I Kubo

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint ent-Isopimarane diterpenoids of the leaves from Rabdosia forrestii
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Fitoterapia 74:643-9. 2003
  2. ncbi request reprint Anti-Salmonella activity of (2E)-alkenals
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    J Appl Microbiol 96:693-9. 2004
  3. ncbi request reprint Antibacterial activity of akyl gallates against Bacillus subtilis
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:1072-6. 2004
  4. ncbi request reprint Antibacterial activity of coriander volatile compounds against Salmonella choleraesuis
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:3329-32. 2004
  5. ncbi request reprint Modes of antifungal action of (2E)-alkenals against Saccharomyces cerevisiae
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 51:3951-7. 2003
  6. ncbi request reprint Oxidation products of quercetin catalyzed by mushroom tyrosinase
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:5343-7. 2004
  7. ncbi request reprint Molecular design of multifunctional antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA)
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 11:4255-62. 2003
  8. ncbi request reprint Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:5349-54. 2004
  9. ncbi request reprint Effect of EDTA alone and in combination with polygodial on the growth of Saccharomyces cerevisiae
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 53:1818-22. 2005
  10. ncbi request reprint 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, USA
    Planta Med 65:19-22. 1999

Collaborators

Detail Information

Publications77

  1. ncbi request reprint ent-Isopimarane diterpenoids of the leaves from Rabdosia forrestii
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Fitoterapia 74:643-9. 2003
    ..The structures were established on the basis of NMR spectroscopic analysis and of the modified Mosher's (1H) method...
  2. ncbi request reprint Anti-Salmonella activity of (2E)-alkenals
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    J Appl Microbiol 96:693-9. 2004
    ..This study investigated the effect of a series of naturally occurring aliphatic (2E)-alkenals against Salmonella choleraesuis subsp. choleraesuis ATCC 35640 and evaluated their antibacterial action...
  3. ncbi request reprint Antibacterial activity of akyl gallates against Bacillus subtilis
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:1072-6. 2004
    ..The antibacterial activity of alkyl gallates likely comes at least in part from their ability to inhibit the membrane respiratory chain but is not due to the prooxidant action...
  4. ncbi request reprint Antibacterial activity of coriander volatile compounds against Salmonella choleraesuis
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:3329-32. 2004
    ..The time-kill curve study showed that these alpha,beta-unsaturated aldehydes are bactericidal against S. choleraesuis at any growth stage and that their bactericidal action comes in part from the ability to act as nonionic surfactants...
  5. ncbi request reprint Modes of antifungal action of (2E)-alkenals against Saccharomyces cerevisiae
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 51:3951-7. 2003
    ..Hence, the antifungal activity of (2E)-alkenals is mediated by biophysical processes, and the maximum activity can be obtained when the balance between the hydrophilic and hydrophobic portions becomes the most appropriate...
  6. ncbi request reprint Oxidation products of quercetin catalyzed by mushroom tyrosinase
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:5343-7. 2004
    ..Fisetin, which lacks the C-5 hydroxyl group, was also oxidized but the rate of oxidation was faster than that of quercetin, indicating that the C-5 hydroxyl group is not essential but is associated with the activity...
  7. ncbi request reprint Molecular design of multifunctional antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA)
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 11:4255-62. 2003
    ..The length of the alkyl chain is not a major contributor but is related to the activity...
  8. ncbi request reprint Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:5349-54. 2004
    ..01 mM) of L-3,4-dihydroxyphenylalanine (L-DOPA) became available as a co-factor. Methyl p-coumarate significantly suppressed the melanin formation in B16 mouse melanoma cells, whereas p-coumaric acid did not show this activity...
  9. ncbi request reprint Effect of EDTA alone and in combination with polygodial on the growth of Saccharomyces cerevisiae
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 53:1818-22. 2005
    ..Once inside the cells, EDTA forms chelation with divalent metals such as Mg(2+) and Ca(2+), which are required by various essential enzymes...
  10. ncbi request reprint 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, USA
    Planta Med 65:19-22. 1999
    ..Based on finding this potent tyrosinase inhibitor, various related analogues were also tested in order to gain new insights into their inhibitory functions on a molecular basis...
