L H Kuller

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Risk factors for dementia in the cardiovascular health cognition study
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, PA 15261, USA
    Neuroepidemiology 22:13-22. 2003
  2. ncbi request reprint Prevention of cardiovascular disease and the future of cardiovascular disease epidemiology
    L H Kuller
    University of Pittsburgh, Department of Epidemiology, GSPH, Pittsburgh, PA 15261, USA
    Int J Epidemiol 30:S66-72. 2001
  3. ncbi request reprint Prevalence and risk factors for abdominal aortic aneurysms in older adults with and without isolated systolic hypertension
    B L Naydeck
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 83:759-64. 1999
  4. pmc Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study
    K I Erickson
    Department of Psychology, University of Pittsburgh, PA, USA
    Neurology 75:1415-22. 2010
  5. ncbi request reprint Coronary artery calcification in older adults to age 99: prevalence and risk factors
    A B Newman
    Division of Geriatric Medicine, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 104:2679-84. 2001
  6. ncbi request reprint A community-based study of postmenopausal white women with back and leg pain: health status and limitations in physical activity
    Molly T Vogt
    Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 57:M544-50. 2002
  7. ncbi request reprint Relationship of adiposity to subclinical atherosclerosis in obese patients with type 2 diabetes
    Refaat A F Hegazi
    Department of Medicine, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Obes Res 11:1597-605. 2003
  8. ncbi request reprint Prevalence and determinants of carotid atherosclerosis in healthy postmenopausal women
    H C Lassila
    Department of Epidemiology, School of Medicine, University of Pittsburgh, PA 15261, USA
    Stroke 28:513-7. 1997
  9. ncbi request reprint The association between a family history of type 2 diabetes and coronary artery disease in a type 1 diabetes population
    J R Erbey
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Diabetes Care 21:610-4. 1998
  10. ncbi request reprint A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-media thickness of the carotid arteries
    Rachel P Wildman
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA
    J Am Coll Cardiol 44:579-85. 2004

Collaborators

Detail Information

Publications164 found, 100 shown here

  1. ncbi request reprint Risk factors for dementia in the cardiovascular health cognition study
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, PA 15261, USA
    Neuroepidemiology 22:13-22. 2003
    ..The Cardiovascular Health Cognition Study has evaluated the determinants of dementia among 3,608 participants that had a magnetic resonance imaging (MRI) of the brain in 1991 and were followed to 1998-1999...
  2. ncbi request reprint Prevention of cardiovascular disease and the future of cardiovascular disease epidemiology
    L H Kuller
    University of Pittsburgh, Department of Epidemiology, GSPH, Pittsburgh, PA 15261, USA
    Int J Epidemiol 30:S66-72. 2001
    ....
  3. ncbi request reprint Prevalence and risk factors for abdominal aortic aneurysms in older adults with and without isolated systolic hypertension
    B L Naydeck
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 83:759-64. 1999
    ..Patients with AAA also had greater wall thickness and greater diameter of the iliac arteries, which are probably associated with the underlying disease process...
  4. pmc Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study
    K I Erickson
    Department of Psychology, University of Pittsburgh, PA, USA
    Neurology 75:1415-22. 2010
    ....
  5. ncbi request reprint Coronary artery calcification in older adults to age 99: prevalence and risk factors
    A B Newman
    Division of Geriatric Medicine, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 104:2679-84. 2001
    ..However, the prevalence and risk factors for coronary artery calcification in populations >65 years have not been well studied...
  6. ncbi request reprint A community-based study of postmenopausal white women with back and leg pain: health status and limitations in physical activity
    Molly T Vogt
    Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 57:M544-50. 2002
    ..The objective of this study was to determine the prevalence of lower back pain and associated leg pain/numbness in postmenopausal Caucasian women and the relationship of these symptoms to health status and function...
  7. ncbi request reprint Relationship of adiposity to subclinical atherosclerosis in obese patients with type 2 diabetes
    Refaat A F Hegazi
    Department of Medicine, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Obes Res 11:1597-605. 2003
    ..This study was designed to examine the relationship between obesity and regional patterns of adiposity, insulin resistance, and five independent measures of subclinical atherosclerosis...
