astrocytes is one mechanism responsible for neuroinflammation in HIV-infected individuals and this is mediated by the NF-κB pathway...
  2. pmc Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes
    Ankit Shah
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, USA
    PLoS ONE 7:e52060. 2012
    ..This study therefore provides novel information regarding the interaction between MA and gp120 in terms of the expression of IL-6 and the mechanisms underlying potential synergy between MA and gp120 in astrocytes...
  3. pmc HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors
    Xun Liu
    Division of Pharmacology and Toxicology, School of Pharmacy
    Sci Rep 4:4450. 2014
    ..The results demonstrated that the PI3K/Akt and p38 MAPK pathways, along with the transcription factors NF-κB, CEBP, and AP-1, are involved in Nef-induced CCL5 production in astrocytes. ..
  4. pmc HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1
    A Shah
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO, USA
    Cell Death Dis 4:e850. 2013
    ....
  5. pmc Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways
    Mohitkumar R Gangwani
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
    J Neuroinflammation 10:136. 2013
    ..The major objective of this study was to determine the effect of Vpr in induction of proinflammatory chemokine CCL5 in astrocytes and to define the underlying mechanism(s)...
  6. pmc Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
    Rajkumar Tulsawani
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68 198, USA
    BMC Neurosci 11:125. 2010
    ..The protein peroxiredoxin 6 (PRDX6) plays a pleiotropic role in negatively regulating death signaling in response to stressors, and thereby stabilizes cellular homeostasis...
  7. pmc Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration
    Anil Kumar
    Division of Pharmacology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
    Virology 371:238-45. 2008
    ..All 8 animals succumbed to disease when challenged with pathogenic viruses...
  8. pmc New approaches to the inhibition of replication of viral pathogens
    Anil Kumar
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, 2464 Charlotte Street, Kansas City, MO 64108, USA
    Expert Rev Anti Infect Ther 9:975-7. 2011
    ....
  9. pmc Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes
    Santosh Kumar
    University of Missouri Kansas City, School of Pharmacy, 2464 Charlotte St, Kansas City, MO 64108, USA
    Expert Opin Drug Metab Toxicol 8:1363-75. 2012
    ..However, little is known about the mechanistic pathways by which alcohol exerts these effects, especially with respect to HIV-1 replication and the patient's response to HAART...
  10. pmc An LC-MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes
    Anusha Ande
    Pharmacology and Toxicology, School of Pharmacy, 3253 Health Sciences Building, University of Missouri Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA
    Drug Alcohol Depend 125:49-59. 2012
    ..This study has been designed to examine the role of CYP2A6 in nicotine metabolism and oxidative stress in SVGA cells, an immortalized human astrocyte cell line...
  11. pmc HIV-1 gp120 and drugs of abuse: interactions in the central nervous system
    Peter S Silverstein
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Curr HIV Res 10:369-83. 2012
    ..This review will summarize the neurotoxic effects of gp120, the deleterious effects of cocaine, methamphetamine and morphine on the CNS, and the combined effects of gp120 in the context of these drugs...
  12. pmc Tobacco smoking effect on HIV-1 pathogenesis: role of cytochrome P450 isozymes
    Anusha Ande
    University of Missouri Kansas City, School of Pharmacy, Division of Pharmacology and Toxicology, Kansas City, MO 64108, USA
    Expert Opin Drug Metab Toxicol 9:1453-64. 2013
    ..However, the mechanism by which tobacco/nicotine increases HIV-1 replication and mediates drug-drug interaction is poorly understood...
  13. pmc Enhanced nicotine metabolism in HIV-1-positive smokers compared with HIV-negative smokers: simultaneous determination of nicotine and its four metabolites in their plasma using a simple and sensitive electrospray ionization liquid chromatography-tandem ma
    Ravinder Earla
    School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri R E, A A, A K, S K and Department of Oral and Craniofacial Science, School of Dentistry, University of Missouri Kansas City, Kansas City, Missouri C M
    Drug Metab Dispos 42:282-93. 2014
    ....
  14. ncbi request reprint Methamphetamine toxicity and its implications during HIV-1 infection
    Peter S Silverstein
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Neurovirol 17:401-15. 2011
    ....
  15. pmc Methamphetamine increases LPS-mediated expression of IL-8, TNF-α and IL-1β in human macrophages through common signaling pathways
    Xun Liu
    Division of Pharmacology and Toxicology, School of Pharmacy, School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America
    PLoS ONE 7:e33822. 2012
    ..Since these pathways are involved in the induction of inflammation in response to other pathogens, this suggests that MA-exacerbated inflammation may be a common feature of infectious disease in MA abusers...