  11. ncbi request reprint Anti-MRSA activity of alkyl gallates
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 12:113-6. 2002
    ..This bactericidal activity comes in part from its ability to inhibit respiratory electron transport systems. The length of the alkyl chain is not a major contributor but plays an important role in eliciting the activity...
  12. ncbi request reprint Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus
    H Muroi
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    J Appl Bacteriol 80:387-94. 1996
    ..The time-kill curves demonstrated synergistic bactericidal activities for these combinations...
  13. ncbi request reprint Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Bioorg Med Chem 8:1749-55. 2000
    ..Kaempferol neither acts as a cofactor nor inhibits monophenolase activity. However, these three flavonols are common to inhibit diphenolase activity by chelating copper in the enzyme...
  14. ncbi request reprint Antifungal mechanism of polygodial
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    J Agric Food Chem 49:1607-11. 2001
    ..However, the potent antifungal activity of polygodial results from its multiple functions...
  15. ncbi request reprint Molecular design of antibrowning agents
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 48:1393-9. 2000
    ..The effects of side-chain length of gallates in relation to their antibrowning activity are studied...
  16. ncbi request reprint Tyrosinase inhibitors from Anacardium occidentale fruits
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720
    J Nat Prod 57:545-51. 1994
    ....
  17. ncbi request reprint Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent
    Ken ichi Fujita
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Phytother Res 21:47-51. 2007
    ..On the other hand, anethole completely restricted the recovery of cell viability. Therefore the expression of the synergistic effect was probably due to a blockade of the recovery process from dodecanol-induced stress...
  18. ncbi request reprint Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells
    Sadaaki Tamura
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    Z Naturforsch C 62:227-33. 2007
    ..Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity...
  19. ncbi request reprint Antifungal activity of octyl gallate: structural criteria and mode of action
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Bioorg Med Chem Lett 11:347-50. 2001
    ..The length of the alkyl chain is not a major contributor but plays an important role in eliciting the activity...
  20. ncbi request reprint Identification of oxidation product of arbutin in mushroom tyrosinase assay system
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, CA 94720 3112, Berkeley, USA
    Bioorg Med Chem Lett 13:2409-12. 2003
    ..A significant enzymatic product was identified as 3,4-dihydroxyphenyl-O-beta-D-glucopyranoside by NMR and MS experiments...
  21. ncbi request reprint Flavonols from saffron flower: tyrosinase inhibitory activity and inhibition mechanism
    I Kubo
    Department of Environmental Science, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 47:4121-5. 1999
    ..This copper chelation mechanism can be applicable for all of the flavonols as long as their 3-hydroxyl group is free. However, quercetin, kaempferol, and galangin each affect the oxidation of L-tyrosine in somewhat different ways...
  22. doi request reprint Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells
    Teruhiko Nitoda
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Phytother Res 22:867-72. 2008
    ..5 microg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity...
  23. ncbi request reprint Naturally occurring anti-Salmonella agents
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 49:5750-4. 2001
    ..However, they showed different effects on the growth of S. choleraesuis. The combination of polygodial and anethole exhibited strong synergism on their bacteriostatic action but only marginal synergism on their bactericidal action...
  24. ncbi request reprint Effects of mushroom tyrosinase on anisaldehyde
    Tae Joung Ha
    Department of Environmental Science, Policy, and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 53:7024-8. 2005
    ..Anisaldehyde significantly suppressed the rate of enzymatic oxidation of L-tyrosine...
  25. ncbi request reprint Kinetics of mushroom tyrosinase inhibition by quercetin
    Qing Xi Chen
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 50:4108-12. 2002
    ..The inhibition of tyrosinase by quercetin is a slow and reversible reaction with residual enzyme activity. The microscopic rate constants were determined for the reaction of quercetin with the enzyme...
  26. ncbi request reprint Rational design of antimicrobial agents: antifungal activity of alk(en)yl dihydroxybenzoates and dihydroxyphenyl alkanoates
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 13:3993-6. 2003
    ..5 and 50 microg/mL. In addition, various 3,4-dihydroxybenzoates, possessing different side chains, namely unsaturated, branched and alicyclic were synthesized and their activity was compared...
