Bassil M Kublaoui

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake
    Bassil M Kublaoui
    Department of Pediatrics, and McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, 75390 8591, USA
    Endocrinology 147:4542-9. 2006
  2. ncbi Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
    Bassil M Kublaoui
    Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8591, USA
    Mol Endocrinol 20:2483-92. 2006
  3. pmc Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
    Bassil M Kublaoui
    Department of Pediatrics, Department of Internal Medicine, McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, TX 75390 8591, USA
    Mol Endocrinol 22:1723-34. 2008
  4. pmc Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
    Kristen P Tolson
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:3803-12. 2010
  5. pmc Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure
    Dong Xi
    Division of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS ONE 7:e36453. 2012
  6. ncbi Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
    J Lloyd Holder
    Dept of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8591, USA
    Am J Physiol Endocrinol Metab 287:E105-13. 2004
  7. doi Screening for type 2 diabetes in obese youth
    Shuchi Shah
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Pediatrics 124:573-9. 2009
  8. ncbi Editorial: MC4R mutations--weight before screening!
    Bassil M Kublaoui
    J Clin Endocrinol Metab 91:1671-2. 2006

Collaborators

Detail Information

Publications8

  1. ncbi SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake
    Bassil M Kublaoui
    Department of Pediatrics, and McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, 75390 8591, USA
    Endocrinology 147:4542-9. 2006
    ..Our results indicate that the melanocortin 4 receptor signals through Sim1 or its transcriptional targets in controlling food intake but not energy expenditure...
  2. ncbi Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
    Bassil M Kublaoui
    Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8591, USA
    Mol Endocrinol 20:2483-92. 2006
    ..Our results demonstrate that Sim1 heterozygotes are resistant to hypothalamic melanocortin signaling and suggest that Sim1-expressing PVN neurons regulate feeding, but not energy expenditure, in response to melanocortin signaling...
  3. pmc Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
    Bassil M Kublaoui
    Department of Pediatrics, Department of Internal Medicine, McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, TX 75390 8591, USA
    Mol Endocrinol 22:1723-34. 2008
    ..Our results support the importance of Oxt neurons in feeding regulation and suggest that reduced Oxt neuropeptide is one mechanism mediating the hyperphagic obesity of Sim1(+/-) mice...
  4. pmc Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
    Kristen P Tolson
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:3803-12. 2010
    ....
  5. pmc Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure
    Dong Xi
    Division of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS ONE 7:e36453. 2012
    ..Based on the body of work in the field, feeding regulation by Sim1 neurons likely occurs in both the PVH and medial amygdala, in contrast to energy expenditure regulation by Sim1 neurons, which likely is localized to the PVH...
  6. ncbi Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
    J Lloyd Holder
    Dept of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8591, USA
    Am J Physiol Endocrinol Metab 287:E105-13. 2004
    ..Our results indicate that Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat and likely plays a physiological role in the regulation of energy balance...
  7. doi Screening for type 2 diabetes in obese youth
    Shuchi Shah
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Pediatrics 124:573-9. 2009
    ..To assess available blood tests as potential screening tools for impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM)...
  8. ncbi Editorial: MC4R mutations--weight before screening!
    Bassil M Kublaoui
    J Clin Endocrinol Metab 91:1671-2. 2006