MATTHEW KRUMMEL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions
    Jordan Jacobelli
    Department of Pathology, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 11:953-61. 2010
  2. pmc Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility
    Aaron J Tooley
    The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
    Nat Cell Biol 11:17-26. 2009
  3. pmc Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung
    Emily E Thornton
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 209:1183-99. 2012
  4. pmc The septin cytoskeleton facilitates membrane retraction during motility and blebbing
    Julia K Gilden
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 196:103-14. 2012
  5. pmc Regulation of T cell priming by lymphoid stroma
    Omar Khan
    Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e26138. 2011
  6. pmc Stabilized imaging of immune surveillance in the mouse lung
    Mark R Looney
    Departments of Medicine and Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA
    Nat Methods 8:91-6. 2011
  7. pmc Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics
    Rachel S Friedman
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:2733-49. 2010
  8. ncbi request reprint Maintenance and modulation of T cell polarity
    Matthew F Krummel
    Department of Pathology, University of California at San Francisco, San Francisco, California 94143 0511, USA
    Nat Immunol 7:1143-9. 2006
  9. pmc The immunological synapse: a dynamic platform for local signaling
    Matthew F Krummel
    Department of Pathology, University of California San Francisco, 513 Parnassus Avenue HSW 0511, San Francisco, CA 94143, USA
    J Clin Immunol 30:364-72. 2010
  10. ncbi request reprint Immunological synapses: breaking up may be good to do
    Matthew F Krummel
    The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
    Cell 129:653-5. 2007