  27. pmc Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae
    C S Lunde
    Comparative Biochemistry Group, Policy, and Management, University of California, Berkeley, California 94720, USA
    Antimicrob Agents Chemother 44:1943-53. 2000
    ..A major target of polygodial in yeast is mitochondrial ATP synthase. Reduction of the ATP supply leads to a suppression of Pma1 ATPase activity and impairs adaptive responses to other facets of polygodial's cellular inhibition...
  28. ncbi request reprint Tyrosinase inhibitory activity of the olive oil flavor compounds
    I Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    J Agric Food Chem 47:4574-8. 1999
    ..In addition, the hydrophobic alkyl chain length from the hydrophilic enal group seems to relate to their affinity to the enzyme, and this results in their inhibitory potency...
  29. ncbi request reprint Plasma membrane injury induced by nonyl gallate in Saccharomyces cerevisiae
    K Fujita
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California, USA
    J Appl Microbiol 92:1035-42. 2002
    ..The aim was to investigate the antifungal actions of nonyl gallate against Saccharomyces cerevisiae ATCC 7754...
  30. ncbi request reprint Synergistic effects of anacardic acids and methicillin against methicillin resistant Staphylococcus aureus
    Hisae Muroi
    Department of Environmental Science, Policy and Management, University of California at Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:583-7. 2004
    ..Notably, the synergistic effects were noted to increase with increasing the alkyl chain length...
  31. ncbi request reprint Lipoxygenase inhibitory activity of octyl gallate
    Tae Joung Ha
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:3177-81. 2004
    ..54 microM. One molecule of octyl gallate scavenged six molecules of 1,1-diphenyl-2-picrylhydrazyl and inhibited autoxidative lipid peroxidation. In addition, octyl gallate was effective in preventing lipid peroxidation...
  32. ncbi request reprint Molecular design of multifunctional food additives: antioxidative antifungal agents
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:5011-20. 2004
    ..However, the primary fungicidal activity of nonyl 3,4-dihydroxybenzoate likely comes from its ability to act as a surfactant...
  33. ncbi request reprint Lipoxygenase inhibitory activity of anacardic acids
    Tae Joung Ha
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 53:4350-4. 2005
    ..However, the hydrophobic interaction alone is not enough because cardanol (C15:1), which possesses the same side chain as anacardic acid (C15:1), acted neither as a substrate nor as an inhibitor...
  34. ncbi request reprint Antifungal activity of octyl gallate
    Ken ichi Fujita
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Int J Food Microbiol 79:193-201. 2002
    ....
  35. ncbi request reprint Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: involvement of pyrrole formation on cell surface in antifungal action
    Ken ichi Fujita
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 13:6742-7. 2005
    ....
  36. ncbi request reprint 2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 14:681-3. 2004
    ..3 microM. The inhibition kinetics analyzed by Dixon plots found that chamaecin is a mixed type inhibitor. This inhibition may come in part from its ability to form a Schiff base with a primary amino group in the enzyme...
  37. ncbi request reprint Lipoxygenase inhibitory activity of 6-pentadecanylsalicylic acid without prooxidant effect
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    Nat Prod Commun 5:85-90. 2010
    ..The inhibition of anacardic acid (C15:0) can be explained by a combination of iron ion-chelation and hydrophobic interaction abilities because of its specific structural feature...
  38. ncbi request reprint Antibacterial activity of polygodial
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Phytother Res 19:1013-7. 2005
    ..The time kill curve study showed that polygodial was bactericidal against B. subtilis and S. choleraesuis. However, there was a difference in its bactericidal action against endospore-forming B. subtilis and food-borne S. choleraesuis...
  39. doi request reprint Inhibition mode of soybean lipoxygenase-1 by quercetin
    Tae Joung Ha
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    Chem Biodivers 7:1893-903. 2010
    ..Rutin and kaempferol also exhibited lipoxygenase-1 inhibitory activity, but to a much lesser extent than quercetin...
  40. ncbi request reprint Evaluation of lipoxygenase inhibitory activity of anacardic acids
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    Z Naturforsch C 63:539-46. 2008
    ..Consequently, the data should be interpreted to mean that changes in the hydrophobic side chain tail portions of the molecules evaluated correlate with the specific activity determined...
