Research Topics
Genomes and Genes | Ilona KryczekSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environmentsIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0669, USA
Blood 114:1141-9. 2009..This study thus provides scientific and clinical rationale for developing novel immune-boosting strategies based on promoting the Th17 cell population in cancer patients...
Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell developmentIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 181:5842-6. 2008..Our study challenges the dogma that IFN-gamma suppresses Th17 and enhances Th1 development...- Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinomaIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
Cancer Res 67:8900-5. 2007..Altogether, our data support the concept that there is a mechanistic interaction between Treg cells and macrophage, and that Treg cells may convey the suppressive activity to APCs through B7-H4 induction in human ovarian cancer... 
IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancerIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 186:4388-95. 2011..Our data therefore challenge commonly held beliefs of the anti-inflammatory role of Treg cells and suggest a more complex Treg cell biology, at least in the context of human chronic inflammation and associated carcinoma...- Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactionsKe Wu
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
Cancer Res 69:8067-75. 2009..Our data indicate that the B7-H1/PD-1 axis contributes to immune suppression in human HCC, with blockade of this pathway carrying important therapeutic implications... - Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppressionIlona Kryczek
Department of Surgery, University of Mechigan, Ann Arbor, MI 48109, USA
J Immunol 179:1423-6. 2007..Thus, the IL-17(+) T cell pool may be controlled by the local cytokine profile in the microenvironment... - Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasisIlona Kryczek
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48105, USA
J Immunol 181:4733-41. 2008.... - Interleukin-2 administration alters the CD4+FOXP3+ T-cell pool and tumor trafficking in patients with ovarian carcinomaShuang Wei
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
Cancer Res 67:7487-94. 2007..These data provide an important insight in evaluating the clinical benefit and therapeutic prediction of IL-2 treatment in patients with cancer... - Bone marrow and the control of immunityEnde Zhao
Department of Surgery, University of Michigan School of Medicine, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0669, USA
Cell Mol Immunol 9:11-9. 2012..We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination... - Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel diseaseCailin M Wilke
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
J Transl Med 9:217. 2011..Th17 cells play a role in inflammation. Interleukin (IL)-10 is a potent anti-inflammatory cytokine. However, it is poorly understood whether and how endogenous IL-10 impacts the development of Th17 cells in human pathologies... - Human TH17 cells are long-lived effector memory cellsIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Sci Transl Med 3:104ra100. 2011..Targeting TH17-associated signaling pathway would be therapeutically meaningful for treating patients with autoimmune disease and advanced tumor... - Endogenous IL-17 contributes to reduced tumor growth and metastasisIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Blood 114:357-9. 2009.... - FOXP3 defines regulatory T cells in human tumor and autoimmune diseaseIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
Cancer Res 69:3995-4000. 2009..We suggest that the combination of FOXP3 and cytokine profile is useful for further functionally distinguishing primary Tregs from activated conventional T cells... - Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironmentIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 178:6730-3. 2007.... - Th17 cells in cancer: help or hindrance?Cailin Moira Wilke
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Carcinogenesis 32:643-9. 2011..In this review, we will describe the phenotype of tumor-associated Th17 cells, review those studies that have examined the population directly, and finally, briefly discuss the studies involving Th17-associated signature cytokines... - Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cellsIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0669, USA
Int J Cancer 130:29-39. 2012..Altogether, the data suggest that ALDH+ and CD133+ cells are enriched with ovarian cancer-initiating (stem) cells and that ALDH and CD133 may be widely used as reliable markers to investigate ovarian cancer stem cell biology... - Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cellsIlona Kryczek
Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
J Immunol 177:40-4. 2006..Altogether, our data provide a novel cellular and molecular mechanism for Treg cell-mediated immunosuppression at the level of APCs, and suggest a plausible mechanism for the suppressive effect of IL-10 in Treg cell-mediated suppression... - Interleukin-10 ablation promotes tumor development, growth, and metastasisTakashi Tanikawa
Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 72:420-9. 2012.... - Antigen-presenting cell (APC) subsets in ovarian cancerCailin Moira Wilke
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0669, USA
Int Rev Immunol 30:120-6. 2011..In this review, we summarize the nature, cellular interactions, and prognostic significance of the main APC populations in ovarian cancer, and discuss the relevance of manipulating APC subsets for patient treatment... - Dual biological effects of the cytokines interleukin-10 and interferon-γCailin Moira Wilke
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, USA
Cancer Immunol Immunother 60:1529-41. 2011..Our progressive understanding of the dual effects of these cytokines is important for dissecting cytokine-associated pathology and provides new avenues for developing effective immune therapy against human diseases, including cancer... - Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesisIlona Kryczek
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109 0669, USA
Am J Physiol Cell Physiol 292:C987-95. 2007..In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed... - B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinomaIlona Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
J Exp Med 203:871-81. 2006..Blocking B7-H4 or depleting B7-H4+ tumor macrophages may represent novel strategies to enhance T cell tumor immunity in cancer...