Anand Kumar

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Age of onset of depression and quantitative neuroanatomic measures: absence of specific correlates
    A Kumar
    UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 91:101-10. 1999
  2. pmc Mood, cognition and in vivo protein imaging: the emerging nexus in clinical neuroscience
    Anand Kumar
    Department of Psychiatry, the Semel Institute for Neuroscience, University of California, Los Angeles, CA 90024, USA
    Int J Geriatr Psychiatry 23:555-63. 2008
  3. ncbi request reprint Gray matter prefrontal changes in type 2 diabetes detected using MRI
    Anand Kumar
    Department of Psychiatry, Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, California, USA
    J Magn Reson Imaging 27:14-9. 2008
  4. ncbi request reprint Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression
    Anand Kumar
    UCLA Neuropsychiatric Institute, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 66:324-30. 2009
  5. ncbi request reprint White matter injury, neural connectivity and the pathophysiology of psychiatric disorders
    Anand Kumar
    Department of Psychiatry and The Neuropsychiatric Institute, University of California, Los Angeles, Calif 90024, USA
    Dev Neurosci 24:255-61. 2002
  6. ncbi request reprint Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy
    Anand Kumar
    Department of Psychiatry, University of California, Los Angeles, School of Medicine, USA
    Am J Psychiatry 159:630-6. 2002
  7. ncbi request reprint Biophysical changes in normal-appearing white matter and subcortical nuclei in late-life major depression detected using magnetization transfer
    Anand Kumar
    Department of Psychiatry C9 938, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychiatry Res 130:131-40. 2004
  8. ncbi request reprint Autonomous neurobiological pathways to late-life major depressive disorder: clinical and pathophysiological implications
    Anand Kumar
    Neuropsychiatric Institute, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 26:229-36. 2002
  9. ncbi request reprint Atrophy and high intensity lesions: complementary neurobiological mechanisms in late-life major depression
    A Kumar
    UCLA Neuropsychiatric Institute, USA
    Neuropsychopharmacology 22:264-74. 2000
  10. ncbi request reprint Volumetric asymmetries in late-onset mood disorders: an attenuation of frontal asymmetry with depression severity
    A Kumar
    Neuropsychiatric Institute, UCLA School of Medicine, 760 Westwood Plaza, Rm 37 384, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 100:41-7. 2000

Detail Information

Publications88

  1. ncbi request reprint Age of onset of depression and quantitative neuroanatomic measures: absence of specific correlates
    A Kumar
    UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 91:101-10. 1999
    ..These data do not support the notion that neuroanatomical contributions to depression increase with a later age of onset of illness...
  2. pmc Mood, cognition and in vivo protein imaging: the emerging nexus in clinical neuroscience
    Anand Kumar
    Department of Psychiatry, the Semel Institute for Neuroscience, University of California, Los Angeles, CA 90024, USA
    Int J Geriatr Psychiatry 23:555-63. 2008
    ..Disorders of mood and cognition overlap in the elderly and there is an emerging consensus that both groups of disorders share neurobiological substrates...
  3. ncbi request reprint Gray matter prefrontal changes in type 2 diabetes detected using MRI
    Anand Kumar
    Department of Psychiatry, Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, California, USA
    J Magn Reson Imaging 27:14-9. 2008
    ..To examine the volumes of the gray and white matter both globally and regionally in patients diagnosed with type 2 diabetes and controls...
  4. ncbi request reprint Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression
    Anand Kumar
    UCLA Neuropsychiatric Institute, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 66:324-30. 2009
    ..Despite its high prevalence and clinical effect, the neurobiological substrates underlying depression in patients with diabetes remain largely unknown...
  5. ncbi request reprint White matter injury, neural connectivity and the pathophysiology of psychiatric disorders
    Anand Kumar
    Department of Psychiatry and The Neuropsychiatric Institute, University of California, Los Angeles, Calif 90024, USA
    Dev Neurosci 24:255-61. 2002
    ..Focused translational research aimed at identifying the links between white matter compromise and specific behaviors are necessary for a more thorough understanding of the etiology of mental illness to emerge...