  8. ncbi request reprint Prevalence and determinants of carotid atherosclerosis in healthy postmenopausal women
    H C Lassila
    Department of Epidemiology, School of Medicine, University of Pittsburgh, PA 15261, USA
    Stroke 28:513-7. 1997
    ..Few studies have included enough younger postmenopausal women to examine risk factors specific to this group that were related to subclinical carotid atherosclerosis...
  9. ncbi request reprint The association between a family history of type 2 diabetes and coronary artery disease in a type 1 diabetes population
    J R Erbey
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Diabetes Care 21:610-4. 1998
    ..Because the etiologies of type 1 and type 2 diabetes are different, it is possible that some CAD in type 1 diabetes may be related to the coexistence of type 2 diabetes susceptibility (i.e., insulin resistance)...
  10. ncbi request reprint A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-media thickness of the carotid arteries
    Rachel P Wildman
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA
    J Am Coll Cardiol 44:579-85. 2004
    ..The object of this study was to assess the effects of menopause and a diet/exercise intervention on subclinical atherosclerosis progression...
  11. pmc Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study
    O L Lopez
    Department of Psychiatry and Neurology, University of Pittsburgh, PA, USA
    Neurology 70:1664-71. 2008
    ....
  12. ncbi request reprint Subclinical atherosclerosis in relation to hysterectomy status in black women
    C M Zeigler-Johnson
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Stroke 29:759-64. 1998
    ..The effects of both surgery and menopausal status were evaluated...
  13. ncbi request reprint Estrogens and women's health: interrelation of coronary heart disease, breast cancer and osteoporosis
    L H Kuller
    Department of Epidemiology, GSPH, University of Pittsburgh, 130 DeSoto Street, 15261, Pittsburgh, PA, USA
    J Steroid Biochem Mol Biol 74:297-309. 2000
    ....
  14. ncbi request reprint Diabetes mellitus: subclinical cardiovascular disease and risk of incident cardiovascular disease and all-cause mortality
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 20:823-9. 2000
    ..Fasting blood glucose levels were a weak predictor of incident coronary heart disease as were most other risk factors. Subclinical CVD was the primary determinant of clinical CVD among diabetics in the Cardiovascular Health Study...
  15. ncbi request reprint Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study
    L H Kuller
    University of Pittsburgh, PA 15261, USA
    Stroke 29:388-98. 1998
    ..We determined the relationship between apolipoprotein (Apo)E, MRI, and low cognitive scores...
  16. pmc Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States
    Koichiro Azuma
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Metabolism 58:1200-7. 2009
    ....
  17. ncbi request reprint Incidence and prevalence of dementia in the Cardiovascular Health Study
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, Washington 98115, USA
    J Am Geriatr Soc 52:195-204. 2004
    ..To estimate the incidence and prevalence of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in the Cardiovascular Health Study (CHS) cohort...
  18. ncbi request reprint Anthropometry and breast cancer risk in Nigerian women
    Michael N Okobia
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Breast J 12:462-6. 2006
    ....
  19. pmc Do carotid artery diameters manifest early evidence of atherosclerosis in women with rheumatoid arthritis?
    Laura L Schott
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Womens Health (Larchmt) 18:21-9. 2009
    ..We take a unique approach by evaluating lumen and interadventitial diameters in addition to intima-media thickness and plaque...
  20. ncbi request reprint Coronary and aortic calcification among women 8 years after menopause and their premenopausal risk factors : the healthy women study
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, The University of Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 19:2189-98. 1999
    ..Thus, risk factors evaluated premenopausally are powerful predictors of coronary and aortic calcification, a marker of atherosclerosis, measured 8 years after menopause, 11 years later in these women...
  21. ncbi request reprint Effect of a lifestyle intervention on bone mineral density in premenopausal women: a randomized trial
    L M Salamone
    University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 70:97-103. 1999
    ..The positive association between body weight and bone mineral density (BMD) is well documented; in contrast, the effect of changes in body weight on BMD is not well understood, particularly, in normal-weight populations...
