R J Kryscio

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi Risk factors for transitions from normal to mild cognitive impairment and dementia
    R J Kryscio
    Sanders Brown Center on Aging, University of Kentucky, KY, USA
    Neurology 66:828-32. 2006
  2. ncbi Designing a large prevention trial: statistical issues
    Richard J Kryscio
    Department of Statistics, University of Kentucky, Lexington 40536 0230, USA
    Stat Med 23:285-96. 2004
  3. ncbi Modelling mini mental state examination changes in Alzheimer's disease
    M S Mendiondo
    Center on Aging, 101 Sanders Brown Building, University of Kentucky, Lexington, KY 40536, USA
    Stat Med 19:1607-16. 2000
  4. ncbi Tooth loss, apolipoprotein E, and decline in delayed word recall
    P S Stein
    Department of Anatomy and Neurobiology, College of Medicine, MN 210 Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA
    J Dent Res 89:473-7. 2010
  5. ncbi Critical decline in fine motor hand movements in human aging
    C D Smith
    Department of Neurology, Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, USA
    Neurology 53:1458-61. 1999
  6. ncbi Posaconazole as salvage therapy for zygomycosis
    R N Greenberg
    Medicine Service, Department of Veterans Affairs Medical Center, Lexington, Kentucky, USA
    Antimicrob Agents Chemother 50:126-33. 2006
  7. ncbi Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging Spectrometry Center Davis Mills Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    J Neuroimaging 15:271-7. 2005
  8. ncbi The effectiveness of a tobacco prevention program with adolescents living in a tobacco-producing region
    M P Noland
    Department of Kinesiology and Health Promotion, University of Kentucky, Lexington 40506 0219, USA
    Am J Public Health 88:1862-5. 1998
  9. ncbi Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter
    Susan C Modesitt
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Markey Cancer Center, Lexington, Kentucky 40536 0298, USA
    Obstet Gynecol 102:594-9. 2003
  10. ncbi Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 53:1391-6. 1999

Detail Information

Publications52

  1. ncbi Risk factors for transitions from normal to mild cognitive impairment and dementia
    R J Kryscio
    Sanders Brown Center on Aging, University of Kentucky, KY, USA
    Neurology 66:828-32. 2006
    ..To identify risk factors associated with transitions from cognitively normal to various forms of mild cognitive impairment (MCI) and then from MCI into early dementia with death as a competing state...
  2. ncbi Designing a large prevention trial: statistical issues
    Richard J Kryscio
    Department of Statistics, University of Kentucky, Lexington 40536 0230, USA
    Stat Med 23:285-96. 2004
    ..This framework is illustrated by PREADVISE, a recently initiated large add-on prevention trial investigating the use of anti-oxidants for preventing AD among men enrolled in a even larger prostate cancer prevention study, SELECT...
  3. ncbi Modelling mini mental state examination changes in Alzheimer's disease
    M S Mendiondo
    Center on Aging, 101 Sanders Brown Building, University of Kentucky, Lexington, KY 40536, USA
    Stat Med 19:1607-16. 2000
    ..Such estimations of disease course are useful when comparing different populations for both clinical and research purposes...
  4. ncbi Tooth loss, apolipoprotein E, and decline in delayed word recall
    P S Stein
    Department of Anatomy and Neurobiology, College of Medicine, MN 210 Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA
    J Dent Res 89:473-7. 2010
    ....
  5. ncbi Critical decline in fine motor hand movements in human aging
    C D Smith
    Department of Neurology, Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, USA
    Neurology 53:1458-61. 1999
    ..Slowing of motor movements in human aging is a well-known occurrence, but its biologic basis is poorly understood. Reliable quantitation may refine observations of this phenomenon to better aid research on this entity...
  6. ncbi Posaconazole as salvage therapy for zygomycosis
    R N Greenberg
    Medicine Service, Department of Veterans Affairs Medical Center, Lexington, Kentucky, USA
    Antimicrob Agents Chemother 50:126-33. 2006
    ..Posaconazole appears promising as an oral therapy for zygomycosis in patients who receive required surgery and control their underlying illness...
  7. ncbi Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging Spectrometry Center Davis Mills Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    J Neuroimaging 15:271-7. 2005
    ..The authors sought to determine whether known alterations of brain function in normal individuals who are at high risk for Alzheimer's disease (AD) worsen or stay the same after a significant interval of time...
  8. ncbi The effectiveness of a tobacco prevention program with adolescents living in a tobacco-producing region
    M P Noland
    Department of Kinesiology and Health Promotion, University of Kentucky, Lexington 40506 0219, USA
    Am J Public Health 88:1862-5. 1998
    ..This study investigated the efficacy of a social-influences tobacco prevention program conducted with adolescents living in a high tobacco production area...