  6. ncbi request reprint Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy
    Anand Kumar
    Department of Psychiatry, University of California, Los Angeles, School of Medicine, USA
    Am J Psychiatry 159:630-6. 2002
    ..This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy...
  7. ncbi request reprint Biophysical changes in normal-appearing white matter and subcortical nuclei in late-life major depression detected using magnetization transfer
    Anand Kumar
    Department of Psychiatry C9 938, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychiatry Res 130:131-40. 2004
    ..These changes may provide important substrates to mood disorders and have implications for neuronal connectivity and its role in the pathophysiology of late-life depression...
  8. ncbi request reprint Autonomous neurobiological pathways to late-life major depressive disorder: clinical and pathophysiological implications
    Anand Kumar
    Neuropsychiatric Institute, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 26:229-36. 2002
    ..These observations further suggest that neurobiological mechanisms acting in parallel may compromise brain structure/function, thereby predisposing individuals to clinical brain disorders such as depression...
  9. ncbi request reprint Atrophy and high intensity lesions: complementary neurobiological mechanisms in late-life major depression
    A Kumar
    UCLA Neuropsychiatric Institute, USA
    Neuropsychopharmacology 22:264-74. 2000
    ..These findings have broad implications for the pathophysiology of mood disorders and suggest that complementary neurobiological processes may lead to cumulative neuronal injury thereby predisposing to clinical depression...
  10. ncbi request reprint Volumetric asymmetries in late-onset mood disorders: an attenuation of frontal asymmetry with depression severity
    A Kumar
    Neuropsychiatric Institute, UCLA School of Medicine, 760 Westwood Plaza, Rm 37 384, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 100:41-7. 2000
    ..Hemispheric and temporal asymmetries were comparable in all three groups. These data suggest that an attenuation of the 'normal' volumetric asymmetry in the frontal regions may provide a structural basis to late-onset mood disorders..
  11. ncbi request reprint Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy
    Olusola Ajilore
    Department of Psychiatry, UCLA Semel Institute, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 32:1224-31. 2007
    ..These findings have broad implications and suggest that alterations in glutamate and glutamine levels in subcortical regions along with white matter changes in myo-inositol provide important neurobiological substrates of mood disorders...
  12. doi request reprint Prefrontal myo-inositol concentration and visuospatial functioning among diabetic depressed patients
    Ebrahim Haroon
    Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 171:10-9. 2009
    ..Progressive weakening of this association across both diabetic groups might be related to progressive changes in neural activity that underlies visuospatial function...
  13. ncbi request reprint Localizing gray matter deficits in late-onset depression using computational cortical pattern matching methods
    Martina Ballmaier
    Laboratory of Neuro Imaging, Department of Neurology, Rm 4238, Reed Neurological Research Center, David Geffen UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Am J Psychiatry 161:2091-9. 2004
    ..The authors used magnetic resonance imaging and an image analysis technique known as cortical pattern matching to map cortical gray matter deficits in elderly depressed patients with an illness onset after age 60 (late-onset depression)...
  14. ncbi request reprint Brain metabolites and cognitive function among older depressed and healthy individuals using 2D MR spectroscopy
    Virginia Elderkin-Thompson
    UCLA Neuropsychiatric Research Institute and Hospital, Los Angeles, CA 90024 1759, USA
    Neuropsychopharmacology 29:2251-7. 2004
    ....
  15. doi request reprint Prefrontal brain morphology and executive function in healthy and depressed elderly
    Virginia Elderkin-Thompson
    Semel Institute for Neuroscience and Human Behavior, Geriatric Division, UCLA, Los Angeles, CA 90024 1759, USA
    Int J Geriatr Psychiatry 24:459-68. 2009
    ....
  16. ncbi request reprint Neuroanatomical correlates of executive functioning in depressed adults with type 2 diabetes
    Kecia Watari
    Department of Neurology, Keck School of Medicine, University of Southern California, 1520 San Pablo Street, Suite 3000, Los Angeles, CA 90033, USA
    J Clin Exp Neuropsychol 30:389-97. 2008
    ....
