Research Topics
| MATTHEW KRUMMELSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Immunological synapses: breaking up may be good to doMatthew F Krummel
The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
Cell 129:653-5. 2007..They also show that re-establishment of a synapse involves the actin regulator WASp...
The immunological synapse: a dynamic platform for local signalingMatthew F Krummel
Department of Pathology, University of California San Francisco, 513 Parnassus Avenue HSW 0511, San Francisco, CA 94143, USA
J Clin Immunol 30:364-72. 2010..Such spatiotemporal signaling in the synapse greatly accelerates kinetics and provides essential checkpoints to validate effective cell-cell communication...- Maintenance and modulation of T cell polarityMatthew F Krummel
Department of Pathology, University of California at San Francisco, San Francisco, California 94143 0511, USA
Nat Immunol 7:1143-9. 2006..Ultimately, the strength of a T cell response may rely on correct T cell polarization. Therefore, loss of polarity regulators or guidance cues may interfere with T cell activation... - CD28 signals in the immature immunological synapsePietro G Andres
Department of Pathology, and Division of Gastroenterology, University of California, San Francisco, CA 93143, USA
J Immunol 172:5880-6. 2004..Together, the data show that CD28 functions in the immunological synapse before the formation of the c-SMAC... - Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sitesJudie Boisvert
Department of Pathology, University of California, San Francisco, CA 94143, USA
J Immunol 173:3647-52. 2004..It may also serve as a site for these molecular aggregates to coassociate and/or internalize alongside other signaling receptors... - Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic miceQizhi Tang
Diabetes Center, Department of Medicine, University of California, San Francisco 94143, USA
Nat Immunol 7:83-92. 2006..Such persistent T(reg) cell-dendritic cell contacts preceded the inhibition of T(H) cell activation by dendritic cells, supporting the idea that dendritic cells are central to T(reg) cell function in vivo... 
Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responsesAndrew Bullen
Department of Pathology and Biological Imaging Development Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
Curr Top Microbiol Immunol 334:1-29. 2009....- Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopyMikala Egeblad
Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Dis Model Mech 1:155-67; discussion 165. 2008..The techniques are not limited to investigations in cancer, but could give new insights into cell behavior more broadly in development and disease... - Dynamics of the immunological synapse: finding, establishing and solidifying a connectionMatthew F Krummel
Department of Pathology, University of California at San Francisco, San Francisco, CA 94143 0511, USA
Curr Opin Immunol 14:66-74. 2002..This unexpected level of complexity of co-clustering and exclusion in the interface has generated much interest in the functional consequences of signaling and/or immune effector function... - T cell synapse assembly: proteins, motors and the underlying cell biologyAaron J Tooley
Department of Pathology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 93143-0511, USA
Semin Immunol 17:65-75. 2005..To this end, imaging-based genetic screens are now coming online to aid in identifying the ubiquitous proteins that function at polarized signaling surfaces... - New views of the immunological synapse: variations in assembly and functionJordan Jacobelli
Department of Pathology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0511, USA
Curr Opin Immunol 16:345-52. 2004..Although many details of the immunological synapse have been established, emerging evidence suggests a great variability in the ultimate form of these contacts and their effects on T-cell functions... - Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motilityAaron J Tooley
The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
Nat Cell Biol 11:17-26. 2009..These data suggest that septins tune actomyosin forces during motility and probably regulate lymphocyte trafficking in confined tissues... - Deletional tolerance mediated by extrathymic Aire-expressing cellsJames M Gardner
Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
Science 321:843-7. 2008..We propose that such a secondary network of self-antigen-expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection... - A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interactionCatherine A Sabatos
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143 0511, USA
Immunity 29:238-48. 2008..Thus, synapse-mediated cytokine delivery accelerates responses in activating T cells... - Surface-bound chemokines capture and prime T cells for synapse formationRachel S Friedman
The Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA
Nat Immunol 7:1101-8. 2006..However, chemokine-tethered T cells were hyper-responsive to subsequent contacts with antigen-presenting cells. Thus, T cells are costimulated 'in trans' and sequentially after initial engagement with their chemokine-rich environment... - Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migrationJordan Jacobelli
Department of Pathology, University of California San Francisco, San Francisco CA 94143, USA
J Immunol 182:2041-50. 2009..This can provide T lymphocytes with motile and adhesive properties that are uniquely suited toward alternative requirements for immune surveillance and response... - Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signalBrian T Fife
UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, California, USA
Nat Immunol 10:1185-92. 2009..Blockade of the immunomodulatory receptor CTLA-4 did not alter T cell motility or abrogate tolerance. Thus, PD-1-PD-L1 interactions maintain peripheral tolerance by mechanisms fundamentally distinct from those of CTLA-4... - Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinantsRachel S Friedman
Department of Pathology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0511, USA
