Hiroshi Kubota

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Variant forms of alpha-fetoprotein transcripts expressed in human hematopoietic progenitors. Implications for their developmental potential towards endoderm
    Hiroshi Kubota
    Department of Cell and Molecular Physiology and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27599 7038, USA
    J Biol Chem 277:27629-35. 2002
  2. ncbi The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts
    Asami Oguro
    Department of Life Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153 8902, Japan
    Genes Cells 11:1253-65. 2006
  3. ncbi Roles of collagen fibers and its specific molecular chaperone: analysis using HSP47-knockout mice
    Hiroshi Kubota
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University
    Biol Sci Space 18:118-9. 2004
  4. ncbi Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression
    Takao Kuroda
    Department of Development and Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan
    Mol Cell Biol 25:2475-85. 2005
  5. ncbi Accumulation of type IV collagen in dilated ER leads to apoptosis in Hsp47-knockout mouse embryos via induction of CHOP
    Toshihiro Marutani
    Department of Molecular and Cellular Biology and CREST JST, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, Japan
    J Cell Sci 117:5913-22. 2004
  6. ncbi ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA
    Hiroshi Ishiguchi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan
    Int J Cancer 111:900-9. 2004
  7. ncbi Culture conditions and single growth factors affect fate determination of mouse spermatogonial stem cells
    Hiroshi Kubota
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 71:722-31. 2004
  8. ncbi Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor
    Yuji Yamazaki
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8397, Japan
    J Biol Chem 278:30642-51. 2003
  9. ncbi Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease
    Shin Ichi Yokota
    Department of Microbiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Biochem Biophys Res Commun 303:413-8. 2003
  10. ncbi Hepatic stem cells and hepatoblasts: identification, isolation, and ex vivo maintenance
    Eliane Wauthier
    Department of Cell Physiology, UNC School of Medicine Chapel Hill, North Carolina 27599, USA
    Methods Cell Biol 86:137-225. 2008

Collaborators

  • Robert W Storms
  • Lola Reid
  • Kazuhiro Nagata
  • Eliane Wauthier
  • Asami Oguro
  • Takao Kuroda
  • Hiroshi Ishiguchi
  • Toshihiro Marutani
  • Shin Ichi Yokota
  • Yuji Yamazaki
  • Claire Barbier
  • Eva Schmelzer
  • M E Furth
  • John Ludlow
  • Ed LeCluyse
  • Joseph Ruiz
  • Lili Zhang
  • Rachael Turner
  • Hsin-lei Yao
  • Randall McClelland
  • Nicholas Moss
  • Oswaldo Lozoya
  • Andrew Bruce
  • William Turner
  • Sachiko Lee
  • Takashi Sakurai
  • Yoshinobu Fujita
  • Yoriko Atomi
  • Hironobu Kimura
  • Takashi Tada
  • Masako Tada
  • Norio Nakatsuji
  • Hirofumi Suemori
  • Shin-ya Hatano
  • Kimitoshi Kohno
  • Naoko Nagai
  • Yoichiro Yoshida
  • Sadatoshi Tsuji
  • Takayuki Torigoe
  • Hiroto Izumi
  • Akitsugu Yamamoto
  • Yasuhiro Matsuoka
  • Masami Nozaki
  • Seiji Minota
  • Motoko Naitoh
  • Daisuke Hirata
  • Hiroki Takahashi
  • Shin-Ichi Yokota
  • Nobuhiro Fujii

Detail Information

Publications10

  1. ncbi Variant forms of alpha-fetoprotein transcripts expressed in human hematopoietic progenitors. Implications for their developmental potential towards endoderm
    Hiroshi Kubota
    Department of Cell and Molecular Physiology and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27599 7038, USA
    J Biol Chem 277:27629-35. 2002
    ..These results suggest that some hematopoietic progenitors are in a state that permits them to express certain types of transcripts that have been considered unique to endoderm...
  2. ncbi The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts
    Asami Oguro
    Department of Life Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153 8902, Japan
    Genes Cells 11:1253-65. 2006
    ..The gravity-regulated HSP47 may play a role in the maintenance of the extracellular matrix by modulating collagen production at the primary stage of adaptation...
  3. ncbi Roles of collagen fibers and its specific molecular chaperone: analysis using HSP47-knockout mice
    Hiroshi Kubota
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University
    Biol Sci Space 18:118-9. 2004
    ..Here, we discuss the role of HSP47 in the folding and maturation of collagen type IV as well as type I...
  4. ncbi Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression
    Takao Kuroda
    Department of Development and Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan
    Mol Cell Biol 25:2475-85. 2005
    ..Thus, Nanog transcription may be regulated through an interaction between Oct4 and Sox2 or a novel pluripotential cell-specific Sox element-binding factor which is prominent in ES cells...
  5. ncbi Accumulation of type IV collagen in dilated ER leads to apoptosis in Hsp47-knockout mouse embryos via induction of CHOP
    Toshihiro Marutani
    Department of Molecular and Cellular Biology and CREST JST, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, Japan
    J Cell Sci 117:5913-22. 2004
    ..5 dpc together with significantly upregulated CHOP mRNA expression. ER stress caused by the accumulation of misfolded collagen may have induced apoptosis in Hsp47-knockout embryos through the upregulation of CHOP...
  6. ncbi ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA
    Hiroshi Ishiguchi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan
    Int J Cancer 111:900-9. 2004
    ..ZNF 143 also binds preferentially to cisplatin-modified DNA. These results suggest that ZNF 143 participates in cellular responses to DNA damage...
  7. ncbi Culture conditions and single growth factors affect fate determination of mouse spermatogonial stem cells
    Hiroshi Kubota
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 71:722-31. 2004
    ..The stem cell enrichment strategies and the culture methods described provide a reproducible and powerful assay system to establish the effect of various environmental factors on SSC survival and replication in vitro...
  8. ncbi Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor
    Yuji Yamazaki
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8397, Japan
    J Biol Chem 278:30642-51. 2003
    ..These results indicate that transcription of the Cctq gene is regulated by TCFs under the control of the Ras/MAPK pathway, probably independently of serum response factor...
  9. ncbi Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease
    Shin Ichi Yokota
    Department of Microbiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Biochem Biophys Res Commun 303:413-8. 2003
    ..The high levels of HSP47 antigen and autoantibody may be useful blood markers of MCTD...
  10. ncbi Hepatic stem cells and hepatoblasts: identification, isolation, and ex vivo maintenance
    Eliane Wauthier
    Department of Cell Physiology, UNC School of Medicine Chapel Hill, North Carolina 27599, USA
    Methods Cell Biol 86:137-225. 2008