ADDANKI KUMAR

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis
    Guiming Li
    Department of Urology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Cancer Prev Res (Phila) 6:27-39. 2013
  2. ncbi Natural products: potential for developing Phellodendron amurense bark extract for prostate cancer management
    Addanki P Kumar
    Department of Urology, School of Medicine, 7703 Floyd Curl Drive, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mini Rev Med Chem 10:388-97. 2010
  3. ncbi Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract
    Addanki P Kumar
    Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Clin Cancer Res 13:2784-94. 2007
  4. ncbi Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management
    Rita Ghosh
    Department of Urology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Anticancer Res 30:857-65. 2010
  5. ncbi Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract
    Gretchen E Garcia
    Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neoplasia 8:523-33. 2006
  6. ncbi 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6
    Gretchen E Garcia
    Departments of Urology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Clin Cancer Res 12:980-8. 2006
  7. ncbi Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model
    Manonmani Ganapathy
    Department of Urology, School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Clin Cancer Res 15:1601-11. 2009
  8. ncbi Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells
    Sri Balasubashini Muralimanoharan
    Department of Urology, School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Prostate 69:494-504. 2009
  9. ncbi Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine
    Rita Ghosh
    The Sandra and Stanley Rosenberg Family Laboratories, Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neoplasia 9:893-9. 2007
  10. ncbi Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells
    Rita Ghosh
    Department of Urology, School of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, United States
    J Steroid Biochem Mol Biol 113:25-35. 2009

Research Grants

  1. Nexrutine, a herbal extract and prostate cancer
    ADDANKI KUMAR; Fiscal Year: 2004
  2. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    ADDANKI KUMAR; Fiscal Year: 2009
  3. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    Addanki P Kumar; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis
    Guiming Li
    Department of Urology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Cancer Prev Res (Phila) 6:27-39. 2013
    ..These data suggest that SIRT1/S6K-mediated inhibition of autophagy drives prostate tumorigenesis. Therefore, modulation of SIRT1/S6K signaling represents an effective strategy for prostate cancer prevention...
  2. ncbi Natural products: potential for developing Phellodendron amurense bark extract for prostate cancer management
    Addanki P Kumar
    Department of Urology, School of Medicine, 7703 Floyd Curl Drive, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mini Rev Med Chem 10:388-97. 2010
    ..We will discuss the utility of natural products in modulating critical signaling pathways for effective cancer prevention with special emphasis on prostate cancer and their potential translational benefit...
  3. ncbi Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract
    Addanki P Kumar
    Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Clin Cancer Res 13:2784-94. 2007
    ..In this study, we used the transgenic adenocarcinoma of mouse prostate (TRAMP) model to examine the ability of Nexrutine to protect TRAMP mice from developing prostate cancer...
  4. ncbi Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management
    Rita Ghosh
    Department of Urology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Anticancer Res 30:857-65. 2010
    ..009) and prevented the development of metastatic lesions. Nexrutine treatment also significantly (p=0.005) inhibited invasion of androgen-independent prostate cancer cells...
  5. ncbi Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract
    Gretchen E Garcia
    Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neoplasia 8:523-33. 2006
    ..Further, Akt kinase activity was reduced in cells treated with Nexrutine, and ectopic expression of myristoylated Akt protected from Nexrutine induced inhibition of proliferation, implicating a role for Akt signaling...
  6. ncbi 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6
    Gretchen E Garcia
    Departments of Urology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Clin Cancer Res 12:980-8. 2006
    ..However, neither the chemopreventive role nor the mechanism of 2-methoxyestradiol-induced biological activities is fully understood...
  7. ncbi Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model
    Manonmani Ganapathy
    Department of Urology, School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Clin Cancer Res 15:1601-11. 2009
    ....
  8. ncbi Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells
    Sri Balasubashini Muralimanoharan
    Department of Urology, School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Prostate 69:494-504. 2009
    ..In the present investigation we conducted studies to further define the mechanism of action of Nexrutine and to identify the active component associated with its biological activity...
  9. ncbi Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine
    Rita Ghosh
    The Sandra and Stanley Rosenberg Family Laboratories, Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neoplasia 9:893-9. 2007
    ....
  10. ncbi Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells
    Rita Ghosh
    Department of Urology, School of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, United States
    J Steroid Biochem Mol Biol 113:25-35. 2009
    ..Combining these agents may allow ameliorating any adverse effects of either 2-ME(2) or eugenol alone by reducing their individual concentrations should these two agents be developed for human use...
  11. ncbi Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity
    Rita Ghosh
    Department of Cancer Causation and Prevention, AMC Cancer Research Center, 1600 Pierce St, Denver, CO 80214, USA
    J Biol Chem 280:5812-9. 2005
    ..Since the E2F transcription factors provide growth impetus for the continuous proliferation of melanoma cells, these results suggest that eugenol could be developed as an E2F-targeted agent for melanoma treatment...
  12. ncbi 4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management
    Addanki P Kumar
    Center for Cancer Causation and Prevention, AMC Cancer Research Center and University of Colorado Comprehensive Cancer Center, Denver, CO 80214, USA
    Neoplasia 5:255-66. 2003
    ..The potential use of HMBME as an agent that targets survival mechanisms in PCA cells is discussed...
  13. ncbi Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: therapeutic implications?
    Rita Ghosh
    Department of Cancer Causation and Prevention, AMC Cancer Research Center and The University of Colorado Comprehensive Cancer Center, Denver, Colorado 80214, USA
    Melanoma Res 13:119-27. 2003
    ..Taken together these results have major implications for the use of 2-ME for melanoma management...

Research Grants4

  1. Nexrutine, a herbal extract and prostate cancer
    ADDANKI KUMAR; Fiscal Year: 2004
    ..abstract_text> ..
  2. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    ADDANKI KUMAR; Fiscal Year: 2009
    ....
  3. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    Addanki P Kumar; Fiscal Year: 2010
    ....