  41. ncbi request reprint Naturally occurring antifungal agents against Zygosaccharomyces bailii and their synergism
    Ken ichi Fujita
    Department of Environmental Science, Policy and Management, University of California, Berkeley, 94720 3112, USA
    J Agric Food Chem 53:5187-91. 2005
    ..The fungicidal activity of sorbic acid was enhanced 512-fold in combination with 1/2 MFC of polygodial. Conversely, the fungicidal activity of polygodial was enhanced 128-fold in combination with 1/2 MFC of sorbic acid...
  42. doi request reprint Multifunctional cytotoxic agents from Anacardium occidentale
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    Phytother Res 25:38-45. 2011
    ..Both anacardic acids and cardols exhibited moderate cytotoxicity...
  43. ncbi request reprint Tyrosinase inhibition kinetics of anisic acid
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Z Naturforsch C 58:713-8. 2003
    ..603 mM. Anisic acid also inhibited the hydroxylation of L-tyrosine catalyzed by tyrosinase. The lag phase caused by the monophenolase activity was lengthened and the steady-state activity of the enzyme was decreased by anisic acid...
  44. ncbi request reprint Tyrosinase inhibitors from galls of Rhus javanica leaves and their effects on insects
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Z Naturforsch C 58:719-25. 2003
    ..18.1) with an IC50 of 22 microM. The aphid would detoxify the ingested toxic tannic acid to relatively nontoxic gallic acid, whereas the non-adapted pink bollworm Pectinophora gossypiella larvae are sensitive to the ingested tannic acid...
  45. ncbi request reprint Modes of antifungal action of alkanols against Saccharomyces cerevisiae
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 11:1117-22. 2003
    ..Hence, the antifungal activity of alkanols is mediated by biophysical process, and the maximum activity can be obtained when balance between hydrophilic and hydrophobic portions becomes the most appropriate...
  46. ncbi request reprint Non-antibiotic antibacterial activity of dodecyl gallate
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, CA 94720 3112, Berkeley, USA
    Bioorg Med Chem 11:573-80. 2003
    ..As far as alkyl gallates are concerned, their antimicrobial spectra and potency depend in part on the hydrophobic portion of the molecule...
  47. ncbi request reprint QSAR and kinetics of the inhibition of benzaldehyde derivatives against Sacrophaga neobelliaria phenoloxidase
    Wei Li
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:701-13. 2004
    ....
  48. ncbi request reprint Antioxidant activity of dodecyl gallate
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 50:3533-9. 2002
    ..Dodecyl gallate protected mitochondrial functions and human red blood cells against oxidative stresses, but gallic acid showed little effect. The hydrophobic dodecyl group is largely associated with the preventive antioxidative activity...
  49. ncbi request reprint Molecular design of antifungal agents
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 50:3992-8. 2002
    ..As far as alkyl gallates are concerned, their antimicrobial spectra and potency depend largely on the hydrophobic portion of the molecules...
  50. ncbi request reprint Effects of quercetin on mushroom tyrosinase and B16-F10 melanoma cells
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3114, USA
    Molecules 12:1045-56. 2007
    ..The concentration leading to 50% viable cells lost was established as 20 microM and almost complete lethality was observed at 80 microM...
  51. ncbi request reprint Anti-Salmonella activity of alkyl gallates
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 50:6692-6. 2002
    ....
  52. ncbi request reprint Antibacterial activity of ent-kaurene diterpenoids from Rabdosia rosthornii
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Phytother Res 18:180-3. 2004
    ..They exhibited antibacterial activity specifically against Gram-positive bacteria, among which Propionibacterium acnes was noted to be the most susceptible...
  53. ncbi request reprint Antibacterial action of anacardic acids against methicillin resistant Staphylococcus aureus (MRSA)
    Isao Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 51:7624-8. 2003
    ..The compounds possessing the similar log P values exhibit similar activity...
  54. ncbi request reprint Anti-Helicobacter pylori agents from the cashew apple
    J Kubo
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    J Agric Food Chem 47:533-7. 1999
    ..The same antibacterial compounds have also been found to inhibit urease (EC 3.5.1.5)...
  55. ncbi request reprint Anisaldehyde, a melanogenesis potentiator
    Teruhiko Nitoda
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720, USA
    Z Naturforsch C 62:143-9. 2007
    ..The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells...