  17. ncbi request reprint Executive dysfunction and memory in older patients with major and minor depression
    Virginia Elderkin-Thompson
    UCLA Neuropsychiatric Research Institute, Geriatric Division, CA 90024 1759, USA
    Arch Clin Neuropsychol 21:669-76. 2006
    ..In conclusion, the verbal memory deficits typically attributed to late-life depression may result from impaired executive functioning during the learning phase of the recall task...
  18. pmc Prefrontal vulnerabilities and whole brain connectivity in aging and depression
    Melissa Lamar
    Department of Psychiatry, University of Illinois at Chicago, 1601W Taylor St, MC912, Chicago, IL 60601, USA
    Neuropsychologia 51:1463-70. 2013
    ..It appears that the whole brain impact of specific fronto-limbic vulnerabilities in aging may be eclipsed in the presence of disease-specific neuropathology like that seen in late life depression...
  19. ncbi request reprint Executive function and MRI prefrontal volumes among healthy older adults
    Virginia Elderkin-Thompson
    Geriatric Division, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90024 1759, USA
    Neuropsychology 22:626-37. 2008
    ..In conclusion, some executive abilities correlate with volumes of specific prefrontal subregions despite a robust neural interconnectedness between the subregions...
  20. ncbi request reprint Sex differences in brain structure in geriatric depression
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 12:653-7. 2004
    ..In an exploratory study, authors compared patients with late-life major depression (MDD) and age-matched control subjects to examine sex differences in frontal and orbito-frontal (OFC) regional brain volumes...
  21. ncbi request reprint The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
    Helen Lavretsky
    UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:55-9. 2008
    ....
  22. pmc Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 15:386-94. 2007
    ..Apathy is one of the most common late-life neuropsychiatric syndromes. The objective of our study was to examine the neuroanatomical correlates of apathy in older subjects with and without geriatric major depression (MDD)...
  23. ncbi request reprint Cognitive function in adults with type 2 diabetes and major depression
    Kecia Watari
    Division of Geriatric Psychiatry, UCLA Semel Institute and Resnick Neuropsychiatric Hospital, 760 Westwood Plaza, 37 372A, Los Angeles, CA 90024 1759, United States
    Arch Clin Neuropsychol 21:787-96. 2006
    ..These findings suggest that depression negatively impacts cognitive performance among adults with type 2 diabetes, which may have implications for neural circuitry underlying cognitive and mood changes in diabetic patients...
  24. pmc Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression
    Melissa Lamar
    Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Neuropsychologia 50:1823-9. 2012
    ..More specifically, it points toward a network of predominantly anterior brain regions that may underlie the executive contribution to list-learning in older adults with depression...
  25. pmc Verbal learning and memory in older adults with minor and major depression
    Raquelle I Mesholam-Gately
    Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Arch Clin Neuropsychol 27:196-207. 2012
    ..The findings suggest that depression in the elderly is a heterogeneous entity and that the CVLT may be a useful tool for characterizing learning and memory in late-onset depressive disorders...
  26. ncbi request reprint Executive dysfunction and memory in older patients with major and minor depression
    Virginia Elderkin-Thompson
    UCLA Neuropsychiatric Research Institute, Geriatric Division, Los Angeles, CA, USA
    Arch Clin Neuropsychol 22:261-70. 2007
    ..In conclusion, the verbal memory deficits typically attributed to late-life depression may result from impaired executive functioning during the learning phase of the recall task...
  27. ncbi request reprint Mapping brain size and cortical gray matter changes in elderly depression
    Martina Ballmaier
    Laboratory of Neuro Imaging, Department of Neurology, David Geffen UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Biol Psychiatry 55:382-9. 2004
    ..Here, we conducted detailed spatial analyses of brain size and gray matter within the cortical mantle in elderly patients with major depression...
  28. ncbi request reprint Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Clin Psychiatry 66:964-7. 2005
    ..Depressed elderly patients with and without antidepressant exposure were compared to normal controls to examine the effects of prior antidepressant exposure on regional brain gray matter volumes using magnetic resonance imaging (MRI)...
