RONALD T KUCZENSKI

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine
    Ronald Kuczenski
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 22:7264-71. 2002
  2. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
  3. pmc Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-h binge
    Ronald Kuczenski
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychopharmacology 34:2430-41. 2009
  4. ncbi request reprint Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse
    Ronald Kuczenski
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
    Biol Psychiatry 57:1391-6. 2005
  5. ncbi request reprint Sensitization of amphetamine-induced stereotyped behaviors during the acute response
    R Kuczenski
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    J Pharmacol Exp Ther 288:699-709. 1999
  6. ncbi request reprint Caudate-putamen and nucleus accumbens extracellular acetylcholine responses to methamphetamine binges
    R Kuczenski
    Psychiatry Department 0603, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Brain Res 923:32-8. 2001
  7. ncbi request reprint Sensitization of amphetamine-induced stereotyped behaviors during the acute response: role of D1 and D2 dopamine receptors
    R Kuczenski
    Department of Psychiatry 0603, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Brain Res 822:164-74. 1999
  8. ncbi request reprint Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine
    R Kuczenski
    Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Pharmacol Exp Ther 296:876-83. 2001
  9. ncbi request reprint Dynamic changes in sensitivity occur during the acute response to cocaine and methylphenidate
    R Kuczenski
    Psychiatry Department 0603, UCSD School of Medicine, La Jolla 92093, USA
    Psychopharmacology (Berl) 147:96-103. 1999
  10. ncbi request reprint Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge
    David S Segal
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Neuropsychopharmacology 28:1730-40. 2003