  22. ncbi request reprint Serum levels of C-reactive protein are associated with obesity, weight gain, and hormone replacement therapy in healthy postmenopausal women
    E Barinas-Mitchell
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 153:1094-101. 2001
    ..29 mg/liter) compared with women not on HRT and in the lowest quartile of visceral fat (0.96 mg/liter). The use of HRT and measures of overall body fatness are important correlates of C-reactive protein among postmenopausal women...
  23. ncbi request reprint Hormone replacement therapy use and menopausal symptoms among women participating in a behavioral lifestyle intervention
    M A Boraz
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Prev Med 33:108-14. 2001
    ..The purpose of this study was to examine the choice to take HRT while participating in a lifestyle intervention to reduce cardiovascular risk through the menopause...
  24. ncbi request reprint Correlates of serum lipids in a lean black population
    C H Bunker
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Atherosclerosis 123:215-25. 1996
    ..Physical activity was lower among the higher SES. We conclude that SES related changes in lifestyle contribute to substantially higher total and LDL-cholesterol even in a generally lean population consuming a low fat diet...
  25. pmc Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study
    Akira Sekikawa
    University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 52:417-24. 2008
    ..We sought to examine whether marine-derived n-3 fatty acids are associated with less atherosclerosis in Japanese versus white populations in the U.S...
  26. pmc Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men
    Kenneth R Motoyama
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 90:49-55. 2009
    ..The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known...
  27. pmc Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans
    L J Hassen
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Eur J Clin Nutr 66:329-35. 2012
    ..However, the association of marine n-3 FAs with plasma fibrinogen, a risk factor for CVD, remains uncertain...
  28. ncbi request reprint Lipid and blood pressure treatment goals for type 1 diabetes: 10-year incidence data from the Pittsburgh Epidemiology of Diabetes Complications Study
    T J Orchard
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 3512 Fifth Avenue, Pittsburgh, PA 15213, USA
    Diabetes Care 24:1053-9. 2001
    ..The objective of this study was to determine at which levels of LDL and HDL cholesterol, triglycerides, and blood pressure the relative risks of type 1 diabetic complications increase significantly...
  29. ncbi request reprint The role of comorbidity in the assessment of intermittent claudication in older adults
    A B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Keystone Blds, Suite 300, 3529 First Avenue, Pittsburgh, PA 15213 3313, USA
    J Clin Epidemiol 54:294-300. 2001
    ..The Rose Questionnaire for IC is specific for PAD, but a negative questionnaire does not indicate a lack of symptoms, rather the presence of PAD along with other conditions that can cause pain...
  30. pmc Neuropsychological characteristics of mild cognitive impairment subgroups
    O L Lopez
    Department of Neurology, University of Pittsburgh, School of Medicine, PA 15213, USA
    J Neurol Neurosurg Psychiatry 77:159-65. 2006
    ..To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study...
  31. ncbi request reprint Maintenance of cardiovascular risk factor changes among middle-aged women in a lifestyle intervention trial
    L R Simkin-Silverman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Womens Health 4:255-71. 1998
    ..Eighty percent of intervention participants compared to 45% of controls were at or under baseline weight at 18 months, suggesting that promoting modest weight loss may be an effective approach to preventing weight gain in these women...
  32. ncbi request reprint Elevated pulse wave velocity increases the odds of coronary calcification in overweight postmenopausal women
    Lakshmi Venkitachalam
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Hypertens 20:469-75. 2007
    ..Our aim is to evaluate the association between both these measures of arterial stiffness and coronary calcification (CAC), in overweight/obese postmenopausal women, without apparent cardiovascular disease...
  33. pmc Brain structure and obesity
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh, Pennsylvania, USA
    Hum Brain Mapp 31:353-64. 2010
    ..Higher BMI was associated with lower brain volumes in overweight and obese elderly subjects. Obesity is therefore associated with detectable brain volume deficits in cognitively normal elderly subjects...