  16. pmc HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by inhibitors of NF-κB pathway
    Ankit Shah
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, Kansas City, MO 64108, United States
    Biochem Biophys Res Commun 414:112-7. 2011
    ..6 ± 4.2% at the level of mRNA and 51.8 ± 5.0% at the protein level. This was further confirmed by knocking down NF-κB through the use of siRNA...
  17. ncbi request reprint A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937 macrophages: implications in oxidative stress in HIV + smokers
    Mengyao Jin
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas, MO 64108, USA
    J Neuroimmune Pharmacol 7:289-99. 2012
    ....
  18. ncbi request reprint Cocaine-mediated enhancement of virus replication in macrophages: implications for human immunodeficiency virus-associated dementia
    Navneet K Dhillon
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurovirol 13:483-95. 2007
    ..The synergistic effect of cocaine on virus replication and its enhancement of host activation markers suggest that cocaine functions at multiple pathways to accelerate HIV-associated dementia (HAD)...
  19. pmc Nonhuman primate models of NeuroAIDS
    Rachel Williams
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66103, USA
    J Neurovirol 14:292-300. 2008
    ....
  20. pmc HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA
    Ankit Shah
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, Kansas City, MO 64108, USA
    J Neuroinflammation 7:96. 2010
    ..In this study, we sought to address whether HIV-1gp120 could affect IL-8 expression in astrocytes and whether the NF-κB pathway is involved in this phenomenon...
  21. pmc Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway
    Mengyao Jin
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, United States of America
    PLoS ONE 7:e35505. 2012
    ..Thus, this study has clinical relevance because of the high incidence of alcohol use among smokers, especially in HIV-infected individuals...
  22. pmc Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
    Ankit Shah
    Division of Pharmacology, UMKC School of Pharmacy, Kansas City, MO 64108, USA
    J Neuroinflammation 9:52. 2012
    ..Furthermore, we showed that blockade of mGluR5 can protect astrocytes from MA-mediated increases of proinflammatory cytokines/chemokines suggesting mGluR5 as a potential therapeutic target in treating MA-mediated neurotoxicity...
  23. pmc HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways
    Anantha R Nookala
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, Kansas City, Missouri, United States of America
    PLoS ONE 8:e78855. 2013
    ..This was further confirmed at transcriptional level that AP-1, C/EBPα and C/EBPγ were involved in CCL5 up-regulation. ..
  24. pmc HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1
    Crystal Bethel-Brown
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 186:4119-29. 2011
    ..Because astrogliosis is linked to disease severity, understanding its regulation by PDGF-BB could aid in the development of therapeutic intervention strategies for HAND...
  25. pmc Morphine enhances Tat-induced activation in murine microglia
    Sirosh M Bokhari
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurovirol 15:219-28. 2009
    ..In summary, these findings shed light on the cooperative effects of morphine and HIV-1 Tat on both microglial activation and HIV coreceptor up-regulation, effects that could result in exacerbated neuropathogenesis...
  26. ncbi request reprint Innate differences between simian-human immunodeficiency virus (SHIV)(KU-2)-infected rhesus and pig-tailed macaques in development of neurological disease
    Shilpa J Buch
    Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Virology 295:54-62. 2002
    ..A supportive role for IL-4 in the CNS disease was suggested by the presence of IL-4 RNA in the encephalitic brains of rhesus macaques and reduced levels of this cytokine in the brains from pig-tailed macaques...
  27. doi request reprint Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir
    Santosh Kumar
    School of Pharmacy, University of Missouri Kansas City, 2464 Charlotte Ave, Kansas City, MO 64108, USA
    Biochem Biophys Res Commun 402:163-7. 2010
    ..This is an important finding because alcoholism is prevalent in HIV-1-infected persons and alcohol is shown to decrease the response to antiretroviral therapy...
  28. pmc Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages
    Mengyao Jin
    University of Missouri Kansas City, 64108, USA
    Alcohol Clin Exp Res 35:132-9. 2011
    ..The U937 cell line has been utilized as an in vitro model of human macrophages...
  29. ncbi request reprint Bleomycin treatment causes enhancement of virus replication in the lungs of SHIV-infected macaques
    Navneet Kaur Dhillon
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1233-40. 2007
    ..Enhanced replication of the virus in the lungs was associated with host factors induced by the drug and supported the hypothesis for a two-stage process of pulmonary pathogenesis...