  9. ncbi Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter
    Susan C Modesitt
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Markey Cancer Center, Lexington, Kentucky 40536 0298, USA
    Obstet Gynecol 102:594-9. 2003
    ..To determine the natural history and to estimate the risk of malignancy of unilocular ovarian cystic tumors less than 10 cm in diameter followed conservatively by transvaginal ultrasound...
  10. ncbi Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 53:1391-6. 1999
    ..To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness...
  11. ncbi Women at risk for AD show increased parietal activation during a fluency task
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 58:1197-202. 2002
    ..A recent study has shown increased parietal activation in high-risk subjects during a paired associates recall task, which the authors postulated might overlap activation typically observed in verbal fluency...
  12. ncbi Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task
    C D Smith
    Department of Neurology, University of Kentucky College of Medicine, Lexington, USA
    J Neuroimaging 11:165-70. 2001
    ..No category differences in activation strength in the left temporal lobe were observed. The authors conclude that visual semantic operations may involve visual association cortex in the right temporal lobe in women...
  13. ncbi Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB
    Peter T Nelson
    Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY, USA
    J Alzheimers Dis 16:29-34. 2009
    ..In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline...
  14. ncbi Salivary biomarkers of existing periodontal disease: a cross-sectional study
    Craig S Miller
    Oral Medicine Section, Department of Oral Health Practice, College of Dentistry, University of Kentucky College of Medicine, MN 324, 800 Rose Street, Lexington, KY 40536 0297, USA
    J Am Dent Assoc 137:322-9. 2006
    ..The authors conducted a study to determine if salivary biomarkers specific for three aspects of periodontitis--inflammation, collagen degradation and bone turnover--correlate with clinica features of periodontal disease...
  15. ncbi Alzheimer's disease and head circumference
    Patricio S Espinosa
    Department of Neurology, Sanders Brown Center on Aging University of Kentucky Alzheimer s Disease Research Center, Lexington, KY 40536 0284, USA
    J Alzheimers Dis 9:77-80. 2006
    ..Larger head circumference (HC) may therefore be associated with later detection and diagnosis of AD. We investigated HC in nondemented individuals and AD patients using cross-sectional and prospective analyses...
  16. ncbi The search for meaning-Symptoms and transvaginal sonography screening for ovarian cancer: predicting malignancy
    Edward J Pavlik
    Department of Obstetrics and Gynecology, The University of Kentucky Chandler Medical Center, Lexington, Kentucky, USA
    Cancer 115:3689-98. 2009
    ..Recently, it was reported that certain symptom patterns are informative for the presence of ovarian malignancy. In this article, the authors report on how symptoms and ultrasound predict ovarian malignancy...
  17. ncbi JC virus detection in bodily fluids: clues to transmission
    Joseph R Berger
    Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY 40536 0284, USA
    Clin Infect Dis 43:e9-12. 2006
    ....
  18. ncbi Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 450:336-9. 2009
    ..Our results are not consistent with the idea that the precuneus is involved in a special way with plaques or tangles relative to other areas of neocortex...
  19. ncbi High prevalence of multiple human herpesviruses in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy
    Craig S Miller
    Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0297, USA
    J Clin Microbiol 44:2409-15. 2006
    ..These findings suggest that saliva is a potential risk factor for the acquisition of multiple HHVs, and several host factors may function to accelerate HHV reactivation or replication in patients with HIV infection...
  20. ncbi Factors associated with return for routine annual screening in an ovarian cancer screening program
    Michael A Andrykowski
    Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY 40536 0086, USA
    Gynecol Oncol 104:695-701. 2007
    ..To identify clinical, demographic, dispositional, and attitudinal variables associated with return for routine, annual transvaginal sonography (TVS) screening for ovarian cancer...
  21. ncbi Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY, USA
    Brain Pathol 20:66-79. 2010
    ..There was no support for independent association between CILA severity and most evaluated indices including diffuse plaques, argyrophilic grains, heart disease, education level, apolipoprotein E alleles or diabetes...
  22. ncbi Tooth loss, dementia and neuropathology in the Nun study
    Pamela Sparks Stein
    Department of Anatomy and Neurobiology, College of Medicine, MN 210 Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA
    J Am Dent Assoc 138:1314-22; quiz 1381-2. 2007
    ..The authors conducted a study to investigate a potential association between a history of oral disease and the development of dementia...
  23. ncbi Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, Univerisity of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 68:774-84. 2009
    ..We conclude that NFT+/NP- cases comprise approximately 5% of aged individuals in multiple data sets; these cases are not necessarily within the spectrum of AD...