  34. pmc Optimism, cynical hostility, and incident coronary heart disease and mortality in the Women's Health Initiative
    Hilary A Tindle
    University of Pittsburgh, PA, USA
    Circulation 120:656-62. 2009
    ..Trait optimism (positive future expectations) and cynical, hostile attitudes toward others have not been studied together in relation to incident coronary heart disease (CHD) and mortality in postmenopausal women...
  35. doi request reprint Progression of carotid intima-media thickness and plaque in women with systemic lupus erythematosus
    Trina Thompson
    University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Arthritis Rheum 58:835-42. 2008
    ....
  36. ncbi request reprint Evaluation of dementia in the cardiovascular health cognition study
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15261, USA
    Neuroepidemiology 22:1-12. 2003
    ..To describe a methodology to evaluate dementia and frequency of different types of dementia and prevalence of the Cardiovascular Health Study (CHS)...
  37. pmc Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men
    I Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 21:1900-7. 2013
    ..A comprehensive array of factors potentially related to fasting serum lipid and lipoprotein levels in African ancestry men was evaluated...
  38. ncbi request reprint Carotid atherosclerosis in premenopausal and postmenopausal women and its association with risk factors measured after menopause
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Stroke 29:1116-21. 1998
    ..This report compares the prevalence and degree of carotid atherosclerosis between 292 premenopausal women and 294 women at 5 to 8 years after menopause...
  39. pmc Age, Alzheimer disease, and brain structure
    C A Raji
    Departments of Pathology, School of Medicine and Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Neurology 73:1899-905. 2009
    ..Lack of clear understanding remains on the overlapping atrophy patterns of aging and early Alzheimer disease (AD) pathology in gray matter (GM) of the brain in vivo...
  40. ncbi request reprint Usefulness of electron beam tomography to detect progression of coronary and aortic calcium in middle-aged women
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, The Cardiovascular Institute Preventive Heart Care Center, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 87:560-4. 2001
    ..Both coronary and aortic calcium were significantly associated with premenopausal cardiovascular risk factors. Thus, progression of coronary and aortic calcium using EBT can be observed over a short time in healthy middle- aged women...
  41. ncbi request reprint IDDM incidence in a multiracial population. The Hawaii IDDM Registry, 1980-1990
    S L Patrick
    World Health Organization Collaborating Center for Diabetes Research, Registries and Training, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    Diabetes Care 20:983-7. 1997
    ..Because of the multiracial population living in Hawaii, it is an ideal state in which to study the effect of migration on IDDM incidence...
  42. ncbi request reprint Factors associated with calcium absorption efficiency in pre- and perimenopausal women
    R L Wolf
    Departments of Epidemiology, Education, and Genetics, University of Pittsburgh, USA
    Am J Clin Nutr 72:466-71. 2000
    ..The amount of calcium ingested by an individual may affect several chronic conditions, including osteoporosis, hypertension, and colon cancer. However, individuals vary in their ability to absorb the calcium they consume...
  43. ncbi request reprint A common promotor variant in the cytochrome P450c17alpha (CYP17) gene is associated with bioavailability testosterone levels and bone size in men
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 16:911-7. 2001
    ..These results suggest that allelic variation at the CYP17 locus may contribute to the genetic influence on stature and femoral size in men...
  44. pmc Midlife and late-life obesity and the risk of dementia: cardiovascular health study
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Collaborative Health Studies Coordinating Center, Seattle, 98115, USA
    Arch Neurol 66:336-42. 2009
    ..While high adiposity in middle age appears to be related to greater dementia risk, studies exploring this association in the elderly are conflicting...
  45. ncbi request reprint Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
    Shirley A A Beresford
    Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
    JAMA 295:643-54. 2006
    ..Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial...
  46. ncbi request reprint Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus
    Faith Selzer
    University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Arthritis Rheum 50:151-9. 2004
    ....
  47. pmc Ginkgo biloba for prevention of dementia: a randomized controlled trial
    Steven T DeKosky
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 300:2253-62. 2008
    ..Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking...
  48. ncbi request reprint Bone mass and breast cancer risk in older women: differences by stage at diagnosis
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Natl Cancer Inst 93:930-6. 2001
    ..Older women with low bone mineral density (BMD) have a decreased incidence of breast cancer. It is not known whether this association is confined to early-stage, slow-growing tumors...