  29. doi request reprint Explicit and implicit memory in late-life depression
    Virginia Elderkin-Thompson
    Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024 1759, USA
    Am J Geriatr Psychiatry 19:249-55. 2011
    ..This study examined cognition in patients with late-life depression with a focus on the assessment of the extent and type of memory loss among elderly depressed patients...
  30. pmc Impaired inter-hemispheric integration in bipolar disorder revealed with brain network analyses
    Alex Leow
    Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Biol Psychiatry 73:183-93. 2013
    ..However, many inconsistencies remain in the literature, and no study to date has conducted brain network analyses with a graph-theoretic approach...
  31. pmc Biophysical correlates of cognition among depressed and nondepressed type 2 diabetic patients
    Virginia Elderkin-Thompson
    Semel Institute for Neuroscience and Human Behavior, Geriatric Division, University of California, Los Angeles, California, USA
    Diabetes Care 32:48-50. 2009
    ..Caudate magnetization transfer (MT) ratios have indicated an abnormality in the macromolecular protein pool of diabetic patients. This study examined the relationship between MT ratios of the caudate and cognitive performance...
  32. pmc Daily functioning and prefrontal brain morphology in healthy and depressed community-dwelling elderly
    Virginia Elderkin-Thompson
    Semel Institute for Neuroscience and Human Behavior, Geriatric Division, UCLA, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 16:633-42. 2008
    ..This study examined relationships between self-reported levels of general functioning and the combined volume of three integrated prefrontal structures associated with self-perception and emotion...
  33. ncbi request reprint Neurochemistry of late-life major depression: a pilot two-dimensional MR spectroscopic study
    Nader Binesh
    Department of Radiological Sciences, University of California Los Angeles, Los Angeles, California 90095 1721, USA
    J Magn Reson Imaging 20:1039-45. 2004
    ..To evaluate a two-dimensional localized chemical shift correlated spectroscopy (L-COSY) sequence in elderly patients with major depression...
  34. pmc Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression
    Olusola Ajilore
    Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA
    Psychiatry Res 184:63-70. 2010
    ..Depression and diabetes are associated with significant cortical gray matter thinning in medial prefrontal areas...
  35. ncbi request reprint Validity of the Boston qualitative scoring system for the Rey-Osterrieth complex figure among depressed elderly patients
    Virginia Elderkin-Thompson
    Neuropsychiatric Research Institute, UCLA, 760 Westwooed Plaza C8 688, Los Angeles, CA 90024 1759, USA
    J Clin Exp Neuropsychol 26:598-607. 2004
    ..No differences emerged between the two scoring methods in their efficiency for predicting depression...
  36. ncbi request reprint Neurocognitive profiles in elderly patients with frontotemporal degeneration or major depressive disorder
    Virginia Elderkin-Thompson
    Neuropsychiatric Research Institute Hospital, Department of Psychiatry Biobehavioral Sciences, University of California, Los Angeles, California 90024 1759, USA
    J Int Neuropsychol Soc 10:753-71. 2004
    ....
  37. pmc Protein binding in patients with late-life depression
    Anand Kumar
    Department of Psychiatry, University of Illinois at Chicago, USA
    Arch Gen Psychiatry 68:1143-50. 2011
    ..Depression has been identified as a risk factor and a prodrome of dementia. Common neurobiological mechanisms may underlie this clinical and phenomenologic overlap...
  38. ncbi request reprint The significance of subsyndromal depression in geriatrics
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles School of Medicine, Room 37 425, 760 Westwood Place, Los Angeles, CA 90095, USA
    Curr Psychiatry Rep 6:25-31. 2004
    ..The authors draw conclusions from the published literature and present clinical criteria for the diagnosis of clinically significant non-major depression in the elderly...
  39. ncbi request reprint Neuropsychological deficits among patients with late-onset minor and major depression
    Virginia Elderkin-Thompson
    Neuropsychiatric Research Institute and Hospital, University of California, 760 Westwood Plaza C8 688, Los Angeles, CA 90024 1759, USA
    Arch Clin Neuropsychol 18:529-49. 2003
    ..This decline in cognitive performance parallels a similar trend observed in neuroanatomical studies in which the volume of the frontal and temporal lobes decrease with increasing severity of depression...