  24. ncbi Ovarian cancer screening with annual transvaginal sonography: findings of 25,000 women screened
    John R van Nagell
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Chandler Medical Center Markey Cancer Center, Lexington, Kentucky 40536, USA
    Cancer 109:1887-96. 2007
    ..The current investigation was performed to determine the efficacy of annual transvaginal sonography (TVS) as a screening method for ovarian cancer...
  25. ncbi Neuropathologic substrate of mild cognitive impairment
    William R Markesbery
    Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Arch Neurol 63:38-46. 2006
    ..To define the neuropathologic findings in amnestic mild cognitive impairment (MCI) and early Alzheimer disease (EAD)...
  26. ncbi The ALS Nutrition/NIPPV Study: design, feasibility, and initial results
    Edward J Kasarskis
    Department of Neurology, University of Kentucky, Lexington, Kentucky, USA
    Amyotroph Lateral Scler 12:17-25. 2011
    ..The results of this study will allow us to model equations to predict the energy requirements in ALS and to plan a study of early intervention with NIPPV...
  27. ncbi Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs
    M Paul Murphy
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 405360230, USA
    J Alzheimers Dis 22:135-50. 2010
    ....
  28. ncbi Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE
    Joseph F Pulliam
    Department of Pathology, University of Kentucky, Lexington, Kentucky 40536, USA
    Am J Med Genet B Neuropsychiatr Genet 119:48-53. 2003
    ....
  29. ncbi Association between male gender and cortical Lewy body pathology in large autopsy series
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, Sanders Brown Center on Aging, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:1875-81. 2010
    ..05 for both). Males are far more likely than females to die with neocortical LB pathology. This phenomenon may help guide medical practice including clinical trial study design...
  30. ncbi Designing a Brief Alzheimer Screen (BAS)
    Marta S Mendiondo
    School of Public Health, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    J Alzheimers Dis 5:391-8. 2003
    ..With advances in the treatment of Alzheimer's disease (AD), clinical focus has shifted to early patient identification. Memory recall tests and category fluency distinguish normal individuals from early AD patients...
  31. ncbi Patterns of colorectal cancer incidence, risk factors, and screening in Kentucky
    Claudia Hopenhayn
    Cancer Control Program, University of Kentucky, Lexington, KY 40504 3381, USA
    South Med J 97:216-23. 2004
    ..Colorectal cancer incidence rates are higher in Kentucky than in the United States in general, and there are regional variations within the state...
  32. ncbi Effect of prophylactic valacyclovir on the presence of human herpesvirus DNA in saliva of healthy individuals after dental treatment
    Craig S Miller
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine and College of Dentistry, Lexington, KY, USA
    J Clin Microbiol 43:2173-80. 2005
    ....
  33. ncbi The accuracy of examination under anesthesia and transvaginal sonography in evaluating ovarian size
    Fred R Ueland
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Medical Center Markey Cancer Center, 800 Rose Street, Lexington, KY 40536 0293, USA
    Gynecol Oncol 99:400-3. 2005
    ..To compare pelvic examination under anesthesia to transvaginal sonography (TVS) as a method for ovarian detection and measurement...
  34. ncbi Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment
    William R Markesbery
    Alzheimer s Disease Research Center, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Ann Neurol 58:730-5. 2005
    ..Our data indicate that lipid peroxidation is present in the brain of MCI patients and suggest that oxidative damage may play a role in the pathogenesis of AD...
  35. ncbi Low sensitivity in clinical diagnoses of dementia with Lewy bodies
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:359-66. 2010
    ..Our data suggest that further work is needed to refine our ability to identify specific aging-related brain disease mechanisms, especially in DLB...
  36. ncbi Focal cerebral ischemia in the TNFalpha-transgenic rat
    L Creed Pettigrew
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA
    J Neuroinflammation 5:47. 2008
    ..To determine if chronic elevation of the inflammatory cytokine, tumor necrosis factor-alpha (TNFalpha), will affect infarct volume or cortical perfusion after focal cerebral ischemia...
  37. ncbi Bone remodeling-associated salivary biomarker MIP-1α distinguishes periodontal disease from health
    M Al-Sabbagh
    Department of Oral Health Practice, Center for Oral Health Research, University of Kentucky, Lexington, KY 40536 0297, USA
    J Periodontal Res 47:389-95. 2012
    ..To address this, we examined levels of salivary biomolecules specifically associated with biological aspects of bone remodeling in subjects with chronic periodontitis in a case-control study...
  38. ncbi Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies
    P T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurology 73:1127-33. 2009
    ..Recent studies raised questions about the severity of cognitive impairment associated with dementia with Lewy bodies (DLB). However, there have been few analyses of large, multicenter data registries for clinical-pathologic correlation...