  49. pmc Premenopausal risk factors for coronary and aortic calcification: a 20-year follow-up in the healthy women study
    Karen A Matthews
    University of Pittsburgh, Department of Psychiatry, Epidemiology and Psychology, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Prev Med 45:302-8. 2007
    ..It is important to understand the early development of subclinical cardiovascular disease (CVD) in women to prevent costly morbidity and mortality associated with CVD events...
  50. ncbi request reprint It is never too late: change in physical activity fosters change in cardiovascular risk factors in middle-aged women
    Jane F Owens
    University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Prev Cardiol 6:22-8. 2003
    ..Thus, for middle-aged women going through the menopausal transition, it is never too late to reduce their cardiovascular risk by increasing their activity level...
  51. pmc Association between depression and coronary artery calcification in women with systemic lupus erythematosus
    Carol M Greco
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Rheumatology (Oxford) 48:576-81. 2009
    ..To determine the associations between depression, cardiovascular risk factors and coronary artery calcification (CAC) in women with SLE and controls...
  52. ncbi request reprint The relationship between physical activity and lipoprotein subclasses in postmenopausal women: the influence of hormone therapy
    Kelley K Pettee
    Department of Epidemiology, Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Menopause 14:115-22. 2007
    ..This study's objective was to determine if the association between physical activity and lipids and lipoprotein subclasses in postmenopausal women varies by hormone therapy (HT) use...
  53. pmc Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: a case control study
    Michael N Okobia
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BMC Cancer 8:338. 2008
    ..This study was designed to assess the role of this polymorphism in breast cancer susceptibility in Nigerian women...
  54. ncbi request reprint Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
    ..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study...
  55. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
    ..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study...
  56. pmc World Health Organization-defined metabolic syndrome is a better predictor of coronary calcium than the adult treatment panel III criteria in American men aged 40-49 years
    Tomoko Takamiya
    University of Pittsburgh Graduate School of Public Health, 130 N Bellefield Ave, Bellefiled Bldg, Room 405, Pittsburgh, PA 15213, USA
    Diabetes Care 27:2977-9. 2004
  57. pmc The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49
    Tomoko Takamiya
    Department of Epidemiology, University of Pittsburgh, PA, United States
    Diabetes Res Clin Pract 72:176-82. 2006
    ..The aim of our study was to compare PAI-1 levels between Americans and the Japanese in the post-war generation and to elucidate the determinants of the PAI-1 levels...
  58. pmc Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy women
    Isabella Soreca
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychosom Med 71:485-90. 2009
    ..Cross-sectional results indicate that reduced GMV may be associated with excess body weight...
  59. ncbi request reprint Optimistic attitudes protect against progression of carotid atherosclerosis in healthy middle-aged women
    Karen A Matthews
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychosom Med 66:640-4. 2004
    ..We evaluated whether pessimists are more likely to show progression in carotid disease than optimists...
  60. ncbi request reprint Hormone therapy and age-related macular degeneration: the Women's Health Initiative Sight Exam Study
    Mary N Haan
    Department of Epidemiology, University of Michigan, 611 Church Street, Ann Arbor, MI 48104, USA
    Arch Ophthalmol 124:988-92. 2006
    ..To determine the effectiveness of treatment with conjugated equine estrogens (CEE) or with CEE combined with progestin (CEE + P) on age-related macular degeneration (AMD)...
  61. pmc Sex steroid hormones, bone mineral density, and risk of breast cancer
    L H Kuller
    University of Pittsburgh, Department of Epidemiology, Pennsylvania 15261, USA
    Environ Health Perspect 105:593-9. 1997
    ..This model of increased risk of breast cancer associated with BMD and HRT needs to be evaluated within clinical trials and larger observational studies that include measures of BMD...