  30. pmc Differential effects of ethanol on spectral binding and inhibition of cytochrome P450 3A4 with eight protease inhibitors antiretroviral drugs
    Santosh Kumar
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, 64108, USA
    Alcohol Clin Exp Res 35:2121-7. 2011
    ..The current study was designed to examine the effect of ethanol on spectral binding and inhibition of CYP3A4 with all currently used PIs that differ in physicochemical properties...
  31. pmc Lipopolysaccharide increases the expression of multidrug resistance-associated protein 1 (MRP1) in RAW 264.7 macrophages
    Peter S Silverstein
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Neuroimmune Pharmacol 5:516-20. 2010
    ..LPS-mediated increases in calcein efflux were repressed by the MRP-specific inhibitor MK-571. These results suggest that the effectiveness of HIV-1 PI therapy may be compromised by the presence of opportunistic infections...
  32. pmc HIV-1 and alcohol: interactions in the central nervous system
    Peter S Silverstein
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri
    Alcohol Clin Exp Res 38:604-10. 2014
    ..Clinical studies also suggest that alcohol exacerbates the CNS effects of HIV-1 infection. This review focuses on the mechanisms by which alcohol causes increased CNS damage in HIV-1 infection. ..
  33. pmc Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response
    Keiichi Ishihara
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA
    FEBS J 279:3048-70. 2012
    ..These studies also provide new evidence of the important role of post-translational modification in controlling LEDGF function...
  34. pmc Synthesis and in vitro characterization of novel dextran-methylprednisolone conjugates with peptide linkers: effects of linker length on hydrolytic and enzymatic release of methylprednisolone and its peptidyl intermediates
    Suman Penugonda
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    J Pharm Sci 97:2649-64. 2008
    ..These newly developed dextran conjugates of MP show promise for controlled delivery of MP in lysosomes...
  35. ncbi request reprint Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver
    Krishna C Chimalakonda
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Bioconjug Chem 18:2097-108. 2007
    ..These studies indicate the feasibility of the synthesis of 3TCS-dextran and its potential use for the selective delivery of 3TC to the liver...
  36. ncbi request reprint Differential virus evolution in blood and genital tract of HIV-infected females: evidence for the involvement of drug and non-drug resistance-associated mutations
    Grissell Tirado
    Laboratory of Viral Immunology, Ponce School of Medicine, Ponce 00732, Puerto Rico
    Virology 324:577-86. 2004
    ..These non-drug-associated mutations were different between plasma and vaginal viruses, suggesting that evolution of HIV-1 was independent in these two compartments...
  37. ncbi request reprint Immunization of macaques with live simian human immunodeficiency virus (SHIV) vaccines conferred protection against AIDS induced by homologous and heterologous SHIVs and simian immunodeficiency virus
    Anil Kumar
    University of Kansas Medical Center, Department of Microbiology, Molecular Genetics and Immunology, Kansas City 66160, USA
    Virology 301:189-205. 2002
    ..The study is still in progress and at this time DNA of SIV has become undetectable in lymph nodes of six of the seven vaccinates, SHIV(89.6)P in five of the seven, and SHIV(KU) in three of the seven animals...
  38. ncbi request reprint Compartmentalization of drug resistance-associated mutations in a treatment-naive HIV-infected female
    Grissell Tirado
    Laboratory of Viral Immunology, Ponce School of Medicine, PuertoRico 00732
    AIDS Res Hum Retroviruses 20:684-6. 2004
    ..In the absence of antiretroviral treatment, a drug-resistant mutant was thought to develop because of immune pressure. This is the first report describing the role of immune pressure in the development of a drug-resistant virus...
  39. ncbi request reprint Changes in the human immunodeficiency virus V3 region that correspond with disease progression: a meta-analysis
    Martin D Hill
    Department of Pharmacology and Toxicology, Ponce School of Medicine, P O Box 7004, Ponce, PR 00732, Puerto Rico
    Virus Res 106:27-33. 2004
    ..The timing of these changes was contrasted to CD4 decline with changes at 324 and 327 appearing before and 306, 320, and 319 appearing after the initiation of CD4 decline...
  40. pmc Modulation by morphine of viral set point in rhesus macaques infected with simian immunodeficiency virus and simian-human immunodeficiency virus
    Rakesh Kumar
    Laboratory of Viral Immunology, Department of Microbiology, Ponce School of Medicine, Ponce 00732, Puerto Rico
    J Virol 78:11425-8. 2004
    ..Likewise, the extent of virus replication in the cerebral compartment was more pronounced in the morphine group. These results provide a definitive evidence for a positive correlation between morphine and levels of viral replication...