Research Grants

Detail Information

Publications20

  1. ncbi request reprint Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine
    Ronald Kuczenski
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 22:7264-71. 2002
    ....
  2. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  3. pmc Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-h binge
    Ronald Kuczenski
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychopharmacology 34:2430-41. 2009
    ..Collectively, the changes we characterized during and after a METH binge suggest that for human beings under similar exposure conditions, multiple time-dependent neurochemical deficits contribute to their behavioral profiles...
  4. ncbi request reprint Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse
    Ronald Kuczenski
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
    Biol Psychiatry 57:1391-6. 2005
    ....
  5. ncbi request reprint Sensitization of amphetamine-induced stereotyped behaviors during the acute response
    R Kuczenski
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    J Pharmacol Exp Ther 288:699-709. 1999
    ..Such a mechanism may be significantly implicated during binge patterns of stimulant abuse and may also play a role in the sensitization associated with repeated amphetamine administration...
  6. ncbi request reprint Caudate-putamen and nucleus accumbens extracellular acetylcholine responses to methamphetamine binges
    R Kuczenski
    Psychiatry Department 0603, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Brain Res 923:32-8. 2001
    ..These results are consistent with our hypothesis and suggest that the regionally differential acetylcholine responses reflect one functional consequence of the escalating-dose, multiple binge stimulant treatment...
  7. ncbi request reprint Sensitization of amphetamine-induced stereotyped behaviors during the acute response: role of D1 and D2 dopamine receptors
    R Kuczenski
    Department of Psychiatry 0603, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Brain Res 822:164-74. 1999
    ..Because these changes are apparent during the amphetamine response, they may have important implications for the evolving behavioral alterations which result when stimulants are administered in a binge pattern of drug abuse...
  8. ncbi request reprint Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine
    R Kuczenski
    Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Pharmacol Exp Ther 296:876-83. 2001
    ..The relevance of these data to the therapeutic uses of these drugs is discussed within the context of the many variables that can affect the behavioral and neurochemical responses to stimulants...
  9. ncbi request reprint Dynamic changes in sensitivity occur during the acute response to cocaine and methylphenidate
    R Kuczenski
    Psychiatry Department 0603, UCSD School of Medicine, La Jolla 92093, USA
    Psychopharmacology (Berl) 147:96-103. 1999
    ....
  10. ncbi request reprint Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge
    David S Segal
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Neuropsychopharmacology 28:1730-40. 2003
    ....
  11. ncbi request reprint Genetic differences in startle gating-disruptive effects of apomorphine: evidence for central mediation
    Neal R Swerdlow
    Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla 92093 0804, USA
    Behav Neurosci 116:682-90. 2002
    ..SD > LE PPI-disruptive effects of apomorphine were also independent of peripheral versus central route of administration. This model for PPI genetics is sensitive to differences in central rather than peripheral substrates...
  12. ncbi request reprint Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in rats
    Robert E Clark
    Veterans Affairs Medical Center, San Diego, California, USA
    Synapse 61:515-22. 2007
    ....
  13. ncbi request reprint Differential regulation of immediate-early gene expression in the prefrontal cortex of rats with a high vs low behavioral response to methamphetamine
    Paul D Shilling
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    Neuropsychopharmacology 31:2359-67. 2006
    ..These gene expression changes may contribute to individual differences in responsiveness to stimulants and the development of mania and psychosis...
  14. ncbi request reprint Forebrain D1 function and sensorimotor gating in rats: effects of D1 blockade, frontal lesions and dopamine denervation
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, United States
    Neurosci Lett 402:40-5. 2006
    ..The effects of systemic SCH23390 were not opposed by NAC DA depletion. D1 receptors regulate PPI in rats, but this effect does not appear to be mediated either by the MPFC or by increased mesolimbic DA activity...
  15. ncbi request reprint Human methamphetamine pharmacokinetics simulated in the rat: single daily intravenous administration reveals elements of sensitization and tolerance
    David S Segal
    Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Neuropsychopharmacology 31:941-55. 2006
    ..Thus, simulation of human METH exposure patterns may be a critical prerequisite to identifying mechanisms relevant to the chronic use of this drug in humans...
  16. ncbi request reprint Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization
    David S Segal
    Department of Psychiatry, University of California, San Diego, School of Medicine, 0603, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 180:501-12. 2005
    ..These data are discussed in terms of damage to dopamine terminals and compensatory adjustments in mechanisms maintaining functional dopaminergic transmission...
  17. ncbi request reprint Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient rats
    David Feifel
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurosci Lett 348:147-50. 2003
    ..These findings suggest that CCK-A receptors play an important role in the regulation of central DA transmission, and support the notion that the OLETF rat is a useful model to study this regulation...
  18. ncbi request reprint Oxidative mechanisms and tardive dyskinesia
    James B Lohr
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    CNS Drugs 17:47-62. 2003
    ..These approaches may include the use of antioxidants as a preventive measure for tardive dyskinesia or the use of other antioxidants or neuroprotective drugs, such as melatonin, for established tardive dyskinesia...
  19. ncbi request reprint Neurochemical analysis of rat strain differences in the startle gating-disruptive effects of dopamine agonists
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92037 0804, USA
    Pharmacol Biochem Behav 80:203-11. 2005
    ..These findings suggest that inherited differences in the dopaminergic regulation of sensorimotor gating do not likely reflect differences in presynaptic forebrain dopaminergic or serotonergic processes...
  20. pmc Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat
    Ronald Kuczenski
    Department of Psychiatry and HIV Neurobehavioral Research Center, University of California, San Diego La Jolla, CA 92093 0624, USA
    Exp Neurol 207:42-51. 2007
    ..Taken together, these studies suggest that selective degeneration of pyramidal neurons and interneurons in the neocortex and limbic system might be involved in the cognitive alterations in METH users...

Research Grants8

  1. Behavioral Characterization of Acute and Chronic Amphetamine
    Ronald Kuczenski; Fiscal Year: 2010
    ....
  2. MECHANISM OF ACTION OF DRUGS OF ABUSE--AMPHETAMINE
    Ronald Kuczenski; Fiscal Year: 2004
    ..The possibility of nonsynaptic release sites on nigrostriatal DA afferents will be assessed by labeling components of the release mechanism and then correlating them with the locations of dopamine receptors. ..
  3. BEHAVIORAL CHARACTERIZATION OF ACUTE&CHRONIC AMPHETAMINE
    Ronald Kuczenski; Fiscal Year: 2005
    ..The results of these studies should provide greater insight into the mechanisms and processes contributing to the behavioral and neurochemical consequences associated with a common pattern of methamphetamine abuse. ..
  4. Simulated Human Pharmacokinetics in Rat: Methylphenidate
    Ronald Kuczenski; Fiscal Year: 2007
    ....
  5. Behavioral Characterization of Acute and Chronic Amphetamine
    Ronald Kuczenski; Fiscal Year: 2009
    ....