RONALD T KUCZENSKI
Affiliation: University of California
- Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamineRonald Kuczenski
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 22:7264-71. 2002....
- Evidence for genetic association of RORB with bipolar disorderCasey L McGrath
Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
BMC Psychiatry 9:70. 2009..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
- Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-h bingeRonald Kuczenski
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0603, USA
Neuropsychopharmacology 34:2430-41. 2009..Collectively, the changes we characterized during and after a METH binge suggest that for human beings under similar exposure conditions, multiple time-dependent neurochemical deficits contribute to their behavioral profiles...
- Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuseRonald Kuczenski
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
Biol Psychiatry 57:1391-6. 2005....
- Sensitization of amphetamine-induced stereotyped behaviors during the acute responseR Kuczenski
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
J Pharmacol Exp Ther 288:699-709. 1999..Such a mechanism may be significantly implicated during binge patterns of stimulant abuse and may also play a role in the sensitization associated with repeated amphetamine administration...
- Caudate-putamen and nucleus accumbens extracellular acetylcholine responses to methamphetamine bingesR Kuczenski
Psychiatry Department 0603, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
Brain Res 923:32-8. 2001..These results are consistent with our hypothesis and suggest that the regionally differential acetylcholine responses reflect one functional consequence of the escalating-dose, multiple binge stimulant treatment...
- Sensitization of amphetamine-induced stereotyped behaviors during the acute response: role of D1 and D2 dopamine receptorsR Kuczenski
Department of Psychiatry 0603, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Brain Res 822:164-74. 1999..Because these changes are apparent during the amphetamine response, they may have important implications for the evolving behavioral alterations which result when stimulants are administered in a binge pattern of drug abuse...
- Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrineR Kuczenski
Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
J Pharmacol Exp Ther 296:876-83. 2001..The relevance of these data to the therapeutic uses of these drugs is discussed within the context of the many variables that can affect the behavioral and neurochemical responses to stimulants...
- Dynamic changes in sensitivity occur during the acute response to cocaine and methylphenidateR Kuczenski
Psychiatry Department 0603, UCSD School of Medicine, La Jolla 92093, USA
Psychopharmacology (Berl) 147:96-103. 1999....
- Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine bingeDavid S Segal
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
Neuropsychopharmacology 28:1730-40. 2003....
- Genetic differences in startle gating-disruptive effects of apomorphine: evidence for central mediationNeal R Swerdlow
Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla 92093 0804, USA
Behav Neurosci 116:682-90. 2002..SD > LE PPI-disruptive effects of apomorphine were also independent of peripheral versus central route of administration. This model for PPI genetics is sensitive to differences in central rather than peripheral substrates...
- Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in ratsRobert E Clark
Veterans Affairs Medical Center, San Diego, California, USA
Synapse 61:515-22. 2007....
- Differential regulation of immediate-early gene expression in the prefrontal cortex of rats with a high vs low behavioral response to methamphetaminePaul D Shilling
Department of Psychiatry, University of California, San Diego, CA 92093, USA
Neuropsychopharmacology 31:2359-67. 2006..These gene expression changes may contribute to individual differences in responsiveness to stimulants and the development of mania and psychosis...
- Forebrain D1 function and sensorimotor gating in rats: effects of D1 blockade, frontal lesions and dopamine denervationNeal R Swerdlow
Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, United States
Neurosci Lett 402:40-5. 2006..The effects of systemic SCH23390 were not opposed by NAC DA depletion. D1 receptors regulate PPI in rats, but this effect does not appear to be mediated either by the MPFC or by increased mesolimbic DA activity...
- Human methamphetamine pharmacokinetics simulated in the rat: single daily intravenous administration reveals elements of sensitization and toleranceDavid S Segal
Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
Neuropsychopharmacology 31:941-55. 2006..Thus, simulation of human METH exposure patterns may be a critical prerequisite to identifying mechanisms relevant to the chronic use of this drug in humans...
- Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterizationDavid S Segal
Department of Psychiatry, University of California, San Diego, School of Medicine, 0603, La Jolla, CA 92093, USA
Psychopharmacology (Berl) 180:501-12. 2005..These data are discussed in terms of damage to dopamine terminals and compensatory adjustments in mechanisms maintaining functional dopaminergic transmission...
- Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient ratsDavid Feifel
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neurosci Lett 348:147-50. 2003..These findings suggest that CCK-A receptors play an important role in the regulation of central DA transmission, and support the notion that the OLETF rat is a useful model to study this regulation...
- Oxidative mechanisms and tardive dyskinesiaJames B Lohr
Department of Psychiatry, University of California San Diego, San Diego, California, USA
CNS Drugs 17:47-62. 2003..These approaches may include the use of antioxidants as a preventive measure for tardive dyskinesia or the use of other antioxidants or neuroprotective drugs, such as melatonin, for established tardive dyskinesia...
- Neurochemical analysis of rat strain differences in the startle gating-disruptive effects of dopamine agonistsNeal R Swerdlow
Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92037 0804, USA
Pharmacol Biochem Behav 80:203-11. 2005..These findings suggest that inherited differences in the dopaminergic regulation of sensorimotor gating do not likely reflect differences in presynaptic forebrain dopaminergic or serotonergic processes...
- Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the ratRonald Kuczenski
Department of Psychiatry and HIV Neurobehavioral Research Center, University of California, San Diego La Jolla, CA 92093 0624, USA
Exp Neurol 207:42-51. 2007..Taken together, these studies suggest that selective degeneration of pyramidal neurons and interneurons in the neocortex and limbic system might be involved in the cognitive alterations in METH users...