  40. ncbi request reprint Executive dysfunction and visuospatial ability among depressed elders in a community setting
    Virginia Elderkin-Thompson
    Neuropsychiatric Research Institute and Hospital, University of California, 760 Westwood Plaza, C8 688, Los Angeles, CA 90024 1759, USA
    Arch Clin Neuropsychol 19:597-611. 2004
    ..This result is consistent with the theory that dysfunction of the prefrontal cortex is a critical feature of late-life depression...
  41. ncbi request reprint Magnetization transfer imaging and magnetic resonance spectroscopy of normal-appearing white matter in late-life major depression
    Nathaniel Wyckoff
    Department of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Magn Reson Imaging 18:537-43. 2003
    ....
  42. doi request reprint Preliminary analysis of age of illness onset effects on symptom profiles in major depressive disorder
    Rebecca A Charlton
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Int J Geriatr Psychiatry 28:1166-74. 2013
    ..Major depressive disorder (MDD) is prevalent across the lifespan, but relatively little is known about how age of illness onset impacts the cognitive and affective presentation of MDD...
  43. pmc White matter tract integrity of anterior limb of internal capsule in major depression and type 2 diabetes
    Aifeng Zhang
    Department of Psychiatry, University of Illinois Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 38:1451-9. 2013
    ..016). Our study demonstrated novel findings of white matter abnormalities of the ALIC in depression and diabetes. These findings have implications for clinical manifestations of depression and diabetes as well as their pathophysiology...
  44. pmc Hierarchical structural mapping for globally optimized estimation of functional networks
    Alex D Leow
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Med Image Comput Comput Assist Interv 15:228-36. 2012
    ..Results revealed that BDD subjects under-utilized several key local connections in the visual system, which may help explain previously reported fMRI findings and further elucidate the underlying pathophysiology of BDD...
  45. ncbi request reprint Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
    Am J Geriatr Psychiatry 14:181-5. 2006
    ..The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressed patients...
  46. pmc Quantitative tract-specific measures of uncinate and cingulum in major depression using diffusion tensor imaging
    Aifeng Zhang
    Department of Psychiatry, University of Illinois Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 37:959-67. 2012
    ..In the MDD group, the severity of depression is associated with reduced NNF in the right UF. These findings have implications for both clinical manifestations of depression as well as its pathophysiology...
  47. ncbi request reprint Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex
    Martina Ballmaier
    Department of Neurology, UCLA Neuropsychiatric Institute, David Geffen School of Medicine, Los Angeles, CA 90024, USA
    Am J Psychiatry 161:99-108. 2004
    ....
  48. ncbi request reprint Adding another spectral dimension to 1H magnetic resonance spectroscopy of hepatic encephalopathy
    Nader Binesh
    Department of Radiological Science, David Geffen School of Medicine at University of California, Los Angeles, California 90024 1721, USA
    J Magn Reson Imaging 21:398-405. 2005
    ....
  49. ncbi request reprint Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
    Thomas McBride
    Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
    Schizophr Res 55:217-27. 2002
    ..Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile...
  50. ncbi request reprint Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles 90095, USA
    J Clin Psychiatry 64:1410-4. 2003
    ..We evaluated the potential of methylphenidate to accelerate antidepressant response to citalopram and the safety and tolerability of the combined treatment in patients with geriatric major depressive disorder...
  51. ncbi request reprint Aging and brain activation with working memory tasks: an fMRI study of connectivity
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, California 90024 1759, USA
    Int J Geriatr Psychiatry 22:332-42. 2007
    ..We hypothesized healthy older subjects would show lower connectivity than younger subjects...
  52. ncbi request reprint Localized two-dimensional shift correlated MR spectroscopy of human brain
    M A Thomas
    Department of Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    Magn Reson Med 46:58-67. 2001
    ..Localized COSY (L-COSY) spectra of cerebral prefrontal and occipital gray/white matter regions in 15 healthy controls are presented. Magn Reson Med 46:58-67, 2001...