Collaborators

Detail Information

Publications36

  1. pmc Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions
    Jordan Jacobelli
    Department of Pathology, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 11:953-61. 2010
    ..Adhesion discrimination provided by myosin IIA is thus necessary for the optimization of motility through complex tissues...
  2. pmc Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility
    Aaron J Tooley
    The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
    Nat Cell Biol 11:17-26. 2009
    ..These data suggest that septins tune actomyosin forces during motility and probably regulate lymphocyte trafficking in confined tissues...
  3. pmc Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung
    Emily E Thornton
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 209:1183-99. 2012
    ....
  4. pmc The septin cytoskeleton facilitates membrane retraction during motility and blebbing
    Julia K Gilden
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 196:103-14. 2012
    ..This function of septins in assembling on an unstable cortex and retracting aberrantly protruding membranes explains the excessive blebbing and protrusion observed in septin-deficient T cells...
  5. pmc Regulation of T cell priming by lymphoid stroma
    Omar Khan
    Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e26138. 2011
    ..Stromal feedback inhibition thus provides basal attenuation of T cell responses, particularly those characterized by strong local inflammatory cues...
  6. pmc Stabilized imaging of immune surveillance in the mouse lung
    Mark R Looney
    Departments of Medicine and Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA
    Nat Methods 8:91-6. 2011
    ..The system permits physiological measurement of motility rates of >1 mm s(-1), observation of detailed cellular morphology and could be applied in the future to other organs and tissues while maintaining intact physiology...
  7. pmc Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics
    Rachel S Friedman
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:2733-49. 2010
    ..Short-lived antigen-independent TCR clustering was also occasionally observed. These in vivo observations demonstrate that varied TCR trafficking and cell arrest dynamics occur during early T cell activation...
  8. ncbi request reprint Maintenance and modulation of T cell polarity
    Matthew F Krummel
    Department of Pathology, University of California at San Francisco, San Francisco, California 94143 0511, USA
    Nat Immunol 7:1143-9. 2006
    ..Ultimately, the strength of a T cell response may rely on correct T cell polarization. Therefore, loss of polarity regulators or guidance cues may interfere with T cell activation...
  9. pmc The immunological synapse: a dynamic platform for local signaling
    Matthew F Krummel
    Department of Pathology, University of California San Francisco, 513 Parnassus Avenue HSW 0511, San Francisco, CA 94143, USA
    J Clin Immunol 30:364-72. 2010
    ..The entire process of IS formation and extinction is now known to entail a dynamic reorganization of membrane domains and proteins within and adjacent to those domains...
  10. ncbi request reprint Immunological synapses: breaking up may be good to do
    Matthew F Krummel
    The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
    Cell 129:653-5. 2007
    ..They also show that re-establishment of a synapse involves the actin regulator WASp...
  11. ncbi request reprint CD28 signals in the immature immunological synapse
    Pietro G Andres
    Department of Pathology, and Division of Gastroenterology, University of California, San Francisco, CA 93143, USA
    J Immunol 172:5880-6. 2004
    ..Together, the data show that CD28 functions in the immunological synapse before the formation of the c-SMAC...
  12. pmc Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
    Qizhi Tang
    Diabetes Center, Department of Medicine, University of California, San Francisco 94143, USA
    Nat Immunol 7:83-92. 2006
    ..Such persistent T(reg) cell-dendritic cell contacts preceded the inhibition of T(H) cell activation by dendritic cells, supporting the idea that dendritic cells are central to T(reg) cell function in vivo...
  13. ncbi request reprint Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites
    Judie Boisvert
    Department of Pathology, University of California, San Francisco, CA 94143, USA
    J Immunol 173:3647-52. 2004
    ..It may also serve as a site for these molecular aggregates to coassociate and/or internalize alongside other signaling receptors...
  14. doi request reprint Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses
    Andrew Bullen
    Department of Pathology and Biological Imaging Development Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
    Curr Top Microbiol Immunol 334:1-29. 2009
    ....
  15. pmc Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy
    Mikala Egeblad
    Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Dis Model Mech 1:155-67; discussion 165. 2008
    ..The techniques are not limited to investigations in cancer, but could give new insights into cell behavior more broadly in development and disease...
  16. ncbi request reprint Dynamics of the immunological synapse: finding, establishing and solidifying a connection
    Matthew F Krummel
    Department of Pathology, University of California at San Francisco, San Francisco, CA 94143 0511, USA
    Curr Opin Immunol 14:66-74. 2002
    ..This unexpected level of complexity of co-clustering and exclusion in the interface has generated much interest in the functional consequences of signaling and/or immune effector function...
  17. ncbi request reprint New views of the immunological synapse: variations in assembly and function
    Jordan Jacobelli
    Department of Pathology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0511, USA
    Curr Opin Immunol 16:345-52. 2004
    ..Although many details of the immunological synapse have been established, emerging evidence suggests a great variability in the ultimate form of these contacts and their effects on T-cell functions...
  18. ncbi request reprint T cell synapse assembly: proteins, motors and the underlying cell biology
    Aaron J Tooley
    Department of Pathology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 93143 0511, USA
    Semin Immunol 17:65-75. 2005
    ..To this end, imaging-based genetic screens are now coming online to aid in identifying the ubiquitous proteins that function at polarized signaling surfaces...
  19. ncbi request reprint A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction
    Catherine A Sabatos
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143 0511, USA
    Immunity 29:238-48. 2008
    ..Thus, synapse-mediated cytokine delivery accelerates responses in activating T cells...
  20. ncbi request reprint Surface-bound chemokines capture and prime T cells for synapse formation
    Rachel S Friedman
    The Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA
    Nat Immunol 7:1101-8. 2006
    ..However, chemokine-tethered T cells were hyper-responsive to subsequent contacts with antigen-presenting cells. Thus, T cells are costimulated 'in trans' and sequentially after initial engagement with their chemokine-rich environment...
  21. pmc Deletional tolerance mediated by extrathymic Aire-expressing cells
    James M Gardner
    Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
    Science 321:843-7. 2008
    ..We propose that such a secondary network of self-antigen-expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection...
  22. pmc Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal
    Brian T Fife
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, California, USA
    Nat Immunol 10:1185-92. 2009
    ..Blockade of the immunomodulatory receptor CTLA-4 did not alter T cell motility or abrogate tolerance. Thus, PD-1-PD-L1 interactions maintain peripheral tolerance by mechanisms fundamentally distinct from those of CTLA-4...
  23. doi request reprint Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration
    Jordan Jacobelli
    Department of Pathology, University of California San Francisco, San Francisco CA 94143, USA
    J Immunol 182:2041-50. 2009
    ..This can provide T lymphocytes with motile and adhesive properties that are uniquely suited toward alternative requirements for immune surveillance and response...
  24. ncbi request reprint Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants
    Rachel S Friedman
    Department of Pathology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0511, USA
    Semin Immunol 17:387-99. 2005
    ..Finally, we discuss how this interplay may give rise to unexpectedly complex motile and morphological behavior...
  25. ncbi request reprint A single class II myosin modulates T cell motility and stopping, but not synapse formation
    Jordan Jacobelli
    Department of Pathology, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 93143, USA
    Nat Immunol 5:531-8. 2004
    ..Phosphorylation of MyH9 in its multimerization domain by T cell receptor-generated signals indicates that inactivation of this motor may be a key step in the 'stop' response during antigen recognition...
  26. pmc Duration of antigen receptor signaling determines T-cell tolerance or activation
    Shoshana D Katzman
    Department of Pathology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:18085-90. 2010
    ..These studies show that the duration of T cell-APC interactions and magnitude of associated TCR-mediated signaling are key determinants of lymphocyte tolerance vs. activation...
  27. doi request reprint The importance of prolonged binding to antigen-presenting cells for T cell fate decisions
    John J Engelhardt
    Department of Pathology, University of California San Francisco, CA 94143 0511, USA
    Immunity 28:143-5. 2008
    ..2008) demonstrate profound effector and memory defects for CD8(+) T cells encountering "nonsticky" antigen-presenting cells lacking intercellular adhesion molecule-1...
  28. pmc Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells
    Alusha A Mamchak
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 181:5374-85. 2008
    ..These data demonstrate that ablation of Fyn expression does not alter most Ag-driven CD4(+) T cell responses, with the exception of cytokine production, which under some circumstances is enhanced in Fyn-deficient CD4(+) T cells...
  29. pmc Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues
    Kristin Melli
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Immunol 182:2590-600. 2009
    ..Therapeutic interventions that intercept this process may be effective at halting the progression of type 1 diabetes...
  30. pmc Control of cortical rigidity by the cytoskeleton: emerging roles for septins
    Julia Gilden
    Department of Pathology, University of California at San Francisco, San Francisco, California 94143 0511, USA
    Cytoskeleton (Hoboken) 67:477-86. 2010
    ..Deficiencies and alterations in the nature of the septin cytoskeleton may thus be relevant in multiple disease settings...
  31. pmc Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    Takaharu Okada
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California, USA
    PLoS Biol 3:e150. 2005
    ..These findings provide evidence of lymphocyte chemotaxis in vivo, and they begin to define the spatiotemporal cellular dynamics associated with T cell-dependent antibody responses...
  32. ncbi request reprint Triggering of T cell activation via CD4 dimers
    Maria Cristina Moldovan
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    J Immunol 176:5438-45. 2006
    ..This supports a role for CD4 dimerization in maintaining active signaling machinery. We suggest that modulation of the dimer/monomer ratio may permit tuning of activation thresholds during initial engagement...
  33. ncbi request reprint Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation
    Lauren I Richie Ehrlich
    Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 17:809-22. 2002
    ..Most surprisingly, we find an intracellular pool of lck associated with recycling endosomes that translocates to mature synapses within 10 min of calcium flux. This bolus of lck may contribute to intermediate-late signal transduction...
  34. pmc Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation
    William C Moss
    Department of Microbiology and Immunology, Stanford University School of Medicine and Howard Hughes Medical Institute, CA 94305, USA
    Proc Natl Acad Sci U S A 99:15024-9. 2002
    ..This method should permit the quantitation of other dynamic membrane events and the associated movement of cell-surface molecules...
  35. ncbi request reprint Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection
    Lauren I Richie
    Program in Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 16:595-606. 2002
    ..This implicates differences in synapse geometry in initiation of alternate signals downstream of the TCR...
  36. pmc Testing the organization of the immunological synapse
    Matthew F Krummel
    Curr Opin Immunol 19:460-2. 2007

