Walter A Kukull
Affiliation: University of Washington
- Generalizability: the trees, the forest, and the low-hanging fruitWalter A Kukull
Department of Epidemiology, University of Washington School of Public Health, Seattle, USA
Neurology 78:1886-91. 2012..They also lay out relevant practical issues in study design, from sample selection to assessment of exposures, in both clinic-based and population-based settings...
- Dementia epidemiologyWalter A Kukull
Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195 7286, USA
Med Clin North Am 86:573-90. 2002..The tasks of public health and epidemiology should still involve prevention, the nonrandom occurrence of disease, and its environmental context in addition to heredity. The tools to address these tasks should continue to be refined...
- Dementia and Alzheimer disease incidence: a prospective cohort studyWalter A Kukull
National Alzheimer Coordinating Center, Department of Epidemiology, Box 357236, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 7236, USA
Arch Neurol 59:1737-46. 2002..Incidence estimates for the United States are few and vary with the population sampled and study design; we present data that will contribute to a consensus of these rates...
- Age-varying association between statin use and incident Alzheimer's diseaseGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
J Am Geriatr Soc 58:1311-7. 2010..To determine whether risk reduction of statins for Alzheimer's disease (AD) varies by age or presence of apolipoprotein E (APOE) epsilon4 allele...
- Biomechanical properties of shoes and risk of falls in older adultsAllan F Tencer
Harborview Injury Prevention and Research Center, Orthopedic Sciences Laboratory, Harborview Medical Center, MS 359798, 325 Ninth Avenue, Seattle, WA 98104, USA
J Am Geriatr Soc 52:1840-6. 2004..To determine the relationships between the biomechanical properties of shoes worn in a cohort of healthy older adults and the risk of falling...
- Calcium channel blockers and beta-blockers in relation to Parkinson's diseaseThanh G N Ton
Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195 7326, USA
Parkinsonism Relat Disord 13:165-9. 2007..The weakness of these associations and the absence of additional influence of dose or duration of use argue against any causal interpretation...
- Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sampleLucy Y Wang
Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
J Geriatr Psychiatry Neurol 22:256-65. 2009..4 +/- 2.1 vs 3.1 +/- 2.7, P = .02). These observations are consistent with the view that nondemented patients with underlying AD may be more likely to present with memory than nonmemory cognitive impairment...
- Subjective memory deterioration and future dementia in people aged 65 and olderLi Wang
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Am Geriatr Soc 52:2045-51. 2004..These findings suggest that a high level of subjective memory deterioration in persons with normal objective cognitive function may identify a subset of individuals at greater risk for developing dementia...
- Interrater reliability and accuracy in identifying ischemic strokes using computed tomography scans in people with dementiaJames D Bowen
Department of Neurology, University of Washington, Seattle, Washington 98195, USA
J Am Geriatr Soc 53:1743-7. 2005..To assess the reliability and interobserver agreement of stroke identification on neuroimaging in patients presenting with dementia...
- Alcohol, gender, and cognitive performance: a longitudinal study comparing older Japanese and non-Hispanic white AmericansGail E Bond
University of Washington, Psychosocial and Community Health, Box 357263, Seattle, WA 98195 7263, USA
J Aging Health 16:615-40. 2004..Background: Recent data demonstrate that moderate consumption of alcohol may be beneficial to cognition...
- Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based studyJames B Leverenz
Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
Arch Neurol 59:1099-106. 2002..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community...
- Survival after initial diagnosis of Alzheimer diseaseEric B Larson
University of Washington and the Group Health Cooperative, Seattle, Washington, USA
Ann Intern Med 140:501-9. 2004..Alzheimer disease is an increasingly common condition in older people. Knowledge of life expectancy after the diagnosis of Alzheimer disease and of associations of patient characteristics with survival may help planning for future care...
- The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data SetDuane L Beekly
Department of Epidemiology, National Alzheimer s Coordinating Center, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98105, USA
Alzheimer Dis Assoc Disord 21:249-58. 2007..Thus, the NACC web site (https://www.alz.washington.edu) was enhanced to provide efficient and secure access data submission and retrieval systems...
- Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer diseaseErin M Ramos
Institute for Public Health Genetics, Department of Medicine, University of Washington, Seattle, WA, USA
Arch Neurol 63:1165-9. 2006..Functional polymorphisms in tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) can affect immune response, inflammation, tissue injury, and possibly the susceptibility to Alzheimer disease (AD)...
- Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort studyGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
J Am Geriatr Soc 55:1161-7. 2007..To assess variation in the association between blood pressure (BP) and risk for dementia across a spectrum of older ages and to examine BP changes before dementia onset...
- Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trialLinda Teri
Department of Psychosocial and Community Health, University of Washington, Seattle 98195, USA
JAMA 290:2015-22. 2003..Exercise training for patients with Alzheimer disease combined with teaching caregivers how to manage behavioral problems may help decrease the frailty and behavioral impairment that are often prevalent in patients with Alzheimer disease...
- Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databasesW T Longstreth
Department of Neurology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2420, USA
Alzheimer Dis Assoc Disord 23:291-4. 2009..9, 95% CI: 1.4, 6.3). These neuropathologic associations suggest that people whose cranial MRI shows macroinfarcts, hemorrhages, or leukoencephalopathy are more likely also to have microinfarcts...
- Risk of decline in functional activities in dementia with Lewy bodies and Alzheimer diseaseDawn P Gill
National Alzheimer s Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA 98105, USA
Alzheimer Dis Assoc Disord 25:17-23. 2011..These findings may provide anticipatory guidance to families and healthcare providers, which may be useful in the planning of care strategies...
- Nonsteroidal anti-inflammatory drugs and risk of Parkinson's diseaseThanh G Ton
Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
Mov Disord 21:964-9. 2006..Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs...
- Older adults and functional decline: a cross-cultural comparisonSusan M McCurry
Department of Psychosocial and Community Health, University of Washington, Seattle 98115 2053, USA
Int Psychogeriatr 14:161-79. 2002....
- Mitochondrial genetic variants and Alzheimer disease: a case-control study of the T4336C and G5460A variantsSteven D Edland
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Alzheimer Dis Assoc Disord 16:1-7. 2002..Substantially larger samples than are currently available would be required to resolve this question. G5460(A/T) variants were also investigated and found not to be associated with Alzheimer disease...
- Comparing measures of decline to dementia in amnestic MCI subjects in the National Alzheimer's Coordinating Center (NACC) Uniform Data SetSarah E Monsell
National Alzheimer s Coordinating Center, University of Washington, Seattle, Washington 98105, USA
Int Psychogeriatr 24:1553-60. 2012....
- Active and passive cigarette smoking and risk of intracranial meningiomaLeslie E Phillips
Department of Neurology, School of Public Health and Community Medicine, University of Washington, Seattle, Wash, USA
Neuroepidemiology 24:117-22. 2005..0; 95% CI 1.1-3.5), and risk increased with increasing duration of exposure (p for trend = 0.02). Uncertain is whether these findings reflect a true biological phenomenon or result from chance or uncontrolled confounding...
- Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patientJames B Leverenz
Department of Veterans Affairs Northwest Network Mental Illness and Parkinson s Disease Research, University of Washington, Seattle, WA 98108, USA
Brain Pathol 18:220-4. 2008..In addition, this modification allows for more limited sampling of brain regions for classification of LRP. We propose that these modified criteria for the categorization of LRP be utilized in patients with a history of dementia...
- Footwear style and risk of falls in older adultsThomas D Koepsell
Department of Epidemiology, University of Washington, Seattle 98195, USA
J Am Geriatr Soc 52:1495-501. 2004..To determine how the risk of a fall in an older adult varies in relation to style of footwear worn...
- Conjugal Alzheimer disease: risk in children when both parents have Alzheimer diseaseSuman Jayadev
Department of Neurology, University of Washington, Seattle, USA
Arch Neurol 65:373-8. 2008..There is limited information regarding children's risk of Alzheimer disease (AD) if both parents are affected...
- The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease databaseDuane L Beekly
National Alzheimer s Coordinating Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98105, USA
Alzheimer Dis Assoc Disord 18:270-7. 2004..NACC also designed a data management system to easily collect and manage these data. The NACC web site (www.alz.washington.edu) was created to allow access to the data...
- Depression as a risk factor for Alzheimer disease: the MIRAGE StudyRobert C Green
Department of Neurology, Genetics Program, Boston University School of Medicine, MA 02118, USA
Arch Neurol 60:753-9. 2003..Depression symptoms may be associated with the development of Alzheimer disease (AD)...
- The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease CentersJohn C Morris
Washington University, St Louis, MO 63108, USA
Alzheimer Dis Assoc Disord 20:210-6. 2006..Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research...
- Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data setWinnie S Liang
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
Physiol Genomics 33:240-56. 2008..We provide this carefully phenotyped, laser capture microdissected intraindividual brain region expression data set to the community as a public resource...
- Perspectives on shared genetic contributions for Parkinson disease and Alzheimer diseaseWalter A Kukull
Arch Neurol 61:1007-8. 2004
- Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brainWinnie S Liang
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
Physiol Genomics 28:311-22. 2007..These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders...
- The growing global burden of dementiaWalter A Kukull
Lancet Neurol 5:199-200. 2006