L H Kuller

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Differences in prevalence of and risk factors for subclinical vascular disease among black and white participants in the Cardiovascular Health Study
    L Kuller
    University of Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 18:283-93. 1998
  2. ncbi Coronary and aortic calcification among women 8 years after menopause and their premenopausal risk factors : the healthy women study
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, The University of Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 19:2189-98. 1999
  3. ncbi Diabetes mellitus: subclinical cardiovascular disease and risk of incident cardiovascular disease and all-cause mortality
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 20:823-9. 2000
  4. ncbi Blood pressure levels and measurement of subclinical vascular disease
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    J Hypertens Suppl 17:S15-9. 1999
  5. ncbi Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study
    L H Kuller
    University of Pittsburgh, PA 15261, USA
    Stroke 29:388-98. 1998
  6. ncbi Sex steroid hormones, bone mineral density, and risk of breast cancer
    L H Kuller
    University of Pittsburgh, Department of Epidemiology, Pennsylvania 15261, USA
    Environ Health Perspect 105:593-9. 1997
  7. ncbi [Risk factors for dementia in the Cardiovascular Health Study cognition study]
    L H Kuller
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Rev Neurol 37:122-6. 2003
  8. ncbi Prevalence and risk factors for abdominal aortic aneurysms in older adults with and without isolated systolic hypertension
    B L Naydeck
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 83:759-64. 1999
  9. ncbi Coronary artery calcification in older adults to age 99: prevalence and risk factors
    A B Newman
    Division of Geriatric Medicine, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 104:2679-84. 2001
  10. ncbi Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study
    K I Erickson
    Department of Psychology, University of Pittsburgh, PA, USA
    Neurology 75:1415-22. 2010

Detail Information

Publications77

  1. ncbi Differences in prevalence of and risk factors for subclinical vascular disease among black and white participants in the Cardiovascular Health Study
    L Kuller
    University of Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 18:283-93. 1998
    ..In black men, blood triglyceride level, use of antihypertensive medications, and family history of myocardial infarction (inverse) were associated with subclinical disease...
  2. ncbi Coronary and aortic calcification among women 8 years after menopause and their premenopausal risk factors : the healthy women study
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, The University of Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 19:2189-98. 1999
    ..Thus, risk factors evaluated premenopausally are powerful predictors of coronary and aortic calcification, a marker of atherosclerosis, measured 8 years after menopause, 11 years later in these women...
  3. ncbi Diabetes mellitus: subclinical cardiovascular disease and risk of incident cardiovascular disease and all-cause mortality
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 20:823-9. 2000
    ..Fasting blood glucose levels were a weak predictor of incident coronary heart disease as were most other risk factors. Subclinical CVD was the primary determinant of clinical CVD among diabetics in the Cardiovascular Health Study...
  4. ncbi Blood pressure levels and measurement of subclinical vascular disease
    L H Kuller
    Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    J Hypertens Suppl 17:S15-9. 1999
    ..The subclinical measures should include those primarily associated with the progression of atherosclerosis and the pathophysiology of elevated blood pressure...
  5. ncbi Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study
    L H Kuller
    University of Pittsburgh, PA 15261, USA
    Stroke 29:388-98. 1998
    ..We determined the relationship between apolipoprotein (Apo)E, MRI, and low cognitive scores...
  6. ncbi Sex steroid hormones, bone mineral density, and risk of breast cancer
    L H Kuller
    University of Pittsburgh, Department of Epidemiology, Pennsylvania 15261, USA
    Environ Health Perspect 105:593-9. 1997
    ..This model of increased risk of breast cancer associated with BMD and HRT needs to be evaluated within clinical trials and larger observational studies that include measures of BMD...
  7. ncbi [Risk factors for dementia in the Cardiovascular Health Study cognition study]
    L H Kuller
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Rev Neurol 37:122-6. 2003
    ..Scores of global cognitive measures, the presence of the APOE 4 allele, and MRI of the brain were strong predictors of dementia and AD...
  8. ncbi Prevalence and risk factors for abdominal aortic aneurysms in older adults with and without isolated systolic hypertension
    B L Naydeck
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 83:759-64. 1999
    ..Patients with AAA also had greater wall thickness and greater diameter of the iliac arteries, which are probably associated with the underlying disease process...