  62. ncbi request reprint Coronary heart disease mortality trends in men in the post World War II birth cohorts aged 35-44 in Japan, South Korea and Taiwan compared with the United States
    A Sekikawa
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, USA
    Int J Epidemiol 28:1044-9. 1999
    ..It is most likely that the post World War II cohorts (1950+) have been more exposed. We hypothesize that there would be an increase in mortality from coronary heart disease (CHD) in men aged 35-44 in these countries...
  63. ncbi request reprint Blood pressure levels and measurement of subclinical vascular disease
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    J Hypertens Suppl 17:S15-9. 1999
    ..The subclinical measures should include those primarily associated with the progression of atherosclerosis and the pathophysiology of elevated blood pressure...
  64. ncbi request reprint Elevated prostate-specific antigen levels up to 25 years prior to death from prostate cancer
    Lewis H Kuller
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer Epidemiol Biomarkers Prev 13:373-7. 2004
    ....
  65. pmc Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    Lewis H Kuller
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS Med 5:e203. 2008
    ..We hypothesized that increased HIV-RNA levels following ART interruption induced activation of tissue factor pathways, thrombosis, and fibrinolysis...
  66. doi request reprint Weight regain and health-related quality of life in postmenopausal women
    David J Yankura
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:2259-65. 2008
    ..Further study is needed to investigate the impact of a decline in mental health and social functioning on future weight regain...
  67. pmc Difference in carotid intima-media thickness between Korean and Japanese men
    Jina Choo
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Epidemiol 18:310-5. 2008
    ..We aimed to evaluate levels of carotid intima-media thickness (IMT) and coronary risk factors in Korean and Japanese men in the post-World War II birth cohort...
  68. ncbi request reprint Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study
    Laura Jean Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 161:639-51. 2005
    ..A similar pattern was observed for Alzheimer's disease and vascular dementia. Mechanisms to explain the observed relations deserve further study...
  69. ncbi request reprint Postbariatric surgery deaths, which fall under the jurisdiction of the coroner
    Bennet I Omalu
    Allegheny County Coroner s Office, Pittsburgh, Pennsylvania, USA
    Am J Forensic Med Pathol 25:237-42. 2004
    ..The majority of decedents were white females who remained morbidly obese after bariatric surgery. Only 2 decedents died of direct inadvertent/accidental surgical complications...
  70. pmc Associations of D-dimer and von Willebrand factor with atherosclerosis in Japanese and white men
    Ryoko W Azuma
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Acta Cardiol 65:449-56. 2010
    ..S.). We examined whether the differences in D-dimer and vWF levels are associated with differences in atherosclerosis between the two populations...
  71. ncbi request reprint Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study
    Rachel H Mackey
    Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, PA 15261, USA
    Am J Hypertens 15:16-23. 2002
    ..Arterial stiffness has been associated with aging, hypertension, and diabetes; however, little data has been published examining risk factors associated with arterial stiffness in elderly individuals...
  72. pmc Health characteristics of postmenopausal women with breast implants
    J Peter Rubin
    Division of Plastic Surgery and Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Plast Reconstr Surg 125:799-810. 2010
    ..Long-term health characteristics and quality of life in patients with breast implants are important issues in plastic surgery...
  73. ncbi request reprint Physical activity and white matter lesion progression: assessment using MRI
    L J Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Neurology 68:1223-6. 2007
    ..Physical activity was not significantly associated with a decreased rate of periventricular or deep WML progression...
  74. ncbi request reprint Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial
    R W Evans
    Department of Epidemiology, University of Pittsburgh, Penn, USA
    Arterioscler Thromb Vasc Biol 17:1947-53. 1997
    ..Homocyst(e)ine levels were weakly associated with the acute-phase protein (C-reactive protein). These results are discussed with respect to the suggestion that homocyst(e)ine is an independent risk factor for heart disease...
  75. pmc Mammography and pap smear use by older rural women
    D G Ives
    Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    Public Health Rep 111:244-50. 1996
    ..To compare the characteristics of older women who did and did not have screening mammograms and Pap smears during the first two years both services were a Medicare Part B benefit...
  76. ncbi request reprint Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial
    R W Evans
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Clin Epidemiol 54:51-7. 2001
    ..When adjusted for age and Lp(a) concentration, logistic regression analysis indicated that small apo(a) isoforms were associated with CHD deaths among smokers (OR 3.31; 95% CI 1.07-10.28)...