  41. ncbi request reprint Genetic characterization of human immunodeficiency virus type 1 Tat before and after highly active antiretroviral therapy
    Eric Lorenzo
    Department of Biochemistry, Ponce School of Medicine, Ponce, Puerto Rico 00732
    AIDS Res Hum Retroviruses 20:1108-12. 2004
    ..This patient also showed a debilitating mutation (25-C/R) in three clones suggesting that some of the post-HAART viral forms were not viable in this patient. The dS/dN ratios in the patients were >2 suggesting lack of positive selection...
  42. ncbi request reprint Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption
    Rakesh Kumar
    Laboratory of Viral Immunology, Department of Microbiology, Ponce School of Medicine, San Juan, PR
    J Acquir Immune Defic Syndr 39:386-90. 2005
    ..The extent of CD4 cell loss in the alcohol group was significantly higher than that in the control animals at week 1 after infection...
  43. ncbi request reprint Virus replication and disease progression inversely correlate with SIV tat evolution in morphine-dependent and SIV/SHIV-infected Indian rhesus macaques
    Richard J Noel
    AIDS Research Program, Ponce School of Medicine, Ponce 00732, Puerto Rico
    Virology 346:127-38. 2006
    ..Our results also suggest that in vivo morphine dependence can contribute to the pathogenesis of SIV/SHIV infection and that it may do so in conjunction with the evolution of viral proteins, such as Tat...
  44. ncbi request reprint Morphine-mediated deterioration of oxidative stress leads to rapid disease progression in SIV/SHIV-infected macaques
    Antonio Pérez-Casanova
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732
    AIDS Res Hum Retroviruses 23:1004-7. 2007
    ..The loss of these antioxidant systems was coincident with significantly increased plasma malondialdehyde upon viral infection that displayed a synergistic increase in conjunction with morphine and rapid disease...
  45. pmc SIV Vpr evolution is inversely related to disease progression in a morphine-dependent rhesus macaque model of AIDS
    Richard J Noel
    Department of Biochemistry, Ponce School of Medicine, Ponce, PR 00716, USA
    Virology 359:397-404. 2007
    ..Interestingly, although our previous work with the accessory gene nef indicated no association between disease progression and evolution, the accessory factor, vpr, behaves similarly to the essential lentiviral genes tat and env...
  46. pmc Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV
    Vanessa Rivera-Amill
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
    Virology 358:373-83. 2007
    ..We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution...
  47. ncbi request reprint Chronic morphine exposure causes pronounced virus replication in cerebral compartment and accelerated onset of AIDS in SIV/SHIV-infected Indian rhesus macaques
    Rakesh Kumar
    Laboratory of Viral Immunology, AIDS Research Program and Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
    Virology 354:192-206. 2006
    ..Three morphine-exposed macaques (euthanized at weeks 18, 19 and 20) did not develop cellular or humoral immune responses, whereas the other 3 morphine-exposed and 3 control macaques developed both cellular and humoral immune responses...
  48. ncbi request reprint Correlation between SIV Tat evolution and AIDS progression in cerebrospinal fluid of morphine-dependent and control macaques infected with SIV and SHIV
    Richard J Noel
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, USA Department of Biochemistry, Ponce School of Medicine, Ponce, PR 00732
    Virology 349:440-52. 2006
    ..Thus, morphine abuse may change the nature and extent of mutations that drive viral evolution...
  49. ncbi request reprint Evolution of SIV envelope in morphine-dependent rhesus macaques with rapid disease progression
    Grissell Tirado
    Laboratory of Viral Immunology, Departments of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    AIDS Res Hum Retroviruses 22:114-9. 2006
    ..These results suggest that morphine dependence diminished virus evolution in SHIV/SIV-infected rhesus macaques and there was an inverse correlation between virus evolution and onset of clinical disease...
  50. ncbi request reprint Therapy of "SHIV" infected macaques with liposomes delivering antisense interleukin-4 DNA
    Navneet K Dhillon
    Department of Microbiology, Immunology and Molecular Genetics, Marion Merrell Dow Laboratory of Viral Pathogenesis, Emory University, Atlanta, Georgia, USA
    AIDS 20:1125-30. 2006
    ..To explore the effects of antisense (AS) interleukin (IL)-4 on virus replication and CD8+ T-cell responses in lymph nodes and blood of macaques infected with simian human immunodeficiency virus, SHIV(89.6)P...