  9. ncbi Coronary artery calcification in older adults to age 99: prevalence and risk factors
    A B Newman
    Division of Geriatric Medicine, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 104:2679-84. 2001
    ..However, the prevalence and risk factors for coronary artery calcification in populations >65 years have not been well studied...
  10. ncbi Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study
    K I Erickson
    Department of Psychology, University of Pittsburgh, PA, USA
    Neurology 75:1415-22. 2010
    ....
  11. ncbi Bone mass and breast cancer risk in older women: differences by stage at diagnosis
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Natl Cancer Inst 93:930-6. 2001
    ..Older women with low bone mineral density (BMD) have a decreased incidence of breast cancer. It is not known whether this association is confined to early-stage, slow-growing tumors...
  12. ncbi The association between a family history of type 2 diabetes and coronary artery disease in a type 1 diabetes population
    J R Erbey
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Diabetes Care 21:610-4. 1998
    ..Because the etiologies of type 1 and type 2 diabetes are different, it is possible that some CAD in type 1 diabetes may be related to the coexistence of type 2 diabetes susceptibility (i.e., insulin resistance)...
  13. ncbi Estrogens and women's health: interrelation of coronary heart disease, breast cancer and osteoporosis
    L H Kuller
    Department of Epidemiology, GSPH, University of Pittsburgh, 130 DeSoto Street, 15261, Pittsburgh, PA, USA
    J Steroid Biochem Mol Biol 74:297-309. 2000
    ....
  14. ncbi Prevalence and determinants of carotid atherosclerosis in healthy postmenopausal women
    H C Lassila
    Department of Epidemiology, School of Medicine, University of Pittsburgh, PA 15261, USA
    Stroke 28:513-7. 1997
    ..Few studies have included enough younger postmenopausal women to examine risk factors specific to this group that were related to subclinical carotid atherosclerosis...
  15. ncbi Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study
    O L Lopez
    Department of Psychiatry and Neurology, University of Pittsburgh, PA, USA
    Neurology 70:1664-71. 2008
    ....
  16. ncbi Subclinical atherosclerosis in relation to hysterectomy status in black women
    C M Zeigler-Johnson
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Stroke 29:759-64. 1998
    ..The effects of both surgery and menopausal status were evaluated...
  17. ncbi Hormone replacement therapy use and menopausal symptoms among women participating in a behavioral lifestyle intervention
    M A Boraz
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Prev Med 33:108-14. 2001
    ..The purpose of this study was to examine the choice to take HRT while participating in a lifestyle intervention to reduce cardiovascular risk through the menopause...
  18. ncbi Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans
    L J Hassen
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Eur J Clin Nutr 66:329-35. 2012
    ..However, the association of marine n-3 FAs with plasma fibrinogen, a risk factor for CVD, remains uncertain...
  19. ncbi Lipid and blood pressure treatment goals for type 1 diabetes: 10-year incidence data from the Pittsburgh Epidemiology of Diabetes Complications Study
    T J Orchard
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 3512 Fifth Avenue, Pittsburgh, PA 15213, USA
    Diabetes Care 24:1053-9. 2001
    ..The objective of this study was to determine at which levels of LDL and HDL cholesterol, triglycerides, and blood pressure the relative risks of type 1 diabetic complications increase significantly...
  20. ncbi Serum levels of C-reactive protein are associated with obesity, weight gain, and hormone replacement therapy in healthy postmenopausal women
    E Barinas-Mitchell
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 153:1094-101. 2001
    ..29 mg/liter) compared with women not on HRT and in the lowest quartile of visceral fat (0.96 mg/liter). The use of HRT and measures of overall body fatness are important correlates of C-reactive protein among postmenopausal women...
  21. ncbi Effect of a lifestyle intervention on bone mineral density in premenopausal women: a randomized trial
    L M Salamone
    University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 70:97-103. 1999
    ..The positive association between body weight and bone mineral density (BMD) is well documented; in contrast, the effect of changes in body weight on BMD is not well understood, particularly, in normal-weight populations...
  22. ncbi Correlates of serum lipids in a lean black population
    C H Bunker
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Atherosclerosis 123:215-25. 1996
    ..Physical activity was lower among the higher SES. We conclude that SES related changes in lifestyle contribute to substantially higher total and LDL-cholesterol even in a generally lean population consuming a low fat diet...
