Liisa T Kuhn

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating
    Yongxing Liu
    Center for Biomaterials, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS ONE 7:e33225. 2012
  2. pmc Chemotherapy drug delivery from calcium phosphate nanoparticles
    Xingguo Cheng
    Oral Rehabilitation, Biomaterials and Skeletal Development, University of Connecticut Health Center, Farmington, CT 06030 1615, USA
    Int J Nanomedicine 2:667-74. 2007
  3. doi request reprint A comparison of the physical and chemical differences between cancellous and cortical bovine bone mineral at two ages
    Liisa T Kuhn
    Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Calcif Tissue Int 83:146-54. 2008
  4. doi request reprint A nondestructive method for evaluating in vitro osteoblast differentiation on biomaterials using osteoblast-specific fluorescence
    Liisa T Kuhn
    Center for Biomaterials, University of Connecticut Health Center, Farmington, Connecticut 06030 1615, USA
    Tissue Eng Part C Methods 16:1357-66. 2010
  5. pmc Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone
    Liisa T Kuhn
    Department of Surgery MC 3105, University of Connecticut Health Center, Farmington, CT 06030 3105
    J Gerontol A Biol Sci Med Sci 68:1170-80. 2013
  6. doi request reprint Modified hyaluronan hydrogels support the maintenance of mouse embryonic stem cells and human induced pluripotent stem cells
    Yongxing Liu
    Center for Biomaterials, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Macromol Biosci 12:1034-42. 2012
  7. ncbi request reprint Fabrication and characterization of hydroxyapatite-coated polystyrene disks for use in osteoprogenitor cell culture
    A Jon Goldberg
    Center for Biomaterials, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Biomater Sci Polym Ed 21:1371-87. 2010
  8. doi request reprint Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells
    Liisa T Kuhn
    1 Department of Reconstructive Sciences, Center for Biomaterials, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut
    Tissue Eng Part A 20:365-77. 2014
  9. ncbi request reprint Effects of the physico-chemical nature of two biomimetic crystals on the innate immune response
    Manish Ramesh
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Int Immunopharmacol 7:1617-29. 2007

Collaborators

Detail Information

Publications9

  1. pmc One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating
    Yongxing Liu
    Center for Biomaterials, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS ONE 7:e33225. 2012
    ..In conclusion, this study demonstrates that bioimimetic, fibrillar, type I collagen coatings applied to cell culture plates can be used to guide a rapid, efficient derivation of MSC-like cells from both human ES and iPS cells...
  2. pmc Chemotherapy drug delivery from calcium phosphate nanoparticles
    Xingguo Cheng
    Oral Rehabilitation, Biomaterials and Skeletal Development, University of Connecticut Health Center, Farmington, CT 06030 1615, USA
    Int J Nanomedicine 2:667-74. 2007
    ..Direct addition cytotoxicity studies revealed that the sterically-stabilized, negatively-charged drug nanoconjugates are unable to overcome drug resistance and had an increased IC50 value as compared to the free drug...
  3. doi request reprint A comparison of the physical and chemical differences between cancellous and cortical bovine bone mineral at two ages
    Liisa T Kuhn
    Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Calcif Tissue Int 83:146-54. 2008
    ..Based on the larger proportion of newly formed bone in cancellous bone relative to cortical bone, the major differences between the cancellous and cortical mineral crystals must be ascribed to differences in average age of the crystals...
  4. doi request reprint A nondestructive method for evaluating in vitro osteoblast differentiation on biomaterials using osteoblast-specific fluorescence
    Liisa T Kuhn
    Center for Biomaterials, University of Connecticut Health Center, Farmington, Connecticut 06030 1615, USA
    Tissue Eng Part C Methods 16:1357-66. 2010
    ..Importantly, the generalized method can be used for rapid, high-throughput, nondestructive screening of biomaterials intended to enhance osteogenic differentiation...
  5. pmc Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone
    Liisa T Kuhn
    Department of Surgery MC 3105, University of Connecticut Health Center, Farmington, CT 06030 3105
    J Gerontol A Biol Sci Med Sci 68:1170-80. 2013
    ..However, coadministration of FGF-2 and BMP-2 increases mineralization more than BMP-2 alone in cultures from old and young mouse long bones and old humans but not in young mouse calvarial cultures. ..
  6. doi request reprint Modified hyaluronan hydrogels support the maintenance of mouse embryonic stem cells and human induced pluripotent stem cells
    Yongxing Liu
    Center for Biomaterials, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Macromol Biosci 12:1034-42. 2012
    ..The addition of fibronectin to HyStem-C™ enabled the attachment of hiPSCs in a xeno-free, fully defined medium...
  7. ncbi request reprint Fabrication and characterization of hydroxyapatite-coated polystyrene disks for use in osteoprogenitor cell culture
    A Jon Goldberg
    Center for Biomaterials, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Biomater Sci Polym Ed 21:1371-87. 2010
    ..This technique can be used to rapidly produce high-quality cHA-coated TCPS disks for cell-culture studies...
  8. doi request reprint Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells
    Liisa T Kuhn
    1 Department of Reconstructive Sciences, Center for Biomaterials, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut
    Tissue Eng Part A 20:365-77. 2014
    ..The hESC-MCs were able to recapitulate the mesenchymal developmental pathway and were able to repair the bone defect semi-autonomously without preimplantation differentiation to osteo- or chondroprogenitors. ..
  9. ncbi request reprint Effects of the physico-chemical nature of two biomimetic crystals on the innate immune response
    Manish Ramesh
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Int Immunopharmacol 7:1617-29. 2007
    ..Proper utilization of the physico-chemical features of particulates offers a new direction for the development of more effective vaccine adjuvants...