  39. ncbi Real-time polymerase chain reaction to determine the prevalence and copy number of epstein-barr virus and cytomegalovirus DNA in subgingival plaque at individual healthy and periodontal disease sites
    Dolphus R Dawson
    Department of Oral Health Practice, University of Kentucky, Lexington, KY, USA
    J Periodontol 80:1133-40. 2009
    ....
  40. ncbi A randomized controlled Alzheimer's disease prevention trial's evolution into an exposure trial: the PREADViSE Trial
    R J Kryscio
    University of Kentucky Sanders Brown Center on Aging, Department of Biostatistics, Lexington, KY, USA
    J Nutr Health Aging 17:72-5. 2013
    ....
  41. ncbi Promoting interactions with basic scientists and clinicians: summary of the panel session
    F A Schmitt
    Department of Neurology and Center on Aging, Room 101, Sanders Brown Building, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    Stat Med 19:1463-8. 2000
    ....
  42. ncbi Salivary levels of Epstein-Barr virus DNA correlate with subgingival levels, not severity of periodontitis
    D R Dawson
    Department of Oral Health Practice, Center for Oral Health Research, University of Kentucky, Lexington, KY, USA
    Oral Dis 15:554-9. 2009
    ..The aim of this study was to determine the presence and quantity of human cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNA in the saliva of patients with periodontitis, and investigate the correlation between these factors...
  43. ncbi Hypodontia as a risk marker for epithelial ovarian cancer: a case-controlled study
    Leigh A Chalothorn
    Division of Orthodontics, University of Kentucky, Lexington, KY 40515, USA
    J Am Dent Assoc 139:163-9. 2008
    ..The authors conducted a study to establish the prevalence rates of hypodontia among subjects with epithelial ovarian cancer (EOC) and control subjects to explore possible genetic associations between these two phenotypes...
  44. ncbi Neural substrates of facial emotion processing using fMRI
    M L Kesler-West
    Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY 40536, USA
    Brain Res Cogn Brain Res 11:213-26. 2001
    ....
  45. ncbi Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia
    Juan C Salazar
    Universidad Nacional de Colombia at Medellín, Escuela de Estadistica, Medellin, Colombia
    Stat Med 26:568-80. 2007
    ....
  46. ncbi Transitions to mild cognitive impairments, dementia, and death: findings from the Nun Study
    Suzanne L Tyas
    Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada
    Am J Epidemiol 165:1231-8. 2007
    ..Thus, risk factors for dementia may operate primarily by predisposing individuals to develop mild cognitive impairments; subsequent progression to dementia then depends on only time and competing mortality...
  47. ncbi Reduced risk of incident AD with elective statin use in a clinical trial cohort
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City AZ, USA
    Curr Alzheimer Res 5:416-21. 2008
    ..Cholesterol levels were lower among statin users compared with non-LLA users, but the MMSE scores were equivalent. The data suggest that statin therapy may be of benefit in reducing the risk of AD...
  48. ncbi Active control trials for epilepsy: avoiding bias in head-to-head trials
    Jacqueline A French
    Neurology 66:1294-5. 2006
  49. ncbi Tamoxifen-associated malignant endometrial tumors: pathologic features and expression of hormone receptors estrogen-alpha, estrogen-beta and progesterone; a case controlled study
    James L Wilder
    Division of Gynecologic Oncology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Gynecol Oncol 92:553-8. 2004
    ..Survival from disease was significantly worse for cases with TAMET as compared to controls...
  50. ncbi Clinical implications of a rising serum CA-125 within the normal range in patients with epithelial ovarian cancer: a preliminary investigation
    James L Wilder
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Medical Center, 800 Rose Street, Whitney Hendrickson Building, Lexington 40536, USA
    Gynecol Oncol 89:233-5. 2003
    ..The goal of this study was to determine the clinical implications of a progressively rising serum CA-125 level in the normal (< 35 U/ml) range in ovarian cancer patients with complete response to therapy...
  51. ncbi Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy
    Jeanne M Schilder
    Department of Ob Gyn, Division of Gynecologic Oncology, Indiana University Medical Center, 535 Barnhill Drive, Rm 436, Indianapolis, IN 46202 6294, USA
    Gynecol Oncol 87:1-7. 2002
    ..The purpose of this study was to determine the recurrence rate, survival, and pregnancy outcome in patients with Stage IA and Stage IC invasive epithelial ovarian cancer treated with unilateral adnexectomy...
  52. ncbi Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis
    Nicolaos Christodoulides
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    Ann N Y Acad Sci 1098:411-28. 2007
    ....