  53. pmc Altered structural brain connectome in young adult fragile X premutation carriers
    Alex Leow
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, and Community Psychiatry, Sacramento, California
    Hum Brain Mapp 35:4518-30. 2014
    ..In female fXPCs, CC in the left superior parietal cortex correlated with counting performance in an enumeration task. Hum Brain Mapp 35:4518-4530, 2014. © 2014 Wiley Periodicals, Inc. ..
  54. pmc Craniofacial surgery, from past pioneers to future promise
    Derrick C Wan
    Dept of Surgery, UCLA David Geffen School of Medicine, Los Angeles, USA Dept of Surgery, Stanford University Medical Center, Los Angeles, USA
    J Maxillofac Oral Surg 8:348-56. 2009
    ....
  55. ncbi request reprint Practical geriatrics: clinically significant nonmajor geriatric depression
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, 90095, USA
    Psychiatr Serv 54:297-9. 2003
  56. ncbi request reprint Amelioration of acquired nasopharyngeal stenosis, with bilateral Z-pharyngoplasty
    Derrick C Wan
    Division of Plastic and Reconstructive Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA
    Ann Plast Surg 64:747-50. 2010
    ..Endoscopic stricture measurement improved from 6.1 x 6.3 mm preoperatively to 28.1 x 39.3 mm in follow-up. Bilateral Z-pharyngoplasty was effective in alleviating severe postsurgical nasopharyngeal stenosis...
  57. ncbi request reprint Exploratory voxel-based analysis of diffusion indices and hemispheric asymmetry in normal aging
    Siamak Ardekani
    Biomedical Engineering IDP, University of California Los Angeles, Los Angeles, CA 90095, USA
    Magn Reson Imaging 25:154-67. 2007
    ..The study shows the feasibility of the VBA of DTI indices for exploratory investigations of subtle differences in population cohorts, especially when findings are not localized and/or known a priori...
  58. ncbi request reprint Clinically significant non-major depression: old concepts, new insights
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 10:239-55. 2002
    ..They draw conclusions from the published literature and propose clinical criteria for the diagnosis of clinically significant non-major depression in elderly persons...
  59. pmc Two-dimensional semi-LASER correlation spectroscopy with well-maintained cross peaks
    Meijin Lin
    University of Illinois at Chicago, Department of Psychiatry, Chicago, Illinois, USA
    Magn Reson Med 72:26-32. 2014
    ....
  60. doi request reprint Correction of frontonasoethmoidal encephalocele: the HULA procedure
    Anand Kumar
    Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at the University of California, Los Angeles, California 90095 6960, USA
    Plast Reconstr Surg 123:661-9. 2009
    ....
  61. doi request reprint Diagnostic accuracy of maxillofacial trauma two-dimensional and three-dimensional computed tomographic scans: comparison of oral surgeons, head and neck surgeons, plastic surgeons, and neuroradiologists
    Reza Jarrahy
    Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif, USA
    Plast Reconstr Surg 127:2432-40. 2011
    ....
  62. ncbi request reprint Methylphenidate augmentation of citalopram in elderly depressed patients
    H Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 9:298-303. 2001
    ..However, patients may require dosage adjustment for tolerability of this combination...
  63. ncbi request reprint Neuroimaging and geriatric psychiatry in the new millennium: the promise, the reality, and the need for more integrated approaches
    Anand Kumar
    Am J Geriatr Psychiatry 10:1-4. 2002
  64. ncbi request reprint Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  65. pmc Mapping callosal morphology in early- and late-onset elderly depression: an index of distinct changes in cortical connectivity
    Martina Ballmaier
    Department of Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
    Neuropsychopharmacology 33:1528-36. 2008
    ..Patients with a late onset of depression may be at higher risk of illness progression and eventually dementia conversion than early-onset depression, with potentially important implications for research and therapy...
  66. pmc Hippocampal morphology and distinguishing late-onset from early-onset elderly depression
    Martina Ballmaier
    Department of Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin
    Am J Psychiatry 165:229-37. 2008
    ..This study used three-dimensional mapping techniques to identify regional hippocampal abnormalities in early- and late-onset depression. Neuropsychological correlates of hippocampal morphology were also investigated...