  23. ncbi The role of comorbidity in the assessment of intermittent claudication in older adults
    A B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Keystone Blds, Suite 300, 3529 First Avenue, Pittsburgh, PA 15213 3313, USA
    J Clin Epidemiol 54:294-300. 2001
    ..The Rose Questionnaire for IC is specific for PAD, but a negative questionnaire does not indicate a lack of symptoms, rather the presence of PAD along with other conditions that can cause pain...
  24. ncbi Usefulness of electron beam tomography to detect progression of coronary and aortic calcium in middle-aged women
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, The Cardiovascular Institute Preventive Heart Care Center, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 87:560-4. 2001
    ..Both coronary and aortic calcium were significantly associated with premenopausal cardiovascular risk factors. Thus, progression of coronary and aortic calcium using EBT can be observed over a short time in healthy middle- aged women...
  25. ncbi Maintenance of cardiovascular risk factor changes among middle-aged women in a lifestyle intervention trial
    L R Simkin-Silverman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Womens Health 4:255-71. 1998
    ..Eighty percent of intervention participants compared to 45% of controls were at or under baseline weight at 18 months, suggesting that promoting modest weight loss may be an effective approach to preventing weight gain in these women...
  26. ncbi Factors associated with calcium absorption efficiency in pre- and perimenopausal women
    R L Wolf
    Departments of Epidemiology, Education, and Genetics, University of Pittsburgh, USA
    Am J Clin Nutr 72:466-71. 2000
    ..The amount of calcium ingested by an individual may affect several chronic conditions, including osteoporosis, hypertension, and colon cancer. However, individuals vary in their ability to absorb the calcium they consume...
  27. ncbi IDDM incidence in a multiracial population. The Hawaii IDDM Registry, 1980-1990
    S L Patrick
    World Health Organization Collaborating Center for Diabetes Research, Registries and Training, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    Diabetes Care 20:983-7. 1997
    ..Because of the multiracial population living in Hawaii, it is an ideal state in which to study the effect of migration on IDDM incidence...
  28. ncbi Neuropsychological characteristics of mild cognitive impairment subgroups
    O L Lopez
    Department of Neurology, University of Pittsburgh, School of Medicine, PA 15213, USA
    J Neurol Neurosurg Psychiatry 77:159-65. 2006
    ..To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study...
  29. ncbi Carotid atherosclerosis in premenopausal and postmenopausal women and its association with risk factors measured after menopause
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Stroke 29:1116-21. 1998
    ..This report compares the prevalence and degree of carotid atherosclerosis between 292 premenopausal women and 294 women at 5 to 8 years after menopause...
  30. ncbi Age, Alzheimer disease, and brain structure
    C A Raji
    Departments of Pathology, School of Medicine and Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Neurology 73:1899-905. 2009
    ..Lack of clear understanding remains on the overlapping atrophy patterns of aging and early Alzheimer disease (AD) pathology in gray matter (GM) of the brain in vivo...
  31. ncbi Coronary heart disease mortality among men aged 35-44 years by prefecture in Japan in 1995-1999 compared with that among white men aged 35-44 by state in the United States in 1995-1998: vital statistics data in recent birth cohort
    A Sekikawa
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15213, USA
    Jpn Circ J 65:887-92. 2001
    ....
  32. ncbi A hypothesis of synergism: the interrelationship of T3 and insulin to disturbances in metabolic homeostasis
    S R Kim
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Med Hypotheses 59:660-6. 2002
    ..The current paper presents an integrative hypothesis of the synergistic relationship of T(3) and insulin in metabolic homeostasis and abnormalities...
  33. ncbi Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years
    S Matsunaga-Irie
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Diabetes Obes Metab 9:591-3. 2007
    ..Recently, several papers reported the ethnic difference in the ghrelin levels. To our knowledge, however, no studies have compared the serum ghrelin levels between Caucasians in the USA and the Japanese in Japan...
  34. ncbi PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study
    A P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    J Thromb Haemost 6:1625-32. 2008
    ..Genes encoding protein C anticoagulant pathways are candidates for atherothrombotic and other aging-related disorders...