  77. pmc Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years
    S Matsunaga-Irie
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Diabetes Obes Metab 9:591-3. 2007
    ..Recently, several papers reported the ethnic difference in the ghrelin levels. To our knowledge, however, no studies have compared the serum ghrelin levels between Caucasians in the USA and the Japanese in Japan...
  78. ncbi request reprint Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes
    M Pietropaolo
    Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Diabetes 49:32-8. 2000
    ..These findings not only have direct implications for adequate classification and treatment of diabetes in the elderly, but also for understanding the autoimmune/inflammatory mechanisms involved in the pathogenesis of hyperglycemia...
  79. pmc Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF)
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:134-43. 2009
    ..These women experienced a lower risk of fractures, disability, and mortality, suggesting that this phenotype may be a marker of successful aging...
  80. ncbi request reprint Are hostility and anxiety associated with carotid atherosclerosis in healthy postmenopausal women?
    K A Matthews
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Psychosom Med 60:633-8. 1998
    ..In this article, we evaluated the prospective association between measures of trait anger, hostility, and anxiety and indices of carotid atherosclerosis in 200 healthy middle-aged postmenopausal women...
  81. ncbi request reprint Assessment of the disturbances in metabolic homeostasis: a hypothesis of synergism
    S R Kim
    University of Pittsburgh, Pittsburgh, USA
    Med Hypotheses 59:655-9. 2002
    ..The present study validated the hypothetical model in a sample of 110 African-American women...
  82. ncbi request reprint A hypothesis of synergism: the interrelationship of T3 and insulin to disturbances in metabolic homeostasis
    S R Kim
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Med Hypotheses 59:660-6. 2002
    ..The current paper presents an integrative hypothesis of the synergistic relationship of T(3) and insulin in metabolic homeostasis and abnormalities...
  83. ncbi request reprint Vascular imaging: changing the face of cardiovascular research
    S Manzi
    University of Pittsburgh School of Medicine, PA 15213, USA
    Lupus 9:176-82. 2000
    ..In this review, we will discuss several vascular imaging techniques and the current trend away from measuring flow-limiting vessel stenosis toward measuring earlier structural and functional aspects of the vascular system...
  84. ncbi request reprint Stress-induced pulse pressure change predicts women's carotid atherosclerosis
    K A Matthews
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Stroke 29:1525-30. 1998
    ..This report evaluates the association between stress-induced hemodynamic responses and carotid atherosclerosis in 254 healthy postmenopausal women...
  85. pmc A "natural experiment" in cardiovascular epidemiology in the early 21st century
    A Sekikawa
    University of Pittsburgh, Pittsburgh, USA
    Heart 89:255-7. 2003
    ..Careful study of such cohorts may help identify novel risk factors for CHD, and contribute to the formulation of new preventive strategies..
  86. ncbi request reprint Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
    David E Kelley
    Department of Medicine, University of Pittsburgh, 810N Montefiore University Hospital, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 285:E906-16. 2003
    ..34; P < 0.01). In summary, fatty liver is relatively common in overweight and obese volunteers with type 2 DM and is an aspect of body composition related to severity of insulin resistance, dyslipidemia, and inflammatory markers...
  87. ncbi request reprint Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
    J Neuroimaging 17:148-55. 2007
    ....
  88. ncbi request reprint Nutrition, lipids, and cardiovascular disease
    Lewis H Kuller
    University of Pittsburgh, GSPH, 130 North Bellefield Avenue, Room 550, Pittsburgh, PA 15213, USA
    Nutr Rev 64:S15-26. 2006
    ..Careful monitoring of the evolving epidemic of CHD, including noninvasive evaluation of atherosclerosis, is important. A high-risk approach is very successful but expensive...