Research Grants13

  1. Myosin Motors in T cell Synapse Formation and Activation
    MATTHEW KRUMMEL; Fiscal Year: 2002
    ..These studies will not only provide fundamental information about the initial steps in lymphocyte activation, but may also lead to clues about ways to manipulate T cell responses in vitro and in vivo. ..
  2. Myosin Motors in T cell Synapse Formation and Activation
    Matthew F Krummel; Fiscal Year: 2010
    ..Here, we seek to understand how these cells control their movements, and how the mechanisms that make them move are changed when they sense dangers. ..
  3. Myosin Motors in T cell Synapse Formation and Activation
    MATTHEW KRUMMEL; Fiscal Year: 2009
    ..Here, we seek to understand how these cells control their movements, and how the mechanisms that make them move are changed when they sense dangers. ..
  4. Imaging-Based Analysis of Tolerance-Induction Mechanisms
    MATTHEW KRUMMEL; Fiscal Year: 2006
    ....
  5. Myosin Motors in T cell Synapse Formation and Activation
    MATTHEW KRUMMEL; Fiscal Year: 2004
    ..These studies will not only provide fundamental information about the initial steps in lymphocyte activation, but may also lead to clues about ways to manipulate T cell responses in vitro and in vivo. ..
  6. Myosin Motors in T cell Synapse Formation and Activation
    MATTHEW KRUMMEL; Fiscal Year: 2003
    ..These studies will not only provide fundamental information about the initial steps in lymphocyte activation, but may also lead to clues about ways to manipulate T cell responses in vitro and in vivo. ..
  7. Myosin Motors in T cell Synapse Formation and Activation
    MATTHEW KRUMMEL; Fiscal Year: 2006
    ..These studies will not only provide fundamental information about the initial steps in lymphocyte activation, but may also lead to clues about ways to manipulate T cell responses in vitro and in vivo. ..
  8. Myosin Motors in T cell Synapse Formation and Activation
    MATTHEW KRUMMEL; Fiscal Year: 2005
    ..These studies will not only provide fundamental information about the initial steps in lymphocyte activation, but may also lead to clues about ways to manipulate T cell responses in vitro and in vivo. ..
  9. Myosin Motors in T cell Synapse Formation and Activation
    MATTHEW KRUMMEL; Fiscal Year: 2004
    ..These studies will not only provide fundamental information about the initial steps in lymphocyte activation, but may also lead to clues about ways to manipulate T cell responses in vitro and in vivo. ..
  10. Regulation of T cell Functions by the Breast Cancer Microenvironment
    MATTHEW KRUMMEL; Fiscal Year: 2009
    ..Finally, and not insignificantly, they will shed considerable light upon a previously inaccessible cell population which may protect the tumor from the immune response and thus permit tumor growth and metastasis. ..
  11. Regulation of T cell Functions by the Breast Cancer Microenvironment
    Matthew F Krummel; Fiscal Year: 2010
    ..Finally, and not insignificantly, they will shed considerable light upon a previously inaccessible cell population which may protect the tumor from the immune response and thus permit tumor growth and metastasis. ..