JOHN KROLEWSKI

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc In vivo MRI volumetric measurement of prostate regression and growth in mice
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA
    BMC Urol 7:12. 2007
  2. ncbi request reprint Cytokine and growth factor receptors in the nucleus: what's up with that?
    John J Krolewski
    Department of Pathology and Laboratory Medicine, Chao Family Comprehensive Cancer Center, College of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    J Cell Biochem 95:478-87. 2005
  3. ncbi request reprint Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate
    Kent L Nastiuk
    Department of Pathology, College of Medicine, University of California, Irvine, USA
    J Cell Physiol 196:386-93. 2003
  4. doi request reprint FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Irvine, Medical Sciences I D450, Irvine, CA 92697 4800, USA
    Mol Cancer Res 6:231-42. 2008
  5. pmc Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9
    Ashraf El Fiky
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA 92679, United States
    Cell Signal 20:1400-8. 2008
  6. ncbi request reprint FLIP-ping out: death receptor signaling in the prostate
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Cancer Biol Ther 7:1171-9. 2008
  7. pmc TNF is necessary for castration-induced prostate regression, whereas TRAIL and FasL are dispensable
    Jennifer S Davis
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Mol Endocrinol 25:611-20. 2011
  8. ncbi request reprint Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling
    Vinh Phuc Nguyen
    Department of Pathology and the Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 277:9713-21. 2002
  9. doi request reprint Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cells
    Kiwon S Yoo
    Department of Pathology and Laboratory Medicine, Medical Sciences I D450, University of California, Irvine, Irvine, CA 92697 4800, USA
    Int J Cancer 124:834-42. 2009

Research Grants

Collaborators

  • David Danielpour
  • Kent L Nastiuk
  • Jennifer S Davis
  • Kiwon S Yoo
  • Kiwon Yoo
  • Ashraf El Fiky
  • Vinh Phuc Nguyen
  • Arif Azam
  • Pete Pioli
  • Karen Lo
  • Kevin Su
  • Patricia Yeung
  • Julia Kutaka
  • L Tugan Muftuler
  • Hui Liu
  • Orhan Nalcioglu
  • Mark Hamamura
  • John W Kim
  • Mana Mann
  • John Kim
  • Abu Z M Saleh
  • Hai Yan
  • Allison E Arch
  • Flavia Piazza

Detail Information

Publications9

  1. pmc In vivo MRI volumetric measurement of prostate regression and growth in mice
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA
    BMC Urol 7:12. 2007
    ..Temporal monitoring of mouse prostate regression requires multiple animals and examination of histological sections...
  2. ncbi request reprint Cytokine and growth factor receptors in the nucleus: what's up with that?
    John J Krolewski
    Department of Pathology and Laboratory Medicine, Chao Family Comprehensive Cancer Center, College of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    J Cell Biochem 95:478-87. 2005
    ....
  3. ncbi request reprint Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate
    Kent L Nastiuk
    Department of Pathology, College of Medicine, University of California, Irvine, USA
    J Cell Physiol 196:386-93. 2003
    ..By acting as an inhibitor of caspase-8, FLIP may protect prostatic epithelium from apoptosis. Androgen withdrawal, by reducing FLIP mRNA levels, might leave the cells vulnerable to as yet unidentified cell death signals...
  4. doi request reprint FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Irvine, Medical Sciences I D450, Irvine, CA 92697 4800, USA
    Mol Cancer Res 6:231-42. 2008
    ....
  5. pmc Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9
    Ashraf El Fiky
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA 92679, United States
    Cell Signal 20:1400-8. 2008
    ..Overall, the data suggest that liberation of the IFNaR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor Stat2 to the nucleus...
  6. ncbi request reprint FLIP-ping out: death receptor signaling in the prostate
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Cancer Biol Ther 7:1171-9. 2008
    ..However, it is not yet known which of the death receptor pathways is required for prostate apoptosis in vivo, and this remains an active topic of research...
  7. pmc TNF is necessary for castration-induced prostate regression, whereas TRAIL and FasL are dispensable
    Jennifer S Davis
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Mol Endocrinol 25:611-20. 2011
    ..These findings support a physiologic role for TNF in prostate regression after androgen withdrawal. Understanding this role may lead to novel therapies for prostate cancer...
  8. ncbi request reprint Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling
    Vinh Phuc Nguyen
    Department of Pathology and the Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 277:9713-21. 2002
    ....
  9. doi request reprint Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cells
    Kiwon S Yoo
    Department of Pathology and Laboratory Medicine, Medical Sciences I D450, University of California, Irvine, Irvine, CA 92697 4800, USA
    Int J Cancer 124:834-42. 2009
    ..Furthermore, inhibition of caspase-8 by siRNA knockdown partially rescued the apoptotic effects of TGFbeta1, suggesting a role for death receptor signaling components in TGFbeta-mediated death of prostate epithelial cells...

Research Grants10

  1. TYK2 TYROSINE KINASE--NORMAL AND PATHOLOGIC FUNCTION
    JOHN KROLEWSKI; Fiscal Year: 1999
    ....
  2. Signaling via proteolysis of the interferon receptor
    JOHN KROLEWSKI; Fiscal Year: 2007
    ..Finally, aim 4 addresses the mechanism of ICD mediated gene regulation by testing the hypothesis that the ICD functions in a complex with Stat2 and Irf9 to regulate gene transcription. ..
  3. TYK2 AND IFNAR1 IN INTERFERON ALPHA SIGNALING
    JOHN KROLEWSKI; Fiscal Year: 2004
    ..3. Identify additional IFNaR1-interacting proteins which regulate IFNalpha signaling. 4. Investigate the role of CIS proteins in the regulation of the Tyk2 kinase and/or the IFNaR1 subunit. ..
  4. Signaling via proteolysis of the interferon receptor
    JOHN KROLEWSKI; Fiscal Year: 2009
    ..Finally, aim 4 addresses the mechanism of ICD mediated gene regulation by testing the hypothesis that the ICD functions in a complex with Stat2 and Irf9 to regulate gene transcription. ..