  89. ncbi request reprint Ernst Wynder and preventive medicine
    Lewis H Kuller
    Graduate School of Public Health, Bellefield Professional Building, Pittsburgh, PA 15213, USA
    Prev Med 43:236-7. 2006
  90. pmc Genetic determination of adiponectin and its relationship with body fat topography in multigenerational families of African heritage
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Metabolism 56:234-8. 2007
    ..Adiponectin may serve as a promising quantitative intermediate trait in studies designed to map the genes underlying diabetes and obesity in this population...
  91. ncbi request reprint Statins and dementia
    Lewis H Kuller
    University of Pittsburgh, GSPH, 130 North Bellefield Avenue, Room 550, Pittsburgh, PA 15213, USA
    Curr Atheroscler Rep 9:154-61. 2007
    ..In spite of negative studies, the possibility remains that statin therapy may reduce risk of dementia and AD. Primary prevention trials are difficult and expensive and will likely not be done in the United States...
  92. ncbi request reprint Lifestyle intervention and coronary heart disease risk factor changes over 18 months in postmenopausal women: the Women On the Move through Activity and Nutrition (WOMAN study) clinical trial
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Womens Health (Larchmt) 15:962-74. 2006
    ..In this paper, we present the results of changes in risk factors by use of hormone therapy (HT) at 18 months in the Women On the Move through Activity and Nutrition (WOMAN) randomized trial...
  93. ncbi request reprint Extent of cardiovascular risk reduction associated with treatment of isolated systolic hypertension
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arch Intern Med 163:2728-31. 2003
    ..However, nearly 20% of older adults remain at high risk of heart disease and stroke from untreated ISH...
  94. pmc Monthly variation in physical activity levels in postmenopausal women
    Mark A Newman
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Med Sci Sports Exerc 41:322-7. 2009
    ..Month-to-month variation in physical activity levels in a cohort of postmenopausal women participating in a single site clinical trial undergoing lifestyle intervention was investigated before and after lifestyle intervention...
  95. ncbi request reprint Geographic variations in stroke incidence and mortality among older populations in four US communities
    Aiman El-Saed
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Rm 405, Pittsburgh, PA 15213, USA
    Stroke 37:1975-9. 2006
    ..The purpose of this study was to compare stroke incidence and mortality rates in 4 US communities...
  96. ncbi request reprint Hormone replacement therapy and risk of cardiovascular disease: implications of the results of the Women's Health Initiative
    Lewis H Kuller
    Department of Epidemiology, GSPH, University of Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 23:11-6. 2003
    ..The increased risk of CHD and stroke with E+P therapy may be attributable to rise in VLDL triglycerides and thrombosis...
  97. ncbi request reprint Relationship of visceral adipose tissue to recurrence of adenomatous polyps
    David A Sass
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 99:687-93. 2004
    ..The aim of this investigation was to determine whether VAT is associated with recurrence of adenomatous polyps, the precursor to colorectal cancer...
  98. ncbi request reprint Commentary: hazards of studying women: the oestrogen oestrogen/progesterone dilemma
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, GSPH, 130 North Bellefield Avenue, Room 550, Pittsburgh, PA 15213, USA
    Int J Epidemiol 33:459-60. 2004
  99. ncbi request reprint Relationship between coronary artery calcification and other measures of subclinical cardiovascular disease in older adults
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, PA 15213, USA
    Arterioscler Thromb Vasc Biol 22:1674-9. 2002
    ..In the Cardiovascular Health Study, subclinical cardiovascular disease (CVD) predicted CVD events in older adults. The extent to which this measure or its components reflect calcified coronary disease is unknown...
  100. ncbi request reprint Lack of association between adipose tissue distribution and IGF-1 and IGFBP-3 in men and women
    Robert E Schoen
    Departments of Epidemiology, Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Cancer Epidemiol Biomarkers Prev 11:581-6. 2002
    ..The lack of association between obesity and the IGF-1 axis suggests that the IGF-1 axis is not a likely mediator between VAT and disease...
  101. ncbi request reprint Subclinical atherosclerosis in multiple vascular beds: an index of atherosclerotic burden evaluated in postmenopausal women
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 160:407-16. 2002
    ..Women with lower premenopausal risk factors did not develop high levels of subclinical atherosclerosis, suggesting that atherosclerosis is a preventable disease in women...