  35. ncbi Educational attainment and coronary and aortic calcification in postmenopausal women
    L C Gallo
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychosom Med 63:925-35. 2001
    ..The current study 1) evaluated the nature of the associations between educational attainment and subclinical atherosclerosis and 2) examined if biologic, behavioral, and psychosocial factors mediated these associations...
  36. ncbi Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF)
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:134-43. 2009
    ..These women experienced a lower risk of fractures, disability, and mortality, suggesting that this phenotype may be a marker of successful aging...
  37. ncbi Determinants of vascular dementia in the Cardiovascular Health Cognition Study
    L H Kuller
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurology 64:1548-52. 2005
    ..The authors evaluated 3,375 participants without dementia at the time of MRI in 1991 to 1994 over 5.7 years for incident dementia and type of dementia...
  38. ncbi Coronary heart disease mortality trends in men in the post World War II birth cohorts aged 35-44 in Japan, South Korea and Taiwan compared with the United States
    A Sekikawa
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, USA
    Int J Epidemiol 28:1044-9. 1999
    ..It is most likely that the post World War II cohorts (1950+) have been more exposed. We hypothesize that there would be an increase in mortality from coronary heart disease (CHD) in men aged 35-44 in these countries...
  39. ncbi Physical activity and white matter lesion progression: assessment using MRI
    L J Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Neurology 68:1223-6. 2007
    ..Physical activity was not significantly associated with a decreased rate of periventricular or deep WML progression...
  40. ncbi Reproductive history in relation to plasma hormone levels in healthy post-menopausal women
    R B Ness
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 517 Parran Hall, 15261, Pittsburgh, PA, USA
    Maturitas 35:149-57. 2000
    ..Previous studies have suggested that there is a negative correlation between parity and post-menopausal serum estrogens, which may be a mechanism by which pregnancies protect women from the development of breast cancer...
  41. ncbi Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial
    R W Evans
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Clin Epidemiol 54:51-7. 2001
    ..When adjusted for age and Lp(a) concentration, logistic regression analysis indicated that small apo(a) isoforms were associated with CHD deaths among smokers (OR 3.31; 95% CI 1.07-10.28)...
  42. ncbi Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial
    R W Evans
    Department of Epidemiology, University of Pittsburgh, Penn, USA
    Arterioscler Thromb Vasc Biol 17:1947-53. 1997
    ..Homocyst(e)ine levels were weakly associated with the acute-phase protein (C-reactive protein). These results are discussed with respect to the suggestion that homocyst(e)ine is an independent risk factor for heart disease...
  43. ncbi Women's Healthy Lifestyle Project: A randomized clinical trial: results at 54 months
    L H Kuller
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA 15261, USA
    Circulation 103:32-7. 2001
    ..The difference in LDL cholesterol between the assessment and intervention groups was most pronounced among postmenopausal women and occurred among hormone users and nonusers...
  44. ncbi Mammography and pap smear use by older rural women
    D G Ives
    Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    Public Health Rep 111:244-50. 1996
    ..To compare the characteristics of older women who did and did not have screening mammograms and Pap smears during the first two years both services were a Medicare Part B benefit...
  45. ncbi Association analysis of 33 lipoprotein candidate genes in multi-generational families of African ancestry
    I Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Lipid Res 51:1823-31. 2010
    ..Future sequencing and functional studies of these loci may advance our understanding of genetic factors contributing to LDL-C in African ancestry populations...
  46. ncbi Menopause in type 1 diabetic women: is it premature?
    J S Dorman
    Department of Epidemiology, Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Diabetes 50:1857-62. 2001
    ..76, P < 0.0001) were independent determinants of earlier menopause in our cohort. We hypothesize that an earlier menopause, which resulted in a 17% decrease in reproductive years, is a major unstudied complication of type 1 diabetes...
  47. ncbi Stress-induced pulse pressure change predicts women's carotid atherosclerosis
    K A Matthews
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Stroke 29:1525-30. 1998
    ..This report evaluates the association between stress-induced hemodynamic responses and carotid atherosclerosis in 254 healthy postmenopausal women...
  48. ncbi Are hostility and anxiety associated with carotid atherosclerosis in healthy postmenopausal women?
    K A Matthews
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Psychosom Med 60:633-8. 1998
    ..In this article, we evaluated the prospective association between measures of trait anger, hostility, and anxiety and indices of carotid atherosclerosis in 200 healthy middle-aged postmenopausal women...