  67. doi request reprint Magnetic resonance imaging and late-life depression: potential biomarkers in the era of personalized medicine
    Anand Kumar
    Am J Psychiatry 165:166-8. 2008
  68. ncbi request reprint Inflammatory myofibroblastic tumor of the abdominal wall simulating rhabdomyosarcoma: report of a case
    Akshay Pratap
    Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Surg Today 37:352-5. 2007
    ..These findings confirmed a diagnosis of an inflammatory myofibroblastic tumor (IMT). To our knowledge, this is the first case report of an extrapulmonary IMT arising from the anterior abdominal wall...
  69. ncbi request reprint Severe anaphylactic reaction at induction of anaesthesia
    Aliya Ahmed
    Department of Anaesthesia, Aga Khan University, Karachi
    J Pak Med Assoc 57:463-6. 2007
    ..The bronchospasm responded slowly to salbutamol and aminophylline. The patient underwent surgery and was discharged home on the third postoperative day...
  70. ncbi request reprint Modular representation of the guideline text: an approach for maintaining and updating the content of medical education
    Anand Kumar
    Laboratory of Medical Informatics, Department of Computer Science, University of Pavia, Pavia, PV2 7100, Italy
    Med Inform Internet Med 28:99-115. 2003
    ..Thus, after marking up using our system, the text components can be exchanged, modified or reconstructed, which, in turn, would help to maintain the updates in medical knowledge...
  71. ncbi request reprint Cerebellar abscess following mastoidectomy for chronic otitis media
    Amit Agrawal
    Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Pediatr Neurosurg 43:327-9. 2007
    ..There is a need to find the factors that will make one suspect the possibility of concurrent intracranial lesions and which will identify the patients prone to intracranial complications...
  72. doi request reprint Multimodal neuroimaging in late-life mental disorders: entering a more mature phase of clinical neuroscience research
    Anand Kumar
    Am J Geriatr Psychiatry 16:251-4. 2008
  73. ncbi request reprint Experimental human endotoxemia is associated with depression of load-independent contractility indices: prevention by the lipid a analogue E5531
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, GE706, 820 Sherbrook St, Winnipeg, MB, Canada, R3A 1R9
    Chest 126:860-7. 2004
    ....
  74. ncbi request reprint Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 33:331-40. 2005
    ..The objective of this study was to assess the efficacy of variations in dose and timing of administration of recombinant human IL-10 (rhIL-10) on inflammatory and cardiovascular responses in a human endotoxemia model of sepsis...
  75. ncbi request reprint Hypoandrogenaemia is associated with subclinical hypothyroidism in men
    Anand Kumar
    Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi 110029, India
    Int J Androl 30:14-20. 2007
    ..Further studies are needed in order to reveal the physiological and molecular mechanisms leading to hypoandrogenaemia in subclinical hypothyroidism (TSH < 10 mIU/L)...
  76. ncbi request reprint Transorbital orbitocranial penetrating injury due to bicycle brake handle in a child
    Amit Agrawal
    Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Pediatr Neurosurg 43:498-500. 2007
    ..In the present case, a child sustained a penetrating injury with the brake handle of a bicycle due to the accidental fall of the bicycle on him and was managed conservatively...
  77. ncbi request reprint Cholecysto-hydatid cyst fistula
    Anand Kumar
    Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005
    Indian J Gastroenterol 23:76-7. 2004
    ..This was followed by albendazole treatment...
  78. pmc Investigating subsumption in SNOMED CT: an exploration into large description logic-based biomedical terminologies
    Olivier Bodenreider
    U S National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
    Artif Intell Med 39:183-95. 2007
    ..The objective of this paper is to study the degree to which one DL-based biomedical terminology (SNOMED CT) does indeed comply with such principles...
  79. ncbi request reprint Early intravenous unfractionated heparin and mortality in septic shock
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 36:2973-9. 2008
    ..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...
  80. ncbi request reprint Doppler study of splanchnic hemodynamics in Hirschsprung's disease
    Akshay Pratap
    Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Eur Surg Res 39:148-52. 2007
    ..The aim of this study was to evaluate hemodynamic changes in celiac artery (CA), superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) using pulsed Doppler sonography (PDS) in Hirschsprung's disease...