  51. ncbi request reprint Influence of CD4+ T cell counts on viral evolution in HIV-infected individuals undergoing suppressive HAART
    Eric Lorenzo
    AIDS Research Program, Ponce School of Medicine, Ponce 00732, Puerto Rico
    Virology 330:116-26. 2004
    ..All these indications may suggest that even when HAART generates viral suppression, quasispecies evolve in the envelope gene probably resulting from host-selective pressure...
  52. pmc Lack of correlation between SIV-Nef evolution and rapid disease progression in morphine-dependent nonhuman primate model of AIDS
    Richard J Noel
    Department of Biochemistry, Ponce School of Medicine, Ponce, PR 00716
    AIDS Res Hum Retroviruses 22:817-23. 2006
    ....
  53. ncbi request reprint Tenofovir disoproxil fumarate
    Anil Kumar
    Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico
    Drugs 63:1609-10. 2003
  54. ncbi request reprint Differential evolution of cell-associated virus in blood and genital tract of HIV-infected females undergoing HAART
    Grissell Tirado
    Laboratory of Viral Immunology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    Virology 334:299-305. 2005
    ..Phylogenetic analysis revealed that VC virus was closer to PBMC virus than either cell-free viruses (P and VS) suggesting comparable evolution among cell-associated viruses...
  55. ncbi request reprint Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque
    Antonio Pérez-Casanova
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, USA
    Mol Cell Biochem 308:169-75. 2008
    ..Our results clearly suggest that morphine interaction with SIV/SHIV infection causes higher oxidative tissue injury that might have implication in the pathogenesis of AIDS in morphine-dependent macaques...

Research Grants17

  1. Alcohol and AIDS: Pathogenesis and Immunity in Macaque
    Anil Kumar; Fiscal Year: 2007
    ....
  2. Effects of Opiate on Virus/Host Responses in SHIV/Macaques
    Anil Kumar; Fiscal Year: 2010
    ..Therefore this study will provide guidelines not only in setting of future AIDS vaccine, but also provide guidelines regarding use of any vaccine in such high-risk population. ..
  3. HIV, Drug Abuse and Neurotoxicity
    Anil Kumar; Fiscal Year: 2009
    ..We will also test pharmacological inhibitors and viral siRNA for their potential to abrogate neurotoxicity. In vitro results will be extended to a model system using transgenic mice. ..
  4. Alcohol and AIDS: Pathogenesis and Immunity in Macaque
    Anil Kumar; Fiscal Year: 2006
    ....
  5. Effects of Opiate on Virus/Host Responses in SHIV/Macaques
    Anil Kumar; Fiscal Year: 2009
    ..Therefore this study will provide guidelines not only in setting of future AIDS vaccine, but also provide guidelines regarding use of any vaccine in such high-risk population. ..
  6. Efffects of opiate virus/host response in SHIV/macaque
    Anil Kumar; Fiscal Year: 2003
    ..These animals will be challenged with pathogenic SHIV KU-2 to determine whether morphine-dependence compromises the live vaccine-induced protection. ..
  7. Methamphetamine and AIDS in a Non-Human Primate Model
    Anil Kumar; Fiscal Year: 2009
    ..The proposed studies are highly warranted because there is no information available regarding effect of methamphetamine abuse. ..
  8. Immune Targets During Natural Dengue Infection
    Anil Kumar; Fiscal Year: 2005
    ..We will also determine functional properties of the CD4 and CD8 T cell clones like cytokine secretion pattern, ability to block/reduce replication of DEN-3 as well as other serotypes. ..
  9. Alcohol and AIDS: Pathogenesis and Immunity in Macaque
    Anil Kumar; Fiscal Year: 2005
    ....
  10. Alcohol and AIDS: Pathogenesis and Immunity in Macaque
    Anil Kumar; Fiscal Year: 2005
    ....
  11. Alcohol and AIDS: Pathogenesis and Immunity in Macaque
    Anil Kumar; Fiscal Year: 2004
    ....
  12. Efffects of opiate virus/host response in SHIV/macaque
    Anil Kumar; Fiscal Year: 2004
    ..These animals will be challenged with pathogenic SHIV KU-2 to determine whether morphine-dependence compromises the live vaccine-induced protection. ..
  13. Efffects of opiate virus/host response in SHIV
    Anil Kumar; Fiscal Year: 2001
    ..These animals will be challenged with pathogenic SHIV KU-2 to determine whether morphine-dependence compromises the live vaccine-induced protection. ..
  14. HIV, Drug Abuse and Neurotoxicity
    Anil Kumar; Fiscal Year: 2010
    ..We will also test pharmacological inhibitors and viral siRNA for their potential to abrogate neurotoxicity. In vitro results will be extended to a model system using transgenic mice. ..