  56. ncbi request reprint Structural criteria for depigmenting mechanism of arbutin
    Ikuyo Hori
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA, USA
    Phytother Res 18:475-9. 2004
    ..The depigmenting mechanism of arbutin previously reported is supportable if a cofactor is not available in the melanocytes. The combination with L-ascorbic acid is a useful application, particularly when oxygen is limited...
  57. doi request reprint Effects of cuminaldehyde on melanoma cells
    Teruhiko Nitoda
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720, USA
    Phytother Res 22:809-13. 2008
    ..25 mm without affecting cell growth. Approximately 30% suppression in melanin production resulted when the cells were cultured with 0.25 mm of cuminaldehyde. This activity was not noticeable with cultured human A375 melanoma cells...
  58. doi request reprint Antifungal activity of alkanols against Zygosaccharomyces bailii and their effects on fungal plasma membrane
    Ken ichi Fujita
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    Phytother Res 22:1349-55. 2008
    ..The antifungal activity of decanol against Z. bailii was slightly enhanced in combination with anethole...
  59. ncbi request reprint Volatile aldehydes are promising broad-spectrum postharvest insecticides
    D G Hammond
    Agricultural and Environmental Chemistry Group and Department of Environmental Science, Policy and Management, 201 Wellman Hall, University of California at Berkeley, Berkeley, California 94720 3112, USA
    J Agric Food Chem 48:4410-7. 2000
    ..Preliminary assays indicate that similar doses are also effective against mealybugs, thrips, and whitefly...
  60. ncbi request reprint Slow-binding inhibition of soybean lipoxygenase-1 by dodecyl gallate
    Tae Joung Ha
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    J Agric Food Chem 55:446-51. 2007
    ..Both the initial velocity and steady-state rate in the progress curve decreased with increasing dodecyl gallate. The kinetic parameters that described the inhibition by dodecyl gallate were evaluated by nonlinear regression fits...
  61. ncbi request reprint Insect antifeedants from tropical plants: structures of dumnin and dumsenin
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 52:3325-8. 2004
    ..0 microg/mL) against the larvae of pink bollworm, Pectinophora gossypiella, and/or fall armyworm, Spodoptera frugiperda, providing results comparable to dumsin and zumsin, previously isolated from the same plant...
  62. ncbi request reprint Insect antifeedants from tropical plants II: structure of zumsin
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    J Agric Food Chem 50:5048-52. 2002
    ..The structure consists of an A'-B trans-fused ring while dumsin (2), a constituent of the same source, maintains an A'-B cis-fused ring, and suggests two unique biosynthetic processes after A ring oxidative expansion...
  63. ncbi request reprint Hydroquinone, a control agent of agglutination and adherence of Streptococcus mutans induced by sucrose
    Masaki Himejima
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem 12:921-5. 2004
    ..The agglutination altering activity of hydroquinone seems to be specific for strains of S. mutans. As a result, hydroquinone inhibits sucrose-induced adherence of S. mutans...
  64. ncbi request reprint Alkanols inhibit respiration of intact mitochondria and display cutoff similar to that measured in vivo
    D G Hammond
    Department of Environmental Science, Policy, and Management, University of California, Berkeley, USA
    J Pharmacol Exp Ther 293:822-8. 2000
    ....
  65. ncbi request reprint Insect antifeedants from Croton jatrophoides: structures of zumketol, zumsenin, and zumsenol
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 31122, USA
    J Nat Prod 68:244-7. 2005
    ..The alpha-ketol 1 may be biosynthesized via the intramolecular acyloin condensation of a dicarboxylate intermediate...
  66. ncbi request reprint Arudonine, an allelopathic steroidal glycoalkaloid from the root bark of Solanum arundo Mattei
    Katsuya Fukuhara
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Phytochemistry 65:1283-6. 2004
    ..This steroidal glycoalkaloid inhibited the growth of lettuce seedlings (Lactuca sativa)...
  67. ncbi request reprint (+)-2,3-dehydro-10-oxo-alpha-isosparteine in Uresiphita reversalis larvae fed on Cytisus monspessulanus leaves
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Phytochemistry 61:987-90. 2002
    ..In addition, the quinolizidine alkaloid, (+)-2,3-dehydro-10-oxo-alpha-isosparteine was characterized in both the insect and host plant...