  49. ncbi Vascular imaging: changing the face of cardiovascular research
    S Manzi
    University of Pittsburgh School of Medicine, PA 15213, USA
    Lupus 9:176-82. 2000
    ..In this review, we will discuss several vascular imaging techniques and the current trend away from measuring flow-limiting vessel stenosis toward measuring earlier structural and functional aspects of the vascular system...
  50. ncbi Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes
    M Pietropaolo
    Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Diabetes 49:32-8. 2000
    ..These findings not only have direct implications for adequate classification and treatment of diabetes in the elderly, but also for understanding the autoimmune/inflammatory mechanisms involved in the pathogenesis of hyperglycemia...
  51. ncbi Was there an epidemic of diabetes in nonwhite adolescents in Allegheny County, Pennsylvania?
    I M Libman
    Diabetes Research Center, Rangos Research Center, Pittsburgh, PA 15213, USA
    Diabetes Care 21:1278-81. 1998
    ....
  52. ncbi Body fat distribution patterns and blood pressure in black and white women
    L L Adams Campbell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania
    J Natl Med Assoc 82:573-6. 1990
    ..In general, among US blacks and whites, there were positive associations among body mass index, waist-hip girth measurements, and blood pressure, particularly for systolic blood pressure...
  53. ncbi Is ankle-brachial blood pressure measurement of clinical utility for asymptomatic elderly?
    L H Kuller
    University of Pittsburgh, Graduate School of Public Health, Dept of Epidemiology, A 527 Crabtree Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    J Clin Epidemiol 54:971-2. 2001
    ..quot;Ankle-Brachial Blood Pressure in Elderly Men and the Risk of Stroke: The Honolulu Heart Program," further extends the strong, consistent association of lower ankle-brachial blood pressure ratios to the risk of stroke...
  54. ncbi A "natural experiment" in cardiovascular epidemiology in the early 21st century
    A Sekikawa
    University of Pittsburgh, Pittsburgh, USA
    Heart 89:255-7. 2003
    ..Careful study of such cohorts may help identify novel risk factors for CHD, and contribute to the formulation of new preventive strategies..
  55. ncbi Prevention of cardiovascular disease and the future of cardiovascular disease epidemiology
    L H Kuller
    University of Pittsburgh, Department of Epidemiology, GSPH, Pittsburgh, PA 15261, USA
    Int J Epidemiol 30:S66-72. 2001
    ....
  56. ncbi Clinical trials: surrogate endpoints or hard endpoints?
    L H Kuller
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 88:59E-61E. 2001
    ....
  57. ncbi Assessment of the disturbances in metabolic homeostasis: a hypothesis of synergism
    S R Kim
    University of Pittsburgh, Pittsburgh, USA
    Med Hypotheses 59:655-9. 2002
    ..The present study validated the hypothetical model in a sample of 110 African-American women...
  58. ncbi Genetic variation in apolipoprotein H (beta2-glycoprotein I) affects the occurrence of antiphospholipid antibodies and apolipoprotein H concentrations in systemic lupus erythematosus
    M I Kamboh
    Department of Human Genetics, University of Pittsburgh, Pennsylvania, USA
    Lupus 8:742-50. 1999
    ....
  59. ncbi Salt and blood pressure: population and individual perspectives
    L H Kuller
    Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pennsylvania 15261, USA
    Am J Hypertens 10:29S-36S. 1997
    ..The public health approach to gradual reduction of available salt in the diet is likely to result in decreased morbidity and mortality with little inconvenience to the public...
  60. ncbi A common promotor variant in the cytochrome P450c17alpha (CYP17) gene is associated with bioavailability testosterone levels and bone size in men
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 16:911-7. 2001
    ..These results suggest that allelic variation at the CYP17 locus may contribute to the genetic influence on stature and femoral size in men...
  61. ncbi Functional neuroimaging indicators of successful executive control in the oldest old
    C Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, PA 15260, USA
    Neuroimage 28:881-9. 2005
    ..Older adults who are able to perform executive control tasks as well as young adults, also seem to implement speed-accuracy trade-off strategies which may rely on increased parietal activation...
  62. ncbi Less salt intake or more salt excretion: is hypertension preventable?