Semin Immunol 17:387-99. 2005..Finally, we discuss how this interplay may give rise to unexpectedly complex motile and morphological behavior... - Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissuesKristin Melli
Department of Surgery, University of California, San Francisco, CA 94143, USA
J Immunol 182:2590-600. 2009..Therapeutic interventions that intercept this process may be effective at halting the progression of type 1 diabetes... - Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesionsJordan Jacobelli
Department of Pathology, University of California San Francisco, San Francisco, California, USA
Nat Immunol 11:953-61. 2010..Adhesion discrimination provided by myosin IIA is thus necessary for the optimization of motility through complex tissues... - Duration of antigen receptor signaling determines T-cell tolerance or activationShoshana D Katzman
Department of Pathology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 107:18085-90. 2010..These studies show that the duration of T cell-APC interactions and magnitude of associated TCR-mediated signaling are key determinants of lymphocyte tolerance vs. activation... - Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cellsAlusha A Mamchak
Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
J Immunol 181:5374-85. 2008..These data demonstrate that ablation of Fyn expression does not alter most Ag-driven CD4(+) T cell responses, with the exception of cytokine production, which under some circumstances is enhanced in Fyn-deficient CD4(+) T cells... - A single class II myosin modulates T cell motility and stopping, but not synapse formationJordan Jacobelli
Department of Pathology, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 93143, USA
Nat Immunol 5:531-8. 2004..Phosphorylation of MyH9 in its multimerization domain by T cell receptor-generated signals indicates that inactivation of this motor may be a key step in the 'stop' response during antigen recognition... - The importance of prolonged binding to antigen-presenting cells for T cell fate decisionsJohn J Engelhardt
Department of Pathology, University of California San Francisco, CA 94143 0511, USA
Immunity 28:143-5. 2008..2008) demonstrate profound effector and memory defects for CD8(+) T cells encountering "nonsticky" antigen-presenting cells lacking intercellular adhesion molecule-1... - Control of cortical rigidity by the cytoskeleton: emerging roles for septinsJulia Gilden
Department of Pathology, University of California at San Francisco, San Francisco, California 94143 0511, USA
Cytoskeleton (Hoboken) 67:477-86. 2010..Deficiencies and alterations in the nature of the septin cytoskeleton may thus be relevant in multiple disease settings... - Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cellsTakaharu Okada
Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California, USA
PLoS Biol 3:e150. 2005..These findings provide evidence of lymphocyte chemotaxis in vivo, and they begin to define the spatiotemporal cellular dynamics associated with T cell-dependent antibody responses... - Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formationWilliam C Moss
Department of Microbiology and Immunology, Stanford University School of Medicine and Howard Hughes Medical Institute, CA 94305, USA
Proc Natl Acad Sci U S A 99:15024-9. 2002..This method should permit the quantitation of other dynamic membrane events and the associated movement of cell-surface molecules... - Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulationLauren I Richie Ehrlich
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 17:809-22. 2002..Most surprisingly, we find an intracellular pool of lck associated with recycling endosomes that translocates to mature synapses within 10 min of calcium flux. This bolus of lck may contribute to intermediate-late signal transduction... - Triggering of T cell activation via CD4 dimersMaria Cristina Moldovan
Department of Microbiology and Immunology, McGill University, Montreal, Canada
J Immunol 176:5438-45. 2006..This supports a role for CD4 dimerization in maintaining active signaling machinery. We suggest that modulation of the dimer/monomer ratio may permit tuning of activation thresholds during initial engagement... - Testing the organization of the immunological synapseMatthew F Krummel
Curr Opin Immunol 19:460-2. 2007 - Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selectionLauren I Richie
Program in Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 16:595-606. 2002..This implicates differences in synapse geometry in initiation of alternate signals downstream of the TCR...
Research Grants
- Myosin Motors in T cell Synapse Formation and ActivationMatthew F Krummel; Fiscal Year: 2010..Here, we seek to understand how these cells control their movements, and how the mechanisms that make them move are changed when they sense dangers. ..
- Regulation of T cell Functions by the Breast Cancer MicroenvironmentMATTHEW KRUMMEL; Fiscal Year: 2009..Finally, and not insignificantly, they will shed considerable light upon a previously inaccessible cell population which may protect the tumor from the immune response and thus permit tumor growth and metastasis. ..
- Myosin Motors in T cell Synapse Formation and ActivationMATTHEW KRUMMEL; Fiscal Year: 2009..Here, we seek to understand how these cells control their movements, and how the mechanisms that make them move are changed when they sense dangers. ..
- Imaging-Based Analysis of Tolerance-Induction MechanismsMATTHEW KRUMMEL; Fiscal Year: 2006....
- Myosin Motors in T cell Synapse Formation and ActivationMATTHEW KRUMMEL; Fiscal Year: 2006..These studies will not only provide fundamental information about the initial steps in lymphocyte activation, but may also lead to clues about ways to manipulate T cell responses in vitro and in vivo. ..
- Regulation of T cell Functions by the Breast Cancer MicroenvironmentMatthew F Krummel; Fiscal Year: 2010..Finally, and not insignificantly, they will shed considerable light upon a previously inaccessible cell population which may protect the tumor from the immune response and thus permit tumor growth and metastasis. ..