  68. ncbi request reprint Pachyelasides A-D, novel molluscicidal triterpene saponins from Pachyelasma tessmannii
    Ken ichi Nihei
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    J Agric Food Chem 53:608-13. 2005
    ..The structures were determined on the basis of extensive nuclear magnetic resonance spectroscopic and matrix-assisted laser desorption/ionization time-of-flight mass spectrometric studies...
  69. ncbi request reprint Anacardic acids and ferric ion chelation
    Kazuo Tsujimoto
    School of Material Sciences, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923 1292, Japan
    Z Naturforsch C 62:710-6. 2007
    ..Formation of the anacardic acids-ferric ion complex was detected in the ratio of 2:1 as the base peak in the negative ion electrospray ionization mass spectrometry. Hence, anacardic acids inhibit both Eox and Ered forms...
  70. ncbi request reprint Design and evaluation of anacardic acid derivatives as anticavity agents
    Ivan R Green
    Department of Chemistry, University of the Western Cape, P Bag X17, Bellville, 7530, South Africa
    Eur J Med Chem 43:1315-20. 2008
    ..Among them, 6-(4',8'-dimethylnonyl)salicylic acid was found to exhibit the most potent antibacterial activity against this cariogenic bacterium with the minimum inhibition concentration (MIC) of 0.78 microg/ml...
  71. ncbi request reprint Molecular design of anti-MRSA agents based on the anacardic acid scaffold
    Ivan R Green
    Department of Chemistry, University of the Western Cape, Bellville 7530, South Africa
    Bioorg Med Chem 15:6236-41. 2007
    ..This activity was superior to that of the most potent antibacterial anacardic acid isolated from the cashew Anacardium occidentale (Anacardiaceae), apple and nut, that is, the 6-[8'(Z),11'(Z),14'-pentadecatrienyl]salicylic acid...
  72. ncbi request reprint Xanthine oxidase inhibitory activity of alkyl gallates
    Noriyoshi Masuoka
    Department of Life Science, Okayama University of Science, Ridai cho, Okayama, Japan
    Mol Nutr Food Res 50:725-31. 2006
    ..The suppression is not due to scavenging activity of these gallates but due to reduction of xanthine oxidase by these gallates. The reduced enzyme catalyzes the reaction to generate hydrogen peroxide and uric acid...
  73. ncbi request reprint Antioxidants from Rabdosia japonica
    Noriyoshi Masuoka
    Department of Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Phytother Res 20:206-13. 2006
    ..On the other hand, isoquercitrin, rutin and rosmarinic acid were effective in scavenging superoxide radicals generated by the xanthine-xanthine oxidase system without inhibiting the enzyme...
  74. ncbi request reprint Synergism of polygodial and trans-cinnamic acid on inhibition of root elongation in lettuce seedling growth bioassays
    Ken ichi Fujita
    Graduate School of Science, Osaka City University, 3 3 138 Sugimoto, Sumiyoshi ku, Osaka 558 8585, Japan
    J Chem Ecol 29:2253-62. 2003
    ..These results suggest that polygodial functions synergistically with trans-cinnamic acid in the inhibition of root elongation via restriction of proton transport from the cytoplasm of germinated cells...
  75. ncbi request reprint Inactivation kinetics of mushroom tyrosinase by cetylpyridinium chloride
    Qing Xi Chen
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Department of Biology, Xiamen University, Xiamen 361005, People s Republic of China
    J Protein Chem 22:481-7. 2003
    ..The micro rate constants of inactivation and the association constant were determined...
  76. ncbi request reprint Characterization of xanthine oxidase inhibition by anacardic acids
    Noriyoshi Masuoka
    Department of Biochemistry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Biochim Biophys Acta 1688:245-9. 2004
    ..Salicylic acid moiety and alkenyl side chain in anacardic acid are associated with the cooperative inhibition and hydrophobic binding, respectively...
  77. ncbi request reprint Musidunin and musiduol, insect antifeedants from Croton jatrophoides
    Ken ichi Nihei
    Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321 0943, Japan
    J Nat Prod 69:975-7. 2006
    ..Interestingly, A,B-seco limonoid 1 contains a unique acetal annulation of A, A', and B' rings. Both limonoids exhibited antifeedant activities against two pests, Pectinophora gossypiella and Spodoptera frugiperda...