    L H Kuller
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Clin Hypertens (Greenwich) 3:32-6. 2001
    ..Once-a-day diuretics may be a better health dose than once-a-day vitamins for our nutrient-rich society. (c)2001 by Le Jacq Communications, Inc...
  63. ncbi Vascular stiffness in women with systemic lupus erythematosus
    F Selzer
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    Hypertension 37:1075-82. 2001
    ..This was seen most clearly among premenopausal women. This finding may partially explain the higher rates of cardiovascular disease and hypertension observed in young women with SLE...
  64. ncbi Morphometric analysis of gray matter volume in demented older adults: exploratory analysis of the cardiovascular health study brain MRI database
    C Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, PA, USA
    Neuroepidemiology 24:221-9. 2005
    ....
  65. ncbi Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset
    J Saxton
    University of Pittsburgh, Oxford Building, Room 738, Pittsburgh, PA 15213, USA
    Neurology 63:2341-7. 2004
    ..To determine if individuals ultimately diagnosed with Alzheimer disease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between 1.5 years and 8.1 years before dementia onset...
  66. ncbi Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults
    N S Jenny
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT, USA
    J Thromb Haemost 4:107-13. 2006
    ..1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events. CONCLUSIONS: While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women...
  67. ncbi No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
    C A Szekely
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 70:2291-8. 2008
    ..One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is responsible for this apparent reduction in AD risk...
  68. ncbi NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type
    C A Szekely
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Hampton House Room 857, 624 North Broadway, Baltimore, MD 21205, USA
    Neurology 70:17-24. 2008
    ..We therefore investigated the association between use of NSAIDs, aspirin, and the non-NSAID analgesic acetaminophen with incidence of dementia and AD...
  69. ncbi Classification of vascular dementia in the Cardiovascular Health Study Cognition Study
    O L Lopez
    Departments of Neurology, University of Pittsburgh School of Medicine, PA, USA
    Neurology 64:1539-47. 2005
    ..To describe the diagnostic classification of subjects with incident vascular dementia (VaD) participating in the Cardiovascular Health Study (CHS) Cognition Study...
  70. ncbi Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4
    T L Huang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Neurology 65:1409-14. 2005
    ..To compare associations of lean fish vs fatty fish (tuna or other fish) intake with dementia, Alzheimer disease (AD), and vascular dementia (VaD) and in relation to APOE epsilon4 status in the Cardiovascular Health Cognition Study (CHCS)...
  71. ncbi Is type 2 diabetes a chronic inflammatory/autoimmune disease?
    M A Syed
    Diabetes Nutr Metab 15:68-83. 2002
    ....
  72. ncbi Lack of association of the plasminogen activator inhibitor-1 4G/5G promoter polymorphism with cardiovascular disease in the elderly
    P Crainich
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05446, USA
    J Thromb Haemost 1:1799-804. 2003
    ..Our results suggest that the PAI-1 4G/5G promoter polymorphism is not associated CVD risk factors or incident CVD events in the elderly...
  73. ncbi Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study
    Owen T Carmichael
    Neurology Department, University of California, Center for Neuroscience, 1544 Newton Court, Davis, CA 95616, United States
    Neurobiol Aging 28:1316-21. 2007
    ..08). Acceleration of ventricular expansion in the elderly may be related to demographic and cardiovascular factors...
  74. ncbi Association between blood pressure level and the risk of myocardial infarction, stroke, and total mortality: the cardiovascular health study
    B M Psaty
    Cardiovascular Health Study, Coordinating Center, Plaza 600 Building, Seattle, WA 98101, USA
    Arch Intern Med 161:1183-92. 2001
    ....
  75. ncbi Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study
    T Kadowaki
    Department of Health Science, Shiga University of Medical Science, Shiga, Japan
    Int J Obes (Lond) 30:1163-5. 2006
    ..The Japanese men had a larger VAT and VSR in each stratum, despite substantially less obesity overall. In multiethnic studies, difference in abdominal fat distribution should be considered in exploring factors related to obesity...
  76. ncbi Knee height and arm span: a reflection of early life environment and risk of dementia
    T L Huang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Neurology 70:1818-26. 2008
    ..To determine if anthropometric measures, as markers of early life environment, are associated with risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD)...