  81. ncbi request reprint Septic shock, multiple organ failure, and acute respiratory distress syndrome
    Sat Sharma
    Section of Pulmonary Care Medicine, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Curr Opin Pulm Med 9:199-209. 2003
    ..This review will highlight and discuss recent advances in the pathophysiology and management of sepsis...
  82. ncbi request reprint Algorithmic evaluation of metabolic control and risk of severe hypoglycemia in type 1 and type 2 diabetes using self-monitoring blood glucose data
    Boris P Kovatchev
    University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Diabetes Technol Ther 5:817-28. 2003
    ..SMBG data allow for accurate estimation of the two most important markers of metabolic control in T1DM and T2DM - HbA(1c) and risk for hypoglycemia...
  83. ncbi request reprint Relating UMLS semantic types and task-based ontology to computer-interpretable clinical practice guidelines
    Anand Kumar
    Laboratory of Medical Informatics, Department of Computer Science, University of Pavia, Pavia, Italy
    Stud Health Technol Inform 95:469-74. 2003
    ..To conclude, we understood that the three STs could be used to represent the semantic network of the task-bases CIGMs. We identified some mapping operators which could be used for the mapping of other STs into these...
  84. ncbi request reprint Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
    ....
  85. pmc Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St, Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care 12:R35. 2008
    ..The objective of this study was to assess cardiovascular and metabolic responses to dobutamine as correlates of outcome in patients with severe sepsis or septic shock...
  86. ncbi request reprint Interleukin-1 gene cluster polymorphisms: all in the family
    Aseem Kumar
    Crit Care Med 30:1168-9. 2002
  87. pmc Application of a plain abdominal radiograph transition zone (PARTZ) in Hirschsprung's disease
    Akshay Pratap
    Division of Pediatric Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    BMC Pediatr 7:5. 2007
    ..The aim of this study was to determine the utility and diagnostic accuracy of a plain abdominal radiograph transition zone (PARTZ) in predicting the level of aganglionosis...
  88. ncbi request reprint Circulating substances and energy metabolism in septic shock
    Anand Kumar
    Crit Care Med 31:632-3. 2003

Research Grants7

  1. LATE-LIFE DEPRESSION
    Anand Kumar; Fiscal Year: 2005
    ..Applicant's abstract) The primary objective of this Research Scientist Development award is to permit Anand Kumar (the candidate) to develop greater sophistication with magnetic resonance imaging (MRI) technique and to apply ..
  2. Protein Molecular Imaging in Patients with Late-Life Major Depression
    Anand Kumar; Fiscal Year: 2007
    ..This will facilitate the early identification of patients who may benefit from aggressive therapy aimed at alleviating both mood and cognitive symptoms. [unreadable] [unreadable] [unreadable]..
  3. Cortical/Subcortical Circuits in Late-Life Depression
    Anand Kumar; Fiscal Year: 2007
    ..The role of the frontal white matter and subcortical nuclei in the etiology of late-life MDD has received scant attention and the proposed studies will help us elucidate the mechanisms and pathways that lead to MDD in late-life. ..
  4. Neurobiological and Behavioral Substrates of Mood Disorders
    Anand Kumar; Fiscal Year: 2007
    ..A parallel objective is for the applicant, Anand Kumar, to continue to mentor junior investigators in POR, both within the host institution, the University of ..
  5. Protein Molecular Imaging in Patients with Late-Life Major Depression
    Anand Kumar; Fiscal Year: 2008
    ..This will facilitate the early identification of patients who may benefit from aggressive therapy aimed at alleviating both mood and cognitive symptoms. [unreadable] [unreadable] [unreadable]..
  6. Cortical/Subcortical Circuits in Late-Life Depression
    Anand Kumar; Fiscal Year: 2008
    ..The role of the frontal white matter and subcortical nuclei in the etiology of late-life MDD has received scant attention and the proposed studies will help us elucidate the mechanisms and pathways that lead to MDD in late-life. ..
  7. Neurobiological and Behavioral Substrates of Mood Disorders
    Anand Kumar; Fiscal Year: 2008
    ..A parallel objective is for the applicant, Anand Kumar, to continue to mentor junior investigators in POR, both within